Genomes and Genes
Affiliation: Forschungszentrum Karlsruhe
- Hypophosphorylation of Mdm2 augments p53 stabilityChristine Blattner
Forschungszentrum Karlsruhe, Institute of Genetics and Toxicology, 76021 Karlsruhe, Germany
Mol Cell Biol 22:6170-82. 2002..Our model suggests that hypophosphorylation of Mdm2 in response to ionizing irradiation inactivates this novel function, thereby contributing to p53 stabilization...
- Binding of p53 to the central domain of Mdm2 is regulated by phosphorylationRoman Kulikov
Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
J Biol Chem 281:28575-83. 2006..p53 mutants that have mutations in the tetramerization domain and that fail to oligomerize do not show such an enhancement of binding in the presence of the other binding site...
- Regulation of p53: the next generationChristine Blattner
Institut fur Genetik, Forschungszentrum Karlsruhe, Karlsruhe, Germany
Cell Cycle 7:3149-53. 2008..This article summarizes the most important principles for the regulation of p53, with a particular focus on recent findings. Furthermore, open questions and possible future directions shall be discussed...
- p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PKKaren A Boehme
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, 76021 Karlsruhe, Germany
Proc Natl Acad Sci U S A 105:7785-90. 2008..We therefore propose a signaling cascade for the regulation of p53 in response to ionizing radiation that involves activation of DNA-PK and Akt/PKB and inactivation of GSK-3 and Mdm2...
- Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundanceRoman Kulikov
Institut fur Genetik, Forschungszentrum Karlsruhe, Germany
Mol Cell Biol 25:7170-80. 2005..We therefore conclude that inhibition of GSK-3 contributes to hypophosphorylation of Mdm2 in response to ionizing rays, and in consequence to p53 stabilization...
- Mdm2 facilitates the association of p53 with the proteasomeRoman Kulikov
Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, P O Box 3640, 76021 Karlsruhe, Germany
Proc Natl Acad Sci U S A 107:10038-43. 2010..We propose that Mdm2 facilitates, or at least enhances, the association of p53 with the proteasome and that phosphorylation of the central domain of Mdm2 regulates this process...
- Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnoverMarkus Winter
Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe, PO Box 3640, 76021 Karlsruhe, Germany
Biochemistry 43:16356-64. 2004..These data establish the identity of a key signaling molecule that promotes the phosphorylation of a major regulatory region in MDM2 under normal growth conditions...
- Regulation of p53 in embryonic stem cellsValeriya Solozobova
Karlsruher Institute of Technology, Institute of Toxicology and Genetics, PO Box 3640, 76021 Karlsruhe, Germany
Exp Cell Res 316:2434-46. 2010..During differentiation, p53 protein and RNA levels are decreased which corresponds to increased expression of miRNA-125a and miRNA-125b...
- Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damageValeriya Solozobova
Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, PO Box 3640, 76021 Karlsruhe, Germany
BMC Cell Biol 10:46. 2009..Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damage response is crucial...
- Regulation of p53--insights into a complex processKaren A Boehme
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Karlsruhe, Germany
Crit Rev Biochem Mol Biol 44:367-92. 2009..This review will summarize our current knowledge on the regulation of p53 abundance and activity...
- p53 in stem cellsValeriya Solozobova
Valeriya Solozobova, Christine Blattner, Institute of Toxicology and Genetics, Institute of Applied Biosciences, PO Box 3640, 76021 Karlsruhe, Germany
World J Biol Chem 2:202-14. 2011..In this review, we summarize our current knowledge about p53 activities in embryonic, adult and induced pluripotent stem cells...
- MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2Yetao Jin
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS4053, Indianapolis, IN 46202, USA
Mol Cell Biol 28:1218-29. 2008..These results demonstrate that MDMX and MDM2 independently and cooperatively regulate the proteasome-mediated degradation of p21 at the G(1) and early S phases...
- Involvement of the DNA repair protein hHR23 in p53 degradationSandra Glockzin
Zentrum für Biochemie, Medizinische Fakultat, Universitat zu Koln, 50931 Cologne, Germany
Mol Cell Biol 23:8960-9. 2003..In this model, the Uba domain of hHR23 binds to polyubiquitin chains formed on p53 and protects them from deubiquitylation, while the Ubl domain delivers the polyubiquitylated p53 molecules to the proteasome...
- Nucleotide excision repair driven by the dissociation of CAK from TFIIHFrederic Coin
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U Strasbourg, France
Mol Cell 31:9-20. 2008..Our findings demonstrate that the composition of TFIIH is dynamic to adapt its engagement in distinct cellular processes...