K Engels

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
  2. doi request reprint VEGF-A and i-NOS expression are prognostic factors in serous epithelial ovarian carcinomas after complete surgical resection
    K Engels
    Department of Pathology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Clin Pathol 62:448-54. 2009
  3. doi request reprint Expression of activation-induced cytidine deaminase in malignant lymphomas infiltrating the bone marrow
    Knut Engels
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Appl Immunohistochem Mol Morphol 16:521-9. 2008
  4. ncbi request reprint Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates
    Knut Engels
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt M, Germany
    Hum Pathol 38:1402-11. 2007
  5. ncbi request reprint Treatment of aggressive, or progressing indolent peripheral T- and NK-cell neoplasias by combination of fludarabine, cyclophosphamide and doxorubicine
    E Weidmann
    Medizinische Klinik III, Universitatsklinik, Johann Wolfgang Goethe Universitat, Frankfurt M
    Onkologie 24:162-4. 2001
  6. ncbi request reprint [Subcutaneous emphysema of unusual extent]
    S Besier
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, 60596, Frankfurt am Main
    Chirurg 78:1148-51. 2007
  7. ncbi request reprint FDG uptake after intraarterial chemotherapy in head and neck cancer
    N Döbert
    Gemeinschaftspraxis Nuklearmedizin, Rheinstr 7 9, 64283 Darmstadt, Germany
    Nuklearmedizin 45:243-7. 2006
  8. ncbi request reprint The prognostic value of FDG PET in head and neck cancer. Correlation with histopathology
    N Döbert
    Department of Nuclear Medicine, Johann Wolfgang Goethe University of Frankfurt, Frankfurt, Germany
    Q J Nucl Med Mol Imaging 49:253-7. 2005
  9. ncbi request reprint Characterization of WNT7A expression in human endometrium and endometriotic lesions
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 88:1534-40. 2007
  10. ncbi request reprint Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007

Collaborators

Detail Information

Publications30

  1. pmc T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers
    Achim Rody
    Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Breast Cancer Res 11:R15. 2009
    ..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
  2. doi request reprint VEGF-A and i-NOS expression are prognostic factors in serous epithelial ovarian carcinomas after complete surgical resection
    K Engels
    Department of Pathology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Clin Pathol 62:448-54. 2009
    ..Therefore, an analysis and evaluation of key angiogenic factors was carried out to determine their diagnostic and prognostic value in serous ovarian cancer...
  3. doi request reprint Expression of activation-induced cytidine deaminase in malignant lymphomas infiltrating the bone marrow
    Knut Engels
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Appl Immunohistochem Mol Morphol 16:521-9. 2008
    ..These results suggest that the expression pattern of AID in lymphoma infiltrates in the bone marrow reflects that of extramedullary lymphoma infiltrates...
  4. ncbi request reprint Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates
    Knut Engels
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt M, Germany
    Hum Pathol 38:1402-11. 2007
    ..Therefore, the detection of clonality has to be interpreted with utmost care and does not qualify for the unequivocal diagnosis of a malignant B-cell lymphoma...
  5. ncbi request reprint Treatment of aggressive, or progressing indolent peripheral T- and NK-cell neoplasias by combination of fludarabine, cyclophosphamide and doxorubicine
    E Weidmann
    Medizinische Klinik III, Universitatsklinik, Johann Wolfgang Goethe Universitat, Frankfurt M
    Onkologie 24:162-4. 2001
    ....
  6. ncbi request reprint [Subcutaneous emphysema of unusual extent]
    S Besier
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, 60596, Frankfurt am Main
    Chirurg 78:1148-51. 2007
    ..agalactiae infections in adults with subcutaneous emphysema...
  7. ncbi request reprint FDG uptake after intraarterial chemotherapy in head and neck cancer
    N Döbert
    Gemeinschaftspraxis Nuklearmedizin, Rheinstr 7 9, 64283 Darmstadt, Germany
    Nuklearmedizin 45:243-7. 2006
    ..a.CHT on the metabolism of fluor-18-deoxyglucose (FDG) in the primary and lymph nodes (LN). The value of FDG positron emission tomography (PET) preoperative and as follow-up method after i.a.CHT is examined...
  8. ncbi request reprint The prognostic value of FDG PET in head and neck cancer. Correlation with histopathology
    N Döbert
    Department of Nuclear Medicine, Johann Wolfgang Goethe University of Frankfurt, Frankfurt, Germany
    Q J Nucl Med Mol Imaging 49:253-7. 2005
    ..The aim of the present FDG PET study was to evaluate the prognostic value of the standardized uptake value (SUVmax) of head and neck cancer (HNSCC) with respect to the chemotherapy response and tumor recurrence...
  9. ncbi request reprint Characterization of WNT7A expression in human endometrium and endometriotic lesions
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 88:1534-40. 2007
    ..To characterize the expression of WNT7A in human eutopic and ectopic endometrium...
  10. ncbi request reprint Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 23:567-73. 2007
    ..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs...
  11. ncbi request reprint In vitro chemosensitivity to gemcitabine, oxaliplatin and zoledronic acid predicts treatment response in metastatic gastric cancer
    Jorg Trojan
    Division of Gastroenterology, Department of Internal Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt, Germany
    Anticancer Drugs 16:87-91. 2005
    ..An initially existing disseminated intravascular coagulopathy quickly resolved and after 6 months of treatment on ongoing complete response was induced, thus confirming the results of in vitro chemosensitivity testing...
  12. doi request reprint Differential expression of claudins in human endometrium and endometriosis
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Gynecol Endocrinol 24:442-9. 2008
    ..The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs...
  13. ncbi request reprint Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract
    Regine Gaetje
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Fertil Steril 87:651-6. 2007
    ..To compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients...
  14. ncbi request reprint Reduced plasma levels of coagulation factors in relation to prostate cancer
    Wolf Dietrich Beecken
    Clinic for Urology and Pediatric Urology, the J W Goethe University, Frankfurt am Main, Germany
    Prostate 53:160-7. 2002
    ..Because coagulation factors have been shown to be involved in tumor angiogenesis, the vascular density of the prostate tumors was assessed...
  15. ncbi request reprint Clinical relevance of maspin expression in bladder cancer
    Wolf D Beecken
    Department of Urology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    World J Urol 24:338-44. 2006
    ..Maspin might be a useful marker to determine the prognosis of invasive TCC. Furthermore, maspin re-expression might become a therapeutic option in the treatment of invasive, metastatic TCC...
  16. ncbi request reprint Methylation of estrogen receptor beta promoter correlates with loss of ER-beta expression in mammary carcinoma and is an early indication marker in premalignant lesions
    A Rody
    Department of Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Endocr Relat Cancer 12:903-16. 2005
    ..Interestingly, by comparing the promoter sequences of ER-beta with other genes known to be epigenetically inactivated in breast cancers, we identified a sequence motif possibly involved in promoter methylation...
  17. doi request reprint Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms after allogeneic stem cell transplantation
    S Mousset
    Medizinische Klinik II, J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Ann Hematol 91:737-42. 2012
    ..Thus, positive PCR results in GI tract samples do not necessarily reflect reactivation of HHV-6. Further studies are needed to define the significance of HHV-6 for GI tract symptoms after allo-SCT...
  18. ncbi request reprint Efficacy and safety of sorafenib in advanced hepatocellular carcinoma under daily practice conditions
    M W Welker
    Medizinische Klinik1, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Chemother 22:205-11. 2010
    ..In conclusion, in daily practice sorafenib is safe and disease stabilization can be achieved in the majority of patients. However, intolerance to sorafenib can affect treatment adherence substantially...
  19. ncbi request reprint Prognostic relevance of volumetric analysis in tumour specimens of hypopharyngeal cancer
    M Baghi
    Department for ENT Surgery, University of Frankfurt am Main, Frankfurt am Main, Germany
    Clin Otolaryngol 32:372-7. 2007
    ..The purpose of this study was to investigate the prognostic relevance of the tumour specimen's volume in patients with squamous cell cancers of the hypopharynx...
  20. ncbi request reprint Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker
    K Engels
    Department of Pathology, University Hospital of Frankfurt, Germany
    J Pathol 211:532-40. 2007
    ..The pharmacogenetic interference with survivin's cytoplasmic localization is also to be pursued as a potential therapeutic strategy...
  21. ncbi request reprint Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1
    Achim Rody
    Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Clin Cancer Res 13:1115-22. 2007
    ..One of those genes is plexin B1, a cell-surface receptor for the semaphorin Sema4D (CD 100). However, the biological role of plexin B1 in breast cancer is largely unknown...
  22. doi request reprint NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas
    Knut Engels
    Department of Pathology, University Hospital of Frankfurt, Frankfurt, Germany
    Cancer Res 68:5159-66. 2008
    ..Pharmacogenetic iNOS/survivin-targeting strategies may hence be pursued to complement current treatment modalities in EOC...
  23. ncbi request reprint Umbilical endometriosis in pregnancy without previous surgery
    Inka Wiegratz
    Division Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt am Main, Germany
    Fertil Steril 90:199.e17-20. 2008
    ..To illustrate the influence of pregnancy on primary umbilical endometriosis...
  24. ncbi request reprint Reversal of bone marrow angiogenesis in chronic myeloid leukemia following imatinib mesylate (STI571) therapy
    Hans Michael Kvasnicka
    Institute of Pathology and First Clinic of Medicine, University of Cologne, Germany
    Blood 103:3549-51. 2004
    ..In conclusion, our data support the anti-angiogenic capacity of imatinib by normalization of vascularity. In contrast, hematologic response following IFN treatment is independent from BM angiogenesis...
  25. ncbi request reprint Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal
    Roland H Stauber
    Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Street 42 44, D 60596 Frankfurt, Germany
    Traffic 7:1461-72. 2006
    ..The survivin-Crm1 axis is essential for the biological activities of murine survivin, and mouse models will allow investigating its functional implications during development and tumorigenesis...
  26. ncbi request reprint The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer
    Inka Seil
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt, Germany
    Int J Cancer 120:2635-42. 2007
    ....
  27. ncbi request reprint The survivin isoform survivin-3B is cytoprotective and can function as a chromosomal passenger complex protein
    Shirley K Knauer
    Department of Molecular and Cellular Oncology, University Hospital of Mainz, Mainz, Germany
    Cell Cycle 6:1502-9. 2007
    ..Our data provide a molecular rationale for the localization and activity of survivin variants, and conclude that survivin isoforms are unlikely to modulate survivin in trans in cancer patients...
  28. ncbi request reprint Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results?
    Mehran Baghi
    Department of ENT Surgery, J W Goethe University, School of Medicine, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Anticancer Res 27:3571-5. 2007
    ..To evaluate the accuracy of ultrasmall paramagnetic iron oxide (USPIO: Sinerem)-enhanced MRI in patients with head and neck cancer and enlarged lymph nodes compared with current staging examinations using histology as a gold standard...
  29. ncbi request reprint BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors
    Nikolaus Lubomierski
    2nd Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
    Cancer 104:952-61. 2005
    ..These alterations were attributed to defective DNA mismatch repair, which underlies MSI. It was the objective of this study to clarify the role of BRAF in colorectal carcinoma with MSI...
  30. ncbi request reprint C-KIT expression in ductal carcinoma in situ of the breast: co-expression with HER-2/neu
    Raihanatou Diallo
    Institute of Pathology, Heinrich Heine University of Dusseldorf, Germany
    Hum Pathol 37:205-11. 2006
    ..The implications of c-KIT and HER-2 co-expression for breast carcinogenesis should be further evaluated...