Research Topics
| F WuestSummaryAffiliation: Forschungszentrum Rossendorf Country: Germany Publications
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Detail Information
Publications
An 86Y-labeled mirror-image oligonucleotide: influence of Y-DOTA isomers on the biodistribution in ratsJoern Schlesinger
Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf, Germany
Bioconjug Chem 19:928-39. 2008..High renal excretions were found for the [(86)Y((S)-p-NH 2-Bn-DOTA)](-) complex isomers as well as for the L-RNA isomers...- Radiolabelling of isopeptide N epsilon-(gamma-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoateF Wüst
Institut fur Bioanorganische und Radiopharmazeutische Chemie, FZ Rossendorf e V, PF 51 01 19, Dresden 01314, Germany
Appl Radiat Isot 59:43-8. 2003..Using the optimized labelling conditions, in a typical experiment 1.3GBq of [18F]SFB could be converted into 447MBq (46%, decay-corrected) of [18F]fluorobenzoylated isopeptide within 45 min, including HPLC purification... - Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitorFrank Wuest
Institute of Radiopharmacy, Research Center Dresden Rossendorf, PO Box 510119, 01314 Dresden, Germany
Bioorg Med Chem 16:7662-70. 2008..However, radioactivity uptake in the tumor could not be blocked by the pre-injection of nonradioactive compound 5. Therefore, it can be concluded that radioactivity uptake in the tumor was not COX-2 mediated... - Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptorsFrank Wuest
Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, POB 51 01 19, D 01314 Dresden, Germany
Bioorg Med Chem Lett 17:4035-9. 2007..However, the inability of high dose corticosterone to block binding would suggest that the radioactivity accumulation in the brain was not receptor-mediated... - Synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18F]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT)F Wuest
Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf, Postfach 510119, 01314 Dresden, Germany
Bioorg Med Chem 15:4511-9. 2007.... - Aspects of positron emission tomography radiochemistry as relevant for food chemistryF Wuest
Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
Amino Acids 29:323-39. 2005.... - Synthesis and radiopharmacological evaluation of 2'-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11beta,17alpha-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET)Frank Wüst
Institut fur Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf e V, PO Box 51 01 19, D 01314 Dresden, Germany
Bioorg Med Chem Lett 15:1303-6. 2005..25+/-0.03% ID/g after 5 min, which remained constant over 60 min. The radiopharmacological evaluation of compound [18F]-2 was completed with autoradiography using rat brain sections and micro-PET imaging... - Synthesis of 18F-labelled cyclooxygenase-2 (COX-2) inhibitors via Stille reaction with 4-[18F]fluoroiodobenzene as radiotracers for positron emission tomography (PET)Frank R Wüst
Institute of Bioinorganic and Radiopharmaceutical Chemistry, FZ Rossendorf, PF 51 01 19, D 01314 Dresden, Germany
Org Biomol Chem 3:503-7. 2005..By using optimized reaction conditions (18)F-labelled COX-2 inhibitors [(18)F]-5 and [(18)F]-13 could be obtained in radiochemical yields of up to 94% and 68%, respectively, based upon 4-[(18)F]fluoroiodobenzene... - Catabolism of native and oxidized low density lipoproteins: in vivo insights from small animal positron emission tomography studiesJ Pietzsch
Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
Amino Acids 29:389-404. 2005..g., LDL iodination methods, and is of value to characterize and to discriminate the kinetics and the metabolic fate of nLDL and oxLDL in small animals in vivo... - Biodistribution and catabolism of 18F-labelled isopeptide N(epsilon)-(gamma-glutamyl)-L-lysineC Hultsch
Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
Amino Acids 29:405-13. 2005..The results suggest that the metabolic fate of isopeptides is likely to be dependent on how they are reabsorbed - free or peptide bound... - Synthesis and biodistribution of an 18F-labelled resveratrol derivative for small animal positron emission tomographyS Gester
Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
Amino Acids 29:415-28. 2005..This study represents the first investigation of polyphenols in vivo by means of PET... - Labeling of low-density lipoproteins using the 18F-labeled thiol-reactive reagent N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimideMathias Berndt
Institute of Radiopharmacy, Research Center Rossendorf, POB 51 01 19, D 01314 Dresden, Germany
Nucl Med Biol 34:5-15. 2007..The compound [18F]FBAM can be considered as an excellent prosthetic group for the selective and mild 18F labeling of thiol-group-containing biomolecules suitable for subsequent investigations in vitro and in vivo... - Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracerFrank Wuest
Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, POB 51 01 19, D 01314 Dresden, Germany
