Christine M Freitag

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Total brain volume and corpus callosum size in medication-naïve adolescents and young adults with autism spectrum disorder
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Biol Psychiatry 66:316-9. 2009
  2. doi Genetic risk in autism: new associations and clinical testing
    Christine M Freitag
    JW Goethe University Frankfurt am Main, Department of Child and Adolescent Psychiatry, Deutschordenstraße 50, 60528 Frankfurt am Main, Germany 49 69 6301 5408 49 69 6301 5843
    Expert Opin Med Diagn 5:347-56. 2011
  3. pmc The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder--study protocol of the randomised, multi-centre controlled SOSTA--net trial
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt, 60528 Frankfurt, Germany
    Trials 14:6. 2013
  4. ncbi The Frankfurt early intervention program FFIP for preschool aged children with autism spectrum disorder: a pilot study
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt am Main, 60528 Frankfurt, Germany
    J Neural Transm 119:1011-21. 2012
  5. doi [Autistic disorders - the state of the art and recent findings: epidemiology, aetiology, diagnostic criteria, and therapeutic interventions]
    Christine M Freitag
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, JW Goethe Universität Frankfurt am Main
    Z Kinder Jugendpsychiatr Psychother 40:139-48; quiz 148-9. 2012
  6. doi Behavioural genetics of childhood disorders
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe Universitat Frankfurt am Main, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany
    Curr Top Behav Neurosci 12:395-428. 2012
  7. doi [Statement on a letter by «Pyramid Educational Consultants Germany UG» of May 2010]
    Christine Freitag
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, Johann Wolfgang Goethe Universitat, Frankfurt
    Z Kinder Jugendpsychiatr Psychother 39:417-9. 2011
  8. doi Biological and psychosocial environmental risk factors influence symptom severity and psychiatric comorbidity in children with ADHD
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University, Deutschordenstraße 50, 60528 Frankfurt am Main, Germany
    J Neural Transm 119:81-94. 2012
  9. doi Phenotypic and measurement influences on heritability estimates in childhood ADHD
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University, Deutschordenstrasse 50, Frankfurt am Main, Germany
    Eur Child Adolesc Psychiatry 19:311-23. 2010
  10. pmc Genetics of autistic disorders: review and clinical implications
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Johann Wolfgang Goethe University, Deutschordenstrasse 50, Frankfurt am Main, Germany
    Eur Child Adolesc Psychiatry 19:169-78. 2010

Collaborators

Detail Information

Publications39

  1. pmc Total brain volume and corpus callosum size in medication-naïve adolescents and young adults with autism spectrum disorder
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Biol Psychiatry 66:316-9. 2009
    ..Similarly, studies of corpus callosum (CC) area in ASD differ with regard to inclusion criteria, age, and IQ...
  2. doi Genetic risk in autism: new associations and clinical testing
    Christine M Freitag
    JW Goethe University Frankfurt am Main, Department of Child and Adolescent Psychiatry, Deutschordenstraße 50, 60528 Frankfurt am Main, Germany 49 69 6301 5408 49 69 6301 5843
    Expert Opin Med Diagn 5:347-56. 2011
    ..Also, validity analyses on most available genetic testing procedures have not been performed so far. The variable risk genotypes, as well as related strongly variable phenotypes, have to be taken into account by genetic counseling...
  3. pmc The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder--study protocol of the randomised, multi-centre controlled SOSTA--net trial
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt, 60528 Frankfurt, Germany
    Trials 14:6. 2013
    ..A neurophysiological study in the Frankfurt HFASD subgroup will be performed pre- and post treatment to assess changes in neural function induced by SST versus TAU...
  4. ncbi The Frankfurt early intervention program FFIP for preschool aged children with autism spectrum disorder: a pilot study
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt am Main, 60528 Frankfurt, Germany
    J Neural Transm 119:1011-21. 2012
    ..Compared to most high-intensity programs (30-40 h/week), lower cognitive gains were observed. Results have to be replicated and assessed by a randomized-controlled study before any final conclusions can be drawn...
