Christopher Heeschen

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis
    Christopher Heeschen
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Am Coll Cardiol 45:229-37. 2005
  2. ncbi request reprint N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes
    Christopher Heeschen
    J W Goethe University, Department of Cardiology, Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 110:3206-12. 2004
  3. ncbi request reprint Prognostic significance of angiogenic growth factor serum levels in patients with acute coronary syndromes
    Christopher Heeschen
    Department of Internal Medicine IV, Molecular Cardiology, University of Frankfurt, Germany
    Circulation 107:524-30. 2003
  4. ncbi request reprint Prognostic value of placental growth factor in patients with acute chest pain
    Christopher Heeschen
    Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany
    JAMA 291:435-41. 2004
  5. ncbi request reprint Soluble CD40 ligand in acute coronary syndromes
    Christopher Heeschen
    c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina CAPTURE Study, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    N Engl J Med 348:1104-11. 2003
  6. ncbi request reprint Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes
    Christopher Heeschen
    Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 107:2109-14. 2003
  7. doi request reprint The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche
    Alexandra Aicher
    Department of Internal Medicine III, J W Goethe University, Frankfurt, Germany
    Circ Res 103:796-803. 2008
  8. ncbi request reprint Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease
    Joerg Honold
    Department of Cardiology and Molecular Cardiology, Internal Medicine III, J W Goethe University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 26:2238-43. 2006
  9. ncbi request reprint Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease
    Christopher Heeschen
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 109:1615-22. 2004
  10. ncbi request reprint Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure
    Christine K Kissel
    Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    J Am Coll Cardiol 49:2341-9. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis
    Christopher Heeschen
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Am Coll Cardiol 45:229-37. 2005
    ..The goal of this study was to determine the predictive value of pregnancy-associated plasma protein-A (PAPP-A) in patients with acute coronary syndromes (ACS)...
  2. ncbi request reprint N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes
    Christopher Heeschen
    J W Goethe University, Department of Cardiology, Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 110:3206-12. 2004
    ....
  3. ncbi request reprint Prognostic significance of angiogenic growth factor serum levels in patients with acute coronary syndromes
    Christopher Heeschen
    Department of Internal Medicine IV, Molecular Cardiology, University of Frankfurt, Germany
    Circulation 107:524-30. 2003
    ..However, it is unknown whether their serum levels are related to clinical outcome...
  4. ncbi request reprint Prognostic value of placental growth factor in patients with acute chest pain
    Christopher Heeschen
    Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany
    JAMA 291:435-41. 2004
    ....
  5. ncbi request reprint Soluble CD40 ligand in acute coronary syndromes
    Christopher Heeschen
    c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina CAPTURE Study, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    N Engl J Med 348:1104-11. 2003
    ..We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the therapeutic effect of glycoprotein IIb/IIIa receptor inhibition in patients with acute coronary syndromes...
  6. ncbi request reprint Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes
    Christopher Heeschen
    Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 107:2109-14. 2003
    ..Therefore, we investigated the prognostic impact of key inflammatory players, namely the inflammatory marker C-reactive protein (CRP) and the antiinflammatory cytokine interleukin-10 (IL-10), in patients with acute coronary syndromes...
  7. doi request reprint The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche
    Alexandra Aicher
    Department of Internal Medicine III, J W Goethe University, Frankfurt, Germany
    Circ Res 103:796-803. 2008
    ..Thus, these data show that Dkk-1 is a mobilizer of vasculogenic progenitors but not of inflammatory cells, which could be of great clinical importance to enhance regenerative cell therapy...
  8. ncbi request reprint Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease
    Joerg Honold
    Department of Cardiology and Molecular Cardiology, Internal Medicine III, J W Goethe University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 26:2238-43. 2006
    ..Therefore, we investigated the effects of G-CSF administration on mobilization and functional activities of blood-derived EPC in patients with chronic ischemic heart disease (CIHD)...
