Harald Hampel

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Are biomarkers harmful to recruitment and retention in Alzheimer's disease clinical trials? An international perspective
    H Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Frankfurt, Germany
    J Nutr Health Aging 16:346-8. 2012
  2. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
  3. doi request reprint Biomarkers for Alzheimer's disease therapeutic trials
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Prog Neurobiol 95:579-93. 2011
  4. doi request reprint The future of Alzheimer's disease: the next 10 years
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Prog Neurobiol 95:718-28. 2011
  5. doi request reprint Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, Heinrich Hoffmann Str 10, 60528 Frankfurt Main, Germany
    Nat Rev Drug Discov 9:560-74. 2010
  6. ncbi request reprint Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurobiol Aging 27:10-5. 2006
  7. doi request reprint Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
    Gilberto Sousa Alves
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Psychiatry Res 203:194-200. 2012
  8. ncbi request reprint Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study
    Harald Hampel
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Gen Psychiatry 61:95-102. 2004
  9. ncbi request reprint Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease
    Harald Hampel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Neurol 62:770-3. 2005
  10. ncbi request reprint CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University Munich, Germany
    Brain 129:3035-41. 2006

Detail Information

Publications80

  1. ncbi request reprint Are biomarkers harmful to recruitment and retention in Alzheimer's disease clinical trials? An international perspective
    H Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Frankfurt, Germany
    J Nutr Health Aging 16:346-8. 2012
    ..Regulatory authorities are generally supportive of biomarker use in clinical trials but potential consequences of biomarker based patient selection on the generalizability of trial results need careful evaluation...
  2. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
    ..These results suggest that TACE activity and soluble TNF receptors may be potential diagnostic candidate biomarkers in AD and MCI...
  3. doi request reprint Biomarkers for Alzheimer's disease therapeutic trials
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Prog Neurobiol 95:579-93. 2011
    ....
  4. doi request reprint The future of Alzheimer's disease: the next 10 years
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Prog Neurobiol 95:718-28. 2011
    ..These still unmet needs call for ever more concerted and focused efforts in research across the world to combat the erupting and as yet uncontrolled epidemic of AD...
  5. doi request reprint Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, Heinrich Hoffmann Str 10, 60528 Frankfurt Main, Germany
    Nat Rev Drug Discov 9:560-74. 2010
    ..Biomarkers that achieve these characteristics should enable objective business decisions in portfolio management and facilitate regulatory approval of new therapies...
  6. ncbi request reprint Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurobiol Aging 27:10-5. 2006
    ..Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD...
  7. doi request reprint Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
    Gilberto Sousa Alves
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Psychiatry Res 203:194-200. 2012
    ..Results provide additional evidence supporting the neuronal disconnection hypothesis in MDD and suggest that cognitive deficits are related to the loss of integrity in WM tracts associated with the disorder...
  8. ncbi request reprint Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study
    Harald Hampel
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Gen Psychiatry 61:95-102. 2004
    ..Different tau phosphoepitopes can be sensitively detected in cerebrospinal fluid (CSF)...
  9. ncbi request reprint Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease
    Harald Hampel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Neurol 62:770-3. 2005
    ..We hypothesized that these variations partially reflect differences in the degree of neuronal damage and therefore may be used to predict structural disease progression...
  10. ncbi request reprint CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University Munich, Germany
    Brain 129:3035-41. 2006
    ..There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease...
  11. pmc Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e48895. 2012
    ..Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties...
  12. doi request reprint Using diffusion tensor imaging and mixed-effects models to investigate primary and secondary white matter degeneration in Alzheimer's disease and mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    J Alzheimers Dis 26:667-82. 2011
    ..A greater understanding of the pattern of WM changes in AD may prove useful for the early detection of AD...
  13. doi request reprint Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment
    Philine Schneider
    Alzheimer Memorial Center, Department of Psychiatry, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
    Biol Psychiatry 70:145-51. 2011
    ..Midregional proatrial natriuretic peptide (MR-proANP), an inactive surrogate molecule of the mature atrial natriuretic peptide, is related to circulatory function and hypertension...
  14. doi request reprint White matter microstructure in relation to education in aging and Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Restock, Restock, Germany
    J Alzheimers Dis 17:571-83. 2009
    ....
  15. doi request reprint Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
    Michael Ewers
    Department of Psychiatry, Alzheimer Memorial Center, Ludwig Maximilian University, Munich, Germany
    Brain 131:1252-8. 2008
    ..The assessment of BACE 1 in CSF may provide a sensitive measure to detect in vivo alterations in the amyloidogenic processing potentially modified by the ApoE genotype...
  16. doi request reprint Regional networks underlying interhemispheric connectivity: an EEG and DTI study in healthy ageing and amnestic mild cognitive impairment
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 30:2098-119. 2009
    ..05). The study provides a methodology to access specific networks of subcortical fiber tracts subserving the maintenance of interhemispheric resting state coherence in the human brain...
  17. ncbi request reprint Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Am J Psychiatry 160:376-9. 2003
    ..The authors asked whether p-tau(231) levels improve the differential diagnosis between geriatric major depression and Alzheimer's disease...
  18. doi request reprint Decreased activation along the dorsal visual pathway after a 3-month treatment with galantamine in mild Alzheimer disease: a functional magnetic resonance imaging study
    Arun L W Bokde
    Dementia and Neuroimaging Research Section, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Clin Psychopharmacol 29:147-56. 2009
    ..A visual perception task recruiting the dorsal visual system may be useful as a biomarker of treatment effects...
  19. doi request reprint Prediction of Alzheimer's disease using midregional proadrenomedullin and midregional proatrial natriuretic peptide: a retrospective analysis of 134 patients with mild cognitive impairment
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Clin Psychiatry 72:556-63. 2011
    ....
  20. ncbi request reprint Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurosci Lett 391:48-50. 2005
    ..Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects...
  21. ncbi request reprint The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    Hum Brain Mapp 32:1349-62. 2011
    ..05, corrected for multiple comparisons). Our findings suggest that a multimodal MRI-DTI approach is supportive to determine atrophy of cholinergic nuclei and its effect on intracortical projecting fiber tracts in AD...
  22. ncbi request reprint Fiber connections between the cerebral cortex and the corpus callosum in Alzheimer's disease: a diffusion tensor imaging and voxel-based morphometry study
    Djyldyz Sydykova
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, D 80366 Munich, Germany
    Cereb Cortex 17:2276-82. 2007
    ..In control subjects, no correlations were detected. Our findings suggest that decline of FA in the corpus callosum may be related to neuronal degeneration in corresponding cortical areas...
  23. ncbi request reprint Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI
    Stefan J Teipel
    Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Neurol 253:794-800. 2006
    ..Early pathological involvement of specific medial temporal lobe areas is characteristic for Alzheimer's disease (AD)...
  24. doi request reprint Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
    ..Critical testing of these predictions will help us to modify or even falsify the currently hold assumptions on the pathogenesis of AD based on in vivo evidence in humans...
  25. pmc Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e32441. 2012
    ..Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical...
  26. doi request reprint Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Psychiatry Res 182:244-50. 2010
    ..Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies...
  27. doi request reprint Blood-based microcirculation markers in Alzheimer's disease-diagnostic value of midregional pro-atrial natriuretic peptide/C-terminal endothelin-1 precursor fragment ratio
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany
    Biol Psychiatry 65:979-84. 2009
    ..We hypothesized that this set of blood-based (micro)circulation parameters is altered in AD...
  28. ncbi request reprint Diagnostic utility of novel MRI-based biomarkers for Alzheimer's disease: diffusion tensor imaging and deformation-based morphometry
    Uwe Friese
    Department of Psychiatry, University of Rostock, Germany Institute of Psychology, University of Osnabrueck, D 49076 Osnabrueck, Germany
    J Alzheimers Dis 20:477-90. 2010
    ..86 after leave-one-out cross-validation. It remains to be shown if this automated multivariate analysis of DTI-measures can improve early diagnosis of AD in predementia stages...
  29. ncbi request reprint Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment
    Stefan J Teipel
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Neuroimage 38:13-24. 2007
    ..Our findings indicate that multivariate network analysis of deformation maps detects typical features of AD pathology and provides a powerful tool to predict conversion into AD in non-demented at risk patients...
  30. ncbi request reprint Advances in the development of biomarkers for Alzheimer's disease: from CSF total tau and Abeta(1-42) proteins to phosphorylated tau protein
    Harald Hampel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig Maximilian University, D 80336 Munich, Germany
    Brain Res Bull 61:243-53. 2003
    ....
  31. doi request reprint Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...
  32. doi request reprint Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrum
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, 60528 Frankfurt Main, Germany
    Cereb Cortex 23:61-70. 2013
    ..Our findings suggest that changes in specific cortical areas may predispose to specific symptoms, as exemplified by the association between temporal cortex thinning and hallucinations...
  33. ncbi request reprint Anatomical MRI and DTI in the diagnosis of Alzheimer's disease: a European multicenter study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 31:S33-47. 2012
    ....
  34. doi request reprint Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relatives
    Christian Knöchel
    Laboratory of Neuroscience, Dept of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe Univ, Frankfurt Main, Germany
    Schizophr Res 140:129-35. 2012
    ..Such endophenotypes may serve as quantitative traits for future genetic studies and as candidate markers for early and preclinical identification of subjects at risk...
  35. pmc Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e37021. 2012
    ..Overall, these data suggest that the same degree of cognitive impairment is associated with greater structural damage in men compared with women...
  36. ncbi request reprint Decreased serum amyloid beta(1-42) autoantibody levels in Alzheimer's disease, determined by a newly developed immuno-precipitation assay with radiolabeled amyloid beta(1-42) peptide
    Sylvia Brettschneider
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Biol Psychiatry 57:813-6. 2005
    ..Autoantibodies against amyloid beta (A beta) peptide found in patients with Alzheimer's disease (AD) also occur naturally in the general population independently of the cognitive status...
  37. ncbi request reprint Morphological substrate of face matching in healthy ageing and mild cognitive impairment: a combined MRI-fMRI study
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Brain 130:1745-58. 2007
    ..These findings support the notion that the functional segregation within the visual system is based on the distribution of cortical grey matter volumes, possibly reflecting the spatial distribution of neuron density...
  38. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
    ....
  39. doi request reprint Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Germany
    Psychiatry Res 194:363-71. 2011
    ..Our findings suggest that a clinical and physical phantom study involving more than two scanners is indispensable to detect potential sources of bias and to reliably estimate effect size in multicenter diagnostic trials using DTI...
  40. doi request reprint Longitudinal changes in fiber tract integrity in healthy aging and mild cognitive impairment: a DTI follow-up study
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    J Alzheimers Dis 22:507-22. 2010
    ..The underlying mechanisms for these changes are unknown...
  41. ncbi request reprint Multivariate network analysis of fiber tract integrity in Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Neuroimage 34:985-95. 2007
    ..In agreement with post-mortem evidence, our study demonstrates dissociation between intracortical and extracortical projecting fiber systems in AD in the living human brain...
  42. ncbi request reprint Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Brain 127:811-24. 2004
    ..The most likely substrate of these changes is alterations or loss of allocortical and neocortical neurons due to Alzheimer's disease-type pathology...
  43. doi request reprint Blood and plasma-based proteomic biomarker research in Alzheimer's disease
    Simone Lista
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt am Main, Germany
    Prog Neurobiol 101:1-17. 2013
    ..Currently, growing evidence suggests that blood protein signatures are helpful to increase the likelihood of successful diagnosis of AD. Accordingly, this area of research promises to yield exciting results in the next future...
  44. doi request reprint Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease
    David Prvulovic
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt, Germany
    Prog Neurobiol 95:557-69. 2011
    ..Potential caveats of functional imaging are critically reviewed with focus on confound variables such as altered neurovascular coupling as well as parameters related to task- and study design...
  45. ncbi request reprint Functional abnormalities of the visual processing system in subjects with mild cognitive impairment: an fMRI study
    Arun Lawrence Warren Bokde
    Dementia and Neuroimaging Research Section, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Psychiatry Res 163:248-59. 2008
    ..To our knowledge, this is the first study that has examined visual processing in MCI...
  46. ncbi request reprint Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial
    Stefan J Teipel
    Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychopharmacology (Berl) 187:86-94. 2006
    ..Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) by measuring cortical metabolic response to activation assesses integrity of neuronal transmission in vivo...
  47. doi request reprint Cognitive and behavioural effects of physical exercise in psychiatric patients
    Christian Knöchel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt Main, Heinrich Hoffmann Str 12, 60528 Frankfurt, Germany
    Prog Neurobiol 96:46-68. 2012
    ..Furthermore, exercise might have the potential to be a preventative treatment within the context of multi-modal therapeutic programs...
  48. doi request reprint White matter microstructure underlying default mode network connectivity in the human brain
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Neuroimage 49:2021-32. 2010
    ....
  49. doi request reprint Biological marker candidates of Alzheimer's disease in blood, plasma, and serum
    Philine Schneider
    Department of Psychiatry, Ludwig Maximilian University, Alzheimer Memorial Center, Munich, Germany
    CNS Neurosci Ther 15:358-74. 2009
    ..The status and emerging perspectives on hypothesis and exploratory-based candidate biomarkers derived from blood, plasma, and serum are reviewed and discussed...
