Eckhard Boles

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering
    Mekonnen M Demeke
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Belgium
    Biotechnol Biofuels 6:89. 2013
  2. pmc Cytosolic re-localization and optimization of valine synthesis and catabolism enables inseased isobutanol production with the yeast Saccharomyces cerevisiae
    Dawid Brat
    Institute of Molecular Biosciences, Goethe University Frankfurt, Max von Laue Str, 9, 60438, Frankfurt am Main, Germany
    Biotechnol Biofuels 5:65. 2012
  3. pmc Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae
    Thorsten Subtil
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Max von Laue Str, 9, D 60438 Frankfurt am Main, Germany
    Biotechnol Biofuels 5:14. 2012
  4. pmc Improving L-arabinose utilization of pentose fermenting Saccharomyces cerevisiae cells by heterologous expression of L-arabinose transporting sugar transporters
    Thorsten Subtil
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Max von Laue Strasse 9, D 60438 Frankfurt am Main, Germany
    Biotechnol Biofuels 4:38. 2011
  5. pmc Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose
    Alexander Farwick
    Institute of Molecular Biosciences, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 111:5159-64. 2014
  6. doi request reprint Isobutanol production from D-xylose by recombinant Saccharomyces cerevisiae
    Dawid Brat
    Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany
    FEMS Yeast Res 13:241-4. 2013
  7. pmc Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates
    Mislav Oreb
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Bioengineered 3:347-51. 2012
  8. doi request reprint Knockout of the DNA ligase IV homolog gene in the sphingoid base producing yeast Pichia ciferrii significantly increases gene targeting efficiency
    Christoph Schorsch
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, 60438, Frankfurt, Germany
    Curr Genet 55:381-9. 2009
  9. doi request reprint Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers
    Wesley Cardoso Generoso
    Institute of Molecular Biosciences, Goethe University Frankfurt, Max von Laue Str 9, 60438 Frankfurt am Main, Germany
    Curr Opin Biotechnol 33:1-7. 2015
  10. pmc Biosynthesis of cis,cis-muconic acid and its aromatic precursors, catechol and protocatechuic acid, from renewable feedstocks by Saccharomyces cerevisiae
    Christian Weber
    Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany
    Appl Environ Microbiol 78:8421-30. 2012

Collaborators

  • Helge B Bode
  • Christoph Schorsch
  • Mislav Oreb
  • Dawid Brat
  • Christian Weber
  • Thorsten Subtil
  • Alexander Farwick
  • Feline Benisch
  • Heiko Dietz
  • Paulina Jordan
  • Wesley Cardoso Generoso
  • Virginia Schadeweg
  • Mekonnen M Demeke
  • Jun Yong Choe
  • Stefan Bruder
  • Alex Verplaetse
  • Tom Den Abt
  • Françoise Dumortier
  • Johan M Thevelein
  • Sarma Mutturi
  • Maria R Foulquié-Moreno
  • Sylvie Deprez
  • Beatriz M Bonini
  • Gunnar Liden
  • Yingying Li
  • Sheila Weinreb
  • Christine Essl
  • Wolfram Lorenzen
  • Christine Brückner
  • Claudia Lehr

