W Holtmeier

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Two groups of porcine TCRgammadelta+ thymocytes behave and diverge differently
    Marek Sinkora
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Doly 183, 549 22 Novy Hradek, Czech Republic
    J Immunol 178:711-9. 2007
  2. ncbi On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over study
    Wolfgang Holtmeier
    Department of Gastroenterology, Med Klinik I, J W Goethe Universitat, Frankfurt, Australia
    J Clin Gastroenterol 41:564-70. 2007
  3. ncbi IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated
    W Holtmeier
    Medizinische Klinik II, Johann Wolfgang Goethe Universitdt, Frankfurt am Main, Germany
    Gastroenterology 119:1253-66. 2000
  4. ncbi [Treatment and management of celiac disease]
    W Holtmeier
    Medizinische Klinik I, Abt für Gastroenterologie, Johann Wolfgang Goethe Universitat
    Z Gastroenterol 44:1167-75. 2006
  5. pmc Celiac disease
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Orphanet J Rare Dis 1:3. 2006
  6. ncbi [Diagnosis of celiac disease]
    W Holtmeier
    Medizinische Klinik I, Abt für Gastroenterologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Gastroenterol 43:1243-52. 2005
  7. ncbi [Definitions of celiac disease--statement of an expert group from the German Society for Celiac Disease]
    W Holtmeier
    Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Gastroenterol 43:751-4. 2005
  8. ncbi gammadelta T cells link innate and adaptive immune responses
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Chem Immunol Allergy 86:151-83. 2005
  9. ncbi Prenatal development of the porcine TCR delta repertoire: dominant expression of an invariant T cell receptor Vdelta3-Jdelta3 chain
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Immunol 34:1941-9. 2004
  10. ncbi Compartmentalization gamma/delta T cells and their putative role in mucosal immunity
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Crit Rev Immunol 23:473-88. 2003

Detail Information

Publications22

  1. ncbi Two groups of porcine TCRgammadelta+ thymocytes behave and diverge differently
    Marek Sinkora
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Doly 183, 549 22 Novy Hradek, Czech Republic
    J Immunol 178:711-9. 2007
    ....
  2. ncbi On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over study
    Wolfgang Holtmeier
    Department of Gastroenterology, Med Klinik I, J W Goethe Universitat, Frankfurt, Australia
    J Clin Gastroenterol 41:564-70. 2007
    ..Antacids are widely used in the self-treatment of gastroesophageal reflux-induced complaints, but respective studies are lacking...
  3. ncbi IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated
    W Holtmeier
    Medizinische Klinik II, Johann Wolfgang Goethe Universitdt, Frankfurt am Main, Germany
    Gastroenterology 119:1253-66. 2000
    ..Because lamina propria B cells should reflect the antigenic experience of the gut, we investigated their immunoglobulin (Ig) repertoire and distribution...
  4. ncbi [Treatment and management of celiac disease]
    W Holtmeier
    Medizinische Klinik I, Abt für Gastroenterologie, Johann Wolfgang Goethe Universitat
    Z Gastroenterol 44:1167-75. 2006
    ..One central point in patient care is the monitoring of a gluten-free diet and the timely recognition of complications. Therefore, the role of antibodies and duodenal histology in monitoring the course of the disease will be discussed...
  5. pmc Celiac disease
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Orphanet J Rare Dis 1:3. 2006
    ..Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years...
  6. ncbi [Diagnosis of celiac disease]
    W Holtmeier
    Medizinische Klinik I, Abt für Gastroenterologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Gastroenterol 43:1243-52. 2005
    ..Since celiac disease implies a lifelong gluten-free diet, a firm diagnosis should be obtained. Thus, one should not rely on a single test but should rather consider serology, histology and clinical response altogether...
  7. ncbi [Definitions of celiac disease--statement of an expert group from the German Society for Celiac Disease]
    W Holtmeier
    Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Gastroenterol 43:751-4. 2005
    ..The consequent usage of these definitions may diminish uncertainties in clinical practice and lead to a more standardized management of the disease which is likely to improve patient care...
  8. ncbi gammadelta T cells link innate and adaptive immune responses
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Chem Immunol Allergy 86:151-83. 2005
    ..Our increasing understanding of the ligand recognition and activation mechanisms of gamma/delta T cells also opens new perspectives for the development of gamma/delta T cell-based immunotherapies...
  9. ncbi Prenatal development of the porcine TCR delta repertoire: dominant expression of an invariant T cell receptor Vdelta3-Jdelta3 chain
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Immunol 34:1941-9. 2004
    ..We speculate that these gamma/delta T cells might have been selectively expanded by (self)-ligands and may have an important function throughout fetal development...
  10. ncbi Compartmentalization gamma/delta T cells and their putative role in mucosal immunity
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Crit Rev Immunol 23:473-88. 2003
    ..This review focuses on the distribution and repertoire of mucosal gamma/delta T cells and discusses what is currently known about the functions of these cells. Furthermore, their potential role in inflammatory bowel disease is examined...
  11. ncbi The TCR-delta repertoire in normal human skin is restricted and distinct from the TCR-delta repertoire in the peripheral blood
    W Holtmeier
    Medizinische Klinik II, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Invest Dermatol 116:275-80. 2001
    ....
  12. ncbi Development and compartmentalization of the porcine TCR delta repertoire at mucosal and extraintestinal sites: the pig as a model for analyzing the effects of age and microbial factors
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Immunol 169:1993-2002. 2002
    ..Furthermore, these data support the hypothesis that in each mucosal site, different Ags are responsible for selecting and maintaining the gammadelta TCR over time...
  13. ncbi T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G1024-34. 2002
    ..In conclusion, those changes indicate that gamma/delta T cells might play an important role in a subset of patients with IBD...
  14. ncbi [Hypertransaminasaemia and impaired liver function in a patient with oligosymptomatic celiac disease]
    W P Hofmann
    Medizinische Klinik II, , Frankfurt/Main, Germany
    Z Gastroenterol 39:1027-32. 2001
    ..Serum aminotransferase levels normalized within 6 months. The clinical course demonstrates involvement of the liver in patients with celiac disease...
  15. ncbi Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis
    Wolfgang Holtmeier
    Department of Medicine II, Division of Gastroenterology, University of Frankfurt, Frankfurt am Main, Germany W Holtmeier em uni frankfurt de
    Exp Dermatol 11:527-31. 2002
    ..Thus, cutaneous gammadelta T cells are not specifically expanded within the involved skin and are unlikely to be derived from the inflamed duodenum...
  16. ncbi Proliferating intestinal gamma/delta T cells recirculate rapidly and are a major source of the gamma/delta T cell pool in the peripheral blood
    Karl Heinz Thielke
    Department of Functional and Applied Anatomy 4120, Medical School of Hannover, Germany
    Eur J Immunol 33:1649-56. 2003
    ....
  17. ncbi Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, The University of Iowa, Iowa City, 52242, USA
    Vet Res 37:417-41. 2006
    ..Improper development of adaptive immunity can be caused by infectious agents like the porcine reproductive and respiratory syndrome virus that causes immune dysregulation resulting in immunological injury and autoimmunity...
  18. ncbi Regional variation of the alphabeta T cell repertoire in the colon of healthy individuals and patients with Crohn's disease
    Ekkehard May
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Hum Immunol 63:467-80. 2002
    ..This does not exclude a pathogenic role of expanded T cells in CD through more subtle changes, but emphasizes the need to distinguish them from a discontinuous distribution of clonally expanded T cells in normal colon...
  19. ncbi Lymphocyte development in fetal piglets: facts and surprises
    Marek Sinkora
    Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Doly 183, 549 22 Novy Hradek, Czech Republic
    Vet Immunol Immunopathol 108:177-84. 2005
    ..Therefore, swine present an example of two highly related receptor systems that have diverged in the same species...
  20. pmc Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny
    Marek Sinkora
    Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Novy Hradek, Czech Republic
    Immunology 115:544-55. 2005
    ..We propose that one subset acquires CD8alphaalpha in the thymus while the second acquires CD8alphaalpha as a result of stimulation in the periphery...
  21. ncbi Epithelial defence by gamma delta T cells
    Dieter Kabelitz
    Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Int Arch Allergy Immunol 137:73-81. 2005
    ..In this article we summarize basic features of intraepithelial gamma delta T cells and discuss their possible role in epithelial defence...
  22. ncbi [Crohn's disease and cancer risk. Incidence/prevalence, clinical characteristics, and potential prevention strategies]
    Hubert Allgayer
    Schwerpunkt Verdauungs und Stoffwechselerkrankungen, Rehaklinik Ob der Tauber, Bad Mergentheim, Akademisches Lehrkrankenhaus der Universität Heidelberg
    Med Klin (Munich) 102:727-33. 2007
    ....