  50. doi request reprint Validation of Alzheimer's disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI)
    Katharina Buerger
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Exp Gerontol 44:579-85. 2009
    ..Data of the pilot European-ADNI (E-ADNI) biological marker programme of cerebrospinal fluid (CSF) and plasma candidate biomarkers are reported...
  51. ncbi request reprint Progression of corpus callosum atrophy in Alzheimer disease
    Stefan J Teipel
    and Harald Hampel, MD, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Arch Neurol 59:243-8. 2002
    ..Atrophy of the corpus callosum in the absence of primary white matter degeneration reflects loss of intracortical projecting neocortical pyramidal neurons in Alzheimer disease (AD)...
  52. ncbi request reprint Measurement of basal forebrain atrophy in Alzheimer's disease using MRI
    Stefan J Teipel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Ludwig Maximilian University, Munich, Germany
    Brain 128:2626-44. 2005
    ..If replicated in an independent sample, our technique may be useful to detect degeneration of basal forebrain cholinergic neurones in vivo...
  53. ncbi request reprint CSF Aβ1-42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease
    Simone Lista
    Department of Psychiatry, Goethe University, Frankfurt am Main, Germany Electronic address
    Alzheimers Dement 10:381-92. 2014
    ....
  54. doi request reprint Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Nerv Ment Dis 200:296-304. 2012
    ..More frequent intrusions from a person's past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms...
  55. ncbi request reprint Repetitive transcranial magnetic stimulation (rTMS) in major depression: relation between efficacy and stimulation intensity
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 27:638-45. 2002
    ..These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficacy...
  56. doi request reprint Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    Prog Neurobiol 95:570-8. 2011
    ..The network based approach provides a new independent method from previous ones to translate preclinical knowledge into the clinical domain...
  57. ncbi request reprint Targets of antidementive therapy: drugs with a specific pharmacological mechanism of action
    Lutz Frolich
    Klinik für Psychiatrie und Psychotherapie I Johann Wolfgang Goethe Universität, Heinrich Hoffmann Str 10, 60528 Frankfurt am Main, Germany
    Curr Pharm Des 10:223-9. 2004
    ..Selection and adaptation of medication becomes easier if such targets are considered and if therapeutic effects are monitored target-specifically...
  58. ncbi request reprint Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Behav Genet 36:405-15. 2006
    ..This has major implications for our understanding of the onset and progression of AD-type pathology both in DS and in sporadic AD...
  59. ncbi request reprint Long-term cost-effectiveness of donepezil for the treatment of Alzheimer's disease
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, Munich, 80336, Germany
    Eur Arch Psychiatry Clin Neurosci 257:330-6. 2007
    ..However, use of ChE inhibitors is limited by budget constraints and disincentives on the side of health insurances and nursing care insurances...
  60. doi request reprint Novel MRI techniques in the assessment of dementia
    Stefan J Teipel
    Dementia and Neuroimaging Section, Department of Psychiatry, Alzheimer Memorial Center, Ludwig Maximilian University, Nussbaumstrasse 7, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:S58-69. 2008
    ..In the near future, these markers will be of high relevance for the selection of at-risk subjects in secondary preventive trials...
  61. doi request reprint Diagnostic usefulness of cognitive auditory event-related p300 subcomponents in patients with Alzheimers disease?
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    J Clin Neurophysiol 25:147-52. 2008
    ....
  62. ncbi request reprint Reliable manual segmentation of the frontal, parietal, temporal, and occipital lobes on magnetic resonance images of healthy subjects
    Arun L W Bokde
    Dementia and Neuro imaging Research Section, Alzheimer s Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, Station D2, 80336 Munich, Germany
    Brain Res Brain Res Protoc 14:135-45. 2005
    ..It is a challenge to reliably measure the lobar volumes from magnetic resonance imaging (MRI) data...
  63. ncbi request reprint Pharmacological treatment of Alzheimer's dementia: state of the art and current dilemmas
    Muamer Omerovic
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 9:69-75. 2008
    ..Furthermore, we discuss current difficulties regarding AD treatment by looking for explanations for a still unsatisfying rate of state-of-the-art treatment of AD-patients...
  64. ncbi request reprint Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease
    Peter Schönknecht
    Department of Psychiatry, University of Heidelberg, Voss Strasse 4, D 69115, Heidelberg, Germany
    Neurosci Lett 339:172-4. 2003
    ..These findings suggest that total and phosphorylated tau protein may facilitate early detection and differential diagnosis of AD...
  65. ncbi request reprint Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study
    Metin Bagli
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:44-8. 2003
    ..We conclude that plasma and CSF levels of sIL-6R are significantly increased in AD patients and that the magnitude of increase is determined by the IL-6 genotype...
  66. doi request reprint Biomarkers for major depression and its delineation from neurodegenerative disorders
    Barbara Schneider
    Section for Neurophysiology and Neuroimaging, Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Prog Neurobiol 95:703-17. 2011
    ..This model delineates common pathways and the intersection between AD and MDD. Applying these concepts to MDD gives hope that positive MDD biomarkers can be successfully identified in the near future...
  67. doi request reprint Ethical considerations of biomarker use in neurodegenerative diseases--a case study of Alzheimer's disease
    David Prvulovic
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Prog Neurobiol 95:517-9. 2011
    ....
  68. ncbi request reprint Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Arch Neurol 59:1267-72. 2002
    ....
  69. ncbi request reprint Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University Munich, Germany
    Psychophysiology 39:175-81. 2002
    ..Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD...
  70. doi request reprint Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease
    David Prvulovic
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Frankfurt, Germany
    Clin Chem Lab Med 49:367-74. 2011
    ..g., cerebrospinal fluid (CSF) analysis and PET imaging], and on their diagnostic and predictive value in preclinical and clinical stages of AD...
  71. ncbi request reprint Total and phosphorylated tau proteins: evaluation as core biomarker candidates in frontotemporal dementia
    Harald Hampel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig Maximilian University, Munich, Germany
    Dement Geriatr Cogn Disord 17:350-4. 2004
    ..Therefore, p-tau is a core biological marker candidate for future evaluation in large national and international multicenter networks...
  72. pmc Common capacity-limited neural mechanisms of selective attention and spatial working memory encoding
    Fabian Fusser
    Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, J W Goethe University, 60528 Frankfurt, Germany
    Eur J Neurosci 34:827-38. 2011
    ....
  73. doi request reprint Galantamine for Alzheimer's disease
    David Prvulovic
    Johann Wolfgang Goethe University of Frankfurt, Deptartment of Psychiatry, Psychosomatics and Psychotherapy, Heinrich Hoffmann Strasse 10, Frankfurt, Germany
    Expert Opin Drug Metab Toxicol 6:345-54. 2010
    ....
  74. pmc Biological markers for early detection and pharmacological treatment of Alzheimer's disease
    Harald Hampel
    Department of Psychiatry, Ludwig Maximilian University Munich, Alzheimer Memorial Center, Munich, Germany
    Dialogues Clin Neurosci 11:141-57. 2009
    ..As a perspective, the important role of biomarkers in the development of innovative drug treatments for AD and the related regulatory process is discussed...
  75. doi request reprint Impact of employment status and work-related factors on risk of completed suicide. A case-control psychological autopsy study
    Barbara Schneider
    Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, Goethe University, Frankfurt Main, Germany
    Psychiatry Res 190:265-70. 2011
    ..Employment and a positive modification of working conditions, may possibly be preventive to important adverse mental health outcomes, including suicidality...
  76. doi request reprint Cognitive intervention in Alzheimer disease
    Verena Buschert
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, D 80366 Munich, Germany
    Nat Rev Neurol 6:508-17. 2010
    ..Finally, we present recommendations for future research on the use of cognitive interventions in AD and discuss potential effects of this therapy on disease modification...
  77. ncbi request reprint Relation between responses to repetitive transcranial magnetic stimulation and partial sleep deprivation in major depression
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 36:131-5. 2002
    ..Apparently, different subgroups of depressed patients respond to both interventions. Further studies are needed to characterize the response to rTMS by means of clinical and biological parameters...
  78. pmc Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 6:e21745. 2011
    ..DA and MD indices were most sensitive at detecting early changes in MCIa...
  79. ncbi request reprint Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    Jens Wiltfang
    Department of Psychiatry, University Erlangen Nurnberg, Germany
    Ann Neurol 54:263-7. 2003
    ..We conclude that the immunoblot shows disease-specific CSF Abeta peptide patterns in CJD and AD and suppose that measurement of the Abeta peptide pattern seems to be a promising diagnostic tool in the differential diagnosis of dementias...
  80. ncbi request reprint Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease
    Harald Hampel
    Dementia Research and Neuroimaging Section, Memory Clinic, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Neurol Sci 194:15-9. 2002
    ..We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD...