Lars Hanker

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint Acid ceramidase (AC)--a key enzyme of sphingolipid metabolism--correlates with better prognosis in epithelial ovarian cancer
    Lars Christian Hanker
    Department of Obstetrics and Gynecology, University of Homburg, Homburg, Germany
    Int J Gynecol Pathol 32:249-57. 2013
  2. ncbi request reprint Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Anticancer Res 33:371-7. 2013
  3. ncbi request reprint The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy
    L C Hanker
    Department of Gynecology and Obstetrics, Johann Wolfgang Goethe University, Frankfurt, Germany
    Ann Oncol 23:2605-12. 2012
  4. doi request reprint SATB1 gene expression and breast cancer prognosis
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Breast 20:309-13. 2011
  5. doi request reprint Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
  6. doi request reprint Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
  7. pmc A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
  8. doi request reprint Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
  9. doi request reprint Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
  10. ncbi request reprint Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
    Eugen Ruckhäberle
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Cancer Res Clin Oncol 135:1005-13. 2009

Collaborators

Detail Information

Publications15

  1. doi request reprint Acid ceramidase (AC)--a key enzyme of sphingolipid metabolism--correlates with better prognosis in epithelial ovarian cancer
    Lars Christian Hanker
    Department of Obstetrics and Gynecology, University of Homburg, Homburg, Germany
    Int J Gynecol Pathol 32:249-57. 2013
    ..These results are in contrast to the concept of AC as a promoter for cancer progression. Nevertheless, they are supported by the lately discovered tumor-suppressing function of sphingosine, the enzymatic product of AC...
  2. ncbi request reprint Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Anticancer Res 33:371-7. 2013
    ..Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC)...
  3. ncbi request reprint The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy
    L C Hanker
    Department of Gynecology and Obstetrics, Johann Wolfgang Goethe University, Frankfurt, Germany
    Ann Oncol 23:2605-12. 2012
    ..Despite recent progress in the treatment of ovarian cancer, the majority of patients eventually relapse. There is little information on the effectiveness of chemotherapy in higher treatment lines...
  4. doi request reprint SATB1 gene expression and breast cancer prognosis
    Lars C Hanker
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Breast 20:309-13. 2011
    ....
  5. doi request reprint Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Breast Cancer Res Treat 120:567-79. 2010
    ..In contrast, markers displaying a continuous distribution like proliferation markers as Ki67 rather describe the composition of the mixture of cells in the tumor...
  6. doi request reprint Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 45:405-13. 2009
    ..In conclusion, this study confirms our previous observations suggesting Plexin B1 as a new prognostic marker in ER positive breast cancers...
  7. pmc A clinically relevant gene signature in triple negative and basal-like breast cancer
    Achim Rody
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
    Breast Cancer Res 13:R97. 2011
    ..Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease...
  8. doi request reprint Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    Eugen Ruckhäberle
    Department of Gynecology, J W Goethe University, Frankfurt, Germany
    J Cancer Res Clin Oncol 135:81-90. 2009
    ....
  9. doi request reprint Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Breast Cancer Res Treat 130:409-20. 2011
    ..However, based on previous findings of NHERF1 functioning in PI3K signalling from basic research, these tumors might be appropriate candidates for a targeted therapy of the PI3K/Akt pathway...
  10. ncbi request reprint Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
    Eugen Ruckhäberle
    Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Cancer Res Clin Oncol 135:1005-13. 2009
    ..Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer...
  11. doi request reprint Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation
    Thomas Karn
    Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
    Eur J Cancer 48:12-23. 2012
    ..Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer...
  12. pmc Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
    Thomas Karn
    Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
    PLoS ONE 6:e28403. 2011
    ..The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes...
  13. pmc T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
    ..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
  14. doi request reprint NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas
    Knut Engels
    Department of Pathology, University Hospital of Frankfurt, Frankfurt, Germany
    Cancer Res 68:5159-66. 2008
    ..Pharmacogenetic iNOS/survivin-targeting strategies may hence be pursued to complement current treatment modalities in EOC...
  15. ncbi request reprint Signal quality of non-invasive fetal electrocardiogram in vaginal breech delivery: a case-controlled study
    Nicole Sänger
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Johann Wolfgang Goethe University Frankfurt am Main, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Arch Gynecol Obstet 288:1017-20. 2013
    ..To determine the fetal signal quality of vaginal breech deliveries in comparison with a case-controlled cephalic group during labour...