  5. doi [Autistic disorders - the state of the art and recent findings: epidemiology, aetiology, diagnostic criteria, and therapeutic interventions]
    Christine M Freitag
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, JW Goethe Universität Frankfurt am Main
    Z Kinder Jugendpsychiatr Psychother 40:139-48; quiz 148-9. 2012
    ..Intensive research over the last years has led to a better understanding of, and improved therapeutic options for, autism spectrum disorders...
  6. doi Behavioural genetics of childhood disorders
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe Universitat Frankfurt am Main, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany
    Curr Top Behav Neurosci 12:395-428. 2012
    ..Recent evidence of linkage, candidate gene, and genome-wide association studies are presented. This chapter ends with a prospectus on further research needs...
  7. doi [Statement on a letter by «Pyramid Educational Consultants Germany UG» of May 2010]
    Christine Freitag
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, Johann Wolfgang Goethe Universitat, Frankfurt
    Z Kinder Jugendpsychiatr Psychother 39:417-9. 2011
    ..In the present statement, a letter by the company «Pyramid Educational Consultants of Germany UG» on training and therapeutic aspects of PECS for children with autism is critically reflected...
  8. doi Biological and psychosocial environmental risk factors influence symptom severity and psychiatric comorbidity in children with ADHD
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University, Deutschordenstraße 50, 60528 Frankfurt am Main, Germany
    J Neural Transm 119:81-94. 2012
    ..The findings are relevant to the prevention and treatment of ADHD with or without comorbid disorders...
  9. doi Phenotypic and measurement influences on heritability estimates in childhood ADHD
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University, Deutschordenstrasse 50, Frankfurt am Main, Germany
    Eur Child Adolesc Psychiatry 19:311-23. 2010
    ....
  10. pmc Genetics of autistic disorders: review and clinical implications
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Johann Wolfgang Goethe University, Deutschordenstrasse 50, Frankfurt am Main, Germany
    Eur Child Adolesc Psychiatry 19:169-78. 2010
    ..Implications of the different genetic findings for genetic counselling and genetic testing at present will be described. The article ends with a prospectus on future directions...
  11. doi Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe Universitat, Deutschordenstrasse 50, 60528 Frankfurt am Main, Germany
    Eur Child Adolesc Psychiatry 19:67-74. 2010
    ..Findings point toward a possible mediating role of ADORA2A variants on phenotypic expression in ASD that need to be replicated in a larger sample...
  12. doi Cortisol awakening response in healthy children and children with ADHD: impact of comorbid disorders and psychosocial risk factors
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
    Psychoneuroendocrinology 34:1019-28. 2009
    ..In addition, current adverse parenting conditions, family conflicts, and acute life events were associated with mean increase in CAR, emphasizing the role of psychosocial risk factors in mediating HPA axis activity in children with ADHD...
  13. ncbi Emotion recognition in girls with conduct problems
    Christina Schwenck
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Deutschordenstraße 50, Frankfurt a M, Germany
    Eur Child Adolesc Psychiatry 23:13-22. 2014
    ..Results need to be replicated with comparable tasks, which might result in subgroup-specific therapeutic recommendations...
  14. doi Association of a functional variant of neuronal nitric oxide synthase gene with self-reported impulsiveness, venturesomeness and empathy in male offenders
    Wolfgang Retz
    Neurocentre, Institute for Forensic Psychology and Psychiatry, Saarland University Hospital, Homburg, Saar, Germany
    J Neural Transm 117:321-4. 2010
    ..The findings give additional evidence that NOS-I is involved in the regulation of impulsive personality traits and support the notion that the NOS1 gene takes part in the regulation of social behavior...
  15. doi Perception of biological motion in autism spectrum disorders
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
    Neuropsychologia 46:1480-94. 2008
    ....
  16. ncbi Validity of the social responsiveness scale to differentiate between autism spectrum disorders and disruptive behaviour disorders
    Hannah Cholemkery
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Hospital, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany
    Eur Child Adolesc Psychiatry 23:81-93. 2014
    ..For clinical screening purposes in children suspicious of ASD and/or ODD/CD, the SRS should be used in combination with additional disorder-specific questionnaires to improve the rate of correct classification of both disorders. ..
