F Wuest

Summary

Affiliation: Forschungszentrum Rossendorf
Country: Germany

Publications

  1. doi request reprint An 86Y-labeled mirror-image oligonucleotide: influence of Y-DOTA isomers on the biodistribution in rats
    Joern Schlesinger
    Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf, Germany
    Bioconjug Chem 19:928-39. 2008
  2. ncbi request reprint Radiolabelling of isopeptide N epsilon-(gamma-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
    F Wüst
    Institut fur Bioanorganische und Radiopharmazeutische Chemie, FZ Rossendorf e V, PF 51 01 19, Dresden 01314, Germany
    Appl Radiat Isot 59:43-8. 2003
  3. doi request reprint Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor
    Frank Wuest
    Institute of Radiopharmacy, Research Center Dresden Rossendorf, PO Box 510119, 01314 Dresden, Germany
    Bioorg Med Chem 16:7662-70. 2008
  4. ncbi request reprint Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors
    Frank Wuest
    Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, POB 51 01 19, D 01314 Dresden, Germany
    Bioorg Med Chem Lett 17:4035-9. 2007
  5. ncbi request reprint Synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18F]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT)
    F Wuest
    Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf, Postfach 510119, 01314 Dresden, Germany
    Bioorg Med Chem 15:4511-9. 2007
  6. ncbi request reprint Aspects of positron emission tomography radiochemistry as relevant for food chemistry
    F Wuest
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:323-39. 2005
  7. ncbi request reprint Synthesis and radiopharmacological evaluation of 2'-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11beta,17alpha-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET)
    Frank Wüst
    Institut fur Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf e V, PO Box 51 01 19, D 01314 Dresden, Germany
    Bioorg Med Chem Lett 15:1303-6. 2005
  8. ncbi request reprint Synthesis of 18F-labelled cyclooxygenase-2 (COX-2) inhibitors via Stille reaction with 4-[18F]fluoroiodobenzene as radiotracers for positron emission tomography (PET)
    Frank R Wüst
    Institute of Bioinorganic and Radiopharmaceutical Chemistry, FZ Rossendorf, PF 51 01 19, D 01314 Dresden, Germany
    Org Biomol Chem 3:503-7. 2005
  9. ncbi request reprint Catabolism of native and oxidized low density lipoproteins: in vivo insights from small animal positron emission tomography studies
    J Pietzsch
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:389-404. 2005
  10. ncbi request reprint Biodistribution and catabolism of 18F-labelled isopeptide N(epsilon)-(gamma-glutamyl)-L-lysine
    C Hultsch
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:405-13. 2005

Collaborators

Detail Information

Publications26

  1. doi request reprint An 86Y-labeled mirror-image oligonucleotide: influence of Y-DOTA isomers on the biodistribution in rats
    Joern Schlesinger
    Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf, Germany
    Bioconjug Chem 19:928-39. 2008
    ..High renal excretions were found for the [(86)Y((S)-p-NH 2-Bn-DOTA)](-) complex isomers as well as for the L-RNA isomers...
  2. ncbi request reprint Radiolabelling of isopeptide N epsilon-(gamma-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
    F Wüst
    Institut fur Bioanorganische und Radiopharmazeutische Chemie, FZ Rossendorf e V, PF 51 01 19, Dresden 01314, Germany
    Appl Radiat Isot 59:43-8. 2003
    ..Using the optimized labelling conditions, in a typical experiment 1.3GBq of [18F]SFB could be converted into 447MBq (46%, decay-corrected) of [18F]fluorobenzoylated isopeptide within 45 min, including HPLC purification...
  3. doi request reprint Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor
    Frank Wuest
    Institute of Radiopharmacy, Research Center Dresden Rossendorf, PO Box 510119, 01314 Dresden, Germany
    Bioorg Med Chem 16:7662-70. 2008
    ..However, radioactivity uptake in the tumor could not be blocked by the pre-injection of nonradioactive compound 5. Therefore, it can be concluded that radioactivity uptake in the tumor was not COX-2 mediated...
  4. ncbi request reprint Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors
    Frank Wuest
    Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, POB 51 01 19, D 01314 Dresden, Germany
    Bioorg Med Chem Lett 17:4035-9. 2007
    ..However, the inability of high dose corticosterone to block binding would suggest that the radioactivity accumulation in the brain was not receptor-mediated...
  5. ncbi request reprint Synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18F]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT)
    F Wuest
    Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf, Postfach 510119, 01314 Dresden, Germany
    Bioorg Med Chem 15:4511-9. 2007
    ....
  6. ncbi request reprint Aspects of positron emission tomography radiochemistry as relevant for food chemistry
    F Wuest
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:323-39. 2005
    ....
  7. ncbi request reprint Synthesis and radiopharmacological evaluation of 2'-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11beta,17alpha-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET)
    Frank Wüst
    Institut fur Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf e V, PO Box 51 01 19, D 01314 Dresden, Germany
    Bioorg Med Chem Lett 15:1303-6. 2005
    ..25+/-0.03% ID/g after 5 min, which remained constant over 60 min. The radiopharmacological evaluation of compound [18F]-2 was completed with autoradiography using rat brain sections and micro-PET imaging...
  8. ncbi request reprint Synthesis of 18F-labelled cyclooxygenase-2 (COX-2) inhibitors via Stille reaction with 4-[18F]fluoroiodobenzene as radiotracers for positron emission tomography (PET)
    Frank R Wüst
    Institute of Bioinorganic and Radiopharmaceutical Chemistry, FZ Rossendorf, PF 51 01 19, D 01314 Dresden, Germany
    Org Biomol Chem 3:503-7. 2005
    ..By using optimized reaction conditions (18)F-labelled COX-2 inhibitors [(18)F]-5 and [(18)F]-13 could be obtained in radiochemical yields of up to 94% and 68%, respectively, based upon 4-[(18)F]fluoroiodobenzene...
  9. ncbi request reprint Catabolism of native and oxidized low density lipoproteins: in vivo insights from small animal positron emission tomography studies
    J Pietzsch
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:389-404. 2005
    ..g., LDL iodination methods, and is of value to characterize and to discriminate the kinetics and the metabolic fate of nLDL and oxLDL in small animals in vivo...
  10. ncbi request reprint Biodistribution and catabolism of 18F-labelled isopeptide N(epsilon)-(gamma-glutamyl)-L-lysine
    C Hultsch
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:405-13. 2005
    ..The results suggest that the metabolic fate of isopeptides is likely to be dependent on how they are reabsorbed - free or peptide bound...
  11. ncbi request reprint Synthesis and biodistribution of an 18F-labelled resveratrol derivative for small animal positron emission tomography
    S Gester
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:415-28. 2005
    ..This study represents the first investigation of polyphenols in vivo by means of PET...
  12. ncbi request reprint Labeling of low-density lipoproteins using the 18F-labeled thiol-reactive reagent N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide
    Mathias Berndt
    Institute of Radiopharmacy, Research Center Rossendorf, POB 51 01 19, D 01314 Dresden, Germany
    Nucl Med Biol 34:5-15. 2007
    ..The compound [18F]FBAM can be considered as an excellent prosthetic group for the selective and mild 18F labeling of thiol-group-containing biomolecules suitable for subsequent investigations in vitro and in vivo...
  13. doi request reprint Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer
    Frank Wuest
    Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, POB 51 01 19, D 01314 Dresden, Germany
    Appl Radiat Isot 67:308-12. 2009