Appl Radiat Isot 67:308-12. 2009..However, involvement of Pgp or species differences requires further clarification to establish whether the radiotracer [N-methyl-(11)C]Org 34850 may still represent a suitable candidate for imaging GRs in humans... - Fluorine-18 radiolabeling of low-density lipoproteins: a potential approach for characterization and differentiation of metabolism of native and oxidized low-density lipoproteins in vivoJens Pietzsch
PET Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf Dresden, D 01314 Dresden, Germany
Nucl Med Biol 31:1043-50. 2004..Thus, radiolabeling of LDL using [(18)F]SFB could prove to be a promising approach for studying the kinetics of oxLDL in vivo... - Practical experiences with the synthesis of [11C]CH3I through gas phase iodination reaction using a TRACERlabFXC synthesis moduleTorsten Kniess
Institute of Radiopharmacy, FZ Dresden Rossendorf, Box 510119, Dresden 01314, Germany
Appl Radiat Isot 66:482-8. 2008..The relatively low specific activity may be mainly due to carbon contaminations originating from the long copper tubing (500 m) between the cyclotron and the radiochemistry facility... - Systematic comparison of two novel, thiol-reactive prosthetic groups for 18F labeling of peptides and proteins with the acylation agent succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)Frank Wuest
Research Center Dresden Rossendorf, Institute for Radiopharmacy, PF 510 119, 01314 Dresden, Germany
Amino Acids 36:283-95. 2009..However, the acylation agent [18F]SFB is the preferred prosthetic group for labeling nLDL under physiological conditions... - Synthesis and application of [18F]FDG-maleimidehexyloxime ([18F]FDG-MHO): a [18F]FDG-based prosthetic group for the chemoselective 18F-labeling of peptides and proteinsFrank Wuest
Research Center Dresden Rossendorf, Institute for Radiopharmacy, PF 510 119, D 01314 Dresden, Germany
Bioconjug Chem 19:1202-10. 2008.... - Fluorine-18 labeling of phosphopeptides: a potential approach for the evaluation of phosphopeptide metabolism in vivoSusan Richter
Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
Biopolymers 92:479-88. 2009..The presented method indicates that radiolabeling of phosphopeptides with [18F]SFB is a promising approach for studying phosphopeptide metabolism in vivo... - Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitorTorsten Kniess
Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf e V, PO Box 510119, D 01314 Dresden, Germany
Bioorg Med Chem 17:7732-42. 2009..After 20min post-injection, only 12% of intact radiotracer has been detected. Consequently, in small animal PET studies with FaDu tumour bearing mice no specific uptake in the tumours could be observed... - Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitorsLena Koehler
Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
Eur J Med Chem 45:727-37. 2010..Both imaging techniques showed only little uptake of both radiotracers in the FaDu tumor xenografts... - Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agentsFrank Wuest
Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, Postfach 510119, 01314 Dresden, Germany
Steroids 73:69-76. 2008..The obtained radiochemical yield was 20-30%. The specific activity was determined to be 20-40GBq/micromol at the end-of-synthesis, and the radiochemical purity exceeded 98%... - Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18Christina Hultsch
Institute of Radiopharmacy, Research Center Rossendorf, P O Box 51 01 19, D 01314 Dresden, Germany
Appl Radiat Isot 65:818-26. 2007..Therefore, [(18)F]FBAM seems to be the most suitable (18)F-labeling agent for multivalent neurotensin(8-13) derivatives... - Iodine-124: a promising positron emitter for organic PET chemistryLena Koehler
Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
Molecules 15:2686-718. 2010..The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging... - Synthesis and evaluation of novel multimeric neurotensin(8-13) analogsChristina Hultsch
Institute of Radiopharmacy, Research Center Rossendorf, Germany
Bioorg Med Chem 14:5913-20. 2006..Moreover, within the multimeric neurotensin(8-13) derivatives with neurotensin(8-13) attached via the N-terminus an increasing number of branching units lead to higher binding affinities toward the neurotensin receptor... - Cyclin-dependent kinase 4/6 (cdk4/6) inhibitors: perspectives in cancer therapy and imagingFranziska Graf
Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden Rossendorf, P O Box 510119, 01314 Dresden, Germany
Mini Rev Med Chem 10:527-39. 2010..The potential of Cdk4/6 inhibitors, particularly, pyrido[2,3-d]pyrimidine derivatives, as both anti-cancer drugs and 124I- and 18F-radiolabeled tracers for cancer imaging using positron emission tomography is discussed... - Advances in the production, processing and microPET image quality of technetium-94mHeather M Bigott
Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA
Nucl Med Biol 33:923-33. 2006..Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination...