Thomas Karn

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    PLoS ONE 6:e28403. 2011
  2. ncbi Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation
    Thomas Karn
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Eur J Cancer 48:12-23. 2012
  3. ncbi Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
  4. ncbi Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
  5. ncbi Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
  6. ncbi Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 112:41-52. 2008
  7. ncbi Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
  8. ncbi A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
  9. ncbi T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
  10. ncbi Differential expression of claudins in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 24:442-9. 2008

Detail Information

Publications19

  1. ncbi Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    PLoS ONE 6:e28403. 2011
    ..The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes...
  2. ncbi Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation
    Thomas Karn
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Eur J Cancer 48:12-23. 2012
    ..Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer...
  3. ncbi Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
    ..However, based on previous findings of NHERF1 functioning in PI3K signalling from basic research, these tumors might be appropriate candidates for a targeted therapy of the PI3K/Akt pathway...
  4. ncbi Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
    ..In contrast, markers displaying a continuous distribution like proliferation markers as Ki67 rather describe the composition of the mixture of cells in the tumor...
  5. ncbi Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
    ..In conclusion, this study confirms our previous observations suggesting Plexin B1 as a new prognostic marker in ER positive breast cancers...
  6. ncbi Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 112:41-52. 2008
    ..Targeting of the sphingolipid rheostat may thus open new treatment options...
  7. ncbi Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
    ....
  8. ncbi A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
    ..Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease...
  9. ncbi T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
    ..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
  10. ncbi Differential expression of claudins in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 24:442-9. 2008
    ..The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs...
  11. ncbi Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007
    ..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs...
  12. ncbi Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
    Eugen Ruckhäberle
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Cancer Res Clin Oncol 135:1005-13. 2009
    ..Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer...
  13. ncbi Characterization of WNT7A expression in human endometrium and endometriotic lesions
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 88:1534-40. 2007
    ..To characterize the expression of WNT7A in human eutopic and ectopic endometrium...
  14. ncbi SATB1 gene expression and breast cancer prognosis
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Breast 20:309-13. 2011
    ....
  15. ncbi Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1
    Achim Rody
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Clin Cancer Res 13:1115-22. 2007
    ..One of those genes is plexin B1, a cell-surface receptor for the semaphorin Sema4D (CD 100). However, the biological role of plexin B1 in breast cancer is largely unknown...
  16. ncbi Controversies concerning the use of neoadjuvant systemic therapy for primary breast cancer
    Manfred Kaufmann
    Department of Obstetrics and Gynecology and Breast Unit, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60 590, Frankfurt, Germany
    World J Surg 36:1480-5. 2012
    ..Although many prospective trials have answered important questions regarding neoadjuvant systemic therapy, several topics remain controversial...
  17. ncbi Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Anticancer Res 33:371-7. 2013
    ..Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC)...
  18. ncbi Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer
    Manfred Kaufmann
    Department of Gynecology and Obstetrics and Breast Unit, Goethe University, Frankfurt, Germany
    Ann Surg Oncol 19:1508-16. 2012
    ..The obtained consensus was updated in two subsequent meetings in 2004 and 2006. The most recent conference on recommendations on the use of NST took place in 2010 and forms the basis of this report...
  19. ncbi Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 87:651-6. 2007
    ..To compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients...