Nathalie Dehne

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1α translation
    Nathalie Dehne
    1 Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Leukoc Biol 95:129-37. 2014
  2. doi request reprint Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    Nathalie Dehne
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Shock 35:632-8. 2011
  3. doi request reprint High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Frankfurt am Main, Germany
    Exp Cell Res 316:1179-89. 2010
  4. doi request reprint Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    Christian Werno
    Institute of Biochemistry I Pathobiochemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Carcinogenesis 31:1863-72. 2010
  5. pmc Redox control of inflammation in macrophages
    Bernhard Brüne
    Faculty of Medicine, Institute of Biochemistry I Pathobiochemistry, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 19:595-637. 2013
  6. doi request reprint Role of sestrin2 in peroxide signaling in macrophages
    Silke Essler
    Goethe University Frankfurt, Faculty of Medicine, Biochemistry I, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    FEBS Lett 583:3531-5. 2009
  7. doi request reprint HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
    Andreas Weigert
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Blood 120:3001-6. 2012
  8. doi request reprint HIF-1 in the inflammatory microenvironment
    Nathalie Dehne
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Exp Cell Res 315:1791-7. 2009
  9. doi request reprint Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids
    Heidi Menrad
    Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Hepatology 51:2183-92. 2010
  10. pmc Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics
    Emeka I Igwe
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    BMC Genomics 10:408. 2009

Collaborators

Detail Information

Publications16

  1. doi request reprint IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1α translation
    Nathalie Dehne
    1 Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Leukoc Biol 95:129-37. 2014
    ..Conclusively, IL-4 reduces HIF-1α translation and thus, its activity in MΦ and concomitantly, attenuates their ability to promote angiogenesis under hypoxic conditions...
  2. doi request reprint Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    Nathalie Dehne
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Shock 35:632-8. 2011
    ..Our data suggest that damaged myofibers activate HIF-1 in neighboring myotubes and precursor myoblasts by direct contact, concomitantly upregulating factors necessary for angiogenesis, tissue regeneration, and phagocyte recruitment...
  3. doi request reprint High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Frankfurt am Main, Germany
    Exp Cell Res 316:1179-89. 2010
    ....
  4. doi request reprint Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    Christian Werno
    Institute of Biochemistry I Pathobiochemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Carcinogenesis 31:1863-72. 2010
    ..Our data suggest that HIF-1α-deficient MФs develop a more prominent TAM marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs...
  5. pmc Redox control of inflammation in macrophages
    Bernhard Brüne
    Faculty of Medicine, Institute of Biochemistry I Pathobiochemistry, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 19:595-637. 2013
    ....
  6. doi request reprint Role of sestrin2 in peroxide signaling in macrophages
    Silke Essler
    Goethe University Frankfurt, Faculty of Medicine, Biochemistry I, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    FEBS Lett 583:3531-5. 2009
    ..We conclude that Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins...
  7. doi request reprint HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
    Andreas Weigert
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Blood 120:3001-6. 2012
    ..Our data indicate that the low oxygen content in the bone marrow might limit pDC development. This might be an environmental mechanism to restrict the numbers of these potentially autoreactive cells...
  8. doi request reprint HIF-1 in the inflammatory microenvironment
    Nathalie Dehne
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Exp Cell Res 315:1791-7. 2009
    ..This review summarizes mechanisms of HIF activation in mammalian immune cells, especially in macrophages and neutrophils, and outlines how HIF moderates inflammation...
  9. doi request reprint Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids
    Heidi Menrad
    Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Hepatology 51:2183-92. 2010
    ..Blocking autophagosome maturation using 3-methyladenine restored cell death in HIF-2alpha-knockdown clones comparable to wildtype cells...
  10. pmc Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics
    Emeka I Igwe
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    BMC Genomics 10:408. 2009
    ..To circumvent these problems, we have focused on the analysis of newly transcribed (nascent) mRNAs by nuclear run on (NRO), followed by microarray analysis...
  11. doi request reprint Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1
    Jie Zhou
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    Free Radic Biol Med 47:741-9. 2009
    ..Our observations strengthen the role of HIF-1 in macrophages as a target of NO in facilitating functional responses such as migration...
  12. doi request reprint The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta
    Barbara Herr
    Institute of Biochemistry I, Faculty of Medicine, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 114:2140-8. 2009
    ..This shows the importance of HIF-1-elicited responses in regulatory macrophages under normoxia...
  13. doi request reprint Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
    Michaela Tausendschön
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cytokine 53:256-62. 2011
    ..We suggest that hypoxia and a concomitant loss of JHDM activity increases H3K9 methylation and decreases chemokine expression...
  14. doi request reprint Chronic hypoxia alters mitochondrial composition in human macrophages
    Dominik Christian Fuhrmann
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Biochim Biophys Acta 1834:2750-60. 2013
    ..Macrophages tolerate periods of chronic hypoxia very well and adaptive responses occur, at least in part, independently of HIF-1α and/or HIF-2α and comprise mitophagy as a pathway of particular importance. ..
  15. ncbi request reprint Hypoxia-inducible factor (HIF) in hormone signaling during health and disease
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Cardiovasc Hematol Agents Med Chem 11:125-35. 2013
    ..We define how these signaling circuits promote or delay the progression of diseases and describe potential outcomes for patients...
  16. doi request reprint Sensors, transmitters, and targets in mitochondrial oxygen shortage-a hypoxia-inducible factor relay story
    Nathalie Dehne
    Faculty of Medicine, Institute of Biochemistry I ZAFES, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 20:339-52. 2014
    ..Cells sense and respond to a shortage of oxygen by activating the hypoxia-inducible transcription factors HIF-1 and HIF-2 and evoking adaptive responses...