    ..However, involvement of Pgp or species differences requires further clarification to establish whether the radiotracer [N-methyl-(11)C]Org 34850 may still represent a suitable candidate for imaging GRs in humans...
  14. ncbi request reprint Fluorine-18 radiolabeling of low-density lipoproteins: a potential approach for characterization and differentiation of metabolism of native and oxidized low-density lipoproteins in vivo
    Jens Pietzsch
    PET Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf Dresden, D 01314 Dresden, Germany
    Nucl Med Biol 31:1043-50. 2004
    ..Thus, radiolabeling of LDL using [(18)F]SFB could prove to be a promising approach for studying the kinetics of oxLDL in vivo...
  15. ncbi request reprint Practical experiences with the synthesis of [11C]CH3I through gas phase iodination reaction using a TRACERlabFXC synthesis module
    Torsten Kniess
    Institute of Radiopharmacy, FZ Dresden Rossendorf, Box 510119, Dresden 01314, Germany
    Appl Radiat Isot 66:482-8. 2008
    ..The relatively low specific activity may be mainly due to carbon contaminations originating from the long copper tubing (500 m) between the cyclotron and the radiochemistry facility...
  16. doi request reprint Systematic comparison of two novel, thiol-reactive prosthetic groups for 18F labeling of peptides and proteins with the acylation agent succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
    Frank Wuest
    Research Center Dresden Rossendorf, Institute for Radiopharmacy, PF 510 119, 01314 Dresden, Germany
    Amino Acids 36:283-95. 2009
    ..However, the acylation agent [18F]SFB is the preferred prosthetic group for labeling nLDL under physiological conditions...
  17. ncbi request reprint Synthesis and application of [18F]FDG-maleimidehexyloxime ([18F]FDG-MHO): a [18F]FDG-based prosthetic group for the chemoselective 18F-labeling of peptides and proteins
    Frank Wuest
    Research Center Dresden Rossendorf, Institute for Radiopharmacy, PF 510 119, D 01314 Dresden, Germany
    Bioconjug Chem 19:1202-10. 2008
    ....
  18. doi request reprint Fluorine-18 labeling of phosphopeptides: a potential approach for the evaluation of phosphopeptide metabolism in vivo
    Susan Richter
    Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
    Biopolymers 92:479-88. 2009
    ..The presented method indicates that radiolabeling of phosphopeptides with [18F]SFB is a promising approach for studying phosphopeptide metabolism in vivo...
  19. doi request reprint Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor
    Torsten Kniess
    Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf e V, PO Box 510119, D 01314 Dresden, Germany
    Bioorg Med Chem 17:7732-42. 2009
    ..After 20min post-injection, only 12% of intact radiotracer has been detected. Consequently, in small animal PET studies with FaDu tumour bearing mice no specific uptake in the tumours could be observed...
  20. doi request reprint Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors
    Lena Koehler
    Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
    Eur J Med Chem 45:727-37. 2010
    ..Both imaging techniques showed only little uptake of both radiotracers in the FaDu tumor xenografts...
  21. ncbi request reprint Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agents
    Frank Wuest
    Institut für Radiopharmazie, Forschungszentrum Dresden Rossendorf e V, Postfach 510119, 01314 Dresden, Germany
    Steroids 73:69-76. 2008
    ..The obtained radiochemical yield was 20-30%. The specific activity was determined to be 20-40GBq/micromol at the end-of-synthesis, and the radiochemical purity exceeded 98%...
  22. ncbi request reprint Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18
    Christina Hultsch
    Institute of Radiopharmacy, Research Center Rossendorf, P O Box 51 01 19, D 01314 Dresden, Germany
    Appl Radiat Isot 65:818-26. 2007
    ..Therefore, [(18)F]FBAM seems to be the most suitable (18)F-labeling agent for multivalent neurotensin(8-13) derivatives...
  23. doi request reprint Iodine-124: a promising positron emitter for organic PET chemistry
    Lena Koehler
    Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
    Molecules 15:2686-718. 2010
    ..The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging...
  24. ncbi request reprint Synthesis and evaluation of novel multimeric neurotensin(8-13) analogs
    Christina Hultsch
    Institute of Radiopharmacy, Research Center Rossendorf, Germany
    Bioorg Med Chem 14:5913-20. 2006
    ..Moreover, within the multimeric neurotensin(8-13) derivatives with neurotensin(8-13) attached via the N-terminus an increasing number of branching units lead to higher binding affinities toward the neurotensin receptor...
  25. ncbi request reprint Cyclin-dependent kinase 4/6 (cdk4/6) inhibitors: perspectives in cancer therapy and imaging
    Franziska Graf
    Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden Rossendorf, P O Box 510119, 01314 Dresden, Germany
    Mini Rev Med Chem 10:527-39. 2010
    ..The potential of Cdk4/6 inhibitors, particularly, pyrido[2,3-d]pyrimidine derivatives, as both anti-cancer drugs and 124I- and 18F-radiolabeled tracers for cancer imaging using positron emission tomography is discussed...
  26. ncbi request reprint Advances in the production, processing and microPET image quality of technetium-94m
    Heather M Bigott
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 33:923-33. 2006
    ..Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination...