Research Topics
| Stephan FichtlschererSummaryAffiliation: Frankfurt am Main Country: Germany Publications
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Detail Information
Publications
Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for 'pleiotropic' functions of statin therapyStephan Fichtlscherer
Department of Internal Medicine III, Division of Cardiology, Johann W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Eur Heart J 27:1182-90. 2006..The clinical availability of ezetimibe, a potent novel cholesterol absorption inhibitor, enables to differentiate lipid-lowering effects from potential non-lipid-lowering (pleiotropic) mechanisms of statins...- Elevated secretory non-pancreatic type II phospholipase A2 serum activity is associated with impaired endothelial vasodilator function in patients with coronary artery diseaseStephan Fichtlscherer
Division of Cardiology, Department of Internal Medicine IV, Johann W Goethe University, 60590 Frankfurt, Germany
Clin Sci (Lond) 106:511-7. 2004..The identification of sPLA(2) as a novel independent predictor for endothelial dysfunction provides another important clue to link a systemic marker of inflammation with coronary atherosclerotic disease... - Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes: further evidence for the existence of the "vulnerable" patientStephan Fichtlscherer
Department of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Circulation 110:1926-32. 2004.... - Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery diseaseStephan Fichtlscherer
Department of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Frankfurt, Germany
J Am Coll Cardiol 44:44-9. 2004..Because the endothelium is a major target for inflammatory cytokines, we investigated whether elevated interleukin (IL)-10 serum levels are associated with improved endothelial vasoreactivity in patients with coronary artery disease (CAD)... - C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery diseaseStephan Fichtlscherer
Department of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Eur Heart J 25:1412-8. 2004..Because inflammatory cytokines experimentally reduce basal and stimulated endothelial nitric oxide (NO) release, we hypothesised that patients with elevated CRP-levels are characterised by a systemic impairment in NO bioavailability... - [Endothelial dysfunction in patients with acute coronary syndrome]S Fichtlscherer
Abteilung Kardiologie, Johann Wolfgang Goethe Universitat Frankfurt
Herz 24:534-43. 1999..Both of these are often temporarily limited. Therefore, "non-invasive examination" of endothelial function by venous occlusion plethysmography or high resolution ultrasound might be useful for monitoring high-risk patients... 
Impact of interventional strategy for unprotected left main coronary artery percutaneous coronary intervention on long-term survivalRalf Lehmann
Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
Can J Cardiol 28:553-60. 2012..In cases involving the left anterior descending-left circumflex bifurcation, the optimal interventional strategy remains unclear. Randomized bifurcation trials in the past excluded ULMCA lesions...- Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosisChristopher Heeschen
Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
J Am Coll Cardiol 45:229-37. 2005..The goal of this study was to determine the predictive value of pregnancy-associated plasma protein-A (PAPP-A) in patients with acute coronary syndromes (ACS)... 
Quantification of circulating endothelial progenitor cells using the modified ISHAGE protocolCaroline Schmidt-Lucke
Department of Molecular Cardiology, Internal Medicine III, J W Goethe University, Frankfurt, Germany
PLoS ONE 5:e13790. 2010..We, therefore developed a novel protocol adapted from the standardised so-called ISHAGE protocol for enumeration of haematopoietic stem cells to enable comparison of clinical and laboratory data...- Complete revascularization in patients undergoing multivessel PCI is an independent predictor of improved long-term survivalRalf Lehmann
Department of Cardiology, Goethe University Frankfurt, Frankfurt, Germany
J Interv Cardiol 23:256-63. 2010..In addition, different definitions of CR have further complicated the interpretation of clinical studies... - Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery diseaseStephan Fichtlscherer
Departments of Internal Medicine IV, Division of Cardiology, Johann W. Goethe-University, Frankfurt am Main, Germany
Circulation 109:178-83. 2004..This effect seems to be related to an increase in the bioavailability of NO, probably as a consequence of an attenuated generation of reactive oxygen species by CYP 2C9 in endothelial cells... - Early remodeling processes as predictors of diastolic function 5 years after reperfused acute myocardial infarction and intracoronary progenitor cell applicationUlrich Fischer-Rasokat
Division of Cardiology, Department of Medicine III, Goethe University of Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany
Clin Res Cardiol 101:209-16. 2012..Therefore, we aimed to identify AMI characteristics, which determine diastolic function after 5 years... - Prognostic value of placental growth factor in patients with acute chest painChristopher Heeschen
Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany
JAMA 291:435-41. 2004.... - Favorable long-term survival in patients undergoing multivessel-PCI compared to predicted prognosis of CABG estimated by EuroSCORE: procedural and clinical determinants of long-term outcomeRalf Lehmann
Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany
J Interv Cardiol 22:511-9. 2009..Expected in-hospital mortality for CABG was calculated using the EuroSCORE and compared to the observed mortality rate during in-hospital as well as long-term follow-up... - Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromesChristopher Heeschen
Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Circulation 107:2109-14. 2003..Therefore, we investigated the prognostic impact of key inflammatory players, namely the inflammatory marker C-reactive protein (CRP) and the antiinflammatory cytokine interleukin-10 (IL-10), in patients with acute coronary syndromes... - Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repairCaroline Schmidt-Lucke
Molecular Cardiology, Department of Medicine III, J.W. Goethe University, Frankfurt, Germany
Circulation 111:2981-7. 2005..05). CONCLUSIONS: Reduced levels of circulating EPCs independently predict atherosclerotic disease progression, thus supporting an important role for endogenous vascular repair to modulate the clinical course of coronary artery disease... - Improvement of endothelial damage and regeneration indexes in patients with coronary artery disease after 4 weeks of statin therapyCaroline Schmidt-Lucke
Department of Internal Medicine III, Johann W Goethe University Frankfurt, Germany
Atherosclerosis 211:249-54. 2010..The availability of ezetimibe, a potent novel cholesterol absorption inhibitor, allows to distinguish between lipid-lowering and pleiotropic properties of statins... - FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cellsCarmen Urbich
Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
FASEB J 19:974-6. 2005..In summary, our results show that FOXO-dependent expression of Bim plays a pivotal role for EPC apoptosis. Statins reduce oxidative stress-induced EPC apoptosis, inactivate FOXO4, and down-regulate Bim... - Microvascular dysfunction and pulse wave reflection characterize different vascular pathologies in patients at cardiovascular riskUlrich Fischer-Rasokat
Division of Cardiology, Department of Medicine III, Goethe University Hospital, Frankfurt Main, Germany
Vasa 41:192-9. 2012..In this study we assessed the interrelationships among these noninvasive measures of vascular function... - Inflammatory markers and coronary artery diseaseStephan Fichtlscherer
Johann W Goethe University, Department of Cardiology, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
Curr Opin Pharmacol 4:124-31. 2004..As a result, different markers are used clinically for risk stratification in stable coronary artery disease as well as in acute coronary syndromes... - Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcomeRalf Lehmann
Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, D 60590 Frankfurt, Germany
J Interv Cardiol 22:311-9. 2009..8 +/- 1.2 years)... - Systemic therapy of plaque-type psoriasis ameliorates endothelial cell function: results of a prospective longitudinal pilot trialSandra Boehncke
Department of Internal Medicine, Clinic of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
Arch Dermatol Res 303:381-8. 2011..Future studies need to compare the cardioprotective effects of different treatment modalities, based on hard end points such as the rate of myocardial infarction... - Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?Stephan Fichtlscherer
Division of Cardiology, Department of Medicine III, Goethe University, Frankfurt, Germany
Arterioscler Thromb Vasc Biol 31:2383-90. 2011..In addition, the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed... - The pro-apoptotic serum activity is an independent mortality predictor of patients with heart failureLothar Rossig
Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Eur Heart J 25:1620-5. 2004..Since serum of patients with HF induces apoptosis of endothelial cells (EC), we aimed to determine whether the pro-apoptotic activity in the serum may predict prognosis of patients with HF... - Benefits of immediate initiation of statin therapy following successful coronary stent implantation in patients with stable and unstable angina pectoris and Q-wave acute myocardial infarctionDirk H Walter
Department of Internal Medicine IV, Division of Cardiology, University of Frankfurt, Germany
Am J Cardiol 89:1-6. 2002.... - Transcoronary concentration gradients of circulating microRNAsSalvatore De Rosa
Division of Cardiology, Department of Medicine III, Goethe University Frankfurt, Frankfurt, Germany
Circulation 124:1936-44. 2011.... - Implementation of the transradial approach for coronary procedures is not associated with an elevated complication rate and elevated radiation patient exposureRalf Lehmann
Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
J Interv Cardiol 24:56-64. 2011..The transradial approach for coronary procedures is associated with a low complication rate, but specific training is considered mandatory... - Pilot trial on determinants of progenitor cell recruitment to the infarcted human myocardiumVolker Schachinger
Department of Medicine III, Division of Cardiology, JW Goethe University Frankfurt, Frankfurt am Main, Germany
Circulation 118:1425-32. 2008..The extent and potential determinants of proangiogenic progenitor cell homing into the damaged myocardium after intracoronary infusion and the underlying mechanisms are still unknown... - Caffeine enhances endothelial repair by an AMPK-dependent mechanismIoakim Spyridopoulos
Department of Internal Medicine III, University of Frankfurt, Germany
Arterioscler Thromb Vasc Biol 28:1967-74. 2008..Migratory capacity of endothelial progenitor cells (EPCs) and mature endothelial cells (ECs) is a key prerequisite for endothelial repair after denuding injury or endothelial damage... - Tumor necrosis factor antagonism with etanercept improves systemic endothelial vasoreactivity in patients with advanced heart failureS Fichtlscherer
Department of Internal Medicine IV, Division of Cardiology, Johann W. Goethe-University Frankfurt, Germany
Circulation 104:3023-5. 2001..Improvement of systemic endothelial function might importantly contribute to the beneficial effects of etanercept on the functional status of patients with CHF... - Statin therapy in patients with coronary artery disease improves the impaired endothelial progenitor cell differentiation into cardiomyogenic cellsStefan Rupp
Molecular Cardiology, Dept. of Internal Medicine IV, University of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
Basic Res Cardiol 99:61-8. 2004..1 micro M atorvastatin did not affect EPC differentiation (116.15% +/- 49.11% of control).EPCs from patients with CAD display impaired differentiation into cardiomyogenic cells. This defect can be improved by in vivo, statin therapy... - The endothelium and inflammationThomas Trepels
Department of Internal Medicine III, Division of Cardiology, Johann Wolfgang Goethe University, Frankfurt, Germany
Endothelium 13:423-9. 2006.... - Angiotensin-converting enzyme (ACE) inhibitors modulate cellular retinol-binding protein 1 and adiponectin expression in adipocytes via the ACE-dependent signaling cascadeKarin Kohlstedt
Institute for Vascular Signaling, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Mol Pharmacol 75:685-92. 2009..The latter may contribute to the beneficial effects of ACE inhibitors on the development of type 2 diabetes in patients with an activated renin-angiotensin system... - Progress in CT imaging for the cardiac surgeonChristopher Herzog
Institute for Diagnostic and Interventional Radiology, J W Goethe University, Frankfurt, Germany
Semin Thorac Cardiovasc Surg 16:242-8. 2004..New technological developments such as 64-row MDCT or flat panel computed tomography will further increase the field of possible indications... - Preprocedural C-reactive protein levels and cardiovascular events after coronary stent implantationD H Walter
Department of Internal Medicine IV, University of Frankfurt, Germans
J Am Coll Cardiol 37:839-46. 2001..This study assessed the predictive value of preprocedural C-reactive protein (CRP) levels on six-month clinical and angiographic outcome in patients undergoing coronary stent implantation... - [Analysis of forearm circulation--a substitute for diagnosis of coronary atherosclerosis?]G Rosenberger
Medizinische Klinik IV, Abteilung fur Kardiologie, Johann Wolfgang Goethe Universitat Frankfurt
Herz 23:130-4. 1998.... - Statin therapy, inflammation and recurrent coronary events in patients following coronary stent implantationD H Walter
Department of Internal Medicine IV, Division of Cardiology, University of Frankfurt, Frankfurt, Germany
J Am Coll Cardiol 38:2006-12. 2001.... - HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathwayS Dimmeler
Division of Molecular Cardiology, Department of Medicine IV, University of Frankfurt, Frankfurt, Germany
J Clin Invest 108:391-7. 2001.... - Risk for permanent pacemaker after transcatheter aortic valve implantation: a comprehensive analysis of the literatureDamir Erkapic
Division of Clinical Electrophysiology, Department of Cardiology, J W Goethe University, Frankfurt, Germany
J Cardiovasc Electrophysiol 23:391-7. 2012..Permanent pacemaker (PM) requirement is a known complication after transcatheter aortic valve implantation (TAVI). There are, however, no systematic data concerning this complication... - Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery diseaseDirk H Walter
Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
Circ Res 97:1142-51. 2005..Stimulating CXCR4 signaling might improve functional properties of EPC and may rescue impaired neovascularization capacity of EPC derived from patients with CAD... - Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery diseaseM Vasa
Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany
Circulation 103:2885-90. 2001..Given the well-established role of EPCs of participating in repair after ischemic injury, stimulation of EPCs by statins may contribute to the clinical benefit of statin therapy in patients with CAD... - Changing incidence and prognostic factors of survival in AIDS-related non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy (HAART)Timo Wolf
Department of Internal Medicine III, Hematology, Oncology and Infectious Diseases, University Hospital Frankfurt, Germany
Leuk Lymphoma 46:207-15. 2005.... - Circulating microRNAs in patients with coronary artery diseaseStephan Fichtlscherer
Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
Circ Res 107:677-84. 2010..MicroRNAs are small RNAs that control gene expression. Besides their cell intrinsic function, recent studies reported that microRNAs are released by cultured cells and can be detected in the blood... - Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery diseaseM Vasa
Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
Circ Res 89:E1-7. 2001..The full text of this article is available at http://www.circresaha.org... - Elevated placental growth factor levels are associated with adverse outcomes at four-year follow-up in patients with acute coronary syndromesTimo Lenderink
Department of Cardiology, Atrium Medical Centre, Heerlen, The Netherlands
J Am Coll Cardiol 47:307-11. 2006..This study sought to evaluate the predictive value of baseline placental growth factor (PlGF) for long-term cardiovascular events in acute coronary syndromes (ACS)... - [Acute coronary syndrome and inflammation. Biomarkers for diagnostics and risk stratification]Thomas Trepels
Medizinische Klinik IV, Kardiologie, , Frankfurt am Main
Herz 29:769-76. 2004..However, the clinical utility of these novel markers has not been established so far... - Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilizationChristopher Heeschen
Department of Internal Medicine IV and Hematology, University of Frankfurt, Germany
Blood 102:1340-6. 2003..Epo appears to physiologically regulate EPC mobilization in patients with ischemic heart disease. Thus, Epo serum levels may help in identifying patients with impaired EPC recruitment capacity... - Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD RegistryBirgit Assmus
Cardiology and Molecular Cardiology, Department of Medicine III, J W Goethe University of Frankfurt, Germany
Circ Res 100:1234-41. 2007..Importantly, infusion of progenitor cells with a high functional capacity is associated with a significantly lower mortality during further follow-up...