Manfred Kaufmann

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update
    Manfred Kaufmann
    Department of Obstetrics and Gynecology, J W Goethe University Hospital, Frankfurt, Germany
    J Clin Oncol 24:1940-9. 2006
  2. doi request reprint Controversies concerning the use of neoadjuvant systemic therapy for primary breast cancer
    Manfred Kaufmann
    Department of Obstetrics and Gynecology and Breast Unit, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60 590, Frankfurt, Germany
    World J Surg 36:1480-5. 2012
  3. doi request reprint Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer
    Manfred Kaufmann
    Department of Gynecology and Obstetrics and Breast Unit, Goethe University, Frankfurt, Germany
    Ann Surg Oncol 19:1508-16. 2012
  4. pmc Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Breast Cancer Res 11:R69. 2009
  5. ncbi request reprint Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: the ARNO 95 Study
    Manfred Kaufmann
    Department of Obstetrics and Gynaecology, J W Goethe University of Frankfurt, Frankfurt am Main, Frankfurt Main, Germany
    J Clin Oncol 25:2664-70. 2007
  6. ncbi request reprint Extended breast cancer treatment with an aromatase inhibitor (Letrozole) after tamoxifen: why, who and how long?
    Manfred Kaufmann
    Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Eur J Obstet Gynecol Reprod Biol 126:146-54. 2006
  7. ncbi request reprint Tamoxifen versus control after adjuvant, risk-adapted chemotherapy in postmenopausal, receptor-negative patients with breast cancer: a randomized trial (GABG-IV D-93)--the German Adjuvant Breast Cancer Group
    Manfred Kaufmann
    Universitats Frauenklinik, Frankfurt, Germany
    J Clin Oncol 23:7842-8. 2005
  8. ncbi request reprint Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006
    M Kaufmann
    J W Goethe University, Frankfurt am Main, Germany
    Ann Oncol 18:1927-34. 2007
  9. ncbi request reprint Survival analyses from the ZEBRA study. goserelin (Zoladex) versus CMF in premenopausal women with node-positive breast cancer
    M Kaufmann
    Universitats Frauenklinik, Frankfurt, Germany
    Eur J Cancer 39:1711-7. 2003
  10. ncbi request reprint Long-term risk of breast cancer recurrence: the need for extended adjuvant therapy
    Manfred Kaufmann
    Klinik fur Gynakologie und Geburtshilfe, J W Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Cancer Res Clin Oncol 131:487-94. 2005

Detail Information

Publications149 found, 100 shown here

  1. ncbi request reprint Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update
    Manfred Kaufmann
    Department of Obstetrics and Gynecology, J W Goethe University Hospital, Frankfurt, Germany
    J Clin Oncol 24:1940-9. 2006
    ..As part of this effort, data published to date were reviewed critically and indications for neoadjuvant treatment were newly defined...
  2. doi request reprint Controversies concerning the use of neoadjuvant systemic therapy for primary breast cancer
    Manfred Kaufmann
    Department of Obstetrics and Gynecology and Breast Unit, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60 590, Frankfurt, Germany
    World J Surg 36:1480-5. 2012
    ..Although many prospective trials have answered important questions regarding neoadjuvant systemic therapy, several topics remain controversial...
  3. doi request reprint Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer
    Manfred Kaufmann
    Department of Gynecology and Obstetrics and Breast Unit, Goethe University, Frankfurt, Germany
    Ann Surg Oncol 19:1508-16. 2012
    ..The obtained consensus was updated in two subsequent meetings in 2004 and 2006. The most recent conference on recommendations on the use of NST took place in 2010 and forms the basis of this report...
  4. pmc Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Breast Cancer Res 11:R69. 2009
    ....
  5. ncbi request reprint Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: the ARNO 95 Study
    Manfred Kaufmann
    Department of Obstetrics and Gynaecology, J W Goethe University of Frankfurt, Frankfurt am Main, Frankfurt Main, Germany
    J Clin Oncol 25:2664-70. 2007
    ..This report presents results of a prospective, open-label, randomized study, designed to evaluate the benefits of switching to anastrozole after 2 years of tamoxifen treatment, compared with continuing on tamoxifen for 5 years...
  6. ncbi request reprint Extended breast cancer treatment with an aromatase inhibitor (Letrozole) after tamoxifen: why, who and how long?
    Manfred Kaufmann
    Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Eur J Obstet Gynecol Reprod Biol 126:146-54. 2006
    ....
