Thomas Karn

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    PLoS ONE 6:e28403. 2011
  2. doi request reprint Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
  3. doi request reprint Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation
    Thomas Karn
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Eur J Cancer 48:12-23. 2012
  4. doi request reprint Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
  5. doi request reprint Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
  6. ncbi request reprint Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 112:41-52. 2008
  7. doi request reprint Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
  8. pmc T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
  9. pmc A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
  10. doi request reprint Differential expression of claudins in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 24:442-9. 2008

Detail Information

Publications21

  1. pmc Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    PLoS ONE 6:e28403. 2011
    ..The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes...
  2. doi request reprint Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
    ..In contrast, markers displaying a continuous distribution like proliferation markers as Ki67 rather describe the composition of the mixture of cells in the tumor...
  3. doi request reprint Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation
    Thomas Karn
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Eur J Cancer 48:12-23. 2012
    ..Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer...
  4. doi request reprint Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
    ..However, based on previous findings of NHERF1 functioning in PI3K signalling from basic research, these tumors might be appropriate candidates for a targeted therapy of the PI3K/Akt pathway...
  5. doi request reprint Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
    ..In conclusion, this study confirms our previous observations suggesting Plexin B1 as a new prognostic marker in ER positive breast cancers...
  6. ncbi request reprint Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 112:41-52. 2008
    ..Targeting of the sphingolipid rheostat may thus open new treatment options...
  7. doi request reprint Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
    ....
  8. pmc T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
    ..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
  9. pmc A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
    ..Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease...
  10. doi request reprint Differential expression of claudins in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 24:442-9. 2008
    ..The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs...
  11. ncbi request reprint Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007
    ..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs...
  12. doi request reprint Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
    Eugen Ruckhäberle
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Cancer Res Clin Oncol 135:1005-13. 2009
    ..Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer...
  13. doi request reprint Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer
    Eugen Ruckhäberle
    Department of Obstetrics and Gynecology, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurter, Germany
    J Cancer Res Clin Oncol 139:1681-9. 2013
    ..Sphingolipids play important roles in apoptosis and cell proliferation. Sphingosine kinase 1 (SphK1) expression has a prognostic impact in primary breast cancer, but its predictive value is currently unknown...
  14. ncbi request reprint Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1
    Achim Rody
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Clin Cancer Res 13:1115-22. 2007
    ..One of those genes is plexin B1, a cell-surface receptor for the semaphorin Sema4D (CD 100). However, the biological role of plexin B1 in breast cancer is largely unknown...
  15. doi request reprint Acid ceramidase (AC)--a key enzyme of sphingolipid metabolism--correlates with better prognosis in epithelial ovarian cancer
    Lars Christian Hanker
    Department of Obstetrics and Gynecology, University of Homburg, Homburg, Germany
    Int J Gynecol Pathol 32:249-57. 2013
    ..These results are in contrast to the concept of AC as a promoter for cancer progression. Nevertheless, they are supported by the lately discovered tumor-suppressing function of sphingosine, the enzymatic product of AC...
  16. ncbi request reprint Characterization of WNT7A expression in human endometrium and endometriotic lesions
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 88:1534-40. 2007
    ..To characterize the expression of WNT7A in human eutopic and ectopic endometrium...
  17. doi request reprint SATB1 gene expression and breast cancer prognosis
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Breast 20:309-13. 2011
    ....
  18. ncbi request reprint Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Anticancer Res 33:371-7. 2013
    ..Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC)...
  19. doi request reprint Controversies concerning the use of neoadjuvant systemic therapy for primary breast cancer
    Manfred Kaufmann
    Department of Obstetrics and Gynecology and Breast Unit, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60 590, Frankfurt, Germany
    World J Surg 36:1480-5. 2012
    ..Although many prospective trials have answered important questions regarding neoadjuvant systemic therapy, several topics remain controversial...
  20. doi request reprint Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer
    Manfred Kaufmann
    Department of Gynecology and Obstetrics and Breast Unit, Goethe University, Frankfurt, Germany
    Ann Surg Oncol 19:1508-16. 2012
    ..The obtained consensus was updated in two subsequent meetings in 2004 and 2006. The most recent conference on recommendations on the use of NST took place in 2010 and forms the basis of this report...
  21. ncbi request reprint Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 87:651-6. 2007
    ..To compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients...