S H Hohnloser

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)
    Stefan H Hohnloser
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Frankfurt, Germany
    Am Heart J 152:442-7. 2006
  2. doi Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, Department of Cardiology, J W Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    Eur Heart J 33:2821-30. 2012
  3. doi Atrial overdrive pacing to prevent atrial fibrillation: insights from ASSERT
    Stefan H Hohnloser
    J W Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Heart Rhythm 9:1667-73. 2012
  4. doi Dabigatran for stroke prevention in atrial fibrillation
    S H Hohnloser
    J W Goethe University, Frankfurt am Main, Germany
    Hamostaseologie 32:216-20. 2012
  5. doi Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, J W Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    Circulation 125:669-76. 2012
  6. ncbi Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter
    Stefan H Hohnloser
    Department of Cardiology, Division of Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 44:99-104. 2004
  7. ncbi Evidence regarding clinical use of microvolt T-wave alternans
    Stefan H Hohnloser
    Division of Cardiology, Department of Medicine, J W Goethe University, Frankfurt, Germany
    Heart Rhythm 6:S36-44. 2009
  8. doi Risk factor assessment: defining populations and individuals at risk
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Cardiol Clin 26:355-66, v-vi. 2008
  9. ncbi Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 41:2220-4. 2003
  10. ncbi Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atria
    Stefan H Hohnloser
    J W Goethe University, Department of Cardiology, Frankfurt, Germany
    J Cardiovasc Electrophysiol 19:69-73. 2008

Detail Information

Publications108 found, 100 shown here

  1. ncbi ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)
    Stefan H Hohnloser
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Frankfurt, Germany
    Am Heart J 152:442-7. 2006
    ..This substudy will determine if atrial electrical remodeling is detectable in pacemaker patients and if it is associated with the development of AF...
  2. doi Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, Department of Cardiology, J W Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    Eur Heart J 33:2821-30. 2012
    ..Apixaban, a novel oral anticoagulant with partial renal excretion, was compared with warfarin and reduced the rate stroke, death and bleeding in the ARISTOTLE trial. We evaluated these outcomes in relation to renal function...
  3. doi Atrial overdrive pacing to prevent atrial fibrillation: insights from ASSERT
    Stefan H Hohnloser
    J W Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Heart Rhythm 9:1667-73. 2012
    ..Pacing algorithms to prevent atrial fibrillation (AF) have been tested in studies of modest size and duration with inconclusive results...
  4. doi Dabigatran for stroke prevention in atrial fibrillation
    S H Hohnloser
    J W Goethe University, Frankfurt am Main, Germany
    Hamostaseologie 32:216-20. 2012
    ..There were numerically more myocardial infarcts in dabigatran-treated patients than in warfarin patients; however, other myocardial ischaemic events were similar in the three treatment arms...
  5. doi Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, J W Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    Circulation 125:669-76. 2012
    ..There is a modest risk of myocardial infarction (MI) and myocardial ischemic events in patients with atrial fibrillation...
  6. ncbi Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter
    Stefan H Hohnloser
    Department of Cardiology, Division of Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 44:99-104. 2004
    ..The goal of the present study was to assess the efficacy and safety of intravenous tedisamil, a new antiarrhythmic compound, for conversion of recent-onset atrial fibrillation (AF) or atrial flutter (AFL) to normal sinus rhythm (NSR)...
  7. ncbi Evidence regarding clinical use of microvolt T-wave alternans
    Stefan H Hohnloser
    Division of Cardiology, Department of Medicine, J W Goethe University, Frankfurt, Germany
    Heart Rhythm 6:S36-44. 2009
    ..In some recent studies involving primary prevention patients with prophylactically implanted cardioverter-defibrillators (ICDs), MTWA has not performed as well...
  8. doi Risk factor assessment: defining populations and individuals at risk
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Cardiol Clin 26:355-66, v-vi. 2008
    ....
  9. ncbi Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 41:2220-4. 2003
    ....
  10. ncbi Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atria
    Stefan H Hohnloser
    J W Goethe University, Department of Cardiology, Frankfurt, Germany
    J Cardiovasc Electrophysiol 19:69-73. 2008
    ..There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia. Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF...
  11. ncbi Electrical storm in patients with an implantable defibrillator: incidence, features, and preventive therapy: insights from a randomized trial
    Stefan H Hohnloser
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Heart J 27:3027-32. 2006
    ..The purpose of this study was to assess the incidence, features, and clinical sequelae of 'electrical storm' (ES)...
  12. ncbi Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 114:104-9. 2006
    ..The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial...
