K D Entian

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach
    K D Entian
    Institut fur Mikrobiologie, Universitat Frankfurt, Frankfurt Main, Germany
    Mol Gen Genet 262:683-702. 1999
  2. ncbi request reprint The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p
    N Bojunga
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Mol Gen Genet 260:453-61. 1998
  3. ncbi request reprint The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7)
    C Charizanis
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Biozentrum, Frankfurt am Main, Germany
    Mol Gen Genet 262:437-47. 1999
  4. pmc Carbon source-dependent phosphorylation of hexokinase PII and its role in the glucose-signaling response in yeast
    F Randez-Gil
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    Mol Cell Biol 18:2940-8. 1998
  5. ncbi request reprint Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress
    H Juhnke
    Institut fur Mikrobiologie, der Johann Wolfgang Goethe Universität Frankfurt, Biozentrum Niederursel, Frankfurt am Main, Germany
    Mol Gen Genet 252:456-64. 1996
  6. pmc Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein
    G Engelke
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Appl Environ Microbiol 58:3730-43. 1992
  7. ncbi request reprint Characterization of null mutants of the glyoxylate cycle and gluconeogenic enzymes in S. cerevisiae through metabolic network modeling verified by chemostat cultivation
    I Stückrath
    Institut fur Mikrobiologie, J W Goethe Universität Frankfurt, Germany
    Biotechnol Bioeng 77:61-72. 2002
  8. pmc Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p
    F Randez-Gil
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Biozentrum, Niederursel, Frankfurt am Main, Germany
    Mol Cell Biol 17:2502-10. 1997
  9. ncbi request reprint Investigation of the yvgW Bacillus subtilis chromosomal gene involved in Cd(2+) ion resistance
    I M Solovieva
    Molecular and Radiation Biophysics Division, St Petersburg Nuclear Physics Institute of the Russian Academy of Sciences, PNPI, Gatchina, 188350, St Petersburg, Russia
    FEMS Microbiol Lett 208:105-9. 2002
  10. ncbi request reprint Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress
    B Krems
    Institut fur Mikrobiologie, Frankfurt Main, Germany
    Curr Genet 27:427-34. 1995

Collaborators

  • H C Lange
  • M Hansen
  • P Sanz
  • P Meyer
  • K Melcher
  • G Jansen
  • M Proft
  • M Rose
  • I M Solovieva
  • Eugen Domann
  • L Frangeul
  • Carmen Buchrieser
  • M A Petit
  • P Cossart
  • Werner Kramer
  • Massoud Ramezani-Rad
  • B Krems
  • H Juhnke
  • C Charizanis
  • F Randez-Gil
  • P Kotter
  • I Stückrath
  • N Bojunga
  • R Marx
  • P Glaser
  • K Mayer
  • T Schule
  • T Jonassen
  • J J Heijnen
  • W M van Gulik
  • F Kunst
  • R Wambutt
  • T Pohl
  • H Fsihi
  • C Rusniok
  • J M Vicente
  • A M van Dodeweerd
  • M W Bevan
  • L Durant
  • H W Mewes
  • P Berche
  • G Kurapkat
  • W Stiekema
  • N Terryn
  • G Murphy
  • I Bancroft
  • S V Tingey
  • P Brandt
  • S Novella
  • K Lemcke
  • H Voss
  • E Madueno
  • M Kuhn
  • T Schlueter
  • L Gautier
  • A Maitournam
  • J Kreft
  • O Dussurget
  • F Baquero
  • H Nedjari
  • A de Daruvar
  • C R Hall
  • T Hain
  • A Charbit
  • E Duchaud
  • U Kaerst
  • G Nordsiek
  • P Dehoux
  • A Amend
  • D Haase
  • D Jackson
  • R Purcell
  • B de Pablos
  • E Ng
  • R Tarchini
  • A Tierrez
  • T Chakraborty
  • J Hauf
  • H Bloecker
  • W Goebel
  • P Garrido
  • G Volckaert
  • T Stein
  • S J Glaser
  • B Remmel
  • J Wehland
  • L M Jones
  • N Simoes
  • F Chetouani
  • D H Wolf

Detail Information

Publications28

  1. ncbi request reprint Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach
    K D Entian
    Institut fur Mikrobiologie, Universitat Frankfurt, Frankfurt Main, Germany
    Mol Gen Genet 262:683-702. 1999
    ..Surprisingly, for seven genes, additional, unexpected phenotypes were found in our tests. This suggests that the type of analysis presented here provides a more complete description of gene function...
  2. ncbi request reprint The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p
    N Bojunga
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Mol Gen Genet 260:453-61. 1998
    ....
  3. ncbi request reprint The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7)
    C Charizanis
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Biozentrum, Frankfurt am Main, Germany
    Mol Gen Genet 262:437-47. 1999
    ..The Ccp1W191F mutant was still capable of activating the Pos9 transcriptional activation domain, suggesting that the signalling function of Ccp1 is independent of electron flux rates...
  4. pmc Carbon source-dependent phosphorylation of hexokinase PII and its role in the glucose-signaling response in yeast
    F Randez-Gil
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    Mol Cell Biol 18:2940-8. 1998
    ..Although we cannot rule out a defect in the metabolic state of the cell as the origin of these phenomena, our results suggest that the phosphorylation of hexokinase is essential in vivo for glucose signal transduction...
  5. ncbi request reprint Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress
    H Juhnke
    Institut fur Mikrobiologie, der Johann Wolfgang Goethe Universität Frankfurt, Biozentrum Niederursel, Frankfurt am Main, Germany
    Mol Gen Genet 252:456-64. 1996
    ..Interestingly, all mutants tested (glucose 6-phosphate dehydrogenase, gluconate 6-phosphate dehydrogenase, ribulose 5-phosphate epimerase, transketolase, transaldolase) are sensitive to hydrogen peroxide...
  6. pmc Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein
    G Engelke
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Appl Environ Microbiol 58:3730-43. 1992
    ..The NisB protein was tightly associated with the vesicle fraction and was released by sodium dodecyl sulfate treatment only. These results suggest that NisB is membrane associated and that nisin biosynthesis occurs at the cell membrane...
  7. ncbi request reprint Characterization of null mutants of the glyoxylate cycle and gluconeogenic enzymes in S. cerevisiae through metabolic network modeling verified by chemostat cultivation
    I Stückrath
    Institut fur Mikrobiologie, J W Goethe Universität Frankfurt, Germany
    Biotechnol Bioeng 77:61-72. 2002
    ..The growth of the fructose- 1,6-bisphosphatase deletion mutant was anticipated less accurate, but the tendency was modeled correctly...
  8. pmc Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p
    F Randez-Gil
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Biozentrum, Niederursel, Frankfurt am Main, Germany
    Mol Cell Biol 17:2502-10. 1997
    ..These results confirm our current model that glucose derepression of gluconeogenic genes needs Cat8p phosphorylation and additionally show that a still unknown transcriptional activator is also involved...
  9. ncbi request reprint Investigation of the yvgW Bacillus subtilis chromosomal gene involved in Cd(2+) ion resistance
    I M Solovieva
    Molecular and Radiation Biophysics Division, St Petersburg Nuclear Physics Institute of the Russian Academy of Sciences, PNPI, Gatchina, 188350, St Petersburg, Russia
    FEMS Microbiol Lett 208:105-9. 2002
    ..Northern hybridization analysis showed that cadmium induces the synthesis of a 2.2-kb cadA transcript. These results indicate that cadA is the chromosomal determinant to cadmium resistance in B. subtilis...
  10. ncbi request reprint Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress
    B Krems
    Institut fur Mikrobiologie, Frankfurt Main, Germany
    Curr Genet 27:427-34. 1995
    ..abstract truncated at 250 words)..
  11. ncbi request reprint New genes in the 170 degrees region of the Bacillus subtilis genome encode DNA gyrase subunits, a thioredoxin, a xylanase and an amino acid transporter
    M Rose
    Johann Wolfgang Goethe Universitat Frankfurt, Institut fur Mikrobiologie, Germany
    Microbiology 142:3097-101. 1996
    ..The prkA gene, which was mapped at 169 degrees, was not present on the respective fragment. Sequence comparison actually showed that prkA is located close to 70 degrees on the B. subtilis genome...
  12. ncbi request reprint Genetic analysis of serine biosynthesis and glucose repression in yeast
    K Melcher
    Institut fur Mikrobiologie, J W Goethe Universitat, Frankfurt Main, Federal Republic of Germany
    Curr Genet 21:295-300. 1992
    ..These results indicate that transcription of glucose-repressible gluconeogenic enzymes is mainly dependent on positive regulatory elements...
  13. ncbi request reprint Structure of the Bacillus subtilis peptide antibiotic subtilosin A determined by 1H-NMR and matrix assisted laser desorption/ionization time-of-flight mass spectrometry
    R Marx

    J Protein Chem 20:501-6. 2001
    ....
  14. ncbi request reprint Comparative genomics of Listeria species
    P Glaser
    , , Service d'Informatique Scientifique, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, France
    Science 294:849-52. 2001
    ..The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events...
  15. ncbi request reprint The essential protein fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae
    H Juhnke
    Institut für Mikrobiologie der Johann Wolfgang Goethe Universität Frankfurt, Biozentrum, Niederursel, Marie Curie Strasse 9, D 60439 Frankfurt am Main, Germany
    Mol Microbiol 35:936-48. 2000
    ..Fluorescence microscopy of Fap7-GFP fusion proteins indicated a nuclear localization of the Fap7 protein. Our data suggest that Fap7 is a nuclear factor important for Pos9-dependent target gene transcription upon oxidative stress...
  16. ncbi request reprint Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast
    D Niederacher
    Institut fur Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Federal Republic of Germany
    Eur J Biochem 200:311-9. 1991
    ..There are two strongly acidic regions within this part of the protein, their possible importance is discussed...
  17. ncbi request reprint Isolation and primary structure of the gene encoding fructose-1,6-bisphosphatase from Saccharomyces cerevisiae
    K D Entian
    Medizinisch Naturwissenschaftliches Forschungszentrum, Universitat Tubingen, FRG
    FEBS Lett 236:195-200. 1988
    ..The cloned promoter size was 318 bp and allowed only low level expression of the gene. This indicates a positive activation site (UAS) upstream of the cloned DNA fragment...
  18. ncbi request reprint PcrA is an essential DNA helicase of Bacillus subtilis fulfilling functions both in repair and rolling-circle replication
    M A Petit
    Laboratoire de Genetique Microbienne, INRA, Jouy en Josas, France
    Mol Microbiol 29:261-73. 1998
    ..Furthermore, it conferred a Rep-phenotype on E. coli. Altogether, these results show that PcrA is an helicase used for plasmid rolling-circle replication and suggest that it is also involved in UV repair...
  19. pmc CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae
    D Hedges
    Institut für Mikrobiologie der Johann Wolfgang Goethe Universität Frankfurt, Germany
    Mol Cell Biol 15:1915-22. 1995
    ..The observation that multicopy expression of CAT8 reverses the inability of cat1 and cat3 mutants to grow on ethanol indicates that Cat8p might be the substrate of the Cat1p/Cat3p protein kinase...
  20. pmc CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae
    M Proft
    Institut für Mikrobiologie der Johann Wolfgang Goethe Universität Frankfurt, Frankfurt am Main, Germany
    EMBO J 14:6116-26. 1995
    ....
  21. ncbi request reprint Molecular analysis of the yeast SER1 gene encoding 3-phosphoserine aminotransferase: regulation by general control and serine repression
    K Melcher
    Institute for Microbiology, University of Frankfurt, Germany
    Curr Genet 27:501-8. 1995
    ..Furthermore, there is evidence for an additional regulation by serine end product repression...
  22. pmc Cloning, expression, and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism
    D Ochs
    Botanisches Institut, Mikrobiologie, Universitat Tubingen, Germany
    J Bacteriol 174:298-302. 1992
    ..According to the DNA sequence, the cyclase contained 627 amino acids with a molecular mass of 69,473 Da. A high percentage of the amino acids were basic. No significant similarity to existing sequenced proteins was found...
  23. ncbi request reprint The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance
    B Krems
    Institute for Microbiology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Curr Genet 29:327-34. 1996
    ..Two-hybrid investigations also suggest an oligomerization of the Pos9 protein. Our results indicate that a two-component system is involved in the oxidative-stress response of yeast...
  24. pmc Conservation of microstructure between a sequenced region of the genome of rice and multiple segments of the genome of Arabidopsis thaliana
    K Mayer
    National Research Center for Environment and Health, Institute for Bioinformatics, Munich Information Centre for Protein Sequences, 85764 Neuherberg, Germany
    Genome Res 11:1167-74. 2001
    ....
  25. pmc Ubc8p functions in catabolite degradation of fructose-1, 6-bisphosphatase in yeast
    T Schule
    Institut fur Biochemie, Universitat Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart and Institut für Mikrobiologie, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strabetae 9, 60439 Frankfurt, Germany
    EMBO J 19:2161-7. 2000
    ..Like FBPase, Ubc8p is found in the cytoplasmic fraction of the cell. We demonstrate cytoplasmic degradation of FBPase...
  26. ncbi request reprint Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis
    T Jonassen
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 273:3351-7. 1998
    ..elegans clk-1 mutants may relate to changes in the amount of ubiquinone, an essential electron transport component and a lipid soluble antioxidant...
  27. pmc Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymes
    H J Schüller
    Institute for Microbiology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Federal Republic of Germany
    J Bacteriol 173:2045-52. 1991
    ..Allelism tests and tetrad analysis clearly proved that the cat4 complementation group is a new class of mutant alleles affecting carbon source-dependent gene expression...
  28. pmc New genes involved in carbon catabolite repression and derepression in the yeast Saccharomyces cerevisiae
    K D Entian
    J Bacteriol 151:1123-8. 1982
    ..cat3 mutants had the same phenotypic properties as cat1 mutants. This showed that carbon metabolism in yeast cells is under a very complex and ramified control of repressing and derepressing genes, which are interdependent...