Research Topics
Species | Annemarie BergerSummaryAffiliation: Frankfurt am Main Country: Germany Publications
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Publications
Case report: risk of virus infection after accidental blood inoculation from a multi-infected AIDS patientAnnemarie Berger
Institute of Medical Virology, Hospital of Johann Wolfgang Goethe University, Frankfurt M, Germany
J Med Virol 84:897-900. 2012..Considering that many HIV carriers are coinfected with hepatitis B and C viruses, this case report support the knowledge that the risk of HCV transmission from a patient with AIDS is greater than that of HIV...
[Antiviral treatment of chronic hepatitis C]Annemarie Berger
Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main
Med Monatsschr Pharm 35:55-60. 2012..In order to reduce the risk of antiviral resistance these drugs are given in combination with pegylated interferon and ribavirin only...- Severe acute respiratory syndrome (SARS)--paradigm of an emerging viral infectionA Berger
Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Paul Ehrlich Street 40, D 60596 Frankfurt a M, Germany
J Clin Virol 29:13-22. 2004.... - Comparative evaluation of the Cobas Amplicor HIV-1 Monitor Ultrasensitive Test, the new Cobas AmpliPrep/Cobas Amplicor HIV-1 Monitor Ultrasensitive Test and the Versant HIV RNA 3.0 assays for quantitation of HIV-1 RNA in plasma samplesAnnemarie Berger
Institute for Medical Virology, J W Goethe University Hospital, Paul Ehrlich Street 40, D 60596 Frankfurt am Main, Germany
J Clin Virol 33:43-51. 2005..There are several commercially available assays for the quantitation of HIV RNA. A new automated specimen preparation system, the Cobas AmpliPrep, was developed to automate this last part of the PCR... - HBV reactivation after kidney transplantationAnnemarie Berger
Institute for Medical Virology, Center of Internal Medicine, J W Goethe University Hospital, Paul Ehrlich Str 40, D 60596 Frankfurt a M, Germany
J Clin Virol 32:162-5. 2005..Periodic follow-up of HBV serology for early diagnosis of reactivation is highly recommended in transplant recipients... - Detection and quantitation of HBV DNA in miniaturized samples: multi centre study to evaluate the performance of the COBAS ® AmpliPrep/COBAS ® TaqMan ® hepatitis B virus (HBV) test v2.0 by the use of plasma or serum specimensAnnemarie Berger
Institut fur Medizinische Virologie, der J W Goethe Universität Frankfurt am Main, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
J Virol Methods 169:404-8. 2010..99 and a mean difference of 0.06 log(10)IU/ml. In conclusion, the new test version HBV v2.0 is highly specific and reproducible and quantifies accurately HBV DNA in EDTA plasma and serum samples from patients with chronic HBV infection... - Problems and challenges in the diagnosis of vertical infection with human cytomegalovirus (CMV): lessons from two accidental casesAnnemarie Berger
Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Paul Ehrlich Str 40, D 60596, Frankfurt am Main, Germany
J Clin Virol 51:285-8. 2011..Passive IgG treatment of the mother was helpful but the ultimate goal in prevention of congenital CMV infection is to develop a vaccine, which would be administered to seronegative women... - Evaluation of the new ARCHITECT anti-HCV screening test under routine laboratory conditionsAnnemarie Berger
Institute for Medical Virology, Frankfurt University Medical School, Paul Ehrlich Street 40, D 60596 Frankfurt am Main, Germany
J Clin Virol 43:158-61. 2008..An improved test version of the Abbott ARCHITECT anti-hepatitis C virus (HCV) test became available at the end of 2005... - Evaluation of the Cobas AmpliPrep/Cobas Amplicor HIV-1 Monitor Ultrasensitive Test: comparison with the Cobas Amplicor HIV-1 Monitor test (manual specimen preparation)Annemarie Berger
Institute for Medical Virology, J W Goethe University Hospital, Paul Ehrlich Street 40, D 60596 Frankfurt Main, Germany
J Clin Virol 25:S103-7. 2002..In comparison to the assay with manual extraction, no significant difference in HIV-1 RNA copy numbers was observed... - The role of viral load determination for the management of human immunodeficiency virus, hepatitis B virus and hepatitis C virus infectionA Berger
Institut fur Medizinische Virologie, Zentrum der Hygiene, Universitatskliniken, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
J Clin Virol 20:23-30. 2001..However, viral load may predict the outcome of antiviral therapy. Genetic diversity is another challenge for HCV RNA quantification... - Measurements of HCV neutralizing antibodies and of HCV-specific CD4+ and CD8+ cells using hepatitis C virus pseudo-particles (HCVpp)Annemarie Berger
Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
J Clin Virol 46:55-60. 2009..For the medical management, it would be of great relevance to get a diagnostic marker predicting the outcome of infection... - Short communication: Different mutation patterns in subtype CRF06_cpx after mother-to-child transmissionMartin Stürmer
J W Goethe University Hospital, Institute for Medical Virology, 60596 Frankfurt, Germany
AIDS Res Hum Retroviruses 24:1429-33. 2008..Whether the nucleoside backbone, course of antiretroviral therapy, or different host environment is responsible for this variability must be determined in larger studies... - HIV-1 genotyping: comparison of two commercially available assaysMartin Stürmer
Institute for Medical Virology, University Clinic Frankfurt, Paul Ehrlich Str 40, 60596 Frankfurt, Germany
Expert Rev Mol Diagn 4:281-91. 2004..A final decision on which system to use must be based on an individual's requirements. The future of this field may lie with the use of microarray systems... - Viral genome quantification as a tool for improving patient management: the example of HIV, HBV, HCV and CMVAnnemarie Berger
Institute for Medical Virology, , Paul Ehrlich-Strasse 40, D-60596 Frankfurt am Main, Germany
J Antimicrob Chemother 49:713-21. 2002.... - Modifications and substitutions of the RNA extraction module in the ViroSeq HIV-1 genotyping system version 2: effects on sensitivity and complexity of the assayMartin Stürmer
Institut fur Medizinische Virologie, J W Goethe Universitat, Frankfurt, Germany
J Med Virol 71:475-9. 2003..This is of great importance as it avoids further time- and cost-intensive steps... - Molecular assays for monitoring HIV infection and antiretroviral therapyMiriam Wittek
Institute for Medical Virology, JW Goethe University Hospital, Frankfurt, Germany
Expert Rev Mol Diagn 7:237-46. 2007..However, a general recommendation to favor one system over the other cannot be given, because the final decision of which system to use should be decided on the individual requirements... 
Regional spread of HIV-1 M subtype B in middle-aged patients by random env-C2V4 region sequencingMartin Stürmer
Institute for Medical Virology, University Hospital Frankfurt, Paul Ehrlich Str 40, 69596, Frankfurt, Germany
Med Microbiol Immunol 199:123-8. 2010....- Verification and validation of diagnostic laboratory tests in clinical virologyHolger F Rabenau
Institute for Medical Virology, Johann Wolfgang Goethe University Frankfurt Main, Germany
J Clin Virol 40:93-8. 2007..It covers techniques useful for detection of virus specific antibodies, for detection of viral antigens, for detection of viral nucleic acids, and for isolation of viruses on cell cultures in the routine virology laboratory... - Clinical utility of the ARCHITECT HCV Ag assay for early treatment monitoring in patients with chronic hepatitis C genotype 1 infectionJohannes Vermehren
Medizinische Klinik 1, Klinikum der JW Goethe Universität, Frankfurt am Main, Germany
J Clin Virol 55:17-22. 2012..However, HCV-RNA assays are time-consuming, expensive and require highly trained personnel. Quantitative determination of HCV core-antigen (HCVAg) levels may be used to supplement treatment monitoring... - A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriersJohannes Vermehren
Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
PLoS ONE 7:e32605. 2012..Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians... - Is transmission of HIV-1 in non-viraemic serodiscordant couples possible?Martin Stürmer
JW Goethe University Hospital, Institute for Medical Virology, Frankfurt, Germany
Antivir Ther 13:729-32. 2008..This should be added to the discussion of prevention strategies, which should not advise the abandonment of safer-sex practices without referring to the relatively low but not impossible risk of HIV-1 transmission in this context... - Impact of tenofovir-containing antiretroviral therapy on chronic hepatitis B in a cohort co-infected with human immunodeficiency virusChristoph Stephan
HIV Research and Treatment Unit at Center for Internal Medicine, Johann Wolfgang Goethe University Hospital Frankfurt, Germany
J Antimicrob Chemother 56:1087-93. 2005..We studied the impact of tenofovir disoproxil fumarate, given as an antiretroviral medication, on patients with chronic hepatitis B virus (HBV) co-infection... - Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of resensitising mutations including K65RC Stephan
HIVCENTER, Johann Wolfgang Goethe University Hospital, Department of Internal Medicine II, Theodor Stern Kai 7, Frankfurt, Germany
J Infect 61:346-50. 2010..The reverse transcriptase (RT)-mutation K65R limits further therapeutic options and has been selected by unfavorable RT-combinations, e.g. tenofovir in combination with abacavir and/or didanosine... - Human immunodeficiency virus and hepatitis B virus infection in pregnancy: diagnostic potential of viral genome detectionA Berger
Institut fur Medizinische Virologie, Zentrum der Hygiene, Universitatskliniken, Frankfurt am Main, Germany
Intervirology 41:201-7. 1998.... - Enterovirus infections in Germany: comparative evaluation of different laboratory diagnostic methodsS Buxbaum
Institute for Medical Virology, JW Goethe University Frankfurt am Main, Germany
Infection 29:138-42. 2001..Serologically, a significant rise in antibody titer may be detected and different enteroviral types can be differentiated using the neutralization assay... - Determination of serum antibodies against swine-origin influenza A virus H1N1/09 by immunofluorescence, haemagglutination inhibition, and by neutralization tests: how is the prevalence rate of protecting antibodies in humans?Regina Allwinn