  13. ncbi Ventricular arrhythmias: antiadrenergic therapy for the patient with coronary artery disease
    Stefan H Hohnloser
    J W Goethe University, Frankfurt, Germany
    J Cardiovasc Pharmacol Ther 10:S23-31. 2005
    ..In addition, several studies have shown that combination therapy with beta-blockers and implantable cardioverter defibrillators have synergistic effects that optimize the benefits of both therapies...
  14. ncbi [Drug therapy of ventricular arrhythmias - a contemporary perspective]
    G C Grönefeld
    Johann Wolfgang Goethe Universitat, Medizinische Klinik IV, Frankfurt am Main, Germany
    Dtsch Med Wochenschr 127:2280-4. 2002
  15. ncbi Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 351:2481-8. 2004
    ..Whether benefit occurs in patients early after myocardial infarction is unknown...
  16. doi Effect of dronedarone on cardiovascular events in atrial fibrillation
    Stefan H Hohnloser
    Department of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 360:668-78. 2009
    ..Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation...
  17. ncbi Combined antiplatelet therapy in atrial fibrillation: review of the literature and future avenues
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University Hospital, Frankfurt, Germany
    J Cardiovasc Electrophysiol 14:S60-3. 2003
    ..The ACTIVE program began patient enrollment in spring 2003...
  18. pmc Dronedarone in patients with congestive heart failure: insights from ATHENA
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, Department of Cardiology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur Heart J 31:1717-21. 2010
    ..The present study aimed to analyse in detail the effects of dronedarone on mortality and morbidity in AF patients CHF...
  19. ncbi T wave alternans as a predictor of recurrent ventricular tachyarrhythmias in ICD recipients: prospective comparison with conventional risk markers
    S H Hohnloser
    Department of Cardiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 9:1258-68. 1998
    ....
  20. ncbi Prevalence, characteristics and prognostic value during long-term follow-up of nonsustained ventricular tachycardia after myocardial infarction in the thrombolytic era
    S H Hohnloser
    Department of Medicine, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 33:1895-902. 1999
    ..The purpose of this study was to determine the prevalence, characteristics and the predictive value of nonsustained ventricular tachycardia (VT) for subsequent death and arrhythmic events after acute myocardial infarction (AMI)...
  21. ncbi The defibrillator in acute myocardial infarction trial (DINAMIT): study protocol
    S H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Am Heart J 140:735-9. 2000
    ..Patients will be followed for approximately 3 years on average with subsequent data analysis based on the intent-to-treat principle. Primary outcome is all-cause death. The trial is expected to be completed in 2003...
  22. ncbi Rhythm or rate control in atrial fibrillation--Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial
    S H Hohnloser
    JW Goethe University, Frankfurt, Germany
    Lancet 356:1789-94. 2000
    ..Restoration and maintenance of sinus rhythm is believed by many physicians to be superior to rate control only. However, there are no prospective data that compare both therapeutic strategies...
  23. doi Benefit-risk assessment of current antiarrhythmic drug therapy of atrial fibrillation
    Stefan H Hohnloser
    Department of Cardiology, J W Goethe University, Frankfurt, Germany
    Clin Cardiol 35:28-32. 2012
    ..However, the drug was associated with increased mortality in patients with recently decompensated heart failure. Hence, antiarrhythmic drug therapy has to be evaluated in patients with AF on an individual patients basis...
  24. ncbi Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy
    Stefan H Hohnloser
    Department of Cardiology, Division of Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 50:2156-61. 2007
    ..Our goal was to determine the risk of stroke or non-cerebral embolism associated with paroxysmal compared with sustained atrial fibrillation (AF)...
  25. ncbi Effect of metoprolol and d,l-sotalol on microvolt-level T-wave alternans. Results of a prospective, double-blind, randomized study
    T Klingenheben
    Department of Medicine, Division of Cardiology, J.W. Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 38:2013-9. 2001
    ..This applies particularly for beta-blocker therapy...
  26. ncbi Prevalence, characteristics and clinical implications of regular atrial tachyarrhythmias in patients with atrial fibrillation: insights from a study using a new implantable device
    C W Israel
    Department of Medicine, J. W. Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 38:355-63. 2001
    ..0001). CONCLUSIONS: The majority of patients with a history of AF show not only disorganized but also highly organized AT episodes, which can be successfully terminated by ATP...
  27. ncbi Septal Q waves in surface electrocardiographic lead V6 exclude minimal ventricular preexcitation
    F Bogun
    Department of Internal Medicine, J W Goethe University, Frankfurt, Germany
    Am J Cardiol 84:101-4, A9. 1999
    ..The presence of a septal Q wave could be used to exclude minimal preexcitation with a high degree of reliability in both patients and controls before and after radiofrequency ablation...
  28. ncbi Pace-termination and pacing for prevention of atrial tachyarrhythmias: results from a multicenter study with an implantable device for atrial therapy
    C W Israel
    Department of Medicine, J.W. Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 12:1121-8. 2001
    ..Preventive pacing and atrial ATP algorithms represent two new functions that can be implemented safely into pacemaker systems for nonpharmacologic treatment of ATs in patients requiring pacemaker therapy...
  29. ncbi Ablation of atypical atrial flutter guided by the use of concealed entrainment in patients without prior cardiac surgery
    F Bogun
    Division of Cardiology, JW Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 11:136-45. 2000
    ..The purpose of this study was to assess prospectively the use of concealed entrainment (CE) in mapping of AF and to assess the clinical benefit of ablation of clinically relevant atypical AF...
  30. ncbi Rate-dependence of QT dispersion and the QT interval: comparison of atrial pacing and exercise testing
    M Zabel
    Department of Medicine, Klinikum Benjamin Franklin, Free University of Berlin, Germany
    J Am Coll Cardiol 36:1654-8. 2000
    ..The study was done to determine whether variables of QT dispersion from the 12-lead electrocardiogram (ECG) are dependent on heart rate...
  31. ncbi Discrimination between ventricular and supraventricular tachycardia by dual chamber cardioverter defibrillators: importance of the atrial sensing function
    C W Israel
    J. W. Goethe University, Department of Medicine, Frankfurt, Germany
    Pacing Clin Electrophysiol 24:183-90. 2001
    ..Due to the VT/SVT discrimination algorithm, atrial sensing errors only led to misclassification in 4 % of all episodes, mainly due to atrial undersensing. No VT underdetection due to atrial oversensing occurred...
  32. ncbi The 1+1 trial: a prospective trial of a dual- versus a single-chamber implantable defibrillator in patients with slow ventricular tachycardias
    Dietmar Bansch
    Department of Cardiology, St Georg Hospital, Hamburg, Germany
    Circulation 110:1022-9. 2004
    ..We hypothesized that patients with slow VTs (<200 bpm) may benefit from a long TDI and a dual-chamber detection algorithm compared with a conventionally programmed single-chamber ICD...
  33. ncbi [Pharmacological cardioversion of atrial fibrillation]
    J R Ehrlich
    Abteilung für klinische Elektrophysiologie, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Z Kardiol 94:14-22. 2005
    ..Finally, we will focus on some important aspects of anticoagulation in the setting of pharmacological cardioversion...
  34. ncbi T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation
    S H Hohnloser
    Johann Wolfgang Goethe University, Frankfurt, Germany
    Lancet 362:125-6. 2003
    ..6% among the remaining patients. Testing of T-wave alternans seems to identify patients who are at low risk of ventricular tachyarrhythmic event and who may not benefit from defibrillator therapy...
  35. ncbi Risk of development of delayed atrioventricular block after slow pathway modification in patients with atrioventricular nodal reentrant tachycardia and a pre-existing prolonged PR interval
    Y G Li
    Department of Internal Medicine, Divison of Cardiology, J. W. Goethe University, Frankfurt, Germany
    Eur Heart J 22:89-95. 2001
    ..However, there is a significant risk of development of delayed atrioventricular block, particularly when the procedure results in total elimination of the slow pathway...
  36. ncbi Clinical value of T-wave alternans assessment
    Thomas Klingenheben
    Department of Medicine, Division of Cardiology Clinical Electrophysiology, J W Goethe University, Frankfurt a M, Germany
    Card Electrophysiol Rev 6:323-8. 2002
    ..e., pharmacological stimulation) in an attempt to reduce the proportion of incomplete tests in patients with insufficient increase in heart rate during exercise testing...
  37. ncbi Proarrhythmia with class III antiarrhythmic drugs: definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications
    S H Hohnloser
    Department of Cardiology, University of Frankfurt, Germany
    J Cardiovasc Electrophysiol 6:920-36. 1995
    ..The ongoing clinical trials with various Class III agents are likely to provide the critical information on this important therapeutic issue...
  38. ncbi Prediction of early recurrence of atrial fibrillation after external cardioversion by means of P wave signal-averaged electrocardiogram
    J R Ehrlich
    J W Goethe Universitat, Frankfurt Medizinische Klinik IV, Abteilung fur Kardiologie, Theodor Stern Kai 7, 60599 Frankfurt Main, Germany
    Z Kardiol 92:540-6. 2003
    ..This prospective study was performed to evaluate if the P wave signal-averaged ECG (PSAECG) is able to identify patients with an increased risk of ERAF after CV...
  39. ncbi Bedside risk stratification after acute myocardial infarction: prospective evaluation of the use of heart rate and left ventricular function
    Oliver Mauss
    Department of Cardiology, Division of Clinical Electrophysiology, J W Goethe University, D 60596 Frankfurt a main, Germany
    J Electrocardiol 38:106-12. 2005
    ..This study evaluated the predictive power of heart rate (HR) assessed from the standard 12-lead electrocardiogram (ECG) or from Holter recordings for future mortality and arrhythmic events in survivors of acute myocardial infarction (AMI)...
  40. doi Arrhythmic death in implantable cardioverter defibrillator patients: a long-term study over a 10 year implantation period
    Gabor Z Duray
    Division of Cardiology, Section Clinical Electrophysiology, Department of Medicine, JW Goethe University, Frankfurt 60590, Germany
    Europace 11:1462-8. 2009
    ..Evaluation of cause-specific mortality in a large cohort of unselected implantable cardioverter defibrillator (ICD) recipients...
  41. ncbi Mechanism of ventricular tachycardia termination by pacing at left ventricular sites in patients with coronary artery disease
    Frank Bogun
    J W Goethe University, Division of Cardiology, Frankfurt, Germany
    J Interv Card Electrophysiol 6:35-41. 2002
    ..The purpose of this study was to compare the mechanisms by which pacing terminates VT at left ventricular (LV) sites with and without concealed entrainment (CE) in patients with prior myocardial infarction...
  42. ncbi Morphology discrimination: a beat-to-beat algorithm for the discrimination of ventricular from supraventricular tachycardia by implantable cardioverter defibrillators
    G C Grönefeld
    Department of Medicine, J W Goethe University, Frankfurt am Main, Germany
    Pacing Clin Electrophysiol 24:1519-24. 2001
    ..Only in patients with documented efficacy of morphology discrimination should this feature be subsequently activated...
  43. pmc Torsade de pointes tachycardia as a rare manifestation of acute enteroviral myocarditis
    C Badorff
    Division of Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Heart 86:489-90. 2001
    ..This case shows that torsade de pointes may occur as a rare manifestation of viral myocarditis. Serial serological tests and endomyocardial biopsies may be helpful in establishing a diagnosis in such patients...
  44. ncbi ICD therapy in coronary artery disease. A reappraisal in 2005
    Gerian Grönefeld
    Division of Cardiology, Department of Medicine, J W Goethe University, Frankfurt Main, Germany
    Herz 30:82-6. 2005
    ..There is convincing evidence that ICD benefit in coronary patients accrues after a considerable time having elapsed from the most recent infarct, presumably at least 6 months or perhaps longer...
  45. ncbi Acute severe cardiac decompensation during cardiac resynchronization therapy: what is the cause?
    Carsten W Israel
    J W Goethe University, Department of Cardiology, Division of Electrophysiology, Frankfurt, Germany
    Pacing Clin Electrophysiol 29:632-6. 2006
  46. ncbi Novel anti-arrhythmic drugs for atrial fibrillation management
    Joachim R Ehrlich
    Division of Cardiology, Section of Electrophysiology, J W Goethe University, Frankfurt, Germany
    Curr Vasc Pharmacol 5:185-95. 2007
    ..This article summarizes relevant aspects of the cellular electrophysiology of AF and reviews the actions of pharmacological agents presently available or in development as novel anti-arrhythmic therapy...
  47. ncbi Analysis during sinus rhythm of critical sites in reentry circuits of postinfarction ventricular tachycardia
    Frank Bogun
    Division of Cardiology, JW Goethe University, Frankfurt, Germany
    J Interv Card Electrophysiol 7:95-103. 2002
    ....
  48. ncbi External cardioversion of atrial fibrillation in patients with implanted pacemaker or cardioverter-defibrillator systems: a randomized comparison of monophasic and biphasic shock energy application
    Johannes C Manegold
    Division of Cardiology, Department of Medicine, J W Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    Eur Heart J 28:1731-8. 2007
    ..This prospective study evaluated the safety and efficacy of ECV comparing mono- to biphasic shock waveforms in patients with implanted rhythm devices...
  49. ncbi Robotically enhanced placement of left ventricular epicardial electrodes during implantation of a biventricular implantable cardioverter defibrillator system
    Peter Kleine
    Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Pacing Clin Electrophysiol 25:989-91. 2002
    ..This report demonstrates the feasibility of totally endoscopic direct placement of an epicardial stimulation lead on the left ventricle using the daVinci surgical system...
  50. ncbi Reversible exercise-induced advanced atrioventricular block due to cardiac sarcoidosis
    Lothar Rossig
    Department of Internal Medicine, JW Goethe University, Frankfurt, Germany
    Heart Rhythm 4:116. 2007
  51. ncbi Amiodarone-associated macroscopic T-wave alternans and torsade de pointes unmasking the inherited long QT syndrome
    Florian T Wegener
    Division of Cardiology, Section of Clinical Electrophysiology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Europace 10:112-3. 2008
  52. ncbi Electrocardiographic hallmark of arrhythmogenic right ventricular cardiomyopathy
    Sergio Richter
    J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 17:563-4. 2006
  53. ncbi Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence
    Joachim R Ehrlich
    Division of Clinical Electrophysiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Heart J 27:512-8. 2006
    ..This exciting field of investigation may lead to significant improvements in therapeutic options for AF patients...
  54. ncbi Towards a consensus in rate versus rhythm control for management of atrial fibrillation: insights from the PIAF trial
    Gerian Grönefeld
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Card Electrophysiol Rev 7:113-7. 2003
    ..This review summarizes the rationale and results of PIAF in an attempt to update and discuss the clinical relevance of these findings in the light of the other studies and with regard to individual treatment options...
  55. ncbi Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization
    Joachim R Ehrlich
    Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Pharmacol Exp Ther 319:898-906. 2006
    ..5 expression, and shows a pharmacological profile typical of K(v)1.5-dependent currents...
  56. doi Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications
    Joern Schmitt
    Section of Electrophysiology, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur Heart J 30:1038-45. 2009
    ..These observations emphasize the need for prospective studies evaluating optimal therapeutic approaches for patients with AMI complicated by AF...
  57. ncbi Suppression of atrial tachyarrhythmias by pacing
    Carsten W Israel
    Department of Medicine, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 13:S31-9. 2002
    ..Accordingly, new therapeutic approaches for AT suppression are evaluated. Atrial pacing may prevent ATs by modifying the electrophysiologic conditions required for sustained ATs...
  58. ncbi Electrophysiologic refinement of risk stratification: can we achieve the goal?
    Carsten W Israel
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 15:177-8. 2004
  59. doi Characterization of human cardiac Kv1.5 inhibition by the novel atrial-selective antiarrhythmic compound AVE1231
    Joachim R Ehrlich
    Division of Cardiology, J W Goethe Universitat, Frankfurt, Germany
    J Cardiovasc Pharmacol 51:380-7. 2008
    ..Atrial-selective drug therapy represents a novel therapeutic approach for atrial fibrillation management. The aim of the present study was to investigate the mechanism of hKv1.5 channel inhibition by the atrial-selective compound AVE1231...
  60. doi Biventricular pacing does not affect microvolt T-wave alternans in heart failure patients
    Joachim R Ehrlich
    Division of Clinical Electrophysiology, J W Goethe University, Frankfurt, Germany
    Heart Rhythm 5:348-52. 2008
    ..Accordingly, it is unknown whether biventricular (BiV) pacing might influence MTWA test results...
  61. doi Atrial-selective approaches for the treatment of atrial fibrillation
    Joachim R Ehrlich
    Division of Cardiology, Section of Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 51:787-92. 2008
    ..It also mentions favorable interventions on the milieu in terms of conventional (such as antifibrotic effects of angiotensin-system antagonism) and innovative gene-therapy approaches that might add to future AF therapeutic options...
  62. ncbi What do implantable cardioverter/defibrillators teach us about the mechanisms of sudden cardiac death?
    G Gronefeld
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cardiovasc Res 50:232-41. 2001
    ..One future research avenue concerns the more detailed analysis of changes in cardiac autonomic tone preceding the occurrence of sustained ventricular tachyarrhythmias which can be assessed from the electrogram storage of the ICD...
  63. ncbi Heart rate turbulence and other autonomic risk markers for arrhythmia risk stratification in dilated cardiomyopathy
    Thomas Klingenheben
    Division of Clinical Electrophysiology, Department of Cardiology, JW Goethe University, Frankfurt, Germany
    J Electrocardiol 41:306-11. 2008
    ..Noninvasive arrhythmia risk stratification in patients with nonischemic dilated cardiomyopathy (DCM) using autonomic markers have yielded disappointing results. Heart rate turbulence is a new method to assess cardiac autonomic function...
  64. ncbi Upgrading to biventricular pacing/defibrillation systems in right ventricular paced congestive heart failure patients: prospective assessment of procedural parameters and response rate
    Gabor Z Duray
    Section Clinical Electrophysiology, Division of Cardiology, Department of Medicine, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
    Europace 10:48-52. 2008
    ..It is less clear whether this includes patients with pre-existing right ventricular pacemaker/defibrillator systems, particularly with respect to implantation success and clinical benefit...
  65. ncbi Usefulness of risk stratification for future cardiac events in infarct survivors with severely depressed versus near-normal left ventricular function: results from a prospective long-term follow-up study
    Thomas Klingenheben
    Department of Medicine, Division of Clinical Electrophysiology, J W Goethe University Hospital, Frankfurt, Germany
    Ann Noninvasive Electrocardiol 8:68-74. 2003
    ..The value of risk stratification in postinfarction patients with versus those without left ventricular dysfunction has not been investigated in detail in infarct survivors treated according to contemporary therapeutic guidelines...
  66. ncbi Dronedarone: an emerging agent with rhythm- and rate-controlling effects
    Florian T Wegener
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 17:S17-20. 2006
    ....
  67. doi Milestones in the management of atrial fibrillation
    Joachim R Ehrlich
    Division of Cardiology, Section of Electrophysiology, Goethe University, Frankfurt, Germany
    Heart Rhythm 6:S62-7. 2009
    ..In summary, the development of novel treatment strategies for AF is highly dynamic and productive. Years to come will likely witness significant changes in perspective and prognosis of affected patients...
  68. ncbi How to analyze T-wave alternans
    Sergio Richter
    Department of Cardiology, Division of Clinical Electrophysiology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Heart Rhythm 2:1268-71. 2005
  69. ncbi Prevention of immediate reinitiation of atrial tachyarrhythmias by high-rate overdrive pacing: results from a prospective randomized trial
    Carsten W Israel
    Department of Medicine, Division of Cardiology, J W Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Cardiovasc Electrophysiol 14:954-9. 2003
    ..Immediate reinitiation of atrial tachyarrhythmia (IRAT) is an important cause of failure to maintain sinus rhythm. IRAT prevention by overdrive pacing has not been evaluated in a prospective randomized trial...
  70. ncbi The Defibrillator in Acute Myocardial Infarction Trial (DINAMIT): rationale, design and specific aims
    Gerian Grönefeld
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Card Electrophysiol Rev 7:447-51. 2003
    ..This paper summarizes the rationale, design and specific contributions of the Defibrillator in Myocardial infarction trial (DINAMIT) in comparison to other relevant studies on primary prevention of sudden cardiac death...
  71. ncbi Quantitative assessment of microvolt T-wave alternans in patients with congestive heart failure
    Thomas Klingenheben
    Division of Clinical Electrophysiology, Department of Cardiology, J W Goethe University, D 60590 Frankfurt, Germany
    J Cardiovasc Electrophysiol 16:620-4. 2005
    ..Currently, only qualitative assessment of microvolt T-wave alternans (MTWA) is recommended in clinical practise. Whether quantitative assessment of MTWA yields complementary information is unknown...
  72. ncbi Immediate reinitiation of atrial tachyarrhythmias after spontaneous restoration of sinus rhythm in patients with an implanted monitoring device
    Carsten W Israel
    J W Goethe University, Division of Cardiology, Frankfurt, Germany
    Pacing Clin Electrophysiol 26:1317-25. 2003
    ..In conclusion, IRAT is frequent after spontaneous restoration of SR. Changes of atrial electrophysiological properties promoting IRAT may already develop during AT of short duration...
  73. ncbi Bundle branch reentrant tachycardia in patients with apparent normal His-Purkinje conduction: the role of functional conduction impairment
    Yi Gang Li
    Department of Internal Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 13:1233-9. 2002
    ..His-Purkinje conduction delay, manifested by bundle branch block QRS complex configuration or by HV interval prolongation, is considered an essential condition for maintenance of bundle branch reentrant tachycardia (BBRT)...
  74. ncbi Pacing to prevent atrial fibrillation
    Carsten W Israel
    Department of Medicine, J W Goethe University Hospital, Frankfurt, Germany
    J Cardiovasc Electrophysiol 14:S20-6. 2003
    ..Pacing has been proposed as a nonpharmacologic treatment option to prevent atrial tachyarrhythmias (ATs) in drug-refractory patients. This article reviews the current state of pacing to prevent ATs...
  75. ncbi Recent primary prevention implantable cardioverter defibrillator trials
    Gabor Duray
    Department of Medicine, J W Goethe University, Frankfurt am Main, Germany
    Curr Opin Cardiol 21:15-9. 2006
    ..The aim of this article is to summarize the most relevant findings of recently published trials on prophylactic implantable cardioverter defibrillator therapy...
  76. ncbi Beta-blocker therapy in atrial fibrillation
    Gerian C Gronefeld
    University Hospital Frankfurt, Frankfurt, Germany
    Pacing Clin Electrophysiol 26:1607-12. 2003
    ..The article summarizes available clinical studies and reviews some experimental data examining the treatment effects of antiadrenergic therapy in AF...
  77. ncbi Impact of rate versus rhythm control on quality of life in patients with persistent atrial fibrillation. Results from a prospective randomized study
    Gerian C Gronefeld
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Eur Heart J 24:1430-6. 2003
    ..This prospective study evaluated QoL in patients with symptomatic persistent AF randomized to therapy aiming at rate versus rhythm control...
  78. ncbi Usefulness of atrial pacing for prevention and termination of atrial tachyarrhythmias in a patient with persistent atrial fibrillation
    Carsten W Israel
    J W Goethe University Hospital, Department of Medicine, Frankfurt, Germany
    Pacing Clin Electrophysiol 25:1527-9. 2002
    ..Thus, selected patients with persistent AF may benefit from preventive atrial pacing since the tachyarrhythmia can organize intermittently to a degree sufficient for pace termination...
  79. ncbi Severe intracranial bleeding mimicking acute inferior myocardial infarction with right ventricular involvement
    F Jung
    Division of Cardiology, Department of Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cardiology 95:48-50. 2001
    ..A rapid diagnostic evaluation has to be initiated to rule out a myocardial infarction and to diagnose intracranial hemorrhage before the use of thrombolytic or anticoagulant therapy...
  80. ncbi Thromboembolic risk of patients referred for radiofrequency catheter ablation of typical atrial flutter without prior appropriate anticoagulation therapy
    Gerian C Gronefeld
    J W Goethe University, Frankfurt, Germany
    Pacing Clin Electrophysiol 26:323-7. 2003
    ..Radiofrequency catheter ablation of isthmus dependent atrial flutter is considered the therapy of choice. There is, however, controversy with regard to the thrombogenicity of atrial flutter in comparison with atrial fibrillation...
  81. ncbi Long-term risk of recurrent atrial fibrillation as documented by an implantable monitoring device: implications for optimal patient care
    Carsten W Israel
    J W Goethe University Hospital, Department of Medicine, Division of Cardiology, Frankfurt, Germany
    J Am Coll Cardiol 43:47-52. 2004
    ..The present study determined the incidence and time course of atrial fibrillation (AF) recurrences in patients with a history of AF and fitted with an implantable monitoring device...
  82. doi Assessment of microvolt T-wave alternans in high-risk patients with the congenital long-QT syndrome
    Jörn Schmitt
    Division of Cardiology, Section of Electrophysiology, J W Goethe University, Frankfurt, Germany
    Ann Noninvasive Electrocardiol 14:340-5. 2009
    ..The role of MTWA testing in patients with LQTS has not been established. Objective: To determine the diagnostic value of MTWA testing in high-risk patients with LQTS...
  83. doi Dronedarone: a novel antiarrhythmic agent for the treatment of atrial fibrillation
    Gabor Z Duray
    J W Goethe University, Frankfurt, Germany
    Curr Opin Cardiol 25:53-8. 2010
    ..To describe the electrophysiological profile and the clinical portfolio of dronedarone, a new multichannel-blocking antiarrhythmic drug developed for the treatment of atrial fibrillation...
  84. ncbi Changing late prognosis of acute myocardial infarction: impact on management of ventricular arrhythmias in the era of reperfusion and the implantable cardioverter-defibrillator
    Stefan H Hohnloser
    J W Goethe University, Department of Medicine, Division of Cardiology, Frankfurt, Germany
    Circulation 107:941-6. 2003
  85. ncbi "Twiddler syndrome" in a subpectorally implanted cardioverter defibrillator
    Gerian Grönefeld
    Department of Medicine, J W Goethe University, Frankfurt Main, Germany
    J Cardiovasc Electrophysiol 13:94. 2002
  86. ncbi Tachycardia after pacemaker implantation in a patient with complete atrioventricular block
    Gabor Z Duray
    Division of Clinical Electrophysiology, Department of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Europace 9:900-3. 2007
    ..Dual-chamber devices therefore have to be programmed accordingly, activating dedicated reactions after ventricular premature beats and automatic ELT detection and termination algorithms...
  87. ncbi [Pathophysiologic relevance and prognostic value of QT dispersion.]
    M Zabel
    Abt Kardiologie und Nephrologie, Medizinische Klinik IV, Theodor Stern Kai 7, 60590, Frankfurt
    Herzschrittmacherther Elektrophysiol 8:223-30. 1997
    ..In other populations, such as postinfarction patients, patients with congestive heart failure or patients with ventricular tachycardia or ventricular fibrillation, determination of QT dispersion is probably not of clinical value...
  88. doi Coronary sinus side branches for cardiac resynchronization therapy: prospective evaluation of availability, implant success, and procedural determinants
    Gabor Z Duray
    Department of Medicine, Division of Cardiology, Section Clinical Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 19:489-94. 2008
    ..There are only sparse data concerning individual coronary side branch (CS-SB) anatomy with respect to LV lead implantation for cardiac resynchronization therapy (CRT)...
  89. ncbi Catheter ablation of frequently recurring ventricular fibrillation in a patient after aortic valve repair
    Yi Gang Li
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 15:90-3. 2004
    ..VPB originating from the Purkinje system may be one possibility for VF initiation in patients with structural heart disease. Eliminating these sources of VPBs by catheter ablation can prevent recurrent VF in such patients...
  90. ncbi Complications leading to surgical revision in implantable cardioverter defibrillator patients: comparison of patients with single-chamber, dual-chamber, and biventricular devices
    Gabor Z Duray
    Division of Cardiology, Section Clinical Electrophysiology, Department of Medicine, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Europace 11:297-302. 2009
    ..The incidence of hardware-related complications in single (SC)-, dual (DC)-, and triple (BiV)-chamber devices requiring surgical revision has not been investigated systematically...
  91. ncbi Design of the SHock Inhibition Evaluation with Azimilide (SHIELD) study: a novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator
    Craig M Pratt
    The Methodist DeBakey Heart Center and the Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Am J Cardiol 95:274-6. 2005
    ..The primary efficacy end points are time to all-cause shocks and time to all-cause shocks plus symptomatic ventricular arrhythmic events triggering antitachycardia pacing measured from randomization...
  92. ncbi Preventing tomorrow's sudden cardiac death today: part II: Translating sudden cardiac death risk assessment strategies into practice and policy
    Gillian D Sanders
    Duke Clinical Research Institute, Duke Medical Center, Durham, NC 27715, USA
    Am Heart J 153:951-9. 2007
    ....
  93. ncbi Highlights of Heart Rhythm 2004, the Annual Scientific Sessions of the Heart Rhythm Society: May 19 to 22, 2004, in San Francisco, California
    Anne B Curtis
    Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Coll Cardiol 44:1550-6. 2004
    ....
  94. ncbi Mechanisms of sudden cardiac death in myocardial infarction survivors: insights from the randomized trials of implantable cardioverter-defibrillators
    T Jared Bunch
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 115:2451-7. 2007
  95. ncbi Can microvolt T-wave alternans testing reduce unnecessary defibrillator implantation?
    Antonis A Armoundas
    Massachusetts General Hospital, USA
    Nat Clin Pract Cardiovasc Med 2:522-8. 2005
    ..In response, patients with a low ejection fraction who are being considered for implantable cardioverter-defibrillator therapy should undergo MTWA testing as part of their evaluation...
  96. ncbi Dronedarone for prevention of atrial fibrillation: a dose-ranging study
    Paul Touboul
    Division of Cardiology, Hopital Cardiologique, Lyon, France
    Eur Heart J 24:1481-7. 2003
    ..This study was designed to determine the most appropriate dose of dronedarone for prevention of atrial fibrillation (AF) after cardioversion...
  97. ncbi Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 295:165-71. 2006
    ..Implantable cardioverter defibrillator (ICD) therapy is effective but is associated with high-voltage shocks that are painful...
  98. ncbi [Pharmacological therapy of atrial fibrillation and atrial flutter]
    Gerian C Gronefeld
    Abteilung Kardiologie, Medizinische Klinik IV, Johann Wolfgang Goethe Universität Frankfurt am Main
    Herz 27:329-44. 2002
    ....
  99. ncbi Highlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana
    Dwight W Reynolds
    Cardiovascular Section, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Heart Rhythm 2:1025-33. 2005
  100. ncbi Rhythm or rate control in atrial fibrillation: insights from the randomized controlled trials
    Gerian Grönefeld
    J Cardiovasc Pharmacol Ther 8:S39-44. 2003
    ..The four randomized trials clearly demonstrate that continuous anticoagulation is mandatory in all patients with atrial fibrillation and risk factors for stroke, irrespective of the initial therapeutic approach of rhythm or rate control...
  101. doi Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...