  9. ncbi request reprint Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease
    Christopher Heeschen
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 109:1615-22. 2004
    ..However, whether this impairment also extends to bone marrow-derived mononuclear cells (BM-MNCs) in patients with chronic ischemic cardiomyopathy (ICMP) is unclear...
  10. ncbi request reprint Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure
    Christine K Kissel
    Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    J Am Coll Cardiol 49:2341-9. 2007
    ....
  11. pmc Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
    J Exp Med 201:1825-35. 2005
    ..Thus, HoxA9 is regulated by HDACs and is critical for postnatal neovascularization...
  12. ncbi request reprint Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease
    Dirk H Walter
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
    Circ Res 97:1142-51. 2005
    ..Stimulating CXCR4 signaling might improve functional properties of EPC and may rescue impaired neovascularization capacity of EPC derived from patients with CAD...
  13. pmc Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Frankfurt am Main, Germany
    J Clin Invest 115:2382-92. 2005
    ..In vivo, Foxo3a deficiency increased eNOS expression and enhanced postnatal vessel formation and maturation. Thus, our data suggest an important role for Foxo transcription factors in the regulation of vessel formation in the adult...
  14. ncbi request reprint Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Stephan Baldus
    University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:1440-5. 2003
    ..However, whether MPO also provides prognostic information in patients with ACS remains unknown...
  15. ncbi request reprint Cathepsin L is required for endothelial progenitor cell-induced neovascularization
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Med 11:206-13. 2005
    ..We concluded that CathL has a critical role in the integration of circulating EPC into ischemic tissue and is required for EPC-mediated neovascularization...
  16. ncbi request reprint Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia
    Alexandra Aicher
    Department of Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 114:2823-30. 2006
    ..Therefore, we investigated the effect of targeted extracorporeal shock wave (SW) application in order to facilitate EPC recruitment into nonischemic and chronic ischemic tissue...
  17. ncbi request reprint Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia
    Alexandra Aicher
    Department of Molecular Cardiology, J W Goethe University, Frankfurt, Germany
    Circ Res 100:581-9. 2007
    ..Intestine and liver represent a rich source for mobilized tissue-residing progenitor cells...
  18. ncbi request reprint Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Mol Cell Cardiol 39:733-42. 2005
    ..In addition to the physical contribution of EPC to newly formed vessels, the enhanced expression of cytokines may be a supportive mechanism to improve blood vessel formation and cardiac regeneration after cell therapy...
  19. ncbi request reprint Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for 'pleiotropic' functions of statin therapy
    Stephan Fichtlscherer
    Department of Internal Medicine III, Division of Cardiology, Johann W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur Heart J 27:1182-90. 2006
    ..The clinical availability of ezetimibe, a potent novel cholesterol absorption inhibitor, enables to differentiate lipid-lowering effects from potential non-lipid-lowering (pleiotropic) mechanisms of statins...
  20. ncbi request reprint Influence of sample type on soluble CD40 ligand assessment in patients with acute coronary syndromes
    Michael Weber
    Kerckhoff Heart Center, Department of Cardiology, Bad Nauheim, Germany
    Thromb Res 120:811-4. 2007
    ..Thus, it was the aim of our prospective study to evaluate the impact of sampling techniques on sCD40L concentrations of patients with acute coronary syndromes compared to controls...
  21. pmc Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy
    Ken ichiro Sasaki
    Department of Internal Medicine III, J W Goethe University, 60590 Frankfurt, Germany
    Proc Natl Acad Sci U S A 103:14537-41. 2006
    ..Here, we show that pharmacological enhancement of eNOS expression with AVE at least partially reverses the impaired functional activity of BMC from ICMP patients, highlighting the critical role of NO for progenitor cell function...
  22. ncbi request reprint Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
    Christopher Heeschen
    Department of Internal Medicine IV and Hematology, University of Frankfurt, Germany
    Blood 102:1340-6. 2003
    ..Epo appears to physiologically regulate EPC mobilization in patients with ischemic heart disease. Thus, Epo serum levels may help in identifying patients with impaired EPC recruitment capacity...
  23. pmc Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells
    Emmanouil Chavakis
    Molecular Cardiology, Dept of Medicine III, University of Frankfurt, 60950 Frankfurt, Germany
    J Exp Med 201:63-72. 2005
    ..Preactivation of the beta2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of beta2-integrins in postnatal vasculogenesis...
  24. ncbi request reprint Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease
    Stephan Fichtlscherer
    Department of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 44:44-9. 2004
    ..Because the endothelium is a major target for inflammatory cytokines, we investigated whether elevated interleukin (IL)-10 serum levels are associated with improved endothelial vasoreactivity in patients with coronary artery disease (CAD)...
  25. ncbi request reprint The pro-apoptotic serum activity is an independent mortality predictor of patients with heart failure
    Lothar Rossig
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Heart J 25:1620-5. 2004
    ..Since serum of patients with HF induces apoptosis of endothelial cells (EC), we aimed to determine whether the pro-apoptotic activity in the serum may predict prognosis of patients with HF...
  26. ncbi request reprint Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    Alexandra Aicher
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Med 9:1370-6. 2003
    ..This may contribute to impaired regeneration processes in ischemic heart disease patients, who are characterized by a reduced systemic NO bioactivity...
  27. ncbi request reprint Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circulation 108:2511-6. 2003
    ..Therefore, we investigated whether the phenotype and functional capacity of EPCs to improve neovascularization depend on their monocytic origin...
  28. ncbi request reprint p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization
    Tom Brühl
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 94:686-92. 2004
    ..In contrast, complete p21 deficiency did not result in an increased neovascularization despite increased mature EC and EPC proliferation. This may be due to the sensitization of ECs against apoptosis...
  29. ncbi request reprint The role of NOS3 in stem cell mobilization
    Alexandra Aicher
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Trends Mol Med 10:421-5. 2004
  30. ncbi request reprint Inflammatory markers and coronary artery disease
    Stephan Fichtlscherer
    Johann W Goethe University, Department of Cardiology, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Curr Opin Pharmacol 4:124-31. 2004
    ..As a result, different markers are used clinically for risk stratification in stable coronary artery disease as well as in acute coronary syndromes...
  31. pmc cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis
    Alexandra Aicher
    Department of Internal Medicine III, JW Goethe University, Frankfurt, Germany
    PLoS ONE 4:e4879. 2009
    ..Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effector cGMP-dependent protein kinase I (cGKI) on postnatal neovascularization...
  32. ncbi request reprint Influence of sample type and storage conditions on soluble CD40 ligand assessment
    Michael Weber
    Kerckhoff Heart Center, Department of Cardiology, Bad Nauheim, Germany
    Clin Chem 52:888-91. 2006
    ..However, few data are available on preanalytic conditions that impact sCD40L values. Thus, the aim of our prospective study was to evaluate the impact of sampling techniques and storage conditions on sCD40L concentrations...
  33. ncbi request reprint Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions
    Alexandra Aicher
    Department of Internal Medicine IV, Molecular Cardiology, University of Frankfurt, Germany
    Circulation 107:604-11. 2003
    ..Therefore, we investigated whether nicotine can stimulate APCs and their T cell-stimulatory capacity using human monocyte-derived DCs and murine bone marrow-derived DCs as APCs...
  34. ncbi request reprint Elevated placental growth factor levels are associated with adverse outcomes at four-year follow-up in patients with acute coronary syndromes
    Timo Lenderink
    Department of Cardiology, Atrium Medical Centre, Heerlen, The Netherlands
    J Am Coll Cardiol 47:307-11. 2006
    ..This study sought to evaluate the predictive value of baseline placental growth factor (PlGF) for long-term cardiovascular events in acute coronary syndromes (ACS)...
