S Dimmeler

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
    J Exp Med 201:1825-35. 2005
  2. pmc Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells
    Emmanouil Chavakis
    Molecular Cardiology, Dept of Medicine III, University of Frankfurt, 60950 Frankfurt, Germany
    J Exp Med 201:63-72. 2005
  3. pmc Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation
    Masamichi Koyanagi
    Institute of Cardiovascular Regeneration, Center for Molecular Medicine, JW Goethe University, Frankfurt, Germany
    PLoS ONE 4:e5765. 2009
  4. pmc MicroRNAs in age-related diseases
    Stefanie Dimmeler
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany
    EMBO Mol Med 5:180-90. 2013
  5. doi request reprint Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells
    David Kaluza
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, University of Frankfurt, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 33:533-43. 2013
  6. ncbi request reprint Atheroprotective mechanisms of shear stress-regulated microRNAs
    Reinier A Boon
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany
    Thromb Haemost 108:616-20. 2012
  7. doi request reprint Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair
    Florian H Seeger
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Haus 25, 4 Stock, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Circ Res 111:854-62. 2012
  8. ncbi request reprint Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction
    Kazuma Iekushi
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt 60590, Germany
    Circulation 125:1765-73, S1-7. 2012
  9. doi request reprint MicroRNAs and stem cells: control of pluripotency, reprogramming, and lineage commitment
    Eva Marie Heinrich
    Institute for Cardiovascular Regeneration, Center of Molecular Medicine, University of Frankfurt, Frankfurt, Germany
    Circ Res 110:1014-22. 2012
  10. pmc Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use
    Gian Paolo Fadini
    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Circ Res 110:624-37. 2012

Research Grants

  1. Cardiac Disease and Regeneration
    Stefanie Dimmeler; Fiscal Year: 2005

Detail Information

Publications136 found, 100 shown here

  1. pmc Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
    J Exp Med 201:1825-35. 2005
    ..Thus, HoxA9 is regulated by HDACs and is critical for postnatal neovascularization...
  2. pmc Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells
    Emmanouil Chavakis
    Molecular Cardiology, Dept of Medicine III, University of Frankfurt, 60950 Frankfurt, Germany
    J Exp Med 201:63-72. 2005
    ..Preactivation of the beta2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of beta2-integrins in postnatal vasculogenesis...
  3. pmc Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation
    Masamichi Koyanagi
    Institute of Cardiovascular Regeneration, Center for Molecular Medicine, JW Goethe University, Frankfurt, Germany
    PLoS ONE 4:e5765. 2009
    ..Since previous studies suggested a contribution of the protein kinase C (PKC) family to the Wnt5a-induced signalling, we investigated which PKC isoforms are activated by non-canonical Wnt5a in human EPC...
  4. pmc MicroRNAs in age-related diseases
    Stefanie Dimmeler
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany
    EMBO Mol Med 5:180-90. 2013
    ..However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems...
  5. doi request reprint Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells
    David Kaluza
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, University of Frankfurt, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 33:533-43. 2013
    ..Histone deacetylases (HDACs) modulate gene expression by deacetylation of histone and nonhistone proteins. Several HDACs control angiogenesis, but the role of HDAC9 is unclear...
  6. ncbi request reprint Atheroprotective mechanisms of shear stress-regulated microRNAs
    Reinier A Boon
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany
    Thromb Haemost 108:616-20. 2012
    ..Together, the regulation of miRs by shear stress contributes to the anti-inflammatory, cell cycle inhibitory and vasculoprotective effects in endothelial cells...
  7. doi request reprint Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair
    Florian H Seeger
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Haus 25, 4 Stock, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Circ Res 111:854-62. 2012
    ..However, a comprehensive analysis of the effects of anticoagulants on the function of the cells is missing...
  8. ncbi request reprint Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction
    Kazuma Iekushi
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt 60590, Germany
    Circulation 125:1765-73, S1-7. 2012
    ..MicroRNAs (miRNAs) are key regulators of gene expression and modulate the pathophysiology of cardiovascular diseases...
  9. doi request reprint MicroRNAs and stem cells: control of pluripotency, reprogramming, and lineage commitment
    Eva Marie Heinrich
    Institute for Cardiovascular Regeneration, Center of Molecular Medicine, University of Frankfurt, Frankfurt, Germany
    Circ Res 110:1014-22. 2012
    ..In addition, some miRs control cell fate decisions. This review summarizes the role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regulation of cardiovascular cell fate decisions by miRs...
  10. pmc Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use
    Gian Paolo Fadini
    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Circ Res 110:624-37. 2012
    ..We also delineate new research avenues to move forward our knowledge on EPC biology...
  11. pmc Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia
    Jens Minnerup
    Department of Neurology, , Albert Schweitzer Strasse 33, , Germany
    Exp Transl Stroke Med 2:3. 2010
    ..A possible reason for the failed neurological improvement after cell therapy might be the delayed treatment initiation compared to other experimental stroke studies that showed efficacy of bone marrow mononuclear cells...
  12. pmc Aging and disease as modifiers of efficacy of cell therapy
    Stefanie Dimmeler
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 102:1319-30. 2008
    ..Pretreatment of cells or the target tissue by small molecules, polymers, growth factors, or a combination thereof may provide useful approaches for enhancement of cell therapy for cardiovascular diseases...
  13. pmc HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    S Dimmeler
    Division of Molecular Cardiology, Department of Medicine IV, University of Frankfurt, Frankfurt, Germany
    J Clin Invest 108:391-7. 2001
    ....
  14. ncbi request reprint A "reductionist" view of cardiomyopathy
    Stefanie Dimmeler
    Department of Internal Medicine III, J W Goethe University, 60590 Frankfurt, Germany
    Cell 130:401-2. 2007
    ..Rajasekaran et al. (2007) now make the surprising discovery that its counterpart "reductive stress," caused by an increase in reduced glutathione, contributes to cardiomyopathy triggered by protein aggregation...
  15. ncbi request reprint [Stem cell transfer in myocardial infarction]
    S Dimmeler
    Molecular Cardiology, Medizinische Klinik III, Universitat Frankfurt
    Dtsch Med Wochenschr 131:881-3. 2006
  16. ncbi request reprint ATVB in focus: novel mediators and mechanisms in angiogenesis and vasculogenesis
    Stefanie Dimmeler
    Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, Germany
    Arterioscler Thromb Vasc Biol 25:2245. 2005
  17. pmc Unchain my heart: the scientific foundations of cardiac repair
    Stefanie Dimmeler
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt am Main, Germany
    J Clin Invest 115:572-83. 2005
    ..Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target...
  18. ncbi request reprint Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?
    Stefanie Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Mol Med (Berl) 82:671-7. 2004
    ..We discuss this novel concept of endothelial regeneration and highlight possible novel strategies to interfere with the balance of injury and repair mechanisms...
  19. ncbi request reprint Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide
    S Dimmeler
    Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 81:970-6. 1997
    ..NO completely abrogated Ang II-induced apoptosis by interfering with the activation of the caspase cascade...
  20. doi request reprint Cell therapy of acute myocardial infarction: open questions
    Stefanie Dimmeler
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Cardiology 113:155-60. 2009
    ..The present review article will discuss the heterogeneity of the clinical results, the timing of the cell delivery and the benefit achieved so far in different patient populations...
  21. ncbi request reprint Cell-based therapy of myocardial infarction
    Stefanie Dimmeler
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 28:208-16. 2008
    ..The present review article summarizes the results of the clinical studies and discusses the open issues...
  22. ncbi request reprint Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxide
    S Dimmeler
    Department of Internal Medicine IV, University of Frankfurt, Germany
    Nitric Oxide 1:275-81. 1997
    ..The present article summarizes these effects and provides insights into the role of NO in apoptotic signal transduction, with special regard to the Bcl-2 homologous proteins, the protease family of caspases and heat shock proteins...
  23. ncbi request reprint Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?
    S Dimmeler
    Department of Internal Medicine IV, Division of Molecular Cardiology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany Tel 49 69 6301 7440, Fax 49 69 6301 7113, E mail
    Eur Cytokine Netw 9:697-8. 1998
    ..The present article summarizes the effects of pro and anti-atherosclerotic factors on endothelial cell apoptosis and provides insights into the underlying signalling events...
  24. ncbi request reprint Nitric oxide-an endothelial cell survival factor
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Cell Death Differ 6:964-8. 1999
    ..Furthermore, the support of endothelial cell survival by NO may further play a central role for the pro-angiogenic effects of NO...
