Hans Willhelm Doerr

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Expression level of neural cell adhesion molecule (NCAM) inversely correlates with the ability of neuroblastoma cells to adhere to endothelium in vitro
    Roman A Blaheta
    Zentrum der Hygiene, , , Frankfurt am Main, Germany
    Cell Commun Adhes 9:131-47. 2002
  2. ncbi Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der J, W, Goethe Universitat, Paul Ehrlich Str, 40, 60596 Frankfurt am Main, Germany
    Mol Cancer 8:80. 2009
  3. ncbi Inhibition of apoptosis prevents West Nile virus induced cell death
    Malte C Kleinschmidt
    Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    BMC Microbiol 7:49. 2007
  4. ncbi Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferon-alpha
    Jindrich Cinatl
    Institute for Medical Virology, Johann Wolfgang Goethe University Medical Center, D 60596 Frankfurt am Main, Germany
    Int J Oncol 20:97-106. 2002
  5. ncbi The threat of avian influenza A (H5N1). Part I: Epidemiologic concerns and virulence determinants
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:181-90. 2007
  6. ncbi The threat of avian influenza A (H5N1). Part III: Antiviral therapy
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:203-12. 2007
  7. ncbi West Nile virus infection induces interferon signalling in human retinal pigment epithelial cells
    Jindrich Cinatl
    Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    Invest Ophthalmol Vis Sci 47:645-51. 2006
  8. ncbi The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:191-201. 2007
  9. ncbi Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
    J Cinatl
    Institute of Medical Virology, Frankfurt University Medical School, Paul Ehrlich Str 40, D 60596, Frankfurt, Germany
    Lancet 361:2045-6. 2003
  10. ncbi Multimutated herpes simplex virus g207 is a potent inhibitor of angiogenesis
    Jindrich Cinatl
    Institute of Medical Virology, Center of Hygiene, Paul Ehrlich Str 40, Frankfurt am Main D 60596, Germany
    Neoplasia 6:725-35. 2004

Detail Information

Publications117 found, 100 shown here

  1. ncbi Expression level of neural cell adhesion molecule (NCAM) inversely correlates with the ability of neuroblastoma cells to adhere to endothelium in vitro
    Roman A Blaheta
    Zentrum der Hygiene, , , Frankfurt am Main, Germany
    Cell Commun Adhes 9:131-47. 2002
    ..The data support the view that low levels of NCAM are necessary for NB cells to leave a tumor cell aggregate and adhere to endothelial cells...
  2. ncbi Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der J, W, Goethe Universitat, Paul Ehrlich Str, 40, 60596 Frankfurt am Main, Germany
    Mol Cancer 8:80. 2009
    ..Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology...
  3. ncbi Inhibition of apoptosis prevents West Nile virus induced cell death
    Malte C Kleinschmidt
    Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    BMC Microbiol 7:49. 2007
    ..Apoptosis was recently shown to contribute to the pathogenesis of WNV encephalitis. Here, we used WNV-infected glioma cells to study WNV-replication and WNV-induced apoptosis in human brain-derived cells...
  4. ncbi Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferon-alpha
    Jindrich Cinatl
    Institute for Medical Virology, Johann Wolfgang Goethe University Medical Center, D 60596 Frankfurt am Main, Germany
    Int J Oncol 20:97-106. 2002
    ....
  5. ncbi The threat of avian influenza A (H5N1). Part I: Epidemiologic concerns and virulence determinants
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:181-90. 2007
    ..Mutations that make the virus more compatible with human-to-human transmission may occur at any time. Nevertheless, no one can currently predict with certainty whether H5N1 will become a human pandemic virus...
  6. ncbi The threat of avian influenza A (H5N1). Part III: Antiviral therapy
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:203-12. 2007
    ..Immune system dysregulation contributes to H5N1 disease. Although current evidence does not support the use of anti-inflammatory drugs beneficial effects cannot be excluded at later disease stages...
  7. ncbi West Nile virus infection induces interferon signalling in human retinal pigment epithelial cells
    Jindrich Cinatl
    Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    Invest Ophthalmol Vis Sci 47:645-51. 2006
    ..The authors therefore established the first model of ocular WNV infection and investigated interaction of WNV with IFN signal-transduction mechanisms...
  8. ncbi The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:191-201. 2007
    ..However, H5N1-induced disease is very severe. More information on the role entry barriers, H5N1 target cells and on H5N1-induced modulation of the host immune response is needed to learn more about the determinants of H5N1 pathogenicity...
  9. ncbi Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
    J Cinatl
    Institute of Medical Virology, Frankfurt University Medical School, Paul Ehrlich Str 40, D 60596, Frankfurt, Germany
    Lancet 361:2045-6. 2003
    ..Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS...
  10. ncbi Multimutated herpes simplex virus g207 is a potent inhibitor of angiogenesis
    Jindrich Cinatl
    Institute of Medical Virology, Center of Hygiene, Paul Ehrlich Str 40, Frankfurt am Main D 60596, Germany
    Neoplasia 6:725-35. 2004
    ..These findings show that G207 may suppress tumor growth, in part, due to inhibition of angiogenesis...
  11. ncbi Treatment of SARS with human interferons
    J Cinatl
    Institute of Medical Virology, Frankfurt University Medical School, Paul Ehrlich Strasse 40, D 60596, Frankfurt, Germany
    Lancet 362:293-4. 2003
    ..Interferon beta could be useful alone or in combination with other antiviral drugs for the treatment of SARS...
  12. ncbi High-dose hydrocortisone reduces expression of the pro-inflammatory chemokines CXCL8 and CXCL10 in SARS coronavirus-infected intestinal cells
    Jindrich Cinatl
    Institute for Medical Virology, University Hospital Medical School, D 60596 Frankfurt am Main, Germany
    Int J Mol Med 15:323-7. 2005
    ..Hydrocortisone neither influenced SARS-CoV titres alone nor in combination with ribavirin. Our results show that corticosteroids may be of limited benefit in the suppression of chemokine production by SARS-CoV-infected cells...
  13. ncbi Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation
    Jindrich Cinatl
    Interdisziplinäres Labor für Tumor und Virusforschung, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Med Res Rev 25:167-85. 2005
    ..This review summarizes recent work on CMV-mediated immune escape mechanisms of tumor cells and oncomodulation and proposes novel aspects that may be important for understanding the CMV-associated tumor progression...
  14. ncbi Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
    J Cinatl
    Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Paul Ehrlich Str 40, 60596, Frankfurt am Main, Germany
    Cell Mol Life Sci 61:2100-12. 2004
    ..In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS...
  15. ncbi Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology
    Jindrich Cinatl
    Zentrum der Hygiene, , , 60596 Frankfurt am Main, Germany
    Trends Mol Med 10:19-23. 2004
  16. ncbi Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression
    Jindrich Cinatl
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    FEMS Microbiol Rev 28:59-77. 2004
    ..As a result, oncomodulatory effects of HCMV infection may lead to a shift to more malignant phenotype of tumor cells contributing to tumor progression...
  17. ncbi Development of antiviral therapy for severe acute respiratory syndrome
    Jindrich Cinatl
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Antiviral Res 66:81-97. 2005
    ..In this review, experimental and clinical data about potential anti-SARS drugs is summarised and discussed. Animal model studies will be needed to help to determine which interventions warrant controlled clinical testing...
  18. ncbi Human cytomegalovirus circumvents NF-kappa B dependence in retinal pigment epithelial cells
    J Cinatl
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Immunol 167:1900-8. 2001
    ..This virus/host cell interaction might be a mechanism that promotes HCMV persistence in immune-privileged organs such as the eye...
  19. ncbi Proinflammatory potential of cytomegalovirus infection. specific inhibition of cytomegalovirus immediate-early expression in combination with antioxidants as a novel treatment strategy?
    J Cinatl
    Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Deutschland
    Intervirology 42:419-24. 1999
    ..The results showed that inhibition of CMV IE expression alone or in combination with antioxidants is promising for the treatment of CMV disease...
  20. ncbi The threat of avian influenza A (H5N1). Part IV: Development of vaccines
    Jindrich Cinatl
    Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596, Frankfurt M, Germany
    Med Microbiol Immunol 196:213-25. 2007
    ..To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable...
  21. ncbi The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts
    J Cinatl
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Med Virol 60:313-23. 2000
    ..Thus, inhibition of HCMV IE expression with ISIS 2922 may be an important strategy for the treatment of HCMV-related immunopathogenesis...
  22. ncbi Potent oncolytic activity of multimutated herpes simplex virus G207 in combination with vincristine against human rhabdomyosarcoma
    Jindrich Cinatl
    Institute of Medical Virology, Center of Hygiene, D 60596 Frankfurt am Main, Germany
    Cancer Res 63:1508-14. 2003
    ..Taking into consideration the proven safety of G207 in humans, we suggest that G207 alone and in combination with vincristine should be additionally evaluated as a potential agent against human rhabdomyosarcoma...