Institute of Medical Virology, University Hospital, Frankfurt M, Germany
Med Microbiol Immunol 199:117-21. 2010..Expecting the next waves of influenza A/H1N1v infections, HI testing may avoid vaccinations under special risk of severe or hidden adverse reactions... - Rapid detection of enterovirus infection by automated RNA extraction and real-time fluorescence PCRHolger F Rabenau
Institute of Medical Virology, JWG University Frankfurt, D 60596 Frankfurt am Main, Germany
J Clin Virol 25:155-64. 2002..Molecular detection has been shown to be superior to tissue culture for the detection of enteroviruses in cerebrospinal fluid (CSF) specimens... - Evaluation of the new LCx HIV RNA quantitative assay: comparison with the Cobas Amplicor HIV Monitor assayA Berger
Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
Med Microbiol Immunol 190:129-34. 2001..The results of the remaining samples showed a higher degree of variation (when testing four replicates of the subtype panel) than the LCx of 14.2-40.3%. Nevertheless, the results were comparable with the LCx data... - Hepatitis E: are psychiatric patients on special risk?Claudia Reinheimer
Institute for Medical Virology, University Hospital, Paul Ehrlich Strasse 40, 60596, Frankfurt am Main, Germany
Med Microbiol Immunol 201:171-5. 2012..0%; 95%CI: 17.86-44.61). Overall seroprevalence of anti-HEV-IgG in FFM is higher than in Germany on average. The group of AELE and PSYCH shows significantly more often marker of HEV infections than other groups in our collective... - High prevalence of anti-HCV antibodies in two metropolitan emergency departments in Germany: a prospective screening analysis of 28,809 patientsJohannes Vermehren
Medizinische Klinik 1, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
PLoS ONE 7:e41206. 2012..The aim of this study was to assess the HCV seroprevalence in patients visiting two tertiary care emergency departments in Berlin and Frankfurt, respectively... - Evaluation of a new automated assay for hepatitis B surface antigen (HBsAg) detection VIDAS HBsAg UltraBernard Weber
Laboratoires Réunis, Junglinster, Luxembourg, Germany
J Virol Methods 135:109-17. 2006..6% (AxSYM HBsAg v2). In conclusion, the VIDAS HBsAg Ultra is highly sensitive and specific and represents an improvement for the detection of HBsAg in routine diagnostic laboratories... - Multicenter evaluation of a new automated fourth-generation human immunodeficiency virus screening assay with a sensitive antigen detection module and high specificityBernard Weber
Laboratoires Réunis Kutter Lieners Hastert, Junglinster, Luxembourg
J Clin Microbiol 40:1938-46. 2002.... - Evaluation of two new automated assays for hepatitis B virus surface antigen (HBsAg) detection: IMMULITE HBsAg and IMMULITE 2000 HBsAgBernard Weber
Laboratoires Réunis Kutter Lieners Hastert, Junglinster, Luxembourg
J Clin Microbiol 41:135-43. 2003..The specificity on repeatedly tested samples was equivalent to that of the alternative assays. The rapid turnaround time, primary tube sampling, and on-board dilution make it an interesting assay system for clinical laboratory diagnosis... - Identification of a novel coronavirus in patients with severe acute respiratory syndromeChristian Drosten
Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany
N Engl J Med 348:1967-76. 2003..The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent... - Slower progression of HIV-1 infection in persons with GB virus C co-infection correlates with an intact T-helper 1 cytokine profileGiuseppe Nunnari
University of Catania, Italy
Ann Intern Med 139:26-30. 2003..Progression to AIDS is slower in persons infected with both HIV-1 and GB virus C (GBV-C), also known as hepatitis G virus... - Haemolytic anaemia after nucleotide antiretroviral treatment discontinuation in a chronic hepatitis B-virus co-infected AIDS patientChristoph Stephan
AIDS 18:1613-4. 2004 - High-throughput purification of viral RNA based on novel aqueous chemistry for nucleic acid isolationMichael K Hourfar
Institute of Transfusion Medicine and Immunohaematology, German Red Cross, Johann Wolfgang Goethe University, Frankfurt, Germany
Clin Chem 51:1217-22. 2005..However, commercially available magnetic-bead-based assays either lack the sensitivity required for viral diagnostics or are disproportionately expensive... - Hepatitis A virus infection in tamarins: experimental transmission via contaminated factor VIII concentratesMichael Chudy
Division of Virology, Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany
J Infect Dis 185:1170-3. 2002..Because a number of HAV transmission episodes have been described for solely solvent/detergent-treated factor VIII preparations, continued use of these agents seems questionable... - Evaluation of a new combined antigen and antibody human immunodeficiency virus screening assay, VIDAS HIV DUO UltraBernard Weber
Laboratoires Réunis Kutter Lieners Hastert, Junglinster, Luxembourg, Germany
J Clin Microbiol 40:1420-6. 2002..The specificity after initial and/or repeated testing of VIDAS HIV DUO Ultra was equivalent to that of a third-generation assay...