  25. ncbi request reprint Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Regul Pept 90:19-25. 2000
    ....
  26. ncbi request reprint Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    FEBS Lett 477:258-62. 2000
    ..Our data indicate that eNOS activation via phosphorylation of Ser-1177 by Akt is necessary and sufficient for VEGF-mediated EC migration...
  27. ncbi request reprint Endothelial cell apoptosis in angiogenesis and vessel regression
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 87:434-9. 2000
    ..The present work critically reviews the existing data that supports a role of endothelial cell apoptosis for vascular growth and remodeling and provides insights into the mechanisms and the potential therapeutic consequences...
  28. doi request reprint Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells
    Kisho Ohtani
    Institute of Cardiovascular Regeneration, Internal Medicine III, University of Frankfurt, Germany
    Circ Res 109:1219-29. 2011
    ..Proangiogenic hematopoietic and endothelial progenitor cells (EPCs) contribute to postnatal neovascularization, but the mechanisms regulating differentiation to the endothelial lineage are unclear...
  29. ncbi request reprint Regulation of bone marrow-derived vascular progenitor cell mobilization and maintenance
    Stefanie Dimmeler
    Institute for Cardiovascular Regeneration, Center of Molecular Medicine, University of Frankfurt, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 30:1088-93. 2010
    ..This review will discuss the impact of cardiovascular disease on stem cell niches and summarize strategies targeting the niche for mobilization of vasculogenic cells...
  30. ncbi request reprint Regulation of endothelial cell apoptosis in atherothrombosis
    Stefanie Dimmeler
    Molecular Cardiology, Derpartment of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Curr Opin Lipidol 13:531-6. 2002
    ..Moreover, the role of S-nitrosylation of protein targets for protection of endothelial cell apoptosis will be discussed...
  31. ncbi request reprint Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide
    J Hoffmann
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 89:709-15. 2001
    ..Thus, aging of endothelial cells is associated with decreased NO synthesis and concomitantly increased sensitivity of apoptosis, which may contribute to functional impairment of the endothelial monolayer...
  32. ncbi request reprint Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway
    E Chavakis
    Department of Internal Medicine IV, University of Frankfurt, Germany
    Circulation 103:2102-7. 2001
    ..CONCLUSIONS: Our data indicate that oxLDL-induced dephosphorylation of Akt, followed by impaired eNOS activation, reduces the intracellular level of NO and thereby inhibits VEGF-induced EC migration...
  33. ncbi request reprint Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt, Germany
    Circ Res 88:E68-75. 2001
    ..Moreover, the dephosphorylation of Thr(495) by PP1 precedes the phosphorylation of Ser(1177) by CaMKII. The full text of this article is available at http://www.circresaha.org...
  34. ncbi request reprint Endothelial progenitor cells: regulation and contribution to adult neovascularization
    Dirk H Walter
    Department of Internal Medicine IV, University of Frankfurt, Germany
    Herz 27:579-88. 2002
    ..Moreover, novel approaches to increase the function and the number of circulating progenitor cells by pharmacological modulation (cytokines, statins) or gene therapy (VEGF) will be highlighted...
  35. ncbi request reprint Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
    Christopher Heeschen
    Department of Internal Medicine IV and Hematology, University of Frankfurt, Germany
    Blood 102:1340-6. 2003
    ..Epo appears to physiologically regulate EPC mobilization in patients with ischemic heart disease. Thus, Epo serum levels may help in identifying patients with impaired EPC recruitment capacity...
  36. ncbi request reprint Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    M Vasa
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 89:E1-7. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  37. ncbi request reprint Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease
    M Vasa
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany
    Circulation 103:2885-90. 2001
    ..Given the well-established role of EPCs of participating in repair after ischemic injury, stimulation of EPCs by statins may contribute to the clinical benefit of statin therapy in patients with CAD...
  38. ncbi request reprint Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy
    C Badorff
    Molecular Cardiology Unit, Department of Medicine IV, Goethe University, Frankfurt, Germany
    Circulation 102:2276-81. 2000
    ..Nitric oxide (NO) is elevated in human dilated cardiomyopathy, but the relevance of this finding is unknown. In mice, NO inhibits CVB3 myocarditis. Therefore, we investigated the effects of NO on the coxsackieviral protease 2A...
  39. ncbi request reprint Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism
    K Breitschopf
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
    FEBS Lett 493:21-5. 2001
    ..Thus, the PI3K/Akt pathway plays an important role in the regulation of telomerase activity. Pro-atherosclerotic factors impair telomerase activity and thereby may promote EC aging...
  40. ncbi request reprint Nitric oxide down-regulates MKP-3 mRNA levels: involvement in endothelial cell protection from apoptosis
    L Rossig
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    J Biol Chem 275:25502-7. 2000
    ..These data demonstrate that upstream of the S-nitrosylation of caspase-3, NO exerts additional antiapoptotic effects in endothelial cells, which rely on the down-regulation of MKP-3 mRNA...
  41. doi request reprint The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche
    Alexandra Aicher
    Department of Internal Medicine III, J W Goethe University, Frankfurt, Germany
    Circ Res 103:796-803. 2008
    ..Thus, these data show that Dkk-1 is a mobilizer of vasculogenic progenitors but not of inflammatory cells, which could be of great clinical importance to enhance regenerative cell therapy...
  42. ncbi request reprint Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
    ..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown...
  43. ncbi request reprint Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
    ..Thus, phosphorylation of eNOS by Akt represents a novel Ca2+-independent regulatory mechanism for activation of eNOS...
  44. ncbi request reprint Normalization of coronary blood flow in the infarct-related artery after intracoronary progenitor cell therapy: intracoronary Doppler substudy of the TOPCARE-AMI trial
    V Schachinger
    Dept of Internal Medicine IV, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Clin Res Cardiol 95:13-22. 2006
    ..Therefore, we investigate coronary blood flow regulation in patients after AMI treated with intracoronary progenitor cell therapy...
  45. ncbi request reprint Vitamin C inhibits endothelial cell apoptosis in congestive heart failure
    L Rossig
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circulation 104:2182-7. 2001
    ..Therefore, we investigated the effects of antioxidative vitamin C therapy on EC apoptosis in CHF patients...
  46. ncbi request reprint Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells
    Ioakim Spyridopoulos
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 110:3136-42. 2004
    ..The purpose of this study was to elucidate a possible role of telomere biology in the functional augmentation of EPCs by statins...
  47. doi request reprint Sox2 transduction enhances cardiovascular repair capacity of blood-derived mesoangioblasts
    Masamichi Koyanagi
    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 106:1290-302. 2010
    ..Complementation of pluripotency genes may improve adult stem cell functions...
  48. ncbi request reprint Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..This review summarizes the mechanisms regulating endothelial progenitor cell-mediated neovascularization and reendothelialization...
  49. ncbi request reprint Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 91:837-44. 2002
    ..These data indicate that HDAC-dependent mechanisms contribute to the regulation of eNOS expression in ECs...
  50. ncbi request reprint Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 110:856-61. 2004
    ..Therefore, we investigated whether statins may exert an antioxidant activity in endothelial cells via S-nitrosylation of thioredoxin...
  51. ncbi request reprint CXCR4 expression determines functional activity of bone marrow-derived mononuclear cells for therapeutic neovascularization in acute ischemia
    Florian H Seeger
    Institute for Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 29:1802-9. 2009
    ..Because cell recruitment is critically dependent on the expression of the SDF-1-receptor CXCR4, we examined whether the expression of CXCR4 may identify a therapeutically active population of BMCs...
  52. ncbi request reprint Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
    ..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
  53. doi request reprint Caspase-8 is involved in neovascularization-promoting progenitor cell functions
    Dörte Scharner
    Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 29:571-8. 2009
    ..Caspases mediate apoptosis but are also involved in other critical biological processes. Therefore, we aimed to address the role of caspases in proangiogenic cells...
  54. ncbi request reprint CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 106:981-6. 2002
    ..Because reendothelialization may play a pivotal role for plaque stabilization, we investigated a potential role of CD40L on endothelial cell (EC) migration...
  55. ncbi request reprint FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    FASEB J 19:974-6. 2005
    ..In summary, our results show that FOXO-dependent expression of Bim plays a pivotal role for EPC apoptosis. Statins reduce oxidative stress-induced EPC apoptosis, inactivate FOXO4, and down-regulate Bim...