  7. ncbi request reprint Tamoxifen versus control after adjuvant, risk-adapted chemotherapy in postmenopausal, receptor-negative patients with breast cancer: a randomized trial (GABG-IV D-93)--the German Adjuvant Breast Cancer Group
    Manfred Kaufmann
    Universitats Frauenklinik, Frankfurt, Germany
    J Clin Oncol 23:7842-8. 2005
    ..To investigate the effect of adjuvant sequential tamoxifen after chemotherapy in postmenopausal patients with hormone receptor-negative breast cancer...
  8. ncbi request reprint Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006
    M Kaufmann
    J W Goethe University, Frankfurt am Main, Germany
    Ann Oncol 18:1927-34. 2007
    ..As part of this effort, data published to date were critically reviewed and indications for neoadjuvant treatment were newly defined...
  9. ncbi request reprint Survival analyses from the ZEBRA study. goserelin (Zoladex) versus CMF in premenopausal women with node-positive breast cancer
    M Kaufmann
    Universitats Frauenklinik, Frankfurt, Germany
    Eur J Cancer 39:1711-7. 2003
    ....
  10. ncbi request reprint Long-term risk of breast cancer recurrence: the need for extended adjuvant therapy
    Manfred Kaufmann
    Klinik fur Gynakologie und Geburtshilfe, J W Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Cancer Res Clin Oncol 131:487-94. 2005
    ..That trial, MA.17, evaluated letrozole as extended adjuvant treatment following standard adjuvant tamoxifen in postmenopausal women with predominantly estrogen receptor--and/or progesterone receptor--positive early breast cancer...
  11. ncbi request reprint Preoperative (neoadjuvant) systemic treatment of breast cancer
    Manfred Kaufmann
    Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast 14:576-81. 2005
    ..PST will lead to individualised (tailored) treatment in patients with primary breast cancer...
  12. ncbi request reprint Exemestane improves survival compared with megoestrol acetate in postmenopausal patients with advanced breast cancer who have failed on tamoxifen. results Of a double-blind randomised phase III trial
    M Kaufmann
    Universitatsklinik, Goethe Universitat, 60596, Frankfurt, Germany
    Eur J Cancer 36:S86-7. 2000
    ..Median time to progression, time to treatment failure and overall survival was significantly longer with exemestane. Drug-related withdrawals and drug-related deaths were more common with megoestrol acetate...
  13. ncbi request reprint A randomised trial of goserelin versus control after adjuvant, risk-adapted chemotherapy in premenopausal patients with primary breast cancer - GABG-IV B-93
    Manfred Kaufmann
    Universitats Frauenklinik, Theodor Stern Kai 7, 60596 Frankfurt, Germany
    Eur J Cancer 43:2351-8. 2007
    ..72-1.42, P=0.97) and 0.77 in HR-positive patients (95% CI 0.47-1.24, P=0.27). These results do not support the general use of goserelin after adjuvant chemotherapy in this group of premenopausal patients...
  14. doi request reprint Use of standard markers and incorporation of molecular markers into breast cancer therapy: Consensus recommendations from an International Expert Panel
    Manfred Kaufmann
    Department of Obstetrics and Gynecology, Breast Unit, Goethe University, Frankfurt, Germany
    Cancer 117:1575-82. 2011
    ..Consensus recommendations are made on the practical use of molecular markers in breast cancer management and their incorporation into future clinical trials...
  15. ncbi request reprint International expert panel on the use of primary (preoperative) systemic treatment of operable breast cancer: review and recommendations
    Manfred Kaufmann
    Department of Gynecology and Obstetrics, Goethe University, Frankfurt am Main, Germany
    J Clin Oncol 21:2600-8. 2003
    ..Recommendations are made regarding terminology, indications, regimen, diagnosis before treatment, monitoring of efficacy, tumor localization, surgery, pathologic evaluation, and postoperative treatment...
  16. doi request reprint Neoadjuvant vinorelbine-capecitabine versus docetaxel-doxorubicin-cyclophosphamide in early nonresponsive breast cancer: phase III randomized GeparTrio trial
    Gunter von Minckwitz
    German Breast Group, Frankfurt, Germany
    J Natl Cancer Inst 100:542-51. 2008
    ..We compared the response of nonresponding patients who continued the same treatment with that of patients who switched to a well-tolerated non-cross-resistant regimen...
  17. pmc Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast
    Gunter von Minckwitz
    Dept of Gynecology and Obstetrics, Goethe University, Frankfurt am Main, Germany
    Breast Cancer Res 10:R30. 2008
    ..To investigate the predictive value of clinical and biological markers for a pathological complete remission after a preoperative dose-dense regimen of doxorubicin and docetaxel, with or without tamoxifen, in primary operable breast cancer...
  18. doi request reprint Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
    ..In contrast, markers displaying a continuous distribution like proliferation markers as Ki67 rather describe the composition of the mixture of cells in the tumor...
  19. ncbi request reprint Down-regulation of Polo-like kinase 1 elevates drug sensitivity of breast cancer cells in vitro and in vivo
    Birgit Spänkuch
    Department of Obstetrics and Gynecology, Medical School, J W Goethe University, Frankfurt, Germany
    Cancer Res 66:5836-46. 2006
    ....
  20. pmc Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol
    Ilija Androic
    Department of Obstetrics and Gynecology, School of Medicine, J, W, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    BMC Cancer 8:391. 2008
    ..Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer cell lines. Its expression is correlated with the malignancy of gynecological cancers...
  21. doi request reprint Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
    ....
  22. ncbi request reprint Surgical procedures after neoadjuvant chemotherapy in operable breast cancer: results of the GEPARDUO trial
    Sibylle Loibl
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Ann Surg Oncol 13:1434-42. 2006
    ..Neoadjuvant chemotherapy can increase the rate of breast-conserving surgery in patients with operable breast cancer. However, uncertainty remains regarding surgical procedures and predictors for successful breast-conserving surgery...
  23. ncbi request reprint Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells
    Birgit Spänkuch-Schmitt
    Department of Obstetrics and Gynecology, School of Medicine, J W Goethe University, Frankfurt, Germany
    J Natl Cancer Inst 94:1863-77. 2002
    ..To investigate the role of PLK1 in neoplastic proliferation, we used the technique of RNA interference...
  24. doi request reprint Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
    ..However, based on previous findings of NHERF1 functioning in PI3K signalling from basic research, these tumors might be appropriate candidates for a targeted therapy of the PI3K/Akt pathway...
  25. ncbi request reprint Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1
    Birgit Spänkuch
    Department of Obstetrics and Gynecology, School of Medicine, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Natl Cancer Inst 96:862-72. 2004
    ..We used a xenograft mouse model to determine whether an RNA interference-based strategy that used short hairpin RNAs (shRNAs) to suppress PLK1 expression could inhibit tumor growth in vivo...
  26. ncbi request reprint Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 112:41-52. 2008
    ..Targeting of the sphingolipid rheostat may thus open new treatment options...
  27. ncbi request reprint Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1)
    Nina Naomi Kreis
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, Frankfurt, Germany
    Cell Cycle 8:460-72. 2009
    ..Importantly, HeLa cells with reduced level of Plk1, which induces an increase of p21, p73 and Bax, are more sensitive to some chemotherapeutic agents, such as cisplatin...
  28. doi request reprint Intensified neoadjuvant chemotherapy in early-responding breast cancer: phase III randomized GeparTrio study
    Gunter von Minckwitz
    German Breast Group, Frankfurt, Germany
    J Natl Cancer Inst 100:552-62. 2008
    ..The relationship between extended chemotherapy and pathological complete response at surgery was investigated in a clinical trial...
  29. pmc Tumor inhibition by genomically integrated inducible RNAi-cassettes
    Sven Kappel
    Department of Gynecology and Obstetrics, School of Medicine, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Nucleic Acids Res 34:4527-36. 2006
    ..Taken together, our data revealed that genomically integrated RNAi-elements are suitable to hamper tumor growth by conditional expression of shRNA...
  30. ncbi request reprint Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells
    Frank Eckerdt
    Department of Gynecology and Obstetrics, J W Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    J Biol Chem 280:36575-83. 2005
    ..Since previous reports suggested that Plk1 is a substrate of Pin1, our work adds a new dimension to this interaction of two important mitotic regulators...
  31. ncbi request reprint Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells
    Juping Yuan
    Department of Gynaecology and Obstetrics, Medical School, JW Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Oncogene 23:5843-52. 2004
    ..These results indicate that siRNAs against cyclin B1 could become a powerful antiproliferative tool in future antitumor therapy...
  32. pmc Clinical feasibility of (neo)adjuvant taxane-based chemotherapy in older patients: analysis of >4,500 patients from four German randomized breast cancer trials
    Sibylle Loibl
    Department of Obstetrics and Gynecology, German Breast Group, Neu Isenburg, Germany
    Breast Cancer Res 10:R77. 2008
    ..Furthermore, most physicians tend towards therapy regimens without the use of dose-dense, highly active taxane-based treatments because of a lack of data regarding toxicities of these compounds in older patients...
  33. doi request reprint Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
    ..In conclusion, this study confirms our previous observations suggesting Plexin B1 as a new prognostic marker in ER positive breast cancers...
  34. doi request reprint Differential expression of claudins in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 24:442-9. 2008
    ..The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs...
  35. pmc T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
    ..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
  36. pmc A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
    ..Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease...
  37. ncbi request reprint Biological impact of freezing Plk1 in its inactive conformation in cancer cells
    Sarah Keppner
    Department of Obstetrics and Gynecology, Medical School, Goethe University, Frankfurt, Germany
    Cell Cycle 9:761-73. 2010
    ..This study suggests that Plk1 kinase inhibitors targeting the inactive conformation of Plk1 may be considered for the development of cancer therapeutics...
  38. doi request reprint Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation
    Thomas Karn
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Eur J Cancer 48:12-23. 2012
    ..Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer...
  39. ncbi request reprint The role of early expression of inducible nitric oxide synthase in human breast cancer
    Sibylle Loibl
    Department of Gynaecology and Obstetrics, J W Goethe University of Frankfurt, Theodor Stern Kai 7 9, 60590 Frankfurt am Main, Germany
    Eur J Cancer 41:265-71. 2005
    ..8% versus 67.1%; P=0.049; log-rank test). To date, this is the largest analysis of i-NOS expression in breast cancer patients and the only study to assess survival...
  40. ncbi request reprint Dose-dense biweekly doxorubicin/docetaxel versus sequential neoadjuvant chemotherapy with doxorubicin/cyclophosphamide/docetaxel in operable breast cancer: second interim analysis
    Christian Jackisch
    Department of Obstetrics and Gynecology, University of Marburg, Pilgrimstein 3, D 35037 Marburg, Germany
    Clin Breast Cancer 3:276-80. 2002
    ..The application of both schedules is safe and feasible in an outpatient setting. Although, results obtained from this interim analysis are encouraging, caution is recommended until the results obtained show statistical difference in pCR...
  41. pmc Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    PLoS ONE 6:e28403. 2011
    ..The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes...
  42. ncbi request reprint Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1
    Yves Matthess
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, Theodor Stern Kai 7, Haus 15, Frankfurt 60590, Germany
    Oncogene 24:2973-80. 2005
    ..Our data indicate that an inducible transcription system for shRNAs based on the human H1 promoter could be a versatile tool for controlled gene silencing in vitro...
  43. ncbi request reprint FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells
    Bernd T Martin
    Department of Gynecology and Obstetrics, Medical School, J W Goethe University, Frankfurt, Germany
    Cell Cycle 6:1779-88. 2007
    ....
  44. ncbi request reprint Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells
    Birgit Spänkuch-Schmitt
    Department of Obstetrics and Gynecology, School of Medicine, JW Goethe University, Theodor Stern Kai 7, 60596 Frankfurt, Germany
    Oncogene 21:3162-71. 2002
    ..Considerable antitumor activity was observed in vivo against A549 cells. This study suggests that antisense inhibitors targeted against PLK1 at well tolerated doses may be considered as a cancer therapeutic agent...
  45. ncbi request reprint Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS
    Sibylle Loibl
    Department of Gynecology and Obstetrics, University of Frankfurt, Theodor Stern Kai 7 9, 60590 Frankfurt am Main, Germany
    Pathol Res Pract 202:1-7. 2006
    ..In conclusion, e-NOS and i-NOS are weakly expressed in the MCF-7 cell line, but are stimulated differently. The MCF-7 cell may contain both a constitutive NOS and an inducible NOS...
  46. pmc Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells
    Timo Faltus
    Department of Obstetrics and Gynecology, Medical School, J W Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    Neoplasia 6:786-95. 2004
    ..Our observations suggest that siRNA targeted against human HER2/neu may be valuable tools as antiproliferative agents that display activity against neoplastic cells at very low doses...
  47. doi request reprint Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
    Eugen Ruckhäberle
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Cancer Res Clin Oncol 135:1005-13. 2009
    ..Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer...
  48. ncbi request reprint Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007
    ..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs...
  49. ncbi request reprint Pituitary tumor-transforming gene (PTTG): a novel target for anti-tumor therapy
    Christine Solbach
    Department of Gynecology and Obstetrics, Johann Wolfgang Goethe University, School of Medicine, Frankfurt am Main, Germany
    Anticancer Res 25:121-5. 2005
    ..Based on these findings, we raised the question as to whether PTTG is a target for an anti-tumor therapy...
  50. pmc Luteinizing hormone-releasing hormone analogues in early breast cancer: updated status of ongoing clinical trials
    M Kaufmann
    Department of Gynaecology and Obstetrics, Johann Wolfgang Goethe University, Frankfurt, Germany
    Br J Cancer 78:9-11. 1998
    ....
  51. ncbi request reprint Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1
    Achim Rody
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Clin Cancer Res 13:1115-22. 2007
    ..One of those genes is plexin B1, a cell-surface receptor for the semaphorin Sema4D (CD 100). However, the biological role of plexin B1 in breast cancer is largely unknown...
  52. ncbi request reprint Use of goserelin in the treatment of breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Expert Rev Anticancer Ther 5:591-604. 2005
    ..Treatment decisions depend upon adjuvant endocrine pretreatment. Clinical data regarding ovarian protection by synchronous use of gonadotropin-releasing hormone in young breast cancer patients receiving chemotherapy are incoherent...
  53. ncbi request reprint Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1
    Juping Yuan
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Oncogene 21:8282-92. 2002
    ..Still, multiple serine mutations are required to prevent nuclear translocation completely indicating that orchestrated phosphorylation within the CRS triggers rapid import of cyclin B1...
  54. doi request reprint SATB1 gene expression and breast cancer prognosis
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Breast 20:309-13. 2011
    ....
  55. ncbi request reprint Anti-epidermal growth factor receptor-antibody therapy for treatment of breast cancer
    Christine Solbach
    Department of Gynecology and Obstetrics, Johann Wolfgang Goethe University, School of Medicine, Frankfurt am Main, Germany
    Int J Cancer 101:390-4. 2002
    ..On the basis of these experimental data and our EGF-R expression analysis of breast cancer specimens, we conclude that up to 15% of breast cancer patients could benefit from this monotherapy with EMD 55900...
  56. ncbi request reprint Rational combinations of siRNAs targeting Plk1 with breast cancer drugs
    B Spänkuch
    Department of Obstetrics and Gynecology, Medical School, JW Goethe University, Frankfurt, Germany
    Oncogene 26:5793-807. 2007
    ..The combination of Plk1-specific siRNAs with modern breast cancer drugs seems to represent rational combinations to be tested in preclinical trials...
  57. doi request reprint Phase I study of apoptosis gene modulation with oblimersen within preoperative chemotherapy in patients with primary breast cancer
    J Rom
    Department of Gynecology and Obstetrics, University of Heidelberg, Germany
    Ann Oncol 20:1829-35. 2009
    ..Nevertheless, we demonstrated feasibility to process clinical samples and to obtain good quality RNA from tumor biopsies and indicated the potential of oblimersen to lower Bcl-2 mRNA in breast cancer...
  58. ncbi request reprint EGF-R and Her2/neu overexpressing tumors: independent collectives for treatment of breast cancer by specific monoclonal antibody-therapy
    Christine Solbach
    Department of Gynecology and Obstetrics, Johann Wolfgang Goethe University, School of Medicine, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    J Cancer Res Clin Oncol 129:250-1. 2003
    ....
  59. ncbi request reprint Characterization of WNT7A expression in human endometrium and endometriotic lesions
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 88:1534-40. 2007
    ..To characterize the expression of WNT7A in human eutopic and ectopic endometrium...
  60. ncbi request reprint Efficient internalization of the polo-box of polo-like kinase 1 fused to an Antennapedia peptide results in inhibition of cancer cell proliferation
    Juping Yuan
    Department of Obstetrics and Gynecology, Medical School, J W Goethe University, 60590 Frankfurt, Germany
    Cancer Res 62:4186-90. 2002
    ..The treatment caused mitotic arrest, misaligned chromosomes, and multiple centrosomes. Taken together, membrane-permeable polo-box peptides inhibit cancer cell proliferation efficiently...
  61. ncbi request reprint PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence
    Christine Solbach
    Department of Gynecology and Obstetrics, School of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt am Main 60590, Germany
    Breast 13:80-1. 2004
    ..Taken together, these results demonstrate that determination of PTTG expression in primary tumors of the breast is a powerful tool for the assessment of potential tumor aggressiveness...
  62. ncbi request reprint Utero-tubal sperm transport and its impairment in endometriosis and adenomyosis
    Stefan Kissler
    Department Obstetrics and Gynecology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Ann N Y Acad Sci 1101:38-48. 2007
    ..Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup...
  63. pmc Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer
    Franz Rodel
    Department of Radiation Therapy and Oncology, University of Frankfurt Main, Frankfurt, Germany
    Am J Pathol 177:918-29. 2010
    ..Therefore, PLK1 may be a novel predictive marker for radiation response as well as a promising therapeutic target in rectal cancer patients...
  64. ncbi request reprint Silencing of mammalian genes by tetracycline-inducible shRNA expression
    Sven Kappel
    Department of Gynaecology and Obstetrics, School of Medicine, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Nat Protoc 2:3257-69. 2007
    ..The entire protocol (preparation of constructs, generation of stable cell lines and functional analysis) can be completed in 3 months...
  65. ncbi request reprint Androgen receptor expression in ductal carcinoma in situ of the breast: not a helpful marker for classification such as estrogen receptor alpha and progesterone receptor
    Achim Rody
    Department of Obstetrics and Gynecology, University Hospital of Frankfurt, Frankfurt, Germany
    Appl Immunohistochem Mol Morphol 13:25-9. 2005
    ..The immunohistochemical assessment of AR status, therefore, may not help in providing a more objective way of classifying DCIS...