  17. doi Risk factors of autistic symptoms in children with ADHD
    Anne Kröger
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Frankfurt Main, Germany
    Eur Child Adolesc Psychiatry 20:561-70. 2011
    ..An additional validity analysis by ROC, area under the curve (AUC), suggested a cut-off of 11 to differentiate between ADHD and high-functioning ASD by the Social Communication Questionnaire (SCQ)...
  18. ncbi Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders
    Regina Waltes
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Johann Wolfgang Goethe University, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany
    Hum Genet 133:781-92. 2014
    ..Both gene products are related to neuronal regulation of synaptic plasticity, a pathomechanism underlying ASD and may thus present future targets for pharmacological therapies in ASD...
  19. doi Executive and visuo-motor function in adolescents and adults with autism spectrum disorder
    Michael Sachse
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann Wolfgang Goethe Universitat Frankfurt Main, Deutschordenstraße 50, 60528 Frankfurt Main, Germany
    J Autism Dev Disord 43:1222-35. 2013
    ..The finding of impaired visuo-motor information processing should be accounted for in further neuropsychological studies in ASD...
  20. doi Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment
    Viola Jucksch
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charite Universitatsmedizin Berlin, Germany
    J Child Psychol Psychiatry 52:686-95. 2011
    ..This study aims to investigate psychosocial adversity and impairment of the CBCL-DP...
  21. ncbi [Autism Spectrum Disorder in DSM-5 - concept, validity, and reliability, impact on clinical care and future research]
    Christine M Freitag
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, Universitätsklinikum der JW Goethe Universität, lt location gt Frankfurt am Main lt location gt
    Z Kinder Jugendpsychiatr Psychother 42:185-92. 2014
    ..The present article compares the diagnostic criteria, presents studies on the validity and reliability of ASD, and discusses open questions. It ends with a clinical and research perspective. ..
  22. ncbi Neuromotor development in nocturnal enuresis
    Alexander Von Gontard
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg Saar, Germany
    Dev Med Child Neurol 48:744-50. 2006
    ..In addition to a maturational deficit of the brainstem, it is proposed that there is a possible maturational deficit of the motor cortex circuitry and related cortical areas in children with nocturnal enuresis...
  23. pmc Monitoring cortical excitability during repetitive transcranial magnetic stimulation in children with ADHD: a single-blind, sham-controlled TMS-EEG study
    Christian Helfrich
    University Hospital for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Frankfurt Main, Germany
    PLoS ONE 7:e50073. 2012
    ..Repetitive transcranial magnetic stimulation (rTMS) allows non-invasive stimulation of the human brain. However, no suitable marker has yet been established to monitor the immediate rTMS effects on cortical areas in children...
  24. ncbi Quantitative assessment of neuromotor function in adolescents with high functioning autism and Asperger Syndrome
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, 66421 Homburg Saar, Germany
    J Autism Dev Disord 37:948-59. 2007
    ..Motor impairment in children with Asperger Syndrome (AS) or High functioning autism (HFA) has been reported previously. This study presents results of a quantitative assessment of neuromotor skills in 14-22 year old HFA/AS...
  25. doi Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
    ..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies...
  26. doi Emotion recognition in children and adolescents with attention-deficit/hyperactivity disorder (ADHD)
    Christina Schwenck
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Frankfurt M, Germany
    Atten Defic Hyperact Disord 5:295-302. 2013
    ..Thus, we suggest that ADHD per se is not associated with deficits in emotion recognition. ..
  27. doi Impaired gamma-band activity during perceptual organization in adults with autism spectrum disorders: evidence for dysfunctional network activity in frontal-posterior cortices
    Limin Sun
    Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt am Main, Germany
    J Neurosci 32:9563-73. 2012
    ..These findings highlight the contribution of impaired gamma-band activity toward complex visual processing in ASD, suggesting atypical modulation of high-frequency power in frontoposterior networks...
  28. doi Empathy in children with autism and conduct disorder: group-specific profiles and developmental aspects
    Christina Schwenck
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt M, Deutschordenstraße 50, Frankfurt am Main, Germany
    J Child Psychol Psychiatry 53:651-9. 2012
    ..The aim of the current study was to compare cognitive and emotional empathy in different age groups of children with ASD, CD with elevated or low callous-unemotional-traits (CU+ vs. CU-) and a matched control group (CG)...
  29. ncbi Imitation and language abilities in adolescents with Autism Spectrum Disorder without language delay
    Christine M Freitag
    Dept of Child and Adolescent Psychiatry, Saarland University Hospital, 66421 Homburg, Saar, Germany
    Eur Child Adolesc Psychiatry 15:282-91. 2006
    ..It has been hypothesized that imitation abilities might be precursors of language abilities in young children with autism. No study on imitation and language abilities in adolescents with ASD has been performed to date...
  30. doi Transmodal comparison of auditory, motor, and visual post-processing with and without intentional short-term memory maintenance
    Stephan Bender
    Psychiatric Hospital, University of Heidelberg, Voßstraße 4, D 69115 Heidelberg, Germany
    Clin Neurophysiol 121:2044-64. 2010
    ..To elucidate the contributions of modality-dependent post-processing in auditory, motor and visual cortical areas to short-term memory...
  31. ncbi Can autism spectrum disorders and social anxiety disorders be differentiated by the social responsiveness scale in children and adolescents?
    Hannah Cholemkery
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Hospital, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany
    J Autism Dev Disord 44:1168-82. 2014
    ..A combination of three disorder specific questionnaires resulted in marginally improved diagnostic accuracy. For the clinically very relevant differential diagnosis of SP/SM, SRS results must be interpreted with caution. ..
  32. pmc Visual processing of biological motion in children and adolescents with attention-deficit/hyperactivity disorder: an event related potential-study
    Anne Kröger
    Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 9:e88585. 2014
    ..These results point towards neuronal determined alterations in the processing of biological motion in ADHD. ..
  33. doi Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine
    Thomas Lempp
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Hospital Frankfurt, Deutschordenstrasse 50, 60528 Frankfurt am Main, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:221-8. 2013
    ..Especially the increased expression of SNAP-25 and GABA-A receptor subunits may indicate additional active therapeutic mechanisms for atomoxetine...
  34. doi [Empirically based early intervention programs for children with autistic disorders - a selective literature review]
    Christine M Freitag
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, J W Goethe Universitat, Frankfurt am Main, Deutschordenstrasse 50, DE 60528 Frankfurt am Main
    Z Kinder Jugendpsychiatr Psychother 38:247-56. 2010
    ..In this review article based on a selective literature search, the relatively best empirically based early intervention programs will be discussed with a focus on the proven efficacy of these interventions...
  35. doi Cortical inhibition at rest and under a focused attention challenge in adults with migraine with and without aura
    Joachim Maier
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Deutschordenstrasse 50, Frankfurt, Germany
    Cephalalgia 31:914-24. 2011
    ..We aimed to further elucidate the functional and attentional regulation of cortical excitability in migraine patients...
  36. ncbi Behavioral comorbidity differs in subtypes of enuresis and urinary incontinence
    Susanne Zink
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Saarbrucken, Saarland, Germany
    J Urol 179:295-8; discussion 298. 2008
    ..The aim of this prospective study is to describe the association of comorbid behavioral and somatic factors in children with different forms of nocturnal enuresis and daytime incontinence referred to a tertiary center...
  37. ncbi Interaction of serotonergic and noradrenergic gene variants in panic disorder
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
    Psychiatr Genet 16:59-65. 2006
    ....
  38. doi [Suicide in children and adolescents - a 13-year study with 78 cases]
    Daniel Radeloff
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie des Kindes und Jugendalters, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Kinder Jugendpsychiatr Psychother 40:263-9. 2012
    ..Updated and regional data about the circumstances of death and the psychosocial backgrounds of suicides can be helpful for improving suicide-preventive strategies in childhood and adolescence...
  39. ncbi Neurophysiology of nocturnal enuresis: evoked potentials and prepulse inhibition of the startle reflex
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg Saar, Germany
    Dev Med Child Neurol 48:278-84. 2006
    ..Differences in VEP latencies might point towards functional cortical differences in children with a family history of nocturnal enuresis...