S Kippenberger

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Mechanical stretch induces clustering of beta1-integrins and facilitates adhesion
    Yvonne Knies
    Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany
    Exp Dermatol 15:347-55. 2006
  2. ncbi Restoration of E-cadherin sensitizes human melanoma cells for apoptosis
    Stefan Kippenberger
    Department of Dermatology, Division of Pneumology, University of Frankfurt Medical School, Frankfurt Main, Germany
    Melanoma Res 16:393-403. 2006
  3. ncbi Detection of human beta defensin-1 and -2 by RT-competitive multiplex PCR
    Stefan Kippenberger
    Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Arch Dermatol Res 296:539-42. 2005
  4. ncbi Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes
    Stefan Kippenberger
    Department of Dermatology and Venerology, J W Goethe University, 60590 Frankfurt Main, Germany
    Nucleic Acids Res 37:3850-64. 2009
  5. ncbi Hypotonic stress induces E-cadherin expression in cultured human keratinocytes
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    FEBS Lett 579:207-14. 2005
  6. ncbi Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament
    Stefan Kippenberger
    Department of Dermatology and Venerology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    Biochim Biophys Acta 1803:940-50. 2010
  7. ncbi Ligation of the beta4 integrin triggers adhesion behavior of human keratinocytes by an "inside-out" mechanism
    Stefan Kippenberger
    Zentrum der Dermatologie und Venerologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    J Invest Dermatol 123:444-51. 2004
  8. ncbi Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation
    S Kippenberger
    Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt Main, Germany
    J Invest Dermatol 117:1430-6. 2001
  9. ncbi Melanocytes respond to mechanical stretch by activation of mitogen-activated protein kinases (MAPK)
    S Kippenberger
    Department of Dermatology and Venerology, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Pigment Cell Res 13:278-80. 2000
  10. ncbi Signaling of mechanical stretch in human keratinocytes via MAP kinases
    S Kippenberger
    Department of Dermatology and Venerology, University Hospital, Frankfurt Main, Germany
    J Invest Dermatol 114:408-12. 2000

Collaborators

  • A Bernd
  • Roland Kaufmann
  • J Muller
  • Matthias Hofmann
  • F Solano
  • D Thaci
  • J Bereiter-Hahn
  • C C Zouboulis
  • H Wiig
  • Jadranka Dujic
  • M Meissner
  • M Schuster
  • Nadja Nicole Zöller
  • Annette Dorn
  • Jurgen Bereiter Hahn
  • Jochen Salber
  • Yvonne Knies
  • E M Valesky
  • F Ochsendorf
  • Karsten Mewes
  • Martina Spiegel
  • Maike Schultz
  • Andrea Sättler
  • Jiandong Ding
  • Ralf Joachim Ludwig
  • Joquin Diaz-Alperi
  • Joquin Diaz Alperi
  • Katja Hardt
  • Stephanie Hoffmann
  • Joachim P Spatz
  • Ana Ramirez Bosca
  • Stefan Gräter
  • Huang Jinghuan
  • Doris Klee
  • Jürgen Groll
  • Martin Möller
  • Marc Harwardt
  • Ana Ramirez-Bosca
  • Andreas Bock
  • Jaime Miquel

Detail Information

Publications25

  1. ncbi Mechanical stretch induces clustering of beta1-integrins and facilitates adhesion
    Yvonne Knies
    Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany
    Exp Dermatol 15:347-55. 2006
    ..In summary, these results show a functional cooperation of beta1-integrins and EGFR in the adhesion complex supporting the transmission of stretch-induced signals...
  2. ncbi Restoration of E-cadherin sensitizes human melanoma cells for apoptosis
    Stefan Kippenberger
    Department of Dermatology, Division of Pneumology, University of Frankfurt Medical School, Frankfurt Main, Germany
    Melanoma Res 16:393-403. 2006
    ..In conclusion, our findings suggest therapeutic strategies that enable expression of E-cadherin in order to sensitize human melanoma cells towards apoptosis...
  3. ncbi Detection of human beta defensin-1 and -2 by RT-competitive multiplex PCR
    Stefan Kippenberger
    Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Arch Dermatol Res 296:539-42. 2005
    ..RT-competitive multiplex PCR is a simple and accurate method that enables new insights into defensin regulation under physiological and pathophysiological conditions...
  4. ncbi Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes
    Stefan Kippenberger
    Department of Dermatology and Venerology, J W Goethe University, 60590 Frankfurt Main, Germany
    Nucleic Acids Res 37:3850-64. 2009
    ..In summary the present data demonstrate DNA as a modulator of apoptosis which specifically targets skin epithelial cells...
  5. ncbi Hypotonic stress induces E-cadherin expression in cultured human keratinocytes
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    FEBS Lett 579:207-14. 2005
    ..It is likely that induction of E-cadherin contributes to the stabilization between adjacent cells in order to withstand the physical forces induced by hypotonicity...
  6. ncbi Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament
    Stefan Kippenberger
    Department of Dermatology and Venerology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    Biochim Biophys Acta 1803:940-50. 2010
    ..Taken together our data define a new model of beta4-dependent PKB/Akt and ERK1/2 activation demonstrating the keratin filament as a structure necessary in signal transmission...
  7. ncbi Ligation of the beta4 integrin triggers adhesion behavior of human keratinocytes by an "inside-out" mechanism
    Stefan Kippenberger
    Zentrum der Dermatologie und Venerologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    J Invest Dermatol 123:444-51. 2004
    ..Hence, these findings provide further insight into the conversion processes during carcinogenesis and show the beta(4) integrin to be a key regulator of cellular adhesion...
  8. ncbi Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation
    S Kippenberger
    Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt Main, Germany
    J Invest Dermatol 117:1430-6. 2001
    ..This work suggests the possibility of PPAR-alpha activators as novel nonsteroidal anti-inflammatory drugs in the topical treatment of common inflammatory skin diseases such as atopic dermatitis, psoriasis, and photodermatitis...
  9. ncbi Melanocytes respond to mechanical stretch by activation of mitogen-activated protein kinases (MAPK)
    S Kippenberger
    Department of Dermatology and Venerology, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Pigment Cell Res 13:278-80. 2000
    ..The different kinetics of both MAPK suggest that different signalling cascades were activated. Future studies should evaluate the relevance of stretch-dependent MAPK activation in triggering the cell proliferation...
  10. ncbi Signaling of mechanical stretch in human keratinocytes via MAP kinases
    S Kippenberger
    Department of Dermatology and Venerology, University Hospital, Frankfurt Main, Germany
    J Invest Dermatol 114:408-12. 2000
    ..It is likely that alterations of skin mechanics in vivo underlying pathogenic processes like wound formation and healing trigger physiologic responses via the MAP kinase pathway...
  11. ncbi Cyclic stretch up-regulates proliferation and heat shock protein 90 expression in human melanocytes
    S Kippenberger
    Department of Dermatology and Venerology, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Pigment Cell Res 12:246-51. 1999
    ..These findings have strong implications for the in vitro cultivation of melanocytes for transplantation purposes...
  12. ncbi Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones
    S Kippenberger
    Department of Dermatology, Klinikum der Johann Wolfgang, Goethe Univesität, Frankfurt Main, Germany
    J Invest Dermatol 110:364-7. 1998
    ..We therefore suggest that hyperpigmentation during pregnancy or under contraceptive treatment is mediated by a direct induction of melanogenesis via sex steroids...
  13. ncbi Candida albicans suppresses transcription of melanogenesis enzymes in cultured melanocytes
    S Kippenberger
    Abteilung 1, , Frankfurt Main, Germany
    Mycoses 40:373-5. 1997
    ..Reverse transcription polymerase chain reaction (RT-PCR) analysis gives evidence that Candida albicans suppresses the transcription of melanogenesis enzymes...
  14. ncbi Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralen
    A Bernd
    Department of Dermatology, Clinical Hospital of the J W Goethe University, Frankfurt, Germany
    Photochem Photobiol 69:218-21. 1999
    ..These results confirm the phototoxic activity of Hypericum extract on human keratinocytes. However, the blood levels that are to be expected during antidepressive therapy are presumably too low to induce phototoxic skin reactions...
  15. ncbi Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?
    M Schuster
    Department of Dermatology, Venereology and Allergology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
    Br J Dermatol 164:182-6. 2011
    ..As peroxisome proliferator-activated receptors (PPARs) are known to control lipid metabolism in several human tissues they have been considered to be involved in the pathogenesis of acne vulgaris...
  16. ncbi Levels of dopachrome tautomerase in human melanocytes cultured in vitro
    A Bernd
    Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Melanoma Res 4:287-91. 1994
    ..Finally, the low level of DCT activity found in normal human melanocytes cultured in vitro cannot be explained by any of the necessary stimulatory factors added to the cell culture media...
  17. ncbi [Dermatobia hominis infection in a 3-year-old child]
    M Meissner
    Klinik fur Dermatologie, Venerologie und Allergologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt am Main, Deutschland
    Hautarzt 63:325-8. 2012
    ..Botflies are mainly encountered in Central and South America; they should be considered if patients demonstrate a furuncle-like lesion and have returned from a holiday in these endemic regions...
  18. ncbi Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C
    Matthias Hofmann
    Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, D 60590 Frankfurt Main, Germany
    Biochem Biophys Res Commun 316:673-9. 2004
    ..These findings suggest mechanical pressure as a new type of effector stimulus for the p38 pathway with implications to (patho-) physiological conditions...
  19. ncbi Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60596 FrankfurtMain, Germany
    J Biol Chem 280:3060-7. 2005
    ..Evidence is provided that stretch-induced activation of PKB/Akt protects cells against induced apoptosis...
  20. ncbi Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin model
    Nadja Nicole Zöller
    Department of Dermatology and Venerology, J W Goethe University, Medical School, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Toxicol In Vitro 22:747-59. 2008
    ..The present study demonstrates the versatility of this FTSM in the validation of effectiveness and safety of GCs...
  21. ncbi Influence of different ECM mimetic peptide sequences embedded in a nonfouling environment on the specific adhesion of human-skin keratinocytes and fibroblasts on deformable substrates
    Jochen Salber
    DWI an der RWTH Aachen e V Pauwelsstr 8, 52074 Aachen, Germany
    Small 3:1023-31. 2007
    ..Thus we present a new toolbox that allows for the detailed analysis of the adhesion of human-skin-derived cells on structurally and biochemically decorated deformable substrates...
  22. ncbi Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
    Jadranka Dujic
    Department of Dermatology and Venerology, Medical School, J W Goethe University, Frankfurt Main, Germany
    J Invest Dermatol 127:1992-2000. 2007
    ..In particular, the latter avoids the use of carcinogenic irradiation that is part of regular phototherapy...
  23. ncbi Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression
    Matthias Hofmann
    Department of Dermatology and Venerology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Biomech 40:2324-9. 2007
    ..While a singular puncture had no effect catheterized tumours showed a significant decrease in Ki-67 expression. Our data suggest that long-term lowering of TIFP is required to reduce tumour proliferation...
  24. ncbi Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model
    Matthias Hofmann
    Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, Frankfurt Main D 60590, Germany
    Neoplasia 8:89-95. 2006
    ..These data suggest that the mechanical stretch induced by TIFP is a positive modulator of tumor proliferation...
  25. ncbi Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo
    Annette Dorn
    Department of Dermatology and Venerology, J W Goethe University, Frankfurt Main, Germany
    J Invest Dermatol 127:846-54. 2007
    ..This effect seems to be independent from Toll-like receptor 9...