I Fleming

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1
    Michael Potente
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Biol Chem 278:29619-25. 2003
  2. ncbi Pulsatile stretch in coronary arteries elicits release of endothelium-derived hyperpolarizing factor: a modulator of arterial compliance
    R Popp
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Franfurt, Germany
    Circ Res 82:696-703. 1998
  3. pmc Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Br J Pharmacol 126:949-60. 1999
  4. ncbi Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR)
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, D 60590 Frankfurt am Main, Germany
    FASEB J 17:770-2. 2003
  5. ncbi Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Cell Sci 118:5489-98. 2005
  6. pmc Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway
    Voahanginirina Randriamboavonjy
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, D 60590 Frankfurt am Main, Germany
    J Exp Med 199:347-56. 2004
  7. pmc 11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction
    Annemarieke E Loot
    Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 7:e46065. 2012
  8. ncbi AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt Main, Germany
    Thromb Haemost 90:863-71. 2003
  9. ncbi The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Pflugers Arch 442:511-8. 2001
  10. ncbi Cytochrome p450 and vascular homeostasis
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Circ Res 89:753-62. 2001

Detail Information

Publications103 found, 100 shown here

  1. ncbi 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1
    Michael Potente
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Biol Chem 278:29619-25. 2003
    ....
  2. ncbi Pulsatile stretch in coronary arteries elicits release of endothelium-derived hyperpolarizing factor: a modulator of arterial compliance
    R Popp
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Franfurt, Germany
    Circ Res 82:696-703. 1998
    ....
  3. pmc Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Br J Pharmacol 126:949-60. 1999
    ..5. These results suggest that the activation of endothelial CB1 receptors appears to be negatively coupled to the production of EDHF...
  4. ncbi Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR)
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, D 60590 Frankfurt am Main, Germany
    FASEB J 17:770-2. 2003
    ..These results indicate that CYP 2C9-derived EETs stimulate angiogenesis by a mechanism involving the activation of the EGF receptor...
  5. ncbi Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Cell Sci 118:5489-98. 2005
    ..Taken together, these data indicate that CYP 2C-derived EETs significantly affect the sequence of angiogenic events under hypoxic conditions...
  6. pmc Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway
    Voahanginirina Randriamboavonjy
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, D 60590 Frankfurt am Main, Germany
    J Exp Med 199:347-56. 2004
    ..The mechanism of dense granule secretion involves the G kinase-dependent association of syntaxin 2 with vesicle-associated membrane protein 3...
  7. pmc 11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction
    Annemarieke E Loot
    Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 7:e46065. 2012
    ..The 11,12-EET-induced activation of BK channels results in loss of the mitochondrial membrane potential and depolarization of the pulmonary artery smooth muscle cells...
  8. ncbi AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt Main, Germany
    Thromb Haemost 90:863-71. 2003
    ....
  9. ncbi The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Pflugers Arch 442:511-8. 2001
    ..These observations indicate that EDHF/11,12-EET is not simply a vasodilator and that its continuous release under pulsatile conditions in vivo may affect vascular cell signalling and proliferation...
  10. ncbi Cytochrome p450 and vascular homeostasis
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Circ Res 89:753-62. 2001
    ..The development of selective pharmacological tools is, however, a prerequisite for the analysis of the involvement of specific CYP isoforms in the regulation of vascular homeostasis in human subjects...
  11. ncbi New fACEs to the renin-angiotensin system
    Ingrid Fleming
    Vascular Signaling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Physiology (Bethesda) 20:91-5. 2005
    ..Moreover, at least one other ACE homolog (ACE2) plays a significant role in the regulation of heart and kidney function...
  12. doi Vascular cytochrome p450 enzymes: physiology and pathophysiology
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, D 60590 Frankfurt am Main, Germany
    Trends Cardiovasc Med 18:20-5. 2008
    ..Epoxyeicosatrienoic acids are recognized as lipid mediators that participate in vascular signaling processes such as the acute regulation of vascular tone and the processes of inflammation and angiogenesis...
  13. ncbi DiscrEET regulators of homeostasis: epoxyeicosatrienoic acids, cytochrome P450 epoxygenases and vascular inflammation
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Germany
    Trends Pharmacol Sci 28:448-52. 2007
    ..There is potential for selecting the anti-inflammatory actions of the EETs by preventing their metabolism by the soluble epoxide hydrolase...
