Nathalie Dehne

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    Nathalie Dehne
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Shock 35:632-8. 2011
  2. ncbi High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Frankfurt am Main, Germany
    Exp Cell Res 316:1179-89. 2010
  3. ncbi Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    Christian Werno
    Institute of Biochemistry I Pathobiochemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Carcinogenesis 31:1863-72. 2010
  4. ncbi HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
    Andreas Weigert
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Blood 120:3001-6. 2012
  5. ncbi Role of sestrin2 in peroxide signaling in macrophages
    Silke Essler
    Goethe University Frankfurt, Faculty of Medicine, Biochemistry I, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    FEBS Lett 583:3531-5. 2009
  6. ncbi Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1
    Jie Zhou
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    Free Radic Biol Med 47:741-9. 2009
  7. ncbi Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids
    Heidi Menrad
    Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Hepatology 51:2183-92. 2010
  8. ncbi Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics
    Emeka I Igwe
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    BMC Genomics 10:408. 2009
  9. ncbi Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
    Michaela Tausendschön
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cytokine 53:256-62. 2011
  10. ncbi The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta
    Barbara Herr
    Institute of Biochemistry I, Faculty of Medicine, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 114:2140-8. 2009

Collaborators

Detail Information

Publications11

  1. ncbi Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    Nathalie Dehne
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Shock 35:632-8. 2011
    ..Our data suggest that damaged myofibers activate HIF-1 in neighboring myotubes and precursor myoblasts by direct contact, concomitantly upregulating factors necessary for angiogenesis, tissue regeneration, and phagocyte recruitment...
  2. ncbi High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Frankfurt am Main, Germany
    Exp Cell Res 316:1179-89. 2010
    ....
  3. ncbi Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    Christian Werno
    Institute of Biochemistry I Pathobiochemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Carcinogenesis 31:1863-72. 2010
    ..Our data suggest that HIF-1α-deficient MФs develop a more prominent TAM marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs...
  4. ncbi HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
    Andreas Weigert
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Blood 120:3001-6. 2012
    ..Our data indicate that the low oxygen content in the bone marrow might limit pDC development. This might be an environmental mechanism to restrict the numbers of these potentially autoreactive cells...
  5. ncbi Role of sestrin2 in peroxide signaling in macrophages
    Silke Essler
    Goethe University Frankfurt, Faculty of Medicine, Biochemistry I, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    FEBS Lett 583:3531-5. 2009
    ..We conclude that Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins...
  6. ncbi Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1
    Jie Zhou
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    Free Radic Biol Med 47:741-9. 2009
    ..Our observations strengthen the role of HIF-1 in macrophages as a target of NO in facilitating functional responses such as migration...
  7. ncbi Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids
    Heidi Menrad
    Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Hepatology 51:2183-92. 2010
    ..Our data indicate that enhanced expression of one HIF-isoform causes a survival advantage in hepatocellular carcinoma development...
  8. ncbi Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics
    Emeka I Igwe
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    BMC Genomics 10:408. 2009
    ..To circumvent these problems, we have focused on the analysis of newly transcribed (nascent) mRNAs by nuclear run on (NRO), followed by microarray analysis...
  9. ncbi Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
    Michaela Tausendschön
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cytokine 53:256-62. 2011
    ..We suggest that hypoxia and a concomitant loss of JHDM activity increases H3K9 methylation and decreases chemokine expression...
  10. ncbi The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta
    Barbara Herr
    Institute of Biochemistry I, Faculty of Medicine, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 114:2140-8. 2009
    ..This shows the importance of HIF-1-elicited responses in regulatory macrophages under normoxia...
  11. ncbi Hypoxia-inducible Factor (HIF) in Hormone Signaling During Health and Disease
    Nathalie Dehne
    Goethe University Frankfurt, Institute of Biochemistry I Pathobiochemistry, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cardiovasc Hematol Agents Med Chem 11:125-35. 2013
    ..We define how these signaling circuits promote or delay the progression of diseases and describe potential outcomes for patients...