Affiliation: Frankfurt am Main
- Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patientsAlexander Koch
Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, JW Goethe University Hospital, Theodor Stern Kai 7, Frankfurt am Main 60590, Germany
Crit Care 15:R109. 2011..To investigate the link to systemic inflammation in this context, we additionally measured 10 different cytokines in the serum...
- Attenuation of myocardial injury by HMGB1 blockade during ischemia/reperfusion is toll-like receptor 2-dependentJan Mersmann
Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Mediators Inflamm 2013:174168. 2013..We here provide evidence that absence of TLR2 signalling abrogates infarct-sparing effects of HMGB1 blockade...
- Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemiaWaltraud Pfeilschifter
Department of Neurology, University Hospital, Goethe University Frankfurt
Biochem Biophys Res Commun 413:212-7. 2011..This suggests that SphK2 activity is an important endogenous protective mechanism in cerebral ischemia and corroborates that the protective effect of FTY720 is mediated via phospho-FTY720...
- Systemic inflammation after aortic cross clamping is influenced by Toll-like receptor 2 preconditioning and deficiencyAlexander Koch
Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt, Germany
J Surg Res 178:833-41. 2012..The influence of TLR2 stimulation or deficiency on systemic cytokine release and organ damage after aortic cross clamping has not been evaluated yet...