Genomes and Genes
Affiliation: Frankfurt am Main
- Mechanical stretch induces clustering of beta1-integrins and facilitates adhesionYvonne Knies
Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Exp Dermatol 15:347-55. 2006..In summary, these results show a functional cooperation of beta1-integrins and EGFR in the adhesion complex supporting the transmission of stretch-induced signals...
- Restoration of E-cadherin sensitizes human melanoma cells for apoptosisStefan Kippenberger
Department of Dermatology, Division of Pneumology, University of Frankfurt Medical School, Frankfurt Main, Germany
Melanoma Res 16:393-403. 2006..In conclusion, our findings suggest therapeutic strategies that enable expression of E-cadherin in order to sensitize human melanoma cells towards apoptosis...
- Detection of human beta defensin-1 and -2 by RT-competitive multiplex PCRStefan Kippenberger
Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
Arch Dermatol Res 296:539-42. 2005..RT-competitive multiplex PCR is a simple and accurate method that enables new insights into defensin regulation under physiological and pathophysiological conditions...
- Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytesStefan Kippenberger
Department of Dermatology and Venerology, J W Goethe University, 60590 Frankfurt Main, Germany
Nucleic Acids Res 37:3850-64. 2009..In summary the present data demonstrate DNA as a modulator of apoptosis which specifically targets skin epithelial cells...
- Hypotonic stress induces E-cadherin expression in cultured human keratinocytesStefan Kippenberger
Department of Dermatology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
FEBS Lett 579:207-14. 2005..It is likely that induction of E-cadherin contributes to the stabilization between adjacent cells in order to withstand the physical forces induced by hypotonicity...
- Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filamentStefan Kippenberger
Department of Dermatology and Venerology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
Biochim Biophys Acta 1803:940-50. 2010..Taken together our data define a new model of beta4-dependent PKB/Akt and ERK1/2 activation demonstrating the keratin filament as a structure necessary in signal transmission...
- Ligation of the beta4 integrin triggers adhesion behavior of human keratinocytes by an "inside-out" mechanismStefan Kippenberger
Zentrum der Dermatologie und Venerologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
J Invest Dermatol 123:444-51. 2004..Hence, these findings provide further insight into the conversion processes during carcinogenesis and show the beta(4) integrin to be a key regulator of cellular adhesion...
- Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammationS Kippenberger
Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt Main, Germany
J Invest Dermatol 117:1430-6. 2001..This work suggests the possibility of PPAR-alpha activators as novel nonsteroidal anti-inflammatory drugs in the topical treatment of common inflammatory skin diseases such as atopic dermatitis, psoriasis, and photodermatitis...
- Melanocytes respond to mechanical stretch by activation of mitogen-activated protein kinases (MAPK)S Kippenberger
Department of Dermatology and Venerology, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
Pigment Cell Res 13:278-80. 2000..The different kinetics of both MAPK suggest that different signalling cascades were activated. Future studies should evaluate the relevance of stretch-dependent MAPK activation in triggering the cell proliferation...
- Signaling of mechanical stretch in human keratinocytes via MAP kinasesS Kippenberger
Department of Dermatology and Venerology, University Hospital, Frankfurt Main, Germany
J Invest Dermatol 114:408-12. 2000..It is likely that alterations of skin mechanics in vivo underlying pathogenic processes like wound formation and healing trigger physiologic responses via the MAP kinase pathway...
- Cyclic stretch up-regulates proliferation and heat shock protein 90 expression in human melanocytesS Kippenberger
Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
Pigment Cell Res 12:246-51. 1999..These findings have strong implications for the in vitro cultivation of melanocytes for transplantation purposes...
- Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormonesS Kippenberger
Department of Dermatology, Klinikum der Johann Wolfgang, Goethe Univesität, Frankfurt Main, Germany
J Invest Dermatol 110:364-7. 1998..We therefore suggest that hyperpigmentation during pregnancy or under contraceptive treatment is mediated by a direct induction of melanogenesis via sex steroids...
