Angela Brieger

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins
    Angela Brieger
    Department of Medicine I, University of Frankfurt M, Frankfurt, Germany
    PLoS ONE 7:e31863. 2012
  2. ncbi Malignant fibrous histiocytoma is a rare Lynch syndrome-associated tumor in two German families
    Angela Brieger
    Medical Clinic 1, Biomedical Research Laboratory, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Fam Cancer 10:591-5. 2011
  3. ncbi A CRM1-dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization
    Angela Brieger
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt a M, Germany
    Genes Chromosomes Cancer 50:59-70. 2011
  4. ncbi Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1
    Angela Brieger
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt, Germany
    Proteomics 10:3343-55. 2010
  5. ncbi Thymosin beta 4 expression and nuclear transport are regulated by hMLH1
    Angela Brieger
    Department of Internal Medicine I, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt a M, Germany
    Biochem Biophys Res Commun 364:731-6. 2007
  6. ncbi hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
    Guido Plotz
    Second Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Nucleic Acids Res 30:711-8. 2002
  7. ncbi Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system
    Joerg Trojan
    Second Department of Medicine, Johann Wolfgang Goethe University, Frankfurt a M, Germany
    Gastroenterology 122:211-9. 2002
  8. ncbi MUTYH gene expression and alternative splicing in controls and polyposis patients
    Guido Plotz
    Biomedical Research Laboratory, Medizinische Klinik 1, Klinik der Johann Wolfgang Goethe Universität, Theodor Stern Kai 7, Frankfurt, Germany
    Hum Mutat 33:1067-74. 2012
  9. ncbi BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
    Joerg Trojan
    2nd Department of Medicine and Senckenberg Center of Pathology, Johann Wolfgang Goethe University Medical Center, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
    Int J Colorectal Dis 19:538-44. 2004
  10. ncbi Expression Defect Size among Unclassified MLH1 Variants Determines Pathogenicity in Lynch Syndrome Diagnosis
    Inga Hinrichsen
    Authors Affiliations Medizinische Klinik 1, Biomedical Research Laboratory, and Medizinische Klinik 1, Johann Wolfgang Goethe Universitat, Frankfurt, Germany HNPCC Register, Clinical Research Centre, Hvidovre Hospital, Copenhagen University, Denmark and Department of Oncology, Lund University, Lund, Sweden
    Clin Cancer Res 19:2432-41. 2013

Collaborators

Detail Information

Publications16

  1. ncbi C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins
    Angela Brieger
    Department of Medicine I, University of Frankfurt M, Frankfurt, Germany
    PLoS ONE 7:e31863. 2012
    ..In contrast, N-terminal tagged MutLαs retained correct functionality and can be recommended both for the analysis of cellular localization and MMR efficiency...
  2. ncbi Malignant fibrous histiocytoma is a rare Lynch syndrome-associated tumor in two German families
    Angela Brieger
    Medical Clinic 1, Biomedical Research Laboratory, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Fam Cancer 10:591-5. 2011
    ..In conclusion, our data further support that patients with Lynch syndrome are at increased risk for rare tumors such as MFH. However, the prognosis compared to sporadic MFH seems to be favorable...
  3. ncbi A CRM1-dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization
    Angela Brieger
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt a M, Germany
    Genes Chromosomes Cancer 50:59-70. 2011
    ..In conclusion, not only a defective MMR but also impaired nucleo-cytoplasmic shuttling might result in the onset of Lynch syndrome...
  4. ncbi Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1
    Angela Brieger
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt, Germany
    Proteomics 10:3343-55. 2010
    ..Our data suggest novel roles of MLH1 in cellular organization and colorectal cancerogenesis...
  5. ncbi Thymosin beta 4 expression and nuclear transport are regulated by hMLH1
    Angela Brieger
    Department of Internal Medicine I, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt a M, Germany
    Biochem Biophys Res Commun 364:731-6. 2007
    ..Moreover, loss of hMLH1 causes Tbeta4 deprivation and results in reduced migratory activity in vitro. These data give insight into novel functions of hMLH1 and probably disease related dysregulated mechanisms...
  6. ncbi hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
    Guido Plotz
    Second Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Nucleic Acids Res 30:711-8. 2002
    ..Purified hMutLalpha showed an intrinsic affinity for DNA, with a preference for single-stranded over double-stranded DNA...
  7. ncbi Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system
    Joerg Trojan
    Second Department of Medicine, Johann Wolfgang Goethe University, Frankfurt a M, Germany
    Gastroenterology 122:211-9. 2002
    ..To date, functional analysis of missense mutations has been performed primarily in Saccharomyces cerevisiae. The aim of this study was to examine the biochemical properties of hMLH1 protein variants in a human expression system...
  8. ncbi MUTYH gene expression and alternative splicing in controls and polyposis patients
    Guido Plotz
    Biomedical Research Laboratory, Medizinische Klinik 1, Klinik der Johann Wolfgang Goethe Universität, Theodor Stern Kai 7, Frankfurt, Germany
    Hum Mutat 33:1067-74. 2012
    ..Since this alteration decreases protein production of the gene, an increased cancer risk for compound heterozygous carriers is possible...
  9. ncbi BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
    Joerg Trojan
    2nd Department of Medicine and Senckenberg Center of Pathology, Johann Wolfgang Goethe University Medical Center, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
    Int J Colorectal Dis 19:538-44. 2004
    ..The aim of this study was to further characterize the role of BAX and cas-5 inactivation for spontaneous apoptosis...
  10. ncbi Expression Defect Size among Unclassified MLH1 Variants Determines Pathogenicity in Lynch Syndrome Diagnosis
    Inga Hinrichsen
    Authors Affiliations Medizinische Klinik 1, Biomedical Research Laboratory, and Medizinische Klinik 1, Johann Wolfgang Goethe Universitat, Frankfurt, Germany HNPCC Register, Clinical Research Centre, Hvidovre Hospital, Copenhagen University, Denmark and Department of Oncology, Lund University, Lund, Sweden
    Clin Cancer Res 19:2432-41. 2013
    ..The functionality of these variants can be tested in the laboratory, but the results cannot be used for clinical diagnosis. We therefore aimed to establish a laboratory test that can be applied clinically...
  11. ncbi In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis
    Simone Boehrer
    Department of Internal Medicine III, Hematology and Oncology, Johann Wolfgang Goethe University Hospital, 60590 Frankfurt am Main, Germany
    Leuk Lymphoma 45:1445-51. 2004
    ..In conclusion we here demonstrate that in the erythroleukemic cell line HEL--in contrast to other cell types Par-4 fails to promote apoptosis and outline the underlying molecular mechanisms...
  12. ncbi In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors
    Angela Brieger
    Department of Internal Medicine III, Hematology and Oncology, Johann Wolfgang Goethe-University Hospital, 60590 Frankfurt am Main, Germany
    Biochem Pharmacol 68:85-93. 2004
    ....
  13. ncbi In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins
    Simone Boehrer
    Department of Internal Medicine III, Hematology and Oncology, Johann Wolfgang Goethe-University Hospital, 60590 Frankfurt am Main, Germany
    Hematol J 5:513-8. 2004
    ..Upon a proapoptotic stimulus such as serum withdrawal Daxx is unable to maintain its influence on expression levels of p53, Bax, IAPs and the procaspase-8, -10 and -7...
  14. ncbi Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status
    Soo Zin Kim
    Department of Internal Medicine III, University Hospital Frankfurt, Germany
    Leuk Lymphoma 45:2037-45. 2004
    ..Furthermore, high levels of ZAP-70 correlated with Binet stages B or C indicating an involvement of ZAP-70 in mechanisms promoting growth of B-CLL cells...
  15. ncbi N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha
    Guido Plotz
    2nd Department of Medicine, University of the Saarland, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Nucleic Acids Res 31:3217-26. 2003
    ..We also examined another human homologue of bacterial MutL, hMutLbeta (hMLH1-hPMS1). We show that hMutLbeta interacts as efficiently with hMutSalpha as hMutLalpha, and that it predominantly binds to hMutSalpha via hMLH1 as well...
  16. ncbi Detection of microsatellite instability from archival, hematoxylin-eosin-stained colorectal cancer specimen
    Joerg Trojan
    Second Department of Internal Medicine, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany
    Arch Pathol Lab Med 126:202-4. 2002
    ..In conclusion, this study demonstrates the feasibility of MSI analysis by direct fluorescence polymerase chain reaction amplification using hematoxylin-eosin-stained tissue specimens without the need for prior DNA extraction...