  23. ncbi Decreased neutrophil adhesion to human cytomegalovirus-infected retinal pigment epithelial cells is mediated by virus-induced up-regulation of Fas ligand independent of neutrophil apoptosis
    J Cinatl
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Immunol 165:4405-13. 2000
    ..This may be an important feature of virus escape mechanisms and for sustaining the immune-privileged character of the retina during HCMV ocular infection...
  24. ncbi Role of interferons in the treatment of severe acute respiratory syndrome
    Jindrich Cinatl
    Klinikum der Johann Wolfgang Goethe Universitat, Institut fur Medizinische Virologie, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Expert Opin Biol Ther 4:827-36. 2004
    ..This review summarises antiviral activities of IFNs with special regard to SARS, and reviews the published clinical and experimental data describing the use of IFNs for SARS...
  25. ncbi Cytomegalovirus infection decreases expression of thrombospondin-1 and -2 in cultured human retinal glial cells: effects of antiviral agents
    J Cinatl
    Institut fur Medizinische Virologie, Zentrum der Hygiene, Klinikum der Johann Wolfgang Goethe Universitat, D 60596 Frankfurt am Main, Germany
    J Infect Dis 182:643-51. 2000
    ..The results showed that HCMV-induced down-modulation of TSP-1 and TSP-2 in retinal glial cells is prevented by inhibition of HCMV IE expression. These findings may be relevant to pathogenesis and treatment of HCMV retinitis...
  26. ncbi Bovine seminal ribonuclease exerts selective cytotoxicity toward neuroblastoma cells both sensitive and resistant to chemotherapeutic drugs
    J Cinatl
    Institute of Medical Virology, Center of Hygiene, Frankfurt am Main, Germany
    Anticancer Res 20:853-9. 2000
    ..The selectivity of the antitumoral activity of BS-RNase was evaluated using cultures of CD34+ hematopoietic stem cells...
  27. ncbi Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expression
    Roman A Blaheta
    Zentrum der Chirurgie, Klinik für Urologie und Kinderurologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    BMC Cancer 6:294. 2006
    ..To investigate this hypothesis, adhesion, transendothelial penetration and NCAM (CD56) adhesion receptor expression of drug-resistant versus drug-sensitive NB tumor cells were evaluated...
  28. ncbi Cytomegalovirus-infected neuroblastoma cells exhibit augmented invasiveness mediated by beta1alpha5 integrin (VLA-5)
    M Scholz
    Interdisciplinary Laboratory of the Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Tissue Antigens 55:412-21. 2000
    ..We conclude that human cytomegalovirus infection contributes to augmented neuroblastoma invasiveness via adhesion of activated beta1alpha5 and subsequent matrix digestion by proteases...
  29. ncbi Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression
    Rouslan Kotchetkov
    Interdisziplinäres Laboratorium für Tumor und Virus Forschung, Institut fur Medizinische Virologie, Clinics of J W Goethe University, Frankfurt am Main, Germany
    Int J Oncol 27:1029-37. 2005
    ..We conclude that acquisition of increased malignant behavior in neuroblastoma occurs concomitantly with multidrug-resistance and is P-gp-independent...
  30. ncbi In vitro analysis of verapamil-induced immunosuppression: potent inhibition of T cell motility and lymphocytic transmigration through allogeneic endothelial cells
    R A Blaheta
    Department of General Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Transplantation 69:588-97. 2000
    ..Because Ca2+ plays a critical role in cell-cell interaction, the Ca2+-channel blocker verapamil might be a good cany. didate for supporting CsA/tacrolimus-based therapy...
  31. ncbi Selective cytotoxic activity of a novel ribonucleoside diphosphate reductase inhibitor MDL-101,731 against thyroid cancer in vitro
    R Kotchetkov
    Pediatric Clinic for Hematology and Oncology, University Clinics of Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Folia Biol (Praha) 45:185-91. 1999
    ..These results demonstrated that MDL-101,731 is a potent antitumor agent against cultured thyroid cancer cells due to its ability to induce apoptosis in association with increased Fas expression...
  32. ncbi Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium
    R A Blaheta
    Zentrum der Chirurgie, Klinik für Urologie und Kinderurologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Br J Cancer 96:1699-706. 2007
    ..Valproic acid also reverted enhanced adhesion properties of drug-resistant UKF-NB-2, UKF-NB-6 and SKNSH cells, and therefore may provide an alternative approach to the treatment of drug-resistant NB by blocking invasive processes...
  33. ncbi Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness
    Roman A Blaheta
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Germany
    Neoplasia 6:323-31. 2004
    ..We conclude that HCMV infection leads to downregulation of NCAM receptors, which is associated with enhanced tumor cell invasiveness...
  34. ncbi Treatment of cytomegalovirus diseases
    J U Vogel
    Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Deutschland
    Intervirology 40:357-67. 1997
    ..Thus, the efficacy of the available drugs is also discussed in the light of their ability to modulate inflammatory components of the cell-mediated immune system...
  35. ncbi Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model
    Rouslan Kotchetkov
    Department of Hematology and Oncology, Center of Pediatrics, Clinic of J. W. Goethe-University, Frankfurt am Main, Germany
    Int J Cancer 104:36-43. 2003
    ..The 2 novel neuroblastoma cell sublines also provide useful models for the study of drug resistance in aggressive forms of neuroblastoma...
  36. ncbi Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo
    J U Vogel
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, D 60596 a M, Frankfurt, Germany
    Antiviral Res 55:179-88. 2002
    ..Since immunopathological factors may play a significant role in HCMV disease it will be of interest to further study whether EDDS is effective in terms of modulation of inflammatory responses to HCMV infections...
  37. ncbi Cytomegalovirus-induced transendothelial cell migration. a closer look at intercellular communication mechanisms
    M Scholz
    Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Deutschland
    Intervirology 42:350-6. 1999
    ....
  38. ncbi Tumor-endothelium cross talk blocks recruitment of neutrophils to endothelial cells: a novel mechanism of endothelial cell anergy
    Roman A Blaheta
    Zentrum der Chirurgie, Klinik für Urologie und Kinderurologie, Johann Wolfgang Goethe Universitat, 60596 Frankfurt am Main, Germany
    Neoplasia 11:1054-63. 2009
    ..A novel tumor escape strategy is presented here. Cell contact-dependent adhesion of tumor cells to the vascular wall promotes down-regulation of endothelial CD44 receptor expression, impairing an effective neutrophil attack...
  39. ncbi Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo
    Martin Michaelis
    , , D-60596 Frankfurt am Main, Germany
    Int J Oncol 28:439-46. 2006
    ..These findings and the favourable toxicity profile of bortezomib in children make it reasonable to further pursue additional development of the drug for the treatment of neuroblastoma and other paediatric solid tumours...
  40. ncbi Treatment of drug-resistant human neuroblastoma cells with cyclodextrin inclusion complexes of aphidicolin
    M Michaelis
    , Zentrum der Hygiene, , Paul-Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany
    Anticancer Drugs 12:467-73. 2001
    ..Hence, taking into account our previous findings that APH acts synergistically with VCR and DOX, APH might be an additive tool for the therapy of NB and is suitable for evaluation in clinical studies of NB treatment protocols...
  41. ncbi Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells
    M Michaelis
    , , Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany
    Cell Death Differ 13:446-53. 2006
    ..Moreover, the combination of VPA with PD98059 synergistically inhibited angiogenesis in vitro and in vivo...
  42. ncbi Stability and inactivation of SARS coronavirus
    H F Rabenau
    Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Germany
    Med Microbiol Immunol 194:1-6. 2005
    ..Nevertheless, the agents tenacity is considerably higher than that of HCoV-229E, and should SARS re-emerge, increased efforts need to be devoted to questions of environmental hygiene...
  43. ncbi Efficacy of various disinfectants against SARS coronavirus
    H F Rabenau
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Paul Ehrlich Strasse 40, 60596 Frankfurt, Germany
    J Hosp Infect 61:107-11. 2005
    ..In summary, SARS-CoV can be inactivated quite easily with many commonly used disinfectants...
  44. ncbi Activity of cellular thymidine kinase 1 in PBMC of HIV-1-infected patients: novel therapy marker
    B Groschel
    Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Infection 28:209-13. 2000
    ....
  45. ncbi The story of human cytomegalovirus and cancer: increasing evidence and open questions
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Neoplasia 11:1-9. 2009
    ....
  46. ncbi Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition
    Martin Michaelis
    , , Paul-Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany
    Invest Ophthalmol Vis Sci 46:3451-7. 2005
    ..Therefore, patients at risk of HCMV retinitis who are treated with VPA or other HDAC inhibitors should be carefully monitored...
  47. ncbi Viral and cellular factors for resistance against antiretroviral agents
    B Groschel
    Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Intervirology 40:400-7. 1997
    ....
  48. ncbi Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option?
    M Scholz
    , , , Frankfurt am Main, Germany
    Antiviral Res 49:129-45. 2001
    ..This review summarizes the biological functions of HCMV-IE gene expression, their relevance in pathogenesis, as well as efforts to develop novel treatment strategies directed against HCMV-IE expression...
  49. ncbi Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines
    Birgit Morgenstern
    Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Str. 40, 60596 Frankfurt, Germany
    Biochem Biophys Res Commun 326:905-8. 2005
    ..Determination of the virus yield indicated highly synergistic anti-SARS-CoV action of the combination suggesting the consideration of ribavirin plus IFN-beta for the treatment of SARS...
  50. ncbi Degradation of microvascular brain endothelial cell beta-catenin after co-culture with activated neutrophils from patients undergoing cardiac surgery with prolonged cardiopulmonary bypass
    Alina Maria Schuller
    Klinik fur Thorax, Herz und thorakale Gefässchirurgie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 329:616-23. 2005
    ..In conclusion, prolonged CPB time entails neutrophil-mediated decrease in MVEC beta-catenin expression, and thus may be an important trigger for BBB disruption...
  51. ncbi Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Germany
    Clin Cancer Res 14:6531-7. 2008
    ..Moreover, the EGFR antibody cetuximab, the EGFR tyrosine kinase inhibitor Tyrphostin B46, and recombinant EGFR-targeted toxins were investigated for their influence on the viability and growth of neuroblastoma cells...
  52. ncbi Valproic acid interferes with antiviral treatment in human cytomegalovirus-infected endothelial cells
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der JW Goethe Universität, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Cardiovasc Res 77:544-50. 2008
    ..Here, the influence of the antiepileptic drug valproic acid (VPA) was investigated on HCMV replication in human umbilical vein endothelial cells alone or in combination with the antiviral drugs ganciclovir, cidofovir or foscarnet...
  53. ncbi The immunosuppressive drug mycophenolate mofetil impairs the adhesion capacity of gastrointestinal tumour cells
    K Leckel
    Zentrum der Chirurgie, , , , Frankfurt, Germany
    Clin Exp Immunol 134:238-45. 2003
    ..This suggests that MMF not only interferes with the invasion of alloactivated T cells, but might also be of value in managing post-transplantation malignancy...
  54. ncbi Contamination of genetically engineered CHO-cells by epizootic haemorrhagic disease virus (EHDV)
    H Rabenau
    University Clinics of Frankfurt Main, Institute of Medical Virology, Germany
    Biologicals 21:207-14. 1993
    ..Potential sources of the contaminating virus and feasible procedures to avoid adventitous virus infections in cell cultures are discussed...
  55. ncbi Cytomegalovirus infection blocks apoptosis in cancer cells
    M Michaelis
    Zentrum der Hygiene, , , Frankfurt am Main, Germany
    Cell Mol Life Sci 61:1307-16. 2004
    ..Antiapoptotic effects mediated by HCMV are inhibited by antiviral treatment in cell culture. Therefore, a better understanding of the influence of HCMV infection on tumor cell apoptosis might translate into improved anti-cancer therapy...
  56. ncbi Human cytomegalovirus infection alters PC3 prostate carcinoma cell adhesion to endothelial cells and extracellular matrix
    Roman A Blaheta
    Zentrum der Chirurgie, , , Frankfurt am Main, Germany
    Neoplasia 8:807-16. 2006
    ..Elevated levels of c-myc found in IEA1-transfected or IEA2-transfected PC3 cell populations might promote further carcinogenic processes through accelerated cell proliferation...
  57. ncbi Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Cancer Lett 250:107-16. 2007
    ..Antitumour activity of Onconase against naïve and drug-resistant neuroblastoma xenografts was confirmed in animals...
  58. ncbi Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies
    Roman A Blaheta
    Zentrum der Chirurgie, , , Frankfurt am Main, Germany
    Med Res Rev 25:383-97. 2005
    ..Clinical studies are underway and the preliminary results indicate that VPA alone or in combination offers a promising avenue of treatment, both in solid and hematopoetic malignancies...
  59. ncbi An influenza A H1N1 virus revival - pandemic H1N1/09 virus
    M Michaelis
    Institute for Medical Virology, Johann Wolfgang Goethe University Clinic, Frankfurt am Main, Germany
    Infection 37:381-9. 2009
    ..Here, the features of pandemic H1N1/09 virus are discussed within the framework of knowledge gained from previous influenza A virus pandemics...
  60. ncbi Cross-talk between human herpesvirus 8 and the transactivator protein in the pathogenesis of Kaposi's sarcoma in HIV-infected patients
    Angelika Chandra
    Institute of Medical Virology, Institute of Transfusion Medicine, Frankfurt University Medical School, 60590 Frankfurt, Germany
    Anticancer Res 23:723-8. 2003
    ..In view of these observations and the published data, we suggest that cross-signalling pathways between the tat protein and HHV8-DNA are involved in the complexity of pathogenesis of Kaposi's sarcoma...
  61. ncbi SARS-coronavirus (SARS-CoV) and the safety of a solvent/detergent (S/D) treated immunoglobulin preparation
    H F Rabenau
    Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
    Biologicals 33:95-9. 2005
    ..m.b.H., Vienna, Austria) for its capacity to inactivate the SARS-CoV. Our results demonstrate that SARS-CoV was completely inactivated below the limit of detection. This was found to occur within 1 min of SD treatment...
  62. ncbi Valproic acid for the treatment of pediatric malignant glioma
    P H Driever
    Department of Pediatric Neurology, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Klin Padiatr 211:323-8. 1999
    ..Broad clinical experience with VPA and its low toxicity encourage the evaluation of VPA in patients that have been submitted to postoperative combined chemo- and radiotherapy for pediatric malignant glioma...
  63. ncbi Valproic acid and interferon-alpha synergistically inhibit neuroblastoma cell growth in vitro and in vivo
    Martin Michaelis
    , , Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany
    Int J Oncol 25:1795-9. 2004
    ..The results of this study together with our previous report strongly encourage the clinical evaluation of VPA and IFN-alpha for NB patients...
  64. ncbi First efficacy and safety results with the antibody containing leukocyte inhibition module in cardiac surgery patients with neutrophil hyperactivity
    Martin Scholz
    Department of Thoracic and Cardiovascular Surgery and Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    ASAIO J 51:144-7. 2005
    ....
  65. ncbi Infection of human retinal pigment epithelial cells with influenza A viruses
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Invest Ophthalmol Vis Sci 50:5419-25. 2009
    ....
  66. ncbi Resistance to cytarabine induces the up-regulation of NKG2D ligands and enhances natural killer cell lysis of leukemic cells
    Henry Ogbomo
    Institut fur Medizinische Virologie, Zentrum der Hygiene, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Neoplasia 10:1402-10. 2008
    ..These results demonstrate that increased sensitivity of araC-resistant leukemic cells to NK cell lysis is caused by higher NKG2D ligand expression, resulting from more active ERK signaling pathway...
  67. ncbi Pharmacology of intracellular cytosine-arabinoside-5'-triphosphate in malignant cells of pediatric patients with initial or relapsed leukemia and in normal lymphocytes
    U Koehl
    Pediatric Hematology and Oncology, Laboratory for Stem Cell Transplantation and Immunotherapy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60596 Frankfurt a M, Germany
    Cancer Chemother Pharmacol 60:467-77. 2007
    ..The purpose of the present study was to investigate the relation between sensitivity and pharmacokinetic parameters Cmax, t1/2 and AUC of ara-CTP. The obtained results were compared to previous studies...
  68. ncbi Cardiac surgery with extracorporeal circulation: neutrophil transendothelial migration is mediated by beta1 integrin (CD29) in the presence of TNF-alpha
    Martin Scholz
    Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Surg 17:239-47. 2004
    ..Inhibition of CD29/TNF-alpha might be a therapeutic option to limit endothelial dysfunction following cardiac surgery with extracorporeal circulation...
  69. ncbi In vitro antiviral activity of aphidicolin and its derivates. Synergistic effects of aphidicolin with other antiviral drugs
    Martin Michaelis
    , , Frankfurt/Main, Germany
    Arzneimittelforschung 52:393-9. 2002
    ..Aphidicolin and its two antiviral active derivatives might represent useful additional tools for antiviral therapy of HSV and HCMV infections, especially in combination with clinically used drugs...
  70. ncbi Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection
    Jens Uwe Vogel
    Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Paul Ehrlich Str 40, 60596, Frankfurt am Main, Germany
    Med Microbiol Immunol 194:55-9. 2005
    ..05). The data suggest that S-GSH is a suitable antiviral agent against HSV-1 both in vitro and in vivo, indicating that this drug may be of benefit in the adjunctive therapy of HSV-1 infections...
  71. ncbi Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein
    Tsanan Giroglou
    Georg-Speyer-Haus, Institute for Biomedical Research, Frankfurt University Medical School, Frankfurt, Germany
    J Virol 78:9007-15. 2004
    ....
  72. ncbi N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus
    Janina Geiler
    Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    Biochem Pharmacol 79:413-20. 2010
    ..Therefore, antioxidants like NAC represent a potential additional treatment option that could be considered in the case of an influenza A virus pandemic...
  73. ncbi In vitro cytotoxic dose-relation of cisplatin and sodium thiosulphate in human tongue and oesophageal squamous carcinoma cell lines
    Adorjan F Kovacs
    Department of Maxillofacial Plastic Surgery, Johann Wolfgang Goethe University Frankfurt Medical School, Frankfurt am Main, Germany
    J Craniomaxillofac Surg 30:54-8. 2002
    ....
  74. ncbi Measurements of HCV neutralizing antibodies and of HCV-specific CD4+ and CD8+ cells using hepatitis C virus pseudo-particles (HCVpp)
    Annemarie Berger
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
    J Clin Virol 46:55-60. 2009
    ..For the medical management, it would be of great relevance to get a diagnostic marker predicting the outcome of infection...
  75. ncbi Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, 60596 Frankfurt am Main, Germany
    Anticancer Drugs 13:149-54. 2002
    ....
  76. ncbi Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der JW Goethe Universität, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Cancer Res 69:416-21. 2009
    ..In conclusion, nutlin-3-induced inhibition of P-gp and MRP-1 was discovered as a novel anticancer mechanism of the substance in this report...
  77. ncbi In vitro replication of varicella-zoster virus in human retinal pigment epithelial cells
    Jonas Schmidt-Chanasit
    Institute of Medical Virology, Hospital of Johann Wolfgang Goethe University, D 60596 Frankfurt am Main, Germany
    J Clin Microbiol 46:2122-4. 2008
    ..Depending on the CPE dissemination, high titers of up to 1.6 x 10(6) PFU of cell-free and cryostable VZV/ml can be recovered...
  78. ncbi Relocalization of endothelial cell beta-catenin after coculture with activated neutrophils from patients undergoing cardiac surgery with cardiopulmonary bypass
    Martin Scholz
    Klinik fur Thorax, Herz und thorakale Gefässchirurgie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Surg 17:143-9. 2004
    ..Activated neutrophils during cardiac surgery with CPB may induce endothelial dysfunction by impairing beta-catenin localization and thus contribute to endothelial hyperpermeability...
  79. ncbi Mycophenolate mofetil increases adhesion capacity of tumor cells in vitro
    Roman A Blaheta
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Transplantation 76:1735-41. 2003
    ..Because decrease of homophilic adhesion receptors correlates with tumor dissemination and metastasis, MMF could trigger development or recurrence of neoplastic tumors...
  80. ncbi New real-time PCR-based method for in vitro susceptibility testing of Anaplasma phagocytophilum against antimicrobial agents
    Klaus Peter Hunfeld
    Institute of Medical Microbiology, University Hospital of Frankfurt, D 60596 Frankfurt Main, Germany
    Int J Antimicrob Agents 23:563-71. 2004
    ....
  81. ncbi Fas/FasL interaction: a novel immune therapy approach with immobilized biologicals
    Martin Scholz
    Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Med Res Rev 25:331-42. 2005
    ..This proof of principal may stimulate the development of other devices based on the regulation of Fas/FasL or other targets relevant for immune disorders...
  82. ncbi Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells
    Martin Scholz
    Zentrum der Hygiene, Institut fur Medizinische Virologie, Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Med Microbiol Immunol 193:195-203. 2004
    ..Our data suggest that thrombin/PAR-1 may inhibit Sp1-dependent HCMV replication, which might be an important regulatory mechanism for HCMV persistence and replication in RPE...
  83. ncbi The human eye (retina): a site of persistent HCMV infection?
    Jens Uwe Vogel
    Institute of Medical Virology, Center of Hygiene, University Hospital, Johann Wolfgang Goethe University, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    Graefes Arch Clin Exp Ophthalmol 243:671-6. 2005
    ..It is conceivable either that during the immunosuppression HCMV infection reactivates in various other organs viremically affecting the retina or that HCMV persisting in the retina may locally reactivate and result in HCMV retinitis...
  84. ncbi Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
    Gerold Hoever
    Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Strasse 40, 60596 Frankfurt, Germany
    J Med Chem 48:1256-9. 2005
    ..Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index...
  85. ncbi The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Cell Mol Life Sci 68:1079-90. 2011
    ..Moreover, we demonstrated for the first time that Raf activation is involved in HCMV IEA expression...
  86. ncbi Impact of persistent cytomegalovirus infection on human neuroblastoma cell gene expression
    Gerold Hoever
    Center of Hygiene, Institute of Medical Virology, J. W. Goethe-University Hospital, Paul-Ehrlich Str. 40, 60596 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 326:395-401. 2005
    ..Thus, this work provides the basis for further functional studies...
  87. ncbi Determination of serum antibodies against swine-origin influenza A virus H1N1/09 by immunofluorescence, haemagglutination inhibition, and by neutralization tests: how is the prevalence rate of protecting antibodies in humans?
    Regina Allwinn
    Institute of Medical Virology, University Hospital, Frankfurt M, Germany
    Med Microbiol Immunol 199:117-21. 2010
    ..Expecting the next waves of influenza A/H1N1v infections, HI testing may avoid vaccinations under special risk of severe or hidden adverse reactions...
  88. ncbi Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha
    E Juengel
    Klinik für Urologie und Kinderurologie, Zentrum der Chirurgie, Klinikum der Johann Wolfgang Goethe Universitat, Interdisziplinäres Forschungs und Laborgebäude, Chirurgische Forschung, Haus 25, Zi 212, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    World J Urol 29:779-86. 2011
    ..The current study investigated the effects of these compounds on gene transcription of metastatic RCC cell line Caki-1 after 3 and 5 days exposure...
  89. ncbi Prions and orthopedic surgery
    H W Doerr
    Institute for Medical Virology, Johann Wolfgang Goethe University, Paul Ehrlich Str 40, D 60596 Frankfurt Main, Germany
    Infection 31:163-71. 2003
    ..The overall risk of prion transmission in orthopedic surgery is considered very low if adequately prepared and sterilized materials and devices are used...
  90. ncbi Valproic acid inhibits angiogenesis in vitro and in vivo
    Martin Michaelis
    , , Frankfurt am Main, Germany
    Mol Pharmacol 65:520-7. 2004
    ..Embryos from VPA-treated mice showed disturbed vessel formation. These results indicate that therapeutic plasma levels of VPA inhibit angiogenesis by a mechanism involving a decrease in eNOS expression preceded by HDAC inhibition...
  91. ncbi Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acid
    Martin Michaelis
    , , Paul Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany
    Biochem Pharmacol 68:531-8. 2004
    ..This demonstrates a strict correlation between inhibition of HDAC and increased HCMV replication...
  92. ncbi Thrombin stimulates IL-6 and IL-8 expression in cytomegalovirus-infected human retinal pigment epithelial cells
    Martin Scholz
    , Zentrum der Hygiene, , Frankfurt am Main, Germany
    Int J Mol Med 13:327-31. 2004
    ..Thus, thrombin/PAR-1-mediated IL-6/IL-8 gene expression is uncoupled from Sp1 inhibition and may support proinflammatory pathomechanisms probably involved in hemorrhage/HCMV retinitis progression...
  93. ncbi Supernatants from human cytomegalovirus (HCMV)-infected retinal glial cells increase transepithelial electrical resistance in a cell culture model: evidence of HCMV immune escape in the eye?
    Martin Scholz
    Zentrum der Hygiene, , Paul-Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany
    Med Microbiol Immunol 193:205-8. 2004
    ..Our findings may help to explain the ocular persistence of HCMV and the maintenance of ocular immune privilege early in infection...
  94. ncbi Increased systemic efficacy of aphidicolin encapsulated in liposomes
    Martin Michaelis
    , Zentrum der Hygiene, , 40, 60596 Frankfurt am Main, Germany
    Oncol Rep 13:157-60. 2005
    ..This shows that liposomal encapsulation is a promising strategy for the improvement of systemic anti-cancer activity of aphidicolin...
  95. ncbi Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    FASEB J 21:81-7. 2007
    ..In conclusion, angiogenesis inhibition by ribavirin has not been described before. This inhibition may contribute to ribavirin-induced pharmacological effects including adverse events...
  96. ncbi A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function
    Henry Ogbomo
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Biochem Pharmacol 79:188-97. 2010
    ..These results reveal a novel mechanism by which ribavirin exerts its immunomodulatory activities...
  97. ncbi Human cytomegalovirus retinitis: pathogenicity, immune evasion and persistence
    Martin Scholz
    Zentrum der Hygiene, , , Paul-Ehrlich-Strasse 40, D-60596 Frankfurt am Main, Germany
    Trends Microbiol 11:171-8. 2003
    ..These specific features of RPE cells in conjunction with deregulated immune responses of immunocompromised patients seem to contribute to virus persistence and pathogenesis within the immune-privileged ocular retina...
  98. ncbi Human immunodeficiency virus type-1 group M quasispecies evolution: diversity and divergence in patients co-infected with active tuberculosis
    T Biru
    Institute for Medical Virology, Hospital of Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Med Microbiol Immunol 199:323-32. 2010
    ..The results demonstrated that active TB has an impact on HIV-1 viral diversity and divergence over time. The influence of active TB on longitudinal evolution of HIV-1 may be predominant for R5 viruses...