- Candida albicans suppresses transcription of melanogenesis enzymes in cultured melanocytesS Kippenberger
Abteilung 1, , Frankfurt Main, Germany
Mycoses 40:373-5. 1997..Reverse transcription polymerase chain reaction (RT-PCR) analysis gives evidence that Candida albicans suppresses the transcription of melanogenesis enzymes...
- Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralenA Bernd
Department of Dermatology, Clinical Hospital of the J W Goethe University, Frankfurt, Germany
Photochem Photobiol 69:218-21. 1999..These results confirm the phototoxic activity of Hypericum extract on human keratinocytes. However, the blood levels that are to be expected during antidepressive therapy are presumably too low to induce phototoxic skin reactions...
- Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?M Schuster
Department of Dermatology, Venereology and Allergology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
Br J Dermatol 164:182-6. 2011..As peroxisome proliferator-activated receptors (PPARs) are known to control lipid metabolism in several human tissues they have been considered to be involved in the pathogenesis of acne vulgaris...
- Levels of dopachrome tautomerase in human melanocytes cultured in vitroA Bernd
Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
Melanoma Res 4:287-91. 1994..Finally, the low level of DCT activity found in normal human melanocytes cultured in vitro cannot be explained by any of the necessary stimulatory factors added to the cell culture media...
- [Dermatobia hominis infection in a 3-year-old child]M Meissner
Klinik fur Dermatologie, Venerologie und Allergologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt am Main, Deutschland
Hautarzt 63:325-8. 2012..Botflies are mainly encountered in Central and South America; they should be considered if patients demonstrate a furuncle-like lesion and have returned from a holiday in these endemic regions...
- Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase CMatthias Hofmann
Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, D 60590 Frankfurt Main, Germany
Biochem Biophys Res Commun 316:673-9. 2004..These findings suggest mechanical pressure as a new type of effector stimulus for the p38 pathway with implications to (patho-) physiological conditions...
- Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptorStefan Kippenberger
Department of Dermatology, University of Frankfurt Medical School, D 60596 FrankfurtMain, Germany
J Biol Chem 280:3060-7. 2005..Evidence is provided that stretch-induced activation of PKB/Akt protects cells against induced apoptosis...
- Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin modelNadja Nicole Zöller
Department of Dermatology and Venerology, J W Goethe University, Medical School, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
Toxicol In Vitro 22:747-59. 2008..The present study demonstrates the versatility of this FTSM in the validation of effectiveness and safety of GCs...
- Influence of different ECM mimetic peptide sequences embedded in a nonfouling environment on the specific adhesion of human-skin keratinocytes and fibroblasts on deformable substratesJochen Salber
DWI an der RWTH Aachen e V Pauwelsstr 8, 52074 Aachen, Germany
Small 3:1023-31. 2007..Thus we present a new toolbox that allows for the detailed analysis of the adhesion of human-skin-derived cells on structurally and biochemically decorated deformable substrates...
- Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible lightJadranka Dujic
Department of Dermatology and Venerology, Medical School, J W Goethe University, Frankfurt Main, Germany
J Invest Dermatol 127:1992-2000. 2007..In particular, the latter avoids the use of carcinogenic irradiation that is part of regular phototherapy...
- Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expressionMatthias Hofmann
Department of Dermatology and Venerology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
J Biomech 40:2324-9. 2007..While a singular puncture had no effect catheterized tumours showed a significant decrease in Ki-67 expression. Our data suggest that long-term lowering of TIFP is required to reduce tumour proliferation...
- Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor modelMatthias Hofmann
Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, Frankfurt Main D 60590, Germany
Neoplasia 8:89-95. 2006..These data suggest that the mechanical stretch induced by TIFP is a positive modulator of tumor proliferation...
- Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivoAnnette Dorn
Department of Dermatology and Venerology, J W Goethe University, Frankfurt Main, Germany
J Invest Dermatol 127:846-54. 2007..This effect seems to be independent from Toll-like receptor 9...