L Frolich

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint The cholinergic pathology in Alzheimer's disease--discrepancies between clinical experience and pathophysiological findings
    L Frolich
    Department of Psychiatry and Psychotherapy, University of Frankfurt, Heinrich Hoffmann Strasse 10, D 60054 Frankfurt, Federal Republic of Germany
    J Neural Transm 109:1003-13. 2002
  2. ncbi request reprint A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
    L Frolich
    Department of Psychiatry I, University of Frankfurt Main, Germany
    Ann N Y Acad Sci 893:290-3. 1999
  3. ncbi request reprint Targets of antidementive therapy: drugs with a specific pharmacological mechanism of action
    Lutz Frolich
    Klinik für Psychiatrie und Psychotherapie I Johann Wolfgang Goethe Universität, Heinrich Hoffmann Str 10, 60528 Frankfurt am Main, Germany
    Curr Pharm Des 10:223-9. 2004
  4. ncbi request reprint [Etiologic and pathogenetic heterogeneity of Alzheimer disease]
    L Frolich
    Klinik für Psychiatrie und Psychotherapie I, Klinikum der Johann Wolfgang Goethe Universitat, Heinrich Hoffmannstrasse 10, 60528 Frankfurt Main
    Nervenarzt 73:422-7. 2002
  5. ncbi request reprint Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington's disease
    T Dierks
    Department of Psychiatry and Psychotherapy I, University of Frankfurt Main, Germany
    Psychiatry Res 84:27-35. 1998
  6. ncbi request reprint Functional imaging of visuospatial processing in Alzheimer's disease
    D Prvulovic
    Department of Psychiatry, University of Frankfurt, Frankfurt, Germany
    Neuroimage 17:1403-14. 2002
  7. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
  8. doi request reprint Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
    M Wagner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neurology 78:379-86. 2012
  9. ncbi request reprint [Dementia and suicide]
    B Schneider
    Zentrum der Psychiatrie, Klinik für Psychiatrie und Psychotherapie I, Johann Wolfgang Goethe Universitat, Frankfurt Main
    Fortschr Neurol Psychiatr 69:164-9. 2001
  10. pmc Psychosocial work factors and dementia
    A Seidler
    Institute of Occupational Medicine, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Occup Environ Med 61:962-71. 2004

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The cholinergic pathology in Alzheimer's disease--discrepancies between clinical experience and pathophysiological findings
    L Frolich
    Department of Psychiatry and Psychotherapy, University of Frankfurt, Heinrich Hoffmann Strasse 10, D 60054 Frankfurt, Federal Republic of Germany
    J Neural Transm 109:1003-13. 2002
    ..g. should stimulate studies on the underlying process, which leads the cholinergic system to increase its activity in patients in the early stage of AD and may have clinical consequences regarding cholinergic drug therapy...
  2. ncbi request reprint A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
    L Frolich
    Department of Psychiatry I, University of Frankfurt Main, Germany
    Ann N Y Acad Sci 893:290-3. 1999
    ..The data are consistent with a neurotrophic role of insulin in the human brain and an upregulation of insulin receptors is SDAT brain as a compensatory mechanism, possibly due to impaired signal transduction mechanism...
  3. ncbi request reprint Targets of antidementive therapy: drugs with a specific pharmacological mechanism of action
    Lutz Frolich
    Klinik für Psychiatrie und Psychotherapie I Johann Wolfgang Goethe Universität, Heinrich Hoffmann Str 10, 60528 Frankfurt am Main, Germany
    Curr Pharm Des 10:223-9. 2004
    ..Selection and adaptation of medication becomes easier if such targets are considered and if therapeutic effects are monitored target-specifically...
  4. ncbi request reprint [Etiologic and pathogenetic heterogeneity of Alzheimer disease]
    L Frolich
    Klinik für Psychiatrie und Psychotherapie I, Klinikum der Johann Wolfgang Goethe Universitat, Heinrich Hoffmannstrasse 10, 60528 Frankfurt Main
    Nervenarzt 73:422-7. 2002
    ..Therefore, the sporadic subtype of AD may be regarded as an age-associated metabolic disease of the brain...