Detail Information

Publications13

  1. pmc Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering
    Mekonnen M Demeke
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Belgium
    Biotechnol Biofuels 6:89. 2013
    ..The purpose of the present work was to develop such a strain from a prime industrial yeast strain, Ethanol Red, used for bioethanol production...
  2. pmc Cytosolic re-localization and optimization of valine synthesis and catabolism enables inseased isobutanol production with the yeast Saccharomyces cerevisiae
    Dawid Brat
    Institute of Molecular Biosciences, Goethe University Frankfurt, Max von Laue Str, 9, 60438, Frankfurt am Main, Germany
    Biotechnol Biofuels 5:65. 2012
    ..abstract:..
  3. pmc Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae
    Thorsten Subtil
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Max von Laue Str, 9, D 60438 Frankfurt am Main, Germany
    Biotechnol Biofuels 5:14. 2012
    ..abstract:..
  4. pmc Improving L-arabinose utilization of pentose fermenting Saccharomyces cerevisiae cells by heterologous expression of L-arabinose transporting sugar transporters
    Thorsten Subtil
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Max von Laue Strasse 9, D 60438 Frankfurt am Main, Germany
    Biotechnol Biofuels 4:38. 2011
    ..abstract:..
  5. pmc Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose
    Alexander Farwick
    Institute of Molecular Biosciences, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 111:5159-64. 2014
    ..Moreover, our data contribute to the mechanistic understanding of sugar transport because the decisive role of the conserved asparagine residue for determining sugar specificity has not been recognized before...
  6. doi request reprint Isobutanol production from D-xylose by recombinant Saccharomyces cerevisiae
    Dawid Brat
    Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany
    FEMS Yeast Res 13:241-4. 2013
    ..Moreover, after additional overexpression of ketoacid decarboxylase Aro10 and alcohol dehydrogenase Adh2, the cells were able to ferment D-xylose directly to isobutanol...
  7. pmc Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates
    Mislav Oreb
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Bioengineered 3:347-51. 2012
    ..In this addendum, we discuss novel approaches to improve utilization of pentoses by development of specific transporters and substrate channeling in enzyme cascades...
  8. doi request reprint Knockout of the DNA ligase IV homolog gene in the sphingoid base producing yeast Pichia ciferrii significantly increases gene targeting efficiency
    Christoph Schorsch
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, 60438, Frankfurt, Germany
    Curr Genet 55:381-9. 2009
    ..Owing to the ability of targeting genomic DNA integration our results pave the way for further genetic and metabolic engineering approaches with P. ciferrii by means of knocking out or overexpressing predestinated genes...
  9. doi request reprint Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers
    Wesley Cardoso Generoso
    Institute of Molecular Biosciences, Goethe University Frankfurt, Max von Laue Str 9, 60438 Frankfurt am Main, Germany
    Curr Opin Biotechnol 33:1-7. 2015
    ..Endogenous 1-butanol pathways have been discovered via threonine or glycine catabolism. 2-Butanol production was established but was limited by B12-dependence. ..
  10. pmc Biosynthesis of cis,cis-muconic acid and its aromatic precursors, catechol and protocatechuic acid, from renewable feedstocks by Saccharomyces cerevisiae
    Christian Weber
    Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany
    Appl Environ Microbiol 78:8421-30. 2012
    ..The recombinant yeast cells finally produced about 1.56 mg/liter cis,cis-muconic acid...
  11. doi request reprint Trends and challenges in the microbial production of lignocellulosic bioalcohol fuels
    Christian Weber
    Institute of Molecular Biosciences, Goethe University Frankfurt am Main, Max von Laue Str 9, 60438 Frankfurt am Main, Germany
    Appl Microbiol Biotechnol 87:1303-15. 2010
    ..In this review, we compare the properties of various microorganisms, bacteria and yeasts, as well as current research efforts to develop a reliable lignocellulosic bioalcohol producing organism...
  12. pmc Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters
    Paulina Jordan
    Institute of Molecular Biosciences, Goethe University, Max von Laue Straße 9, 60438 Frankfurt am Main, Germany
    Sci Rep 6:23502. 2016
    ..In addition, we determined the kinetic parameters of mannitol and sorbitol dehydrogenases encoded in the yeast genome, showing that they discriminate between mannitol and sorbitol to a much higher degree than the transporters. ..
  13. doi request reprint The bacterial Entner-Doudoroff pathway does not replace glycolysis in Saccharomyces cerevisiae due to the lack of activity of iron-sulfur cluster enzyme 6-phosphogluconate dehydratase
    Feline Benisch
    Institute of Molecular Biosciences, Goethe University Frankfurt, Max von Laue Str 9, 60438 Frankfurt Main, Germany
    J Biotechnol 171:45-55. 2014
    ..From our results we conclude that establishing functional expression of iron-sulfur cluster enzymes will be a major task for the integration of the EDP and other biochemical pathways in yeast. ..