Estifanos Ghebremedhin

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains
    Estifanos Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Neurosci Lett 320:25-8. 2002
  2. ncbi Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele
    E Ghebremedhin
    Department of Anatomy, J W Goethe University, Frankfurt Main, Germany
    Acta Neuropathol 96:222-4. 1998
  3. ncbi Gender and age modify the association between APOE and AD-related neuropathology
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
    Neurology 56:1696-701. 2001
  4. ncbi Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 28:308-13. 2002
  5. ncbi Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages
    Estifanos Ghebremedhin
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Acta Neuropathol 114:359-63. 2007
  6. ncbi Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Neuropathol Exp Neurol 65:116-23. 2006
  7. ncbi Two types of sporadic cerebral amyloid angiopathy
    Dietmar Rudolf Thal
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:282-93. 2002
  8. doi Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neuropathol Exp Neurol 69:442-8. 2010
  9. ncbi High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
    Christian Schultz
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60590 Frankfurt Main, Germany
    Neurobiol Aging 25:397-405. 2004
  10. ncbi Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons
    Christian Schultz
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Mol Cell Neurosci 33:68-80. 2006

Detail Information

Publications22

  1. ncbi Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains
    Estifanos Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Neurosci Lett 320:25-8. 2002
    ..036 for NFTs, and P=0.045 for A beta-deposits) at ages > or = 70 years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE...
  2. ncbi Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele
    E Ghebremedhin
    Department of Anatomy, J W Goethe University, Frankfurt Main, Germany
    Acta Neuropathol 96:222-4. 1998
    ..0002). The association between AGD and epsilon2 allele of ApoE suggests that AGD can be distinguished from other neurodegenerative disorders not only neuropathologically, but also genetically...
  3. ncbi Gender and age modify the association between APOE and AD-related neuropathology
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
    Neurology 56:1696-701. 2001
    ..To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP)...
  4. ncbi Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes
    E Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 28:308-13. 2002
    ..9% vs. 13.2%, P=0.93). This association, however, is only apparent in the presence of the LRP CC genotype. In conclusion, the present study shows that AGD is associated with the LRP, A2M and ApoE genes...
  5. ncbi Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages
    Estifanos Ghebremedhin
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Acta Neuropathol 114:359-63. 2007
    ..These findings suggest that homozygosity, but not heterozygosity, for BCHE-K is a potential risk factor for the development of NFT pathology in young individuals implicating BCHE-K in the pathogenesis of early AD...
  6. ncbi Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Neuropathol Exp Neurol 65:116-23. 2006
    ..001). In conclusion, our findings suggest that APOE may express its effect on the risk of PD by modifying the occurrence of PD pathology, but age of PD onset seems to be the principal determinant of the progression rate of PD pathology...
  7. ncbi Two types of sporadic cerebral amyloid angiopathy
    Dietmar Rudolf Thal
    Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:282-93. 2002
    ..CAA-Type 2 is not associated with the epsilon4 allele as a risk factor but shows a higher epsilon2 allele frequency than CAA-Type 1 cases and controls in our sample...
  8. doi Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases
    Estifanos Ghebremedhin
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neuropathol Exp Neurol 69:442-8. 2010
    ..05 each). In conclusion, DLB and PD patients with advanced LB pathology were less likely to show severe cerebrovascular disease or history of stroke...
  9. ncbi High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
    Christian Schultz
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60590 Frankfurt Main, Germany
    Neurobiol Aging 25:397-405. 2004
    ..In summary, this study suggests that TSA is a distinct form of glial tau pathology that occurs with a high frequency in elderly individuals...
  10. ncbi Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons
    Christian Schultz
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Mol Cell Neurosci 33:68-80. 2006
    ..These data provide the first evidence for a compartmentalized clustering of NF-kappaB pathway components in the AIS and implicate this neuronal compartment in the activation of NF-kappaB...
  11. ncbi Stages in the development of Parkinson's disease-related pathology
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Cell Tissue Res 318:121-34. 2004
    ..At this point, most individuals probably cross the threshold to the symptomatic phase of the illness. In the end-stages 5-6, the process enters the mature neocortex, and the disease manifests itself in all of its clinical dimensions...
  12. doi Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study
    Estifanos Ghebremedhin
    Institute of Clinical Neuroanatomy, Goethe University Frankfurt, 60590, Frankfurt am Main, Germany
    Acta Neuropathol 118:777-84. 2009
    ....
  13. ncbi Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage
    Guido J Burbach
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Neurobiol Aging 28:202-12. 2007
    ..Minor structural alterations of the vessel wall, however, cannot be excluded due to the sample size of our study and the high complexity of the three-dimensional vessel wall ultrastructure...
  14. ncbi Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions
    Udo Rüb
    Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe Univeristy, Frankfurt Main, Germany
    Brain Pathol 16:218-27. 2006
    ..This lack of correlation may suggest that ataxin-3 immunopositive NI are not immediately decisive for the fate of affected nerve cells but rather represent unspecific and pathognomonic morphological markers of SCA3...
  15. ncbi Cerebral amyloid angiopathy and cortical microinfarcts as putative substrates of vascular dementia
    Mattias Haglund
    Division of Neuropathology, Department of Pathology and Cytology, Lund University Hospital, Sweden
    Int J Geriatr Psychiatry 21:681-7. 2006
    ..Therefore, we investigated the presence and characteristics of CAA in brains of VaD cases...
  16. ncbi The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism
    Elizabeth H Corder
    Duke University, Center for Demographic Studies, Durham, NC 27708 0408, USA
    Ann N Y Acad Sci 1019:24-8. 2004
    ..The gender gap in SPs at early NFT stages was large and specific to women who carried the APOE4 allele (P <.001) and in addition to the acceleration in NFT stage also found for APOE4+ women...
  17. ncbi Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  18. doi Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes
    Sabrina Utter
    Department of Neuropathology, University of Bonn, Bonn, Germany
    J Neuropathol Exp Neurol 67:842-56. 2008
    ..It is therefore tempting to speculate that apoE represents a pathogenetic link between SVD and AD...
  19. ncbi Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease
    Chris Conrad
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Neurochem 89:179-88. 2004
    ..More detailed studies confirm the H2 haplotype to be the ancestral tau gene. This situation is reminiscent of the evolution of the apolipoprotein (ApoE) gene, another locus that is potentially important for the risk of development of AD...
  20. ncbi Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Acta Neuropathol 110:459-71. 2005
    ..Moreover, apoE-positive newly formed plaques were seen more frequently in APOE epsilon4/4 cases than in non-APOE epsilon4/4 individuals, thereby underlining the potentially crucial role of apoE for the development of Abeta deposits...
  21. ncbi Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 62:1287-301. 2003
    ..A combination of both CAA and AS/LH may, therefore, contribute to neurodegeneration in AD. These data also suggest that small vessel disease due to arteriosclerosis and fibrolipohyalinosis is a potential target for the treatment of AD...
  22. doi Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, University of Ulm, Albert Einstein Allee 7, 89081 Ulm, Germany
    Acta Neuropathol 115:599-609. 2008
    ..Thus, blood flow alterations with subsequent hypoperfusion induced by CAA-related capillary occlusion presumably point to a second mechanism in which A beta adversely affects the brain in AD in addition to its direct neurotoxic effects...