  35. ncbi request reprint Withdrawal of statins increases event rates in patients with acute coronary syndromes
    Christopher Heeschen
    University Hospital Frankfurt, Germany
    Circulation 105:1446-52. 2002
    ..Withdrawal of chronic statin treatment during acute coronary syndromes may impair vascular function independent of lipid-lowering effects and thus increase cardiac event rate...
  36. ncbi request reprint Withdrawal of statins in patients with acute coronary syndromes
    Christopher Heeschen
    Circulation 107:e27. 2003
  37. ncbi request reprint Quantitative bedside testing of troponin T: is it equal to laboratory testing? The Cardiac Reader Troponin T (CARE T) study
    Britta U Goldmann
    Med Clinic III Division of Cardiology, University Hospital Eppendorf, Hamburg, Germany
    Clin Lab 50:1-10. 2004
    ..However, point-of-care testing of troponin T is advantageous whenever marker results could positively effect initial triage decisions and interventional management choices...
  38. ncbi request reprint Biomarkers in acute coronary syndromes and their role in diabetic patients
    Christopher Heeschen
    Experimental Surgery, Department of Surgery, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Diab Vasc Dis Res 2:122-7. 2005
    ..Eventually, tailored medical and interventional treatment of diabetic patients should help to prevent these cardiac events in a cost-effective manner...
  39. ncbi request reprint Statins have biphasic effects on angiogenesis
    Michael Weis
    Stanford University School of Medicine, Division of Cardiovascular Medicine, Stanford, Calif 94305, USA
    Circulation 105:739-45. 2002
    ..Statins inhibit HMG-CoA reductase to reduce the synthesis of cholesterol and isoprenoids that modulate diverse cell functions. We investigated the effect of the statins cerivastatin and atorvastatin on angiogenesis in vitro and in vivo...
  40. ncbi request reprint Concentration of bone marrow total nucleated cells by a point-of-care device provides a high yield and preserves their functional activity
    Patrick C Hermann
    Department of Surgery, Ludwig Maximilians University, 81377 Munich, Germany
    Cell Transplant 16:1059-69. 2008
    ..However, the greater yield of cells and the wider range of cell types for the Harvest device may translate into an even greater therapeutic effect...
  41. ncbi request reprint Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Ultrasound Med Biol 34:559-66. 2008
    ..3DE allows precise quantitation of myocardial borderzone and identification of transmural scar tissue noninvasively. Assessment of contractile reserve improves characterization and estimation of myocardial borderzone after CMI...
  42. ncbi request reprint Nonbone marrow-derived endothelial progenitor cells: what is their exact location?
    Alexandra Aicher
    Circ Res 101:e102. 2007
  43. ncbi request reprint 111In-labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model
    Winfried Brenner
    Department of Nuclear Medicine, University Hospital Kiel, Kiel, Germany
    J Nucl Med 45:512-8. 2004
    ....
  44. pmc A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors
    Christopher Heeschen
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 110:527-36. 2002
    ..To our knowledge, this is the first description of a cholinergic angiogenic pathway, and it suggests a novel avenue for therapeutic modulation of angiogenesis...
  45. ncbi request reprint The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1
    Gerald Schmid
    Department of Surgery, Ludwig Maximilian University, Klinikum Grosshadern, Munich, Germany
    J Cell Biochem 101:259-70. 2007
    ..Thus, in organ transplant patients, FTY720 may prove efficacious in preventing graft rejection as well as tumor development...
  46. ncbi request reprint Nicotine promotes arteriogenesis
    Christopher Heeschen
    Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
    J Am Coll Cardiol 41:489-96. 2003
    ....
  47. ncbi request reprint Second hand smoke stimulates tumor angiogenesis and growth
    Bo Qing Zhu
    Cardiology Research, VA Medical Center, University of California, San Francisco, CA 94143, USA
    Cancer Cell 4:191-6. 2003
    ..These studies reveal that SHS promotes tumor angiogenesis and growth. These effects of SHS are associated with increases in plasma VEGF and MCP-1 levels, and EPC, mediated in part by isoprenylation and nicotinic acetylcholine receptors...