  14. ncbi Epoxyeicosatrienoic acids, cell signaling and angiogenesis
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Prostaglandins Other Lipid Mediat 82:60-7. 2007
    ..This also means that the contribution of CYP-derived products in the vast majority of the experimental models based on cell culture systems to address topics related to vascular signaling/homeostasis and angiogenesis has been overlooked...
  15. ncbi Signaling by the angiotensin-converting enzyme
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 98:887-96. 2006
    ..These data reveal hitherto unexpected levels of internal regulation of the renin-angiotensin system...
  16. ncbi Endothelium-derived epoxyeicosatrienoic acids and vascular function
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Hypertension 47:629-33. 2006
    ....
  17. ncbi Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there?
    Voahanginirina Randriamboavonjy
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiology, Johann Wolfgang Goethe Universitat, Theoder Stern Kai 7, D 60590 Frankfurt, Germany
    Pharmacol Rep 57:59-65. 2005
    ..hypertension and diabetes). In this review, we will summarize the current knowledge of the role of platelet eNOS and the regulation of its activity as well as the fate of platelet-derived NO in physiological and pathological situations...
  18. ncbi Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, J W Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Am J Physiol Regul Integr Comp Physiol 284:R1-12. 2003
    ..eNOS associated proteins, such as caveolin, heat shock protein 90, eNOS interacting protein, and possibly also motor proteins provide the scaffold for the formation of the protein complex as well as its intracellular localization...
  19. ncbi The tissue renin-angiotensin system and intracellular signalling
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Curr Opin Nephrol Hypertens 15:8-13. 2006
    ..For example, there is a novel angiotensin I-metabolizing enzyme that generates angiotensin 1-7 rather than angiotensin II. Moreover, we are slowly realizing the importance of local rather than circulating angiotensin II...
  20. doi Molecular mechanisms underlying the activation of eNOS
    Ingrid Fleming
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany
    Pflugers Arch 459:793-806. 2010
    ..This review summarizes some of the recent findings relating to the molecular events regulating eNOS activity...
  21. ncbi Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt, Germany
    Circ Res 88:E68-75. 2001
    ..Moreover, the dephosphorylation of Thr(495) by PP1 precedes the phosphorylation of Ser(1177) by CaMKII. The full text of this article is available at http://www.circresaha.org...
  22. ncbi Cytochrome P450 2C is an EDHF synthase in coronary arteries
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Theodor Stern Kai 7, D 60590, Frankfurt am Main, Germany
    Trends Cardiovasc Med 10:166-70. 2000
    ....
  23. ncbi Calcium-dependent and calcium-independent activation of the endothelial NO synthase
    I Fleming
    Zentrum der Physiologie, Klinikum der J W Goethe Universitat, Frankfurt Main, Deutschland
    J Vasc Res 34:165-74. 1997
    ..Thus in a departure from widely held beliefs, we propose that the endothelial cells are able to respond to mechanical and humoral stimuli activating NOS III by at least two separate pathways...
  24. ncbi Ca2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stress
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 82:686-95. 1998
    ....
  25. ncbi Cytochrome P450 epoxygenases as EDHF synthase(s)
    Ingrid Fleming
    Klinikum der J W Goethe Universitat, Institut für Kardiovaskuläre Physiologie, J W Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Pharmacol Res 49:525-33. 2004
    ..This review summarizes the role played by EETs, and the enzymes that generate and metabolize them, in EDHF-mediated responses...
  26. doi Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis
    Hanna Müller
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 32:442-8. 2012
    ..Here we studied the role of DMBT1 in endothelial cells...
  27. doi The cytochrome P450 pathway in angiogenesis and endothelial cell biology
    Ingrid Fleming
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cancer Metastasis Rev 30:541-55. 2011
    ..This review summarizes current knowledge on the aspects of the cytochrome P450/soluble epoxide hydrolase pathway related to vascular homeostasis and cancer...
  28. pmc Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 96:1123-8. 1999
    ..Thus, isometric contraction activates eNOS via a Ca2+-independent, tyrosine kinase inhibitor-sensitive pathway and, like shear stress, seems to be an independent determinant of mechanically induced NO formation...
  29. ncbi Signal transduction of eNOS activation
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Cardiovasc Res 43:532-41. 1999
    ....
  30. doi Cytochrome P450-dependent eicosanoid production and crosstalk
    Ingrid Fleming
    Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany
    Curr Opin Lipidol 22:403-9. 2011
    ..This review highlights recent advances in eicosanoid biology, especially linked to the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) axis in vascular biology and disease...
  31. ncbi Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 27:2612-8. 2007
    ..Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells...
  32. ncbi Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cardiovasc Res 65:897-906. 2005
    ..We assessed whether the uncoupling of eNOS was associated with alterations in eNOS phosphorylation and/or the assembly of the eNOS signaling complex...
  33. ncbi Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Cell Sci 118:4103-11. 2005
    ....
  34. ncbi Endothelium-derived hyperpolarizing factor, but not nitric oxide, is reversibly inhibited by brefeldin A
    J Bauersachs
    Institut für Kardiovaskuläre Physiologie, Zentrum der Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Hypertension 30:1598-605. 1997
    ....
  35. ncbi Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase
    B Fisslthaler
    , , Frankfurt am Main, Germany
    Hypertension 38:1427-32. 2001
    ..Because this enzyme generates both EETs and superoxide anions, this finding has wide-reaching implications for vascular homeostasis in conditions of manifest endothelial dysfunction...
  36. pmc An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice
    R P Brandes
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 97:9747-52. 2000
    ....
  37. ncbi Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries
    I Fleming
    , , Frankfurt, Germany
    Circ Res 88:44-51. 2001
    ..These results suggest that a CYP isozyme homologous to CYP 2C9 is a physiologically relevant generator of ROS in coronary endothelial cells and modulates both vascular tone and homeostasis...
  38. ncbi Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery
    E Büssemaker
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Cardiovasc Res 59:181-8. 2003
    ..Hyperthyroidism has pronounced effects on vascular function and endothelium-dependent relaxation. The aim of the present study was to identify mechanisms underlying hyperthyroidism-induced alterations in endothelial function in rats...
  39. ncbi Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production
    A Bouloumie
    Zentrum der Physiologie, Klinikum der J W Goethe Universitat, Frankfurt Main, Germany
    Hypertension 30:934-41. 1997
    ..This would suggest that the development of endothelial dysfunction is linked to an overproduction of not one, but two, endothelium-derived radicals that might lead to the formation of peroxynitrite...
  40. ncbi Calcium signalling and autacoid production in endothelial cells are modulated by changes in tyrosine kinase and phosphatase activity
    I Fleming
    Zentrum der Physiologie, Klinikum der J W Goethe Universitat, Frankfurt Main, Germany
    J Vasc Res 33:225-34. 1996
    ..These observations suggest that alterations in cellular levels of phosphotyrosine may have profound effects on vascular homeostasis by modulating Ca2+ signalling and autacoid production in endothelial cells...
  41. pmc The extracellular regulated kinases (ERK) 1/2 mediate cannabinoid-induced inhibition of gap junctional communication in endothelial cells
    R P Brandes
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60596 Frankfurt am Main, Germany
    Br J Pharmacol 136:709-16. 2002
    ..Moreover, the activation of ERK1/2 by endothelial cell agonists such as bradykinin, appears to exert a negative feedback inhibition on EDHF-mediated responses...
  42. ncbi Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin
    Beate Fisslthaler
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Circ Res 102:1520-8. 2008
    ..The PYK2-dependent inhibition of NO production may serve to keep eNOS activity low and limit the detrimental consequences of maintained high NO output, ie, the generation of peroxynitrite...
  43. ncbi Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells
    Karin Kohlstedt
    Vascular Signaling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Hypertension 45:126-32. 2005
    ..These results indicate that ACE signaling may underlie the increase in COX-2 and prostacyclin levels in patients treated with ACE inhibitors...
  44. ncbi Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495
    Helena Lenasi
    Institut für Kardiovaskuläre Physiologie, Klinikum der JWG Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cardiovasc Res 59:844-53. 2003
    ..The aim of this investigation was to determine whether or not the activation of the endothelial NO synthase (eNOS) by this Ca2+ antagonist is related to alterations in eNOS phosphorylation...
  45. doi Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4
    Anke C Webler
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 28:1123-9. 2008
    ..Because EphB4 is involved in vascular development, the aim of this study was to investigate whether, and to what extent, EphB4 is part of the signaling cascade that results in CYP2C9-mediated angiogenesis...
  46. ncbi Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1
    Beate Fisslthaler
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 100:e12-21. 2007
    ..These data indicate that fluid shear stress regulates the activity and expression of the HCR in endothelial cells and determines responsiveness to stimuli, such as bradykinin via a mechanism involving NO, AMPK, FoxO1a, and p21Ras...
  47. ncbi Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress
    Madhulika Dixit
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 97:1236-44. 2005
    ..Thus, the shear stress-induced activation of eNOS depends on Gab1 and SHP2, which, in turn, regulate the phosphorylation and activity of eNOS by a PKA-dependent but Akt-independent mechanism...
  48. ncbi Thrombin receptor expression is increased by angiotensin II in cultured and native vascular smooth muscle cells
    B Fisslthaler
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Cardiovasc Res 38:263-71. 1998
    ..We investigated the possibility of a synergistic interaction between AII and thrombin by studying the effects of AII on the expression of the thrombin receptor in rat aortic smooth muscle cells (VMSC)...
  49. ncbi Cytochrome P450 epoxygenases and vascular tone: novel role for HMG-CoA reductase inhibitors in the regulation of CYP 2C expression
    Beate Fisslthaler
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Theodor Stern Kai 7, D 60590, Frankfurt am Main, Germany
    Biochim Biophys Acta 1619:332-9. 2003
    ..These data highlight the role played by CYP 2C in vascular homeostasis and its potential regulation by cardiovascular drugs...
  50. ncbi Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (S1177D) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity
    Claudius Teupe
    Molecular Cardiology, Department of Medicine IV, Institut für Kardiovaskuläre Physiologie, University of Frankfurt, Germany
    Circulation 105:1104-9. 2002
    ..For gene transfer, we used a phosphomimetic, active endothelial nitric oxide synthase (eNOS) construct in which Ser1177 was replaced by aspartic acid (S1177D) and exhibits a 2-fold higher basal activity than the wild-type enzyme...
  51. ncbi Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells
    M Michaelis
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Cell Death Differ 13:446-53. 2006
    ..Moreover, the combination of VPA with PD98059 synergistically inhibited angiogenesis in vitro and in vivo...
  52. ncbi Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 25:321-6. 2005
    ..Because cyclooxygenase-2 (COX-2) is involved in angiogenesis, we determined whether a link exists between CYP2C9 and COX-2 expression...
  53. ncbi Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells
    Karin Kohlstedt
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 94:60-7. 2004
    ..Thus, ACE is involved in outside-in signaling in endothelial cells and "ACE signaling" may be an important cellular mechanism contributing to the beneficial effects of ACE inhibitors...
  54. ncbi Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid
    Rüdiger Popp
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Circ Res 90:800-6. 2002
    ....
  55. ncbi Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1
    Beate Fisslthaler
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main D 60590, Germany
    Nitric Oxide 8:253-61. 2003
    ..Insulin however enhances eNOS mRNA and protein by a mechanism involving the combined activation of a PI 3-K- and AP-1-dependent pathway...
  56. pmc Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis
    Anke C Webler
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Am J Physiol Cell Physiol 295:C1292-301. 2008
    ..Taken together, our data indicate that CYP2C-derived EETs participate as second messengers in the angiogenic response initiated by VEGF and that preventing the increase in CYP expression curtails the angiogenic response to VEGF...
  57. ncbi Cirrhosis serum induces a nitric oxide-associated vascular hyporeactivity of aortic segments from healthy rats in vitro
    T C Schmandra
    Department of General and Vascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Eur J Gastroenterol Hepatol 13:957-62. 2001
    ..Reversibility of this effect after nitric oxide synthesis blockade suggests an induction of nitric oxide synthesis by systemic factors as a major point in vascular hyporeactivity to vasoconstrictors in cirrhosis...
  58. ncbi EDHF: a cytochrome P450 metabolite in coronary arteries
    B Fisslthaler
    Institut für Kardiovaskuläre Physiologie Klinikum der J W Goethe Universität, Frankfurt am Main, Germany
    Semin Perinatol 24:15-9. 2000
    ..Thus, CYP 2C appears to play a crucial role in the generation of EDHF-mediated responses in porcine coronary arteries...
  59. ncbi Pulsatile stretch and shear stress: physical stimuli determining the production of endothelium-derived relaxing factors
    R Busse
    Institut für Kardiovaskuläre Physiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Deutschland, Germany
    J Vasc Res 35:73-84. 1998
    ..Rhythmic vessel distension is also able to elicit the synthesis of superoxide anions and the endothelium-derived hyperpolarizing factor which play a role in modulating arterial compliance in certain vascular beds...
  60. doi Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Invest Ophthalmol Vis Sci 49:1242-7. 2008
    ..The aim of this study was to determine the expression of CYP epoxygenases in the bovine retina and the potential role of EETs in hypoxia-induced angiogenesis in bovine retinal endothelial cells...
  61. doi Activation and signaling by the AMP-activated protein kinase in endothelial cells
    Beate Fisslthaler
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Circ Res 105:114-27. 2009
    ..Moreover, there is evidence indicating that the activation of the AMPK may help to prevent the vascular complications associated with the metabolic syndrome...
  62. pmc Inhibition of the soluble epoxide hydrolase by tyrosine nitration
    Eduardo Barbosa-Sicard
    Institute for Vascular Signalling, Johann Wolfgang Goethe University, D 60590 Frankfurt am Main, Germany
    J Biol Chem 284:28156-63. 2009
    ..Moreover, nitrosative stress would be expected to potentiate the physiological actions of arachidonic acid epoxides by preventing their metabolism to the corresponding diols...
  63. ncbi Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery
    Eckhart Büssemaker
    Institut für Kardiovaskuläre Physiologie, and Klinik für Urologie und Kinderurologie, Klinikum der J W G Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Kidney Int 63:1749-55. 2003
    ..The present study was performed to determine the characteristics of the EDHF that mediates the NO/PGI2-independent hyperpolarization and relaxation of human renal interlobar arteries...
  64. ncbi Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery
    Eckhart Büssemaker
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 42:562-8. 2003
    ....
  65. doi Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation
    Annemarieke E Loot
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cardiovasc Res 80:445-52. 2008
    ..We therefore hypothesized that the TRPV4 channel is involved in the flow-induced vasodilatation attributed to the endothelium-derived hyperpolarizing factor (EDHF)...
  66. ncbi 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase
    Voahanginirina Randriamboavonjy
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Hypertension 41:801-6. 2003
    ..The latter response is associated with the activation of Rho-kinase, phosphorylation of MLC20, and sensitization of the contractile apparatus to Ca2+...
  67. ncbi CK2 phosphorylates the angiotensin-converting enzyme and regulates its retention in the endothelial cell plasma membrane
    Karin Kohlstedt
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Circ Res 91:749-56. 2002
    ..These results indicate that the CK2-mediated phosphorylation of ACE regulates its retention in the plasma membrane and may determine plasma ACE levels...
  68. ncbi Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension
    Oliver Jung
    Institut für Kardiovaskuläre Physiologie and ZAFES, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Hypertension 45:759-65. 2005
    ..Direct vasodilatation of resistance arteries in skeletal muscles does not appear to contribute to the antihypertensive effects of sEH inhibition in mice...
  69. ncbi Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1
    Michael Potente
    Institut für Kardiovaskuläre Physiologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Biol Chem 277:15671-6. 2002
    ....
  70. ncbi Identification of a cis-element regulating transcriptional activity in response to fluid shear stress in bovine aortic endothelial cells
    Beate Fisslthaler
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Endothelium 10:267-75. 2003
    ..Our results indicate that the sequence ACC(G)/(T)AGACCAG represents a novel SSRE and that a protein that binds a CREB-specific oligonucleotide is part of the complex implicated in response to shear stress...
  71. pmc Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: dependence on cyclooxygenase and cell polarity
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Am J Physiol Renal Physiol 293:F288-98. 2007
    ..We suggest a role for this P450 epoxygenase product in the regulation of electrolyte transport, especially as a saluretic compound acting from the luminal side of tubular cells in the mammalian kidney...
  72. ncbi Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease
    Stephan Fichtlscherer
    Departments of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Frankfurt am Main, Germany
    Circulation 109:178-83. 2004
    ..Here, we studied the involvement of CYP 2C9 in modulating endothelium-dependent and -independent changes in forearm blood flow (FBF) in healthy volunteers and in patients with manifest coronary artery disease...
  73. ncbi The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation
    Voahanginirina Randriamboavonjy
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cardiovasc Res 65:487-94. 2005
    ..Here, we determined whether 20-HETE is involved in the regulation of coronary artery tone as well as its role in the modulation of endothelium-derived hyperpolarizing factor (EDHF)-mediated responses...
  74. ncbi Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells
    Madhulika Dixit
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cardiovasc Res 77:160-8. 2008
    ..Here, we investigated the effect of fluid shear stress on FoxO1a in primary cultures of human endothelial cells and the kinases that regulate its phosphorylation...
  75. doi Adipocyte-derived lipids increase angiotensin-converting enzyme (ACE) expression and modulate macrophage phenotype
    Karin Kohlstedt
    Institute for Vascular Signalling, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Basic Res Cardiol 106:205-15. 2011
    ..These data indicate that mature adipocytes modulate the expression profile of macrophages by releasing lipid mediators that increase ACE expression via AMPK. This prevents the pro-inflammatory cytokine production by macrophages...
  76. pmc Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase
    Annemarieke E Loot
    Institute for Vascular Signaling, Center for Molecular Medicine, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany
    J Exp Med 206:2889-96. 2009
    ..This mechanism may contribute to the endothelial dysfunction observed in cardiovascular diseases associated with increased activity of the renin-angiotensin system and elevated redox stress...
  77. ncbi Endothelial aging
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Cardiovasc Res 66:286-94. 2005
    ..Aging is also associated with a reduction in the regenerative capacity of the endothelium and endothelial senescence, which is characterized by an increased rate of endothelial cell apoptosis...
  78. ncbi From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling
    U Ruth Michaelis
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Pharmacol Ther 111:584-95. 2006
    ..The angiogenic properties of CYP epoxygenases and CYP-derived EETs implicate that these enzymes may well be accessible targets for anti-angiogenic as well as angiogenic therapies...
  79. pmc Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice
    Marc Revermann
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 30:909-14. 2010
    ..The soluble epoxide hydrolase (sEH) metabolizes EETs to their less active diols. We hypothesized that knockout and inhibition of sEH prevents neointima formation in hyperlipidemic ApoE(-/-) mice...
  80. doi The S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes
    Voahanginirina Randriamboavonjy
    Institut für Vascular Signalling, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Basic Res Cardiol 104:333-40. 2009
    ..Moreover, in platelets from patients with type 2 diabetes, responses to S1P are attenuated via a phenomenon attributed to the calpain-dependent cleavage of the S1P(2) receptor...
  81. doi Angiotensin-converting enzyme (ACE) inhibitors modulate cellular retinol-binding protein 1 and adiponectin expression in adipocytes via the ACE-dependent signaling cascade
    Karin Kohlstedt
    Institute for Vascular Signaling, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Mol Pharmacol 75:685-92. 2009
    ..The latter may contribute to the beneficial effects of ACE inhibitors on the development of type 2 diabetes in patients with an activated renin-angiotensin system...
  82. pmc The Na-K-ATPase is a target for an EDHF displaying characteristics similar to potassium ions in the porcine renal interlobar artery
    Eckhart Büssemaker
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Br J Pharmacol 137:647-54. 2002
    ..Smooth muscle cell hyperpolarization and relaxation appear to be dependent on the activation of highly ouabain-sensitive subunits of the Na-K-ATPase...
  83. doi Impaired interaction of platelets with endothelial progenitor cells in patients with cardiovascular risk factors
    Elisabeth Dernbach
    Molecular Cardiology, Dept of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Basic Res Cardiol 103:572-81. 2008
    ..Patients with cardiovascular risk factors (CVRF) demonstrate a reduced number and impaired function of EPC, as well as platelet hyper-reactivity. Therefore, we investigated the interaction of platelets and EPC from patients with CVRF...
  84. pmc Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1
    Ellen Dreieicher
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Am Soc Nephrol 20:1963-74. 2009
    ..In summary, these data suggest that NO attenuates SMOC-1 expression in acute glomerular inflammation, thereby limiting TGF-beta-mediated profibrotic signaling...
  85. ncbi Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species
    Alexandra Keller
    Institut für Kardiovaskuläre Physiologie, Klinikum der JW Goethe Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Free Radic Res 38:1257-67. 2004
    ..These observations indicate that H2-DCF is an indicator for intracellular ROS, whereas the oxidation of H2-calcein most likely occurs as a consequence of direct electron transfer to mitochondrial complex I...
  86. ncbi Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells
    Karin Kohlstedt
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Pharmacol 69:1725-32. 2006
    ..Together, our data suggest that ACE inhibitors can initiate the ACE signaling pathway by inducing ACE dimerization, most probably via the C-terminal active site of the enzyme...