  5. ncbi request reprint Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington's disease
    T Dierks
    Department of Psychiatry and Psychotherapy I, University of Frankfurt Main, Germany
    Psychiatry Res 84:27-35. 1998
    ..We propose that fMRI should be considered as a tool for the assessment of functionality of morphologically abnormal cortex and for the investigation of compensatory resource allocation in neurodegenerative disorders...
  6. ncbi request reprint Functional imaging of visuospatial processing in Alzheimer's disease
    D Prvulovic
    Department of Psychiatry, University of Frankfurt, Frankfurt, Germany
    Neuroimage 17:1403-14. 2002
    ..We furthermore suggest that local cerebral atrophy should be considered as a covariate in functional imaging studies of neurodegenerative disorders...
  7. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
    ..Our findings reconfirm the hypothesis that alterations of biomarker concentrations occur early in a preclinical AD stage and that these alterations are also reflected in plasma...
  8. doi request reprint Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
    M Wagner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neurology 78:379-86. 2012
    ..To compare cued recall measures with other memory and nonmemory tests regarding their association with a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients with mild cognitive impairment (MCI)...
  9. ncbi request reprint [Dementia and suicide]
    B Schneider
    Zentrum der Psychiatrie, Klinik für Psychiatrie und Psychotherapie I, Johann Wolfgang Goethe Universitat, Frankfurt Main
    Fortschr Neurol Psychiatr 69:164-9. 2001
    ..This review comprehensively presents the association between cognitive deficits, insight in early stages of dementia and suicidality and possible confounders which have not systematically been investigated up to now...
  10. pmc Psychosocial work factors and dementia
    A Seidler
    Institute of Occupational Medicine, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Occup Environ Med 61:962-71. 2004
    ..To evaluate the association between psychosocial workplace factors and dementia in a case-control study...
  11. ncbi request reprint Treatment with donepezil in Alzheimer patients with and without cerebrovascular disease
    L Frolich
    Klinik für Psychiatrie und Psychotherapie I, Klinikum der Universität Frankfurt am Main, Heinrich Hoffmannstr 10, D 60528, Frankfurt am Main, Germany
    J Neurol Sci 203:137-9. 2002
    ..This suggests that donepezil therapy is effective and well tolerated in AD patients, both with and without concomitant cerebrovascular disease...
  12. ncbi request reprint Subclinical hyperthyroidism in dementia and correlation of the metabolic index in FDG-PET
    N Döbert
    Department of Nuclear Medicine, University of Frankfurt, Frankfurt, Germany
    Acta Med Austriaca 30:130-3. 2003
    ..Thyroid hormone status and thyroid antibodies were evaluated in patients suffering from dementia for further study of an association of hyperthyroidism with AD and vascular dementia (VD), respectively...
  13. ncbi request reprint Event-related potentials and psychopharmacology. Cholinergic modulation of P300
    T Dierks
    Department of Psychiatry I, University of Frankfurt, Germany
    Pharmacopsychiatry 27:72-4. 1994
    ....
  14. ncbi request reprint Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington's disease
    T Dierks
    Department of Psychiatry and Psychotherapy I, University of Frankfurt Main, Frankfurt, Germany
    Psychiatry Res 90:67-75. 1999
    ..We propose that fMRI should be considered as a tool for the assessment of functionality of morphologically abnormal cortex and for the investigation of compensatory resource allocation in neurodegenerative disorders...
  15. ncbi request reprint [The effect of psychosocial factors on risk of dementia]
    T Bernhardt
    Klinik für Psychiatrie und Psychotherapie I, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Fortschr Neurol Psychiatr 70:283-8. 2002
    ....
  16. ncbi request reprint [Etiology and pathogenesis of Alzheimer dementia]
    T Kratzsch
    Klinik für Psychiatrie und Psychotherapie I, Universitätsklinik der Johann Wolfgang Goethe Universität Frankfurt am Main, Heinrich Hoffmann Strasse 10, D 60528 Frankfurt am Main, Deutschland
    Wien Med Wochenschr 152:72-6. 2002
    ..The wide-spread loss of cortical cholinergic neurotransmission associated with the cognitive deficits is of importance to the comprehension of the symptoms and the present pharmacotherapy of Alzheimer's disease...
  17. doi request reprint Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 15:138-45. 2010
    ..001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP alpha and sAPP beta might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD...