Christian Hofstetter

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Treatment of uncomplicated hydatid cyst of the liver by closed marsupialization and fibrin glue obliteration
    Christian Hofstetter
    Department of General Surgery, Hospital Clinico, University of Granada, San Cecilio, University of Granada, Avenida del Doctor Oloriz 16, E 18012 Granada, Spain
    World J Surg 28:173-8. 2004
  2. ncbi request reprint Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats
    Christian Hofstetter
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University, D 60590 Frankfurt Main, Germany
    Int J Mol Med 20:597-604. 2007
  3. ncbi request reprint Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats
    C Hofstetter
    Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University of Frankfurt, Frankfurt, Germany
    Acta Anaesthesiol Scand 51:893-9. 2007
  4. ncbi request reprint [Videolaryngoscopy versus direct laryngoscopy for elective endotracheal intubation]
    C Hofstetter
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt a M, Germany
    Anaesthesist 55:535-40. 2006
  5. doi request reprint Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats
    Patrick Scheiermann
    Pharmazentrum frankfurt ZAFES, Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Theodor Stern Kai 7, Frankfurt Main, Germany
    Int Immunopharmacol 11:719-23. 2011
  6. ncbi request reprint A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats
    Christian Hofstetter
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Int Immunopharmacol 5:1519-22. 2005
  7. ncbi request reprint Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats
    Kim A Boost
    Department of Anaesthesiology, Intensive Care and Pain Therapy, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Int J Mol Med 17:1139-44. 2006
  8. ncbi request reprint Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat
    Christian Hofstetter
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University of Frankfurt, Germany
    Crit Care Med 33:2317-22. 2005
  9. doi request reprint Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury
    Kim A Boost
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Crit Care Med 36:1873-9. 2008
  10. ncbi request reprint Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
    Kim A Boost
    Department of Anaesthesiology, Intensive Care and Pain Therapy, University Hospital of Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Intensive Care Med 33:863-71. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Treatment of uncomplicated hydatid cyst of the liver by closed marsupialization and fibrin glue obliteration
    Christian Hofstetter
    Department of General Surgery, Hospital Clinico, University of Granada, San Cecilio, University of Granada, Avenida del Doctor Oloriz 16, E 18012 Granada, Spain
    World J Surg 28:173-8. 2004
    ..The results were also compared to those of a former study reported by our group in which the experience of another 19 years was presented...
  2. ncbi request reprint Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats
    Christian Hofstetter
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University, D 60590 Frankfurt Main, Germany
    Int J Mol Med 20:597-604. 2007
    ..The data demonstrate that the administration of norepinephrine or vasopressin both counteracted the anti-inflammatory effects of inhaled isoflurane on proinflammatory cytokine release during experimental endotoxemia in rats...
  3. ncbi request reprint Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats
    C Hofstetter
    Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University of Frankfurt, Frankfurt, Germany
    Acta Anaesthesiol Scand 51:893-9. 2007
    ..Volatile anesthetics and hypothermia attenuate the inflammatory response. We aimed to compare the anti-inflammatory effects of sevoflurane and mild hypothermia during experimental endotoxemia in the rat...
  4. ncbi request reprint [Videolaryngoscopy versus direct laryngoscopy for elective endotracheal intubation]
    C Hofstetter
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590, Frankfurt a M, Germany
    Anaesthesist 55:535-40. 2006
    ..We compared the ease of viewing the glottis under direct vision during conventional laryngoscopy with the quality of indirectly viewing on a monitor during laryngoscopy with a Macintosh videolaryngoscope in a multicenter study...
  5. doi request reprint Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats
    Patrick Scheiermann
    Pharmazentrum frankfurt ZAFES, Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Theodor Stern Kai 7, Frankfurt Main, Germany
    Int Immunopharmacol 11:719-23. 2011
    ..Low TNF-α concentrations 300 min after sepsis induction could be interpreted as considerable immunosuppression during CLI sepsis...
  6. ncbi request reprint A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats
    Christian Hofstetter
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Int Immunopharmacol 5:1519-22. 2005
    ..These unforeseen observations suggest that short-term inhalation of isoflurane for induction of anesthesia may be an unsuitable procedure particularly in animal models of acute inflammation...
  7. ncbi request reprint Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats
    Kim A Boost
    Department of Anaesthesiology, Intensive Care and Pain Therapy, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Int J Mol Med 17:1139-44. 2006
    ..Our data implicate that inhalation of 1MAC Desflurane during experimental endotoxemia differentially affects the inflammatory response in rats...
  8. ncbi request reprint Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat
    Christian Hofstetter
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University of Frankfurt, Germany
    Crit Care Med 33:2317-22. 2005
    ....
  9. doi request reprint Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury
    Kim A Boost
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Crit Care Med 36:1873-9. 2008
    ..We therefore aimed to evaluate whether inhalation therapy with levosimendan, a calcium-sensitizer with pulmonary vasodilating properties, could attenuate VILI and improve short-term survival in a rat experimental model...
  10. ncbi request reprint Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
    Kim A Boost
    Department of Anaesthesiology, Intensive Care and Pain Therapy, University Hospital of Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Intensive Care Med 33:863-71. 2007
    ....
  11. doi request reprint Cecal ligation and incision: an acute onset model of severe sepsis in rats
    Patrick Scheiermann
    Department of Anesthesiology, Intensive Care Medicine, and Pain Therapy, Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Germany
    J Surg Res 151:132-7. 2009
    ..We therefore aimed to establish a surgical model of severe sepsis in rodents fulfilling international sepsis criteria...
  12. doi request reprint Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury
    Sandra Hoegl
    Clinic for Anesthesiology, University Hospital of Ludwig Maximilians University, Munich, Germany
    Am J Respir Cell Mol Biol 44:369-76. 2011
    ..These data support the hypothesis that IL-22, likely via activation of STAT3 and downstream genes (e.g., SOCS3), is able to protect against cell stretch and pulmonary baro-/biotrauma by enhancing epithelial cell resistibility...
  13. ncbi request reprint Aerosol delivery during mechanical ventilation to the rat
    Christian Hofstetter
    Department of Anaesthesiology, University of Frankfurt, Frankfurt, Germany
    Exp Lung Res 30:635-51. 2004
    ..There was no evidence for any adverse event as assessed from heart rate, mean arterial pressure, PaO2 and PaCO2 before, during, and after nebulization. No pulmonary tissue trauma was detected histologically...
  14. ncbi request reprint Isoflurane inhalation after induction of endotoxemia in rats attenuates the systemic cytokine response
    M Flondor
    Department of Anesthesiology, Intensive Care and Pain Therapy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Eur Surg Res 40:1-6. 2008
    ..We aimed therefore to evaluate the effect of isoflurane after administration of LPS on the cytokine release as a therapeutic option...
  15. ncbi request reprint The beta-adrenoceptor antagonist propranolol counteracts anti-inflammatory effects of isoflurane in rat endotoxemia
    K A Boost
    Department of Anaesthesiology, Intensive Care and Pain Therapy, University Hospital of Johann Wolfgang Goethe University Frankfurt am Main, Germany
    Acta Anaesthesiol Scand 51:900-8. 2007
    ..We therefore aimed to investigate whether the beta-adrenoceptor antagonist propranolol might modulate the anti-inflammatory effects of isoflurane on the systemic and pulmonary release of pro-inflammatory cytokines in endotoxemic rats...
  16. ncbi request reprint The effect of inhaled nitric oxide and inhaled iloprost on hypoxaemia in a patient with pulmonary hypertension after pulmonary thrombarterectomy
    M Flondor
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    Anaesthesia 61:1200-3. 2006
    ..Hence, the combination of both drugs may be reasonable in cases where the standard therapy fails. The effect has been demonstrated by means of continuous blood gas monitoring...
  17. ncbi request reprint Prehospital emergency endotracheal intubation using the Bonfils intubation fiberscope
    Christian Byhahn
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, J W Goethe University Medical School, Frankfurt, Germany
    Eur J Emerg Med 14:43-6. 2007
    ..The Bonfils intubation fiberscope therefore demonstrated its value as an additional airway management device in both emergency and prehospital settings...
  18. pmc Inhalation of the BK(Ca)-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension
    Marc Revermann
    Department of Anesthesiology and Critical Care Medicine, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany Institute for Cardiovascular Physiology, Medical Faculty of the Goethe University Frankfurt, Frankfurt, Germany
    PLoS ONE 9:e86636. 2014
    ..On this basis, we hypothesized that treatment with the nebulized BK channel opener NS1619 might be a therapy option for pulmonary hypertension and tested this in rats...
  19. pmc Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo
    E Ziesché
    Pharmazentrum frankfurt ZAFES, Intensive Care Medicine and Pain Therapy, University Hospital Goethe University, 60590 Frankfurt am Main, Germany
    Clin Exp Immunol 157:370-6. 2009
    ..epidermidis-activated PBMC and rat sepsis, respectively. The data presented herein suggest that insufficient IL-22 function may contribute to impaired intestinal host defence in the context of corticosteroid therapy...
  20. ncbi request reprint Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat
    Sandra Hoegl
    Clinic of Anaesthesiology, University Hospital of Ludwig Maximilians University, D 81377 Munich, Germany
    Int J Mol Med 21:513-9. 2008
    ..Thus, by combining barotrauma with biotrauma, this animal model may be suitable for studying therapeutical approaches to VILI...
  21. ncbi request reprint Comparison of direct and video-assisted views of the larynx during routine intubation
    Marshal B Kaplan
    Department of Anesthesiology, UCLA and Cedars Sinai Medical Center, Los Angeles, CA 90095, USA, and Department of Anesthesiology, Cantonal Hospital, St Gallen, Switzerland
    J Clin Anesth 18:357-62. 2006
    ..To compare the direct and indirect (video monitor) views of the glottic opening using a new Macintosh blade that is modified to provide a video image of airway structures during laryngoscopy...