  66. pmc Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology
    Christine Solbach
    Department of Gynecology and Obstetrics, School of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neoplasia 4:237-42. 2002
    ..These results will be helpful for evaluation of patients who would benefit from tumor therapy with anti-EGF-R antibody...
  67. ncbi request reprint In vivo chemosensitivity-adapted preoperative chemotherapy in patients with early-stage breast cancer: the GEPARTRIO pilot study
    G von Minckwitz
    The German Breast Group, Frankfurt, Germany
    Ann Oncol 16:56-63. 2005
    ..Response to the first two cycles of preoperative chemotherapy might differentiate subgroups of breast cancer patients with high or minimal chances for a pathologic complete response (pCR) and may be used as an in vivo chemosensitivity test...
  68. ncbi request reprint Cancer of the uterine cervix is susceptible to anti-EGF-R antibody EMD 55,900 therapy
    Christine Solbach
    Department of Gynaecology and Obstetrics, Johann Wolfgang Goethe University, School of Medicine Frankfurt am Main, Germany
    Anticancer Res 25:4261-7. 2005
    ..Tumours of the uterine cervix represent a group, in which the response to anti-EGF-R treatment is hardly predictable, despite a relatively high expression of the receptor...
  69. ncbi request reprint Breast carcinoma during pregnancy. International recommendations from an expert meeting
    Sibylle Loibl
    Department of Obstetrics and Gynaecology, J W Goethe University, Frankfurt am Main, Germany
    Cancer 106:237-46. 2006
    ..Breast carcinoma during pregnancy (BCP) is a difficult clinical situation, as it appears to put the health of the mother in conflict with that of the fetus...
  70. ncbi request reprint The impact of breast cancer awareness and socioeconomic status on willingness to receive breast cancer prevention drugs
    Peter A Fasching
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitaetsstrasse 21 23, D 91054, Erlangen, Germany
    Breast Cancer Res Treat 101:95-104. 2007
    ..To find associations between knowledge about risk factors for breast cancer and the socioeconomic status of healthy women, as well as their attitude toward taking chemopreventive drugs...
  71. ncbi request reprint Bendamustine prolongs progression-free survival in metastatic breast cancer (MBC): a phase III prospective, randomized, multicenter trial of bendamustine hydrochloride, methotrexate and 5-fluorouracil (BMF) versus cyclophosphamide, methotrexate and 5-fluo
    G von Minckwitz
    University Women s Hospital, Frankfurt, Germany
    Anticancer Drugs 16:871-7. 2005
    ..BMF caused more mucositis and leukopenias. Thus, bendamustine, when replacing cyclophosphamide in the CMF combination, can be expected to produce longer progression-free survival in first-line treatment of MBC...
  72. doi request reprint Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical data
    E Ruckhäberle
    Department of Obstetrics and Gynecology, Goethe University, Frankfurt M, Germany
    Eur J Cancer 46:549-57. 2010
    ..In conclusion, the tumour infiltrating immune cells seem to be a major source of TP expression and predict a favourable prognosis in ER-negative breast cancer. Our data point to a role of TP in host immune response...
  73. doi request reprint Ceramide synthases and ceramide levels are increased in breast cancer tissue
    Susanne Schiffmann
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, 60590 Frankfurt am Main, Germany
    Carcinogenesis 30:745-52. 2009
    ..In conclusion, progression in breast cancer is associated with increased ceramide levels due to an upregulation of specific LASS genes...
  74. ncbi request reprint Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy
    Sibylle Loibl
    Department of Gynecology and Obstetrics, University of Frankfurt, Frankfurt am Main, Germany
    Cancer 95:1191-8. 2002
    ..An increased NO concentration catalyzed by NO synthase (NOS) is cytotoxic and can promote apoptosis. The expression of endothelial NOS (e-NOS) and induced NOS (i-NOS) was examined in various breast tumors...
  75. doi request reprint Oblimersen combined with docetaxel, adriamycin and cyclophosphamide as neo-adjuvant systemic treatment in primary breast cancer: final results of a multicentric phase I study
    J Rom
    Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
    Ann Oncol 19:1698-705. 2008
    ....
  76. ncbi request reprint Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 87:651-6. 2007
    ..To compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients...
  77. doi request reprint Brief report: tracheal intubation using the Bonfils intubation fibrescope or direct laryngoscopy for patients with a simulated difficult airway
    Christian Byhahn
    Department of Anesthesiology, Intensive Care Medicine, and Pain Management, J W Goethe University Medical School, Frankfurt M, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Can J Anaesth 55:232-7. 2008
    ..We tested the hypothesis that, with the BIF compared to direct laryngoscopy, the rate of failed endotracheal intubation could be reduced in patients with a difficult airway, simulated by means of a rigid cervical immobilization collar...
  78. ncbi request reprint Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV)
    Thomas Diebold
    Institute for Diagnostic and Interventional Radiology, J W G University Frankfurt Main, Germany
    Invest Radiol 40:465-71. 2005
    ..The purpose of this study was to evaluate the potential of the new 8G stereotactic vacuum-assisted breast biopsy (ST-driver, Mammotome; Ethicon Endosurgery) in the histologic evaluation of BI-RADS IV microcalcifications...
  79. ncbi request reprint Value of electrical impedance scanning (EIS) in the evaluation of BI-RADS III/IV/V-lesions
    Thomas Diebold
    Institute for Diagnostic and Interventional Radiology, J W G University Frankfurt Main, Interdisciplinary Breast Care Unit, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Technol Cancer Res Treat 4:93-7. 2005
    ..However, the overall sensitivity and specificity with this setup of EIS is still far too low. Further improvements especially including the measurement of higher frequencies should be realized...
  80. doi request reprint "Stem cell like" breast cancers-a model for the identification of new prognostic/predictive markers in endocrine responsive breast cancer exemplified by Plexin B1
    A Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Obstet Gynecol Reprod Biol 139:11-5. 2008
    ..032; ER positive: p=0.022). In conclusion those strategies of gene expression analysis in a context of biological meaningful classifications could be helpful to reveal new prognostic/predictive markers...
  81. ncbi request reprint Molecular classification of breast cancer patients by gene expression profiling
    A Ahr
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Pathol 195:312-20. 2001
    ....
  82. doi request reprint Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer
    E Ruckhäberle
    Departments of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    Climacteric 12:502-13. 2009
    ..We investigated the relevance of ceramide- and sphingosine-generating enzymes in breast cancer (acid ceramidase 1 (ASAH1), ceramide synthases 4 (LASS4) and 6 (LASS6)) by means of gene expression analysis...
  83. doi request reprint Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer
    A Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Breast Cancer Res Treat 113:457-66. 2009
    ..There is growing evidence that TOP2A protein expression is a strong prognostic and TOP2A gene amplification might be a predictive marker (particularly for the use of anthracyclines)...
  84. ncbi request reprint Factors influencing the prognostic role of oestrogen and progesterone receptor levels in breast cancer--results of the analysis of 670 patients with 11 years of follow-up
    S D Costa
    Department of Obstetrics and Gynecology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Eur J Cancer 38:1329-34. 2002
    ..In most analyses, PR appeared to be superior to ER in predicting the prognosis of primary breast cancer patients...
  85. ncbi request reprint Mepivacaine for spinal anesthesia in parturients undergoing elective cesarean delivery: maternal and neonatal plasma concentrations and neonatal outcome
    D H Bremerich
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johannes Wolfgang Goethe Universität, Frankfurt am Main
    Zentralbl Gynakol 125:518-21. 2003
    ..However, advances in surgical technique and shorter duration of surgery make short-acting local anesthetic like mepivacaine appropriate, particularly if combined with opioids to enhance postoperative maternal pain relief...
  86. ncbi request reprint Adjuvant hormone therapy following primary therapy for endometrial cancer
    S Loibl
    Universitatsfrauenklinik, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Eur J Cancer 38:S41-3. 2002
  87. ncbi request reprint The erbB2+ cluster of the intrinsic gene set predicts tumor response of breast cancer patients receiving neoadjuvant chemotherapy with docetaxel, doxorubicin and cyclophosphamide within the GEPARTRIO trial
    A Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    Breast 16:235-40. 2007
    ..6%), basal-like (30.0%) and luminal (13.6%) cluster (P=0.215). Our data suggest that the molecular tumor subtypes based on the "intrinsic gene set" can be used to predict tumor response according to NAC...
  88. ncbi request reprint [Management of HIV-positive pregnancies -- results from a retrospective study]
    A Ahr
    Zentrum für Frauenheilkunde der J W G Universität Frankfurt M
    Zentralbl Gynakol 127:242-7. 2005
    ..The management of HIV-positive pregnancies was investigated in conjunction to pre-, peri and postpartal complications and the HIV transmission rate...
  89. doi request reprint Differentially expressed genes of reprogrammed human pluripotent stem cells in breast cancer
    A Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 44:1789-92. 2008
    ..This analysis reveals two breast cancer subgroups with stem cell-like features, differing in ER-status and proliferation as well as in their clinical course of disease...
  90. doi request reprint VEGF-A and i-NOS expression are prognostic factors in serous epithelial ovarian carcinomas after complete surgical resection
    K Engels
    Department of Pathology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Clin Pathol 62:448-54. 2009
    ..Therefore, an analysis and evaluation of key angiogenic factors was carried out to determine their diagnostic and prognostic value in serous ovarian cancer...
  91. ncbi request reprint [New strategies for therapy of breast cancer. San Antonio Breast Cancer Symposium, 2002]
    S Loibl
    Universitätsfrauenklinik Frankfurt am Main
    Zentralbl Gynakol 124:451-3. 2002
  92. ncbi request reprint [Preoperative chemotherapy in primary operable breast cancer with a dose-dense combination of doxorubicin and docetaxel (ADoc) - Experience of the GEPARDO-GABG study group]
    G von Minckwitz
    Universitäts Frauenklinik Frankfurt am Main
    Zentralbl Gynakol 123:497-504. 2001
    ..The German Adjuvant Breast Cancer Study Group (GABG) conducts trials of preoperative chemotherapy in patients with primary breast cancer using a combination of doxorubicin and docetaxel (ADoc). -..
  93. ncbi request reprint [New aspects of carcinoma of the breast therapy and of gynaecological carcinoma treatment]
    S Loibl
    Universitätsfrauenklinik Frankfurt am Main, Germany
    Zentralbl Gynakol 125:346-52. 2003
    ..Primary and recurrent ovarian cancer therapy needs to be improved further. The optimal primary therapy for endometrial cancer and cervical cancer with radiotherapy and/or chemotherapy was another addressed issue...
  94. ncbi request reprint [Anesthetic regimen for HIV positive parturients undergoing elective cesarean section]
    D H Bremerich
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt
    Anaesthesist 52:1124-31. 2003
    ..The goal of the present study was to prospectively record perioperative maternal and neonatal complications in the largest HIV positive collective undergoing elective Cesarean section with spinal anesthesia published to date...
  95. ncbi request reprint Venlafaxine is superior to clonidine as treatment of hot flashes in breast cancer patients--a double-blind, randomized study
    S Loibl
    Department of Obstetrics and Gynecology, University Hospital Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Ann Oncol 18:689-93. 2007
    ..Classical hormone replacement therapy for hot flashes is contraindicated in breast cancer especially in endocrine responsive disease...
  96. ncbi request reprint [Risk factors for recurrence of vulvar intraepithelial neoplasia III (VIN III)]
    A Ahr
    Gynäkologische Praxis am Ziegelturm, Gelnhausen
    Zentralbl Gynakol 128:347-51. 2006
    ..The therapy of VIN is the in toto resection. Still some patients develop VIN recurrence. The aim of this retrospective study is the identification of risk factors for VIN recurrence...
  97. ncbi request reprint Gene expression profiles of breast cancer obtained from core cut biopsies before neoadjuvant docetaxel, adriamycin, and cyclophoshamide chemotherapy correlate with routine prognostic markers and could be used to identify predictive signatures
    A Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    Zentralbl Gynakol 128:76-81. 2006
    ..Furthermore we evaluated the predictive significance of prognostic gene signatures as described by Sorlie, van't Veer and Ahr for response to neoadjuvant chemotherapy...
  98. ncbi request reprint Dose-dense doxorubicin, docetaxel, and granulocyte colony-stimulating factor support with or without tamoxifen as preoperative therapy in patients with operable carcinoma of the breast: a randomized, controlled, open phase IIb study
    G von Minckwitz
    Department of Gynecology and Obstetrics, Goethe University, Frankfurt am Main, Germany
    J Clin Oncol 19:3506-15. 2001
    ..To investigate the effect of adding tamoxifen to a preoperative dose-dense doxorubicin and docetaxel regimen on the pathologic response of primary operable breast cancer...
  99. ncbi request reprint [Uterine adenomyosis in infertile patients: MR imaging findings and clinical conclusions]
    S Zangos
    Institut für Diagnostische und Interventionelle Radiologie, J W Goethe Universität Frankfurt
    Rofo 176:1641-7. 2004
    ..To evaluate the clinical value of magnetic resonance imaging (MRI) of the uterus and the pelvis in infertile female with symptomatic endometriosis for the assessment of uterine morphology and function...
  100. ncbi request reprint [Diagnosis and therapy of breast cancer--meeting highlights ASCO 2005]
    A Rody
    Zentrum für Gynäkologie und Geburtshilfe, J W Goethe Universität Frankfurt, Frankfurt Main
    Zentralbl Gynakol 127:389-94. 2005
  101. ncbi request reprint Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo
    J Yuan
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, 60590 Frankfurt, Germany
    Oncogene 25:1753-62. 2006
    ....