Nathalie Dehne

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1α translation
    Nathalie Dehne
    1 Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Leukoc Biol 95:129-37. 2014
  2. doi request reprint Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    Nathalie Dehne
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Shock 35:632-8. 2011
  3. doi request reprint High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Frankfurt am Main, Germany
    Exp Cell Res 316:1179-89. 2010
  4. doi request reprint Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    Christian Werno
    Institute of Biochemistry I Pathobiochemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Carcinogenesis 31:1863-72. 2010
  5. pmc Redox control of inflammation in macrophages
    Bernhard Brüne
    Faculty of Medicine, Institute of Biochemistry I Pathobiochemistry, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 19:595-637. 2013
  6. doi request reprint Role of sestrin2 in peroxide signaling in macrophages
    Silke Essler
    Goethe University Frankfurt, Faculty of Medicine, Biochemistry I, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    FEBS Lett 583:3531-5. 2009
  7. doi request reprint Sensors, transmitters, and targets in mitochondrial oxygen shortage-a hypoxia-inducible factor relay story
    Nathalie Dehne
    Faculty of Medicine, Institute of Biochemistry I ZAFES, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 20:339-52. 2014
  8. doi request reprint HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma
    Theresa Geis
    Institute of Biochemistry I Pathobiochemistry, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany Electronic address
    Exp Cell Res 331:46-57. 2015
  9. doi request reprint HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
    Andreas Weigert
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Blood 120:3001-6. 2012
  10. doi request reprint HIF-1 in the inflammatory microenvironment
    Nathalie Dehne
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Exp Cell Res 315:1791-7. 2009

Collaborators

  • Julia Kzhyshkowska
  • Tobias Schmid
  • Jie Zhou
  • Dieter Steinhilber
  • Katrin Schröder
  • Uta Kerkweg
  • Bernhard Brüne
  • Joachim Fandrey
  • Stefanie B Flohé
  • Thomas Deller
  • Wei Cui
  • Michaela Tausendschön
  • Andreas Weigert
  • Heidi Menrad
  • Christian Werno
  • Silke Essler
  • Claudia Döring
  • Theresa Geis
  • Martin Leo Hansmann
  • Dominik C Fuhrmann
  • Ilka Wittig
  • Michael Sze Ka Wong
  • Dominik Christian Fuhrmann
  • Barbara Herr
  • Emeka I Igwe
  • Michael Rehli
  • Martina G Ding
  • Mirco Steger
  • Christian Schmidl
  • Nina Grossmann
  • Rüdiger Popp
  • Ingrid Fleming
  • Eva Herrmann
  • Christoph Schürmann
  • Christoph Kruse
  • Ralf P Brandes
  • Juri Vogel
  • Geert Carmeliet
  • Matthias S Leisegang
  • Stefan Offermanns
  • Klaus Badenhoop
  • Ajay M Shah
  • Heinrich Heide
  • Stephanie Ley
  • Weixiao Sha
  • Javier Mora
  • Benjamin Weichand
  • Divya Sekar
  • Christina Hahn
  • Ekaterini Copanaki
  • Kai Schledzewski
  • Sergij Goerdt
  • Natalie Al-Furoukh
  • Dmitry Namgaladze

Detail Information

Publications21

  1. doi request reprint IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1α translation
    Nathalie Dehne
    1 Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Leukoc Biol 95:129-37. 2014
    ..Conclusively, IL-4 reduces HIF-1α translation and thus, its activity in MΦ and concomitantly, attenuates their ability to promote angiogenesis under hypoxic conditions...
  2. doi request reprint Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    Nathalie Dehne
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Shock 35:632-8. 2011
    ..Our data suggest that damaged myofibers activate HIF-1 in neighboring myotubes and precursor myoblasts by direct contact, concomitantly upregulating factors necessary for angiogenesis, tissue regeneration, and phagocyte recruitment...
  3. doi request reprint High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Frankfurt am Main, Germany
    Exp Cell Res 316:1179-89. 2010
    ....
  4. doi request reprint Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    Christian Werno
    Institute of Biochemistry I Pathobiochemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Carcinogenesis 31:1863-72. 2010
    ..Our data suggest that HIF-1α-deficient MФs develop a more prominent TAM marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs...
  5. pmc Redox control of inflammation in macrophages
    Bernhard Brüne
    Faculty of Medicine, Institute of Biochemistry I Pathobiochemistry, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 19:595-637. 2013
    ....
  6. doi request reprint Role of sestrin2 in peroxide signaling in macrophages
    Silke Essler
    Goethe University Frankfurt, Faculty of Medicine, Biochemistry I, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    FEBS Lett 583:3531-5. 2009
    ..We conclude that Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins...
  7. doi request reprint Sensors, transmitters, and targets in mitochondrial oxygen shortage-a hypoxia-inducible factor relay story
    Nathalie Dehne
    Faculty of Medicine, Institute of Biochemistry I ZAFES, Goethe University Frankfurt, Frankfurt, Germany
    Antioxid Redox Signal 20:339-52. 2014
    ..Cells sense and respond to a shortage of oxygen by activating the hypoxia-inducible transcription factors HIF-1 and HIF-2 and evoking adaptive responses...
  8. doi request reprint HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma
    Theresa Geis
    Institute of Biochemistry I Pathobiochemistry, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany Electronic address
    Exp Cell Res 331:46-57. 2015
    ..Suggestively, HIF-2α increases PAI-1 to lower concentrations of active plasmin, thereby supporting angiogenesis. We conclude that the HIF-2α target gene PAI-1 favors the angiogenic switch in HCC...
  9. doi request reprint HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
    Andreas Weigert
    Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany
    Blood 120:3001-6. 2012
    ..Our data indicate that the low oxygen content in the bone marrow might limit pDC development. This might be an environmental mechanism to restrict the numbers of these potentially autoreactive cells...
  10. doi request reprint HIF-1 in the inflammatory microenvironment
    Nathalie Dehne
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Exp Cell Res 315:1791-7. 2009
    ..This review summarizes mechanisms of HIF activation in mammalian immune cells, especially in macrophages and neutrophils, and outlines how HIF moderates inflammation...
  11. doi request reprint Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids
    Heidi Menrad
    Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Hepatology 51:2183-92. 2010
    ..Blocking autophagosome maturation using 3-methyladenine restored cell death in HIF-2alpha-knockdown clones comparable to wildtype cells...
  12. pmc Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics
    Emeka I Igwe
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    BMC Genomics 10:408. 2009
    ..To circumvent these problems, we have focused on the analysis of newly transcribed (nascent) mRNAs by nuclear run on (NRO), followed by microarray analysis...
  13. doi request reprint Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1
    Jie Zhou
    Institute of Biochemistry I ZAFES, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    Free Radic Biol Med 47:741-9. 2009
    ..Our observations strengthen the role of HIF-1 in macrophages as a target of NO in facilitating functional responses such as migration...
  14. pmc Inactivation of tristetraprolin in chronic hypoxia provokes the expression of cathepsin B
    Dominik C Fuhrmann
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, Frankfurt, Germany
    Mol Cell Biol 35:619-30. 2015
    ..We postulate a TTP-dependent mechanism to explain delayed expression of CTSB under chronic hypoxia. ..
  15. doi request reprint Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10
    Michaela Tausendschön
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    Biochim Biophys Acta 1849:10-22. 2015
    ..Taken together IL-10 influences the DNA binding pattern of HIF and the level of gene induction. ..
  16. doi request reprint The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta
    Barbara Herr
    Institute of Biochemistry I, Faculty of Medicine, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 114:2140-8. 2009
    ..This shows the importance of HIF-1-elicited responses in regulatory macrophages under normoxia...
  17. doi request reprint Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
    Michaela Tausendschön
    Institute of Biochemistry I Pathobiochemistry ZAFES, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cytokine 53:256-62. 2011
    ..We suggest that hypoxia and a concomitant loss of JHDM activity increases H3K9 methylation and decreases chemokine expression...
  18. doi request reprint Chronic hypoxia alters mitochondrial composition in human macrophages
    Dominik Christian Fuhrmann
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Biochim Biophys Acta 1834:2750-60. 2013
    ..Macrophages tolerate periods of chronic hypoxia very well and adaptive responses occur, at least in part, independently of HIF-1α and/or HIF-2α and comprise mitophagy as a pathway of particular importance. ..
  19. pmc Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages
    Wei Cui
    College of Life Sciences, Beijing Normal University, 100875 Beijing, China Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Cell Biosci 5:36. 2015
    ..However, the signal crosstalk between TGFβ and hypoxia is ill defined...
  20. doi request reprint Vitamin D promotes vascular regeneration
    Michael Sze Ka Wong
    From the Institute for Cardiovascular Physiology M S K W, M S L, C K, J V, C S, K S, R P B, Institute of Biochemistry I N D, A W, B B, Institute for Biostatistics and Mathematical Modeling E H, Institute of Pharmaceutical Chemistry Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit D S, Goethe University, Frankfurt, Germany German Center for Cardiovascular Research, partner site RheinMain, Frankfurt, Germany M S L, C K, C S, E H, S O, K S, R P B Cardiovascular Division, King s College London British Heart Foundation Center of Excellence, London, United Kingdom A M S Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany S O Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium G C and Department of Endocrinology and Diabetes, San Diego
    Circulation 130:976-86. 2014
    ..We therefore hypothesized that 1,25-VitD3 promotes regeneration after vascular injury...
  21. ncbi request reprint Hypoxia-inducible factor (HIF) in hormone signaling during health and disease
    Nathalie Dehne
    Institute of Biochemistry I ZAFES, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Cardiovasc Hematol Agents Med Chem 11:125-35. 2013
    ..We define how these signaling circuits promote or delay the progression of diseases and describe potential outcomes for patients...