  87. ncbi Valproic acid inhibits angiogenesis in vitro and in vivo
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der JW Goethe Universität, Frankfurt am Main, Germany
    Mol Pharmacol 65:520-7. 2004
    ..Embryos from VPA-treated mice showed disturbed vessel formation. These results indicate that therapeutic plasma levels of VPA inhibit angiogenesis by a mechanism involving a decrease in eNOS expression preceded by HDAC inhibition...
  88. doi The role of calpain in diabetes-associated platelet hyperactivation
    Voahanginirina Randriamboavonjy
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Adv Pharmacol 59:235-57. 2010
    ..Finally, we will discuss future therapeutic possibilities for the improvement of diabetes-associated vascular diseases...
  89. ncbi Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA
    Karin Kohlstedt
    Vascular Signaling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Pharmacol 69:19-26. 2006
    ..Furthermore, because ACE inhibitors affect the phosphorylation of MYH9, the phosphorylation of this class II myosin might contribute to the phenomenon of ACE signaling in endothelial cells...
  90. doi AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability
    Voahanginirina Randriamboavonjy
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Blood 116:2134-40. 2010
    ..These data indicate that AMPKα2-by affecting Fyn phosphorylation and activity-plays a key role in platelet αIIbβ3 integrin signaling, leading to clot retraction and thrombus stability...
  91. ncbi Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole
    Jens Passauer
    Division of Nephrology, Carl Gustav Carus University Hospital, Technical University Dresden, Dresden, Germany
    Clin Sci (Lond) 105:513-8. 2003
    ..However, determining the contribution of this enzyme to regulation of blood flow in pathological conditions associated with endothelial dysfunction requires further studies...
  92. pmc Bradykinin-induced relaxation of coronary microarteries: S-nitrosothiols as EDHF?
    Wendy W Batenburg
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Br J Pharmacol 142:125-35. 2004
    ..S-nitrosothiols, via stereoselective activation of endothelial IK(Ca) and SK(Ca) channels, and through direct effects on smooth muscle cells, may function as an EDHF in porcine coronary microarteries...
  93. ncbi Bobbing along on the crest of a wave: NO ascends hamster cheek pouch arterioles
    Ingrid Fleming
    Circ Res 93:9-11. 2003
  94. ncbi Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production
    Michelle I Lin
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 278:44719-26. 2003
    ..Thus, the phosphorylation/dephosphorylation of Thr497 may be an intrinsic switch mechanism that determines whether eNOS generates NO versus superoxide in cells...
  95. doi Double tribble: two TRIB3 variants, insulin, Akt, and eNOS
    Ingrid Fleming
    Arterioscler Thromb Vasc Biol 28:1216-8. 2008
  96. pmc Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling
    Peter Pokreisz
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute of Biotechnology, University of Leuven, Belgium
    Hypertension 47:762-70. 2006
    ..These observations indicate potential novel targets for the treatment of pulmonary hypertension and highlight a pivotal role for CYP epoxygenases in pulmonary responses to hypoxia...
  97. ncbi Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9
    Jens Passauer
    Division of Nephrology, Department of Medicine, University Hospital Carl Gustav Carus, Dresden, Germany
    Kidney Int 67:1907-12. 2005
    ..We therefore determined whether one of these pathways is involved in endothelial dysfunction of uremia...
  98. ncbi Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension
    Ingrid Fleming
    Circulation 111:5-7. 2005
  99. ncbi Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 91:837-44. 2002
    ..These data indicate that HDAC-dependent mechanisms contribute to the regulation of eNOS expression in ECs...
  100. ncbi NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice
    Matthias Oelze
    II Medizinische Klinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Arterioscler Thromb Vasc Biol 26:1753-9. 2006
    ..A regulatory BKbeta1 subunit confers Ca2+, voltage, and NO/cGMP sensitivity to the BK channel. We investigated whether endothelial function and NO/cGMP signaling is affected by a deletion of the beta1-subunit...
  101. ncbi The ADMA/DDAH pathway is a critical regulator of endothelial cell motility
    Beata Wojciak-Stothard
    BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, WC1 E6JJ, UK
    J Cell Sci 120:929-42. 2007
    ..These results are the first demonstration that metabolism of cardiovascular risk factor ADMA regulates endothelial cell motility, an important factor in angiogenesis and vascular repair...