  56. ncbi request reprint Restoration of cardiac function with progenitor cells
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Novartis Found Symp 274:214-23; discussion 223-7, 272-6. 2006
    ....
  57. doi request reprint Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction
    Jana S Burchfield
    Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 103:203-11. 2008
    ..These results suggest that BM-MNCs mediate cardiac protection after myocardial infarction and this is, at least in part, dependent on IL-10...
  58. ncbi request reprint Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging
    M B Britten
    Department of Cardiology, J W Goethe University Frankfurt, Frankfurt, Germany
    Circulation 108:2212-8. 2003
    ....
  59. ncbi request reprint MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice
    Angelika Bonauer
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Science 324:1710-3. 2009
    ..MiR-92a appears to target mRNAs corresponding to several proangiogenic proteins, including the integrin subunit alpha5. Thus, miR-92a may serve as a valuable therapeutic target in the setting of ischemic disease...
  60. ncbi request reprint Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease
    Stephan Fichtlscherer
    Departments of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Frankfurt am Main, Germany
    Circulation 109:178-83. 2004
    ..Here, we studied the involvement of CYP 2C9 in modulating endothelium-dependent and -independent changes in forearm blood flow (FBF) in healthy volunteers and in patients with manifest coronary artery disease...
  61. ncbi request reprint Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 94:768-75. 2004
    ..We conclude that both antioxidants and statins can delay the onset of replicative senescence by counteracting the increased ROS production linked to aging of endothelial cells...
  62. doi request reprint Red blood cell contamination of the final cell product impairs the efficacy of autologous bone marrow mononuclear cell therapy
    Birgit Assmus
    Cardiology, Department of Medicine III, Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 55:1385-94. 2010
    ....
  63. ncbi request reprint Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction
    Volker Schachinger
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1210-21. 2006
    ..Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction...
  64. ncbi request reprint Transcoronary transplantation of progenitor cells after myocardial infarction
    Birgit Assmus
    Division of Cardiology and Molecular Cardiology, Department of Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1222-32. 2006
    ..The effects of cell transplantation in patients with healed myocardial infarction are unknown...
  65. ncbi request reprint Tumor necrosis factor antagonism with etanercept improves systemic endothelial vasoreactivity in patients with advanced heart failure
    S Fichtlscherer
    Department of Internal Medicine IV, Division of Cardiology, Johann W. Goethe-University Frankfurt, Germany
    Circulation 104:3023-5. 2001
    ..Improvement of systemic endothelial function might importantly contribute to the beneficial effects of etanercept on the functional status of patients with CHF...
  66. ncbi request reprint Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction
    K Breitschopf
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Biol Chem 275:21648-52. 2000
    ..Similarly, tBid-induced apoptosis was considerably amplified by inhibition of tBid degradation using the proteasome-specific inhibitor MG-132. Thus, proteasomal degradation of tBid limits the extent of apoptosis in living cells...
  67. doi request reprint NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Circ Res 105:537-44. 2009
    ..The role of hypoxia and reactive oxygen species (ROS) in mobilization and function of these cells is incompletely understood...
  68. doi request reprint Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine III, Centre of Biological Chemistry, University of Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 29:929-35. 2009
    ..Recent studies provided evidence for a mitochondrial localization of TERT. Therefore, we investigated the exact localization of TERT within the mitochondria and its function...
  69. ncbi request reprint Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circulation 108:2511-6. 2003
    ..Therefore, we investigated whether the phenotype and functional capacity of EPCs to improve neovascularization depend on their monocytic origin...
  70. ncbi request reprint Low doses of reactive oxygen species protect endothelial cells from apoptosis by increasing thioredoxin-1 expression
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    FEBS Lett 577:427-33. 2004
    ..Taken together, our results demonstrate that low doses of ROS act as signaling molecules and exert anti-apoptotic functions in endothelial cells via upregulation of the redox-regulator Trx-1...
  71. ncbi request reprint Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin
    Carmen Urbich
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, 60590 Frankfurt, Germany
    FASEB J 16:706-8. 2002
    ..Inhibition of PP2A prevented the inhibitory effect of endostatin. Thus, endostatin inhibits VEGF-induced EC migration and angiogenesis upstream of NO-synthesis via dephosphorylation of eNOS at Ser1177...
  72. ncbi request reprint Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment
    Chang Hwan Yoon
    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Germany
    Circulation 121:2001-11. 2010
    ....
  73. pmc Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine IV Department of Physiology, University of Frankfurt, Frankfurt, Germany
    Mol Cell Biol 23:4598-610. 2003
    ..Taken together, depletion of nuclear TERT by tyrosine phosphorylation-dependent nuclear export of TERT is a novel mechanism for regulation of TERT localization, which reduces the antiapoptotic activity of TERT...
  74. ncbi request reprint Chronic hypoxia induces apoptosis in cardiac myocytes: a possible role for Bcl-2-like proteins
    F Jung
    Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Biochem Biophys Res Commun 286:419-25. 2001
    ..However, Bcl-2 and Bax protein levels essentially remained unchanged. Our results may suggest a different molecular mechanism of hypoxia-induced apoptosis in vivo and in vitro...
  75. doi request reprint Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarcti
    Volker Schachinger
    Internal Medicine III, J W Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur J Heart Fail 11:973-9. 2009
    ....
  76. pmc Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells
    L Rossig
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, 60590 Frankfurt, Germany
    Mol Cell Biol 21:5644-57. 2001
    ..These data suggest that the modulation of p21(Cip1) cell cycle functions by Akt-mediated phosphorylation regulates endothelial cell proliferation in response to stimuli that activate Akt...
  77. ncbi request reprint TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells
    J Hoffmann
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany
    J Biol Chem 276:41383-7. 2001
    ....
  78. ncbi request reprint Characterization of long-term endogenous cardiac repair in children after heart transplantation
    Stefan Rupp
    Department of Molecular Cardiology, Internal Medicine III, JW Goethe University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Heart J 29:1867-72. 2008
    ..This study investigates the endogenous repair capacity and the long-term incorporation of circulating cells in heart-transplanted children...
  79. doi request reprint Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
    Guillaume Carmona
    Molecular Cardiology, Department of Internal Medicine III, J W Goethe University Frankfurt, Frankfurt
    Blood 113:488-97. 2009
    ..Our data demonstrate a critical role of Rap1 in the regulation of beta(1)-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization...
  80. ncbi request reprint Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease
    Christopher Heeschen
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 109:1615-22. 2004
    ..However, whether this impairment also extends to bone marrow-derived mononuclear cells (BM-MNCs) in patients with chronic ischemic cardiomyopathy (ICMP) is unclear...
  81. ncbi request reprint Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure
    Christine K Kissel
    Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    J Am Coll Cardiol 49:2341-9. 2007
    ....
  82. ncbi request reprint Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress
    Elisabeth Dernbach
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Blood 104:3591-7. 2004
    ..Taken together, EPCs reveal a higher expression of antioxidative enzymes and, thus, are exquisitely equipped to be protected against oxidative stress consistent with their progenitor cell character...
  83. ncbi request reprint Endothelial progenitor cells functional characterization
    Carmen Urbich
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Trends Cardiovasc Med 14:318-22. 2004
    ..The present review article summarizes the different subtypes of (endothelial) progenitor cells that can give rise to endothelial cells, enhance neovascularization, and may be suitable for therapeutic neovascularization...
  84. ncbi request reprint p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization
    Tom Brühl
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 94:686-92. 2004
    ..In contrast, complete p21 deficiency did not result in an increased neovascularization despite increased mature EC and EPC proliferation. This may be due to the sensitization of ECs against apoptosis...
  85. pmc Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway
    K Breitschopf
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Mol Cell Biol 20:1886-96. 2000
    ..Taken together, these results demonstrate a direct protective role for Bcl-2 phosphorylation by MAP kinase against apoptotic challenges to endothelial cells and other cells...
  86. ncbi request reprint Inhibition of caspase-3 improves contractile recovery of stunned myocardium, independent of apoptosis-inhibitory effects
    H Ruetten
    Aventis Pharmaceuticals, Frankfurt, Germany
    J Am Coll Cardiol 38:2063-70. 2001
    ..The mechanism(s) of protection by Ac-DEVD-CHO appear to be independent of apoptosis. Inhibition of caspase-3 is a novel therapeutic strategy to improve functional recovery of stunned myocardium...
  87. ncbi request reprint Activation of Epac stimulates integrin-dependent homing of progenitor cells
    Guillaume Carmona
    Molecular Cardiology, Department of Internal Medicine III, J W Goethe University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 111:2640-6. 2008
    ..These results may provide a platform for the development of novel therapeutic approaches to improve progenitor cell homing...
  88. ncbi request reprint Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction
    Florian H Seeger
    Department of Molecular Cardiology, University of Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Eur Heart J 28:766-72. 2007
    ....
  89. ncbi request reprint Intracoronary infusion of progenitor cells is not associated with aggravated restenosis development or atherosclerotic disease progression in patients with acute myocardial infarction
    Birgit Assmus
    Department of Cardiology and Molecular Cardiology, Internal Medicine III, J W Goethe University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Heart J 27:2989-95. 2006
    ..Since progenitor cells are also known to be involved in restenosis development and atherosclerosis progression, an increased restenosis rate may be a risk of intracoronary cell therapy...
  90. ncbi request reprint Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes
    Cornel Badorff
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 107:1024-32. 2003
    ..Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial progenitor cells (EPCs) is unknown...
  91. ncbi request reprint Effects of statins on endothelium and endothelial progenitor cell recruitment
    Dirk H Walter
    Department of Internal Medicine IV, Division of Cardiology and Molecular Cardiology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Semin Vasc Med 4:385-93. 2004
    ....
  92. ncbi request reprint Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
    Lothar Rossig
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Biol Chem 277:9684-9. 2002
    ..001). These data indicate that GSK-3 triggers p21(Cip1) degradation. In contrast, stimulation of AKT increases p21(Cip1) via inhibitory phosphorylation of GSK-3...
  93. doi request reprint Improvement of endothelial damage and regeneration indexes in patients with coronary artery disease after 4 weeks of statin therapy
    Caroline Schmidt-Lucke
    Department of Internal Medicine III, Johann W Goethe University Frankfurt, Germany
    Atherosclerosis 211:249-54. 2010
    ..The availability of ezetimibe, a potent novel cholesterol absorption inhibitor, allows to distinguish between lipid-lowering and pleiotropic properties of statins...
  94. ncbi request reprint Platelet-derived growth factor CC--a clinically useful angiogenic factor at last?
    Stefanie Dimmeler
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    N Engl J Med 352:1815-6. 2005
  95. ncbi request reprint Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells
    Masamichi Koyanagi
    Department of Molecular Cardiology, Internal Medicine IV and Institute of Cardiovascular Physiology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Biol Chem 280:16838-42. 2005
    ..Our data demonstrate that Wnt11, but not Wnt3A, augments cardiomyogenic differentiation of human CPCs. Wnt11 promotes cardiac differentiation via the non-canonical PKC-dependent signaling pathway...
  96. ncbi request reprint Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease
    Dirk H Walter
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
    Circ Res 97:1142-51. 2005
    ..Stimulating CXCR4 signaling might improve functional properties of EPC and may rescue impaired neovascularization capacity of EPC derived from patients with CAD...
  97. ncbi request reprint Mobilizing endothelial progenitor cells
    Alexandra Aicher
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Germany
    Hypertension 45:321-5. 2005
    ....
  98. ncbi request reprint Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (S1177D) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity
    Claudius Teupe
    Molecular Cardiology, Department of Medicine IV, Institut für Kardiovaskuläre Physiologie, University of Frankfurt, Germany
    Circulation 105:1104-9. 2002
    ..For gene transfer, we used a phosphomimetic, active endothelial nitric oxide synthase (eNOS) construct in which Ser1177 was replaced by aspartic acid (S1177D) and exhibits a 2-fold higher basal activity than the wild-type enzyme...
  99. ncbi request reprint Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Cell Biol 4:743-9. 2002
    ..S-nitrosylation of Trx also contributes to the anti-apoptotic function of Trx. Thus, Trx can exert its complete redox regulatory and anti-apoptotic functions in endothelial cells only when cysteine 69 is S-nitrosylated...
  100. ncbi request reprint Double-edged role of statins in angiogenesis signaling
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 90:737-44. 2002
    ....

Research Grants1

  1. Cardiac Disease and Regeneration
    Stefanie Dimmeler; Fiscal Year: 2005
    ..As aging is a major risk factor for cardiovascular disease a special session will focus on the molecular determinants of aging and its role in cardiac diseases. ..