Agnes Floel

Summary

Country: Germany

Publications

  1. ncbi request reprint Language and spatial attention can lateralize to the same hemisphere in healthy humans
    A Floel
    Department of Neurology, University of Munster, Germany
    Neurology 57:1018-24. 2001
  2. ncbi request reprint Contribution of noninvasive cortical stimulation to the study of memory functions
    A Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA
    Brain Res Rev 53:250-9. 2007
  3. pmc Levodopa increases memory encoding and dopamine release in the striatum in the elderly
    A Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA
    Neurobiol Aging 29:267-79. 2008
  4. doi request reprint Noninvasive brain stimulation improves language learning
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    J Cogn Neurosci 20:1415-22. 2008
  5. doi request reprint Levodopa improves skilled hand functions in the elderly
    Agnes Floel
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Eur J Neurosci 27:1301-7. 2008
  6. doi request reprint Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke
    Agnes Floel
    Department of Neurology, University of Muenster, Germany
    Neurobiol Dis 37:243-51. 2010
  7. doi request reprint Lifestyle and memory in the elderly
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Neuroepidemiology 31:39-47. 2008
  8. doi request reprint White matter integrity in the vicinity of Broca's area predicts grammar learning success
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Neuroimage 47:1974-81. 2009
  9. ncbi request reprint [Neuropsychological disorders in amyotrophic lateral sclerosis]
    A Floel
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Munster
    Nervenarzt 73:1144-52. 2002
  10. ncbi request reprint Therapy of Sneddon syndrome
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Eur Neurol 48:126-32. 2002

Detail Information

Publications52

  1. ncbi request reprint Language and spatial attention can lateralize to the same hemisphere in healthy humans
    A Floel
    Department of Neurology, University of Munster, Germany
    Neurology 57:1018-24. 2001
    ..Disorders of language classically occur after left brain lesions, and disorders of spatial attention after right brain lesions. It is unclear whether the hemispheric dissociation of functions is a fixed pattern of brain organization...
  2. ncbi request reprint Contribution of noninvasive cortical stimulation to the study of memory functions
    A Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA
    Brain Res Rev 53:250-9. 2007
    ....
  3. pmc Levodopa increases memory encoding and dopamine release in the striatum in the elderly
    A Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA
    Neurobiol Aging 29:267-79. 2008
    ..These results demonstrate that levodopa may ameliorate dopamine deficiencies in the elderly by replenishing dopaminergic presynaptic stores, actively engaged in phasic dopamine release during motor training...
  4. doi request reprint Noninvasive brain stimulation improves language learning
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    J Cogn Neurosci 20:1415-22. 2008
    ..Our results demonstrate that anodal tDCS is a promising technique to enhance language learning in healthy adults and may also have the potential to improve language reacquisition after stroke...
  5. doi request reprint Levodopa improves skilled hand functions in the elderly
    Agnes Floel
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Eur J Neurosci 27:1301-7. 2008
    ..These results demonstrate that increasing the dopaminergic drive pharmacologically may be helpful when the motor system is challenged in the ageing process...
  6. doi request reprint Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke
    Agnes Floel
    Department of Neurology, University of Muenster, Germany
    Neurobiol Dis 37:243-51. 2010
    ..Subsequently, we expand on possibilities of adjuvant therapy in human rehabilitation using cortical stimulation and pharmacological treatments. Finally, we suggest future directions for research in this field...
  7. doi request reprint Lifestyle and memory in the elderly
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Neuroepidemiology 31:39-47. 2008
    ..This study aims to analyze the association between a composite lifestyle index and memory performance...
  8. doi request reprint White matter integrity in the vicinity of Broca's area predicts grammar learning success
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Neuroimage 47:1974-81. 2009
    ..The relevance of these findings for acquisition of a natural language has to be established in future studies...
  9. ncbi request reprint [Neuropsychological disorders in amyotrophic lateral sclerosis]
    A Floel
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Munster
    Nervenarzt 73:1144-52. 2002
    ..It is still not known whether patients with ALS and neuropsychological impairment form a distinct subgroup or if they are part of a continuous spectrum that runs from pure motor impairment to pure neuropsychological impairment...
  10. ncbi request reprint Therapy of Sneddon syndrome
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Eur Neurol 48:126-32. 2002
    ..Therapeutic options in SNS in both aPL-positive and aPL-negative patients with SNS are discussed...
  11. ncbi request reprint Reproducibility of hemispheric blood flow increases during line bisectioning
    Agnes Floel
    Department of Neurology, University Hospital of Munster, University of Munster, Albert Schweitzer Strasse 33, Munster, Germany
    Clin Neurophysiol 113:917-24. 2002
    ..To determine if attention-related changes of hemispheric perfusion increases, as assessed by blood-flow sensitive techniques, are as reliable as language-related hemispheric perfusion increases...
  12. ncbi request reprint Dopaminergic influences on formation of a motor memory
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 58:121-30. 2005
    ....
  13. doi request reprint Lack of improvement in odor identification by levodopa in humans
    Nina Rösser
    Department of Neurology, University of Muenster, Munster, Germany
    Physiol Behav 93:1024-9. 2008
    ..These hypotheses have to be tested in future experiments, but our study demonstrates that results from animal studies cannot be directly transferred to the human situation...
  14. doi request reprint Levodopa improves procedural motor learning in chronic stroke patients
    Nina Rösser
    Department of Neurology, University of Munster, Munster, Germany
    Arch Phys Med Rehabil 89:1633-41. 2008
    ....
  15. doi request reprint Electrical stimulation of Broca's area enhances implicit learning of an artificial grammar
    Meinou H de Vries
    University of Munster, Germany
    J Cogn Neurosci 22:2427-36. 2010
    ..This is the first study that demonstrates that tDCS may facilitate acquisition of grammatical knowledge, a finding of potential interest for rehabilitation of aphasia...
  16. doi request reprint Walking the talk--speech activates the leg motor cortex
    Gianpiero Liuzzi
    Department of Neurology, University of Munster, Germany
    Neuropsychologia 46:2824-30. 2008
    ..In the frame of the motor theory of speech this finding suggests that the system of gestural communication, from which speech may have evolved, is not confined to the hand but includes gestural movements of other body parts as well...
  17. ncbi request reprint Crossed cerebro-cerebellar language dominance
    Andreas Jansen
    Department of Neurology, University of Munster, Munster, Germany
    Hum Brain Mapp 24:165-72. 2005
    ..The functional significance of the reported activations can now be tested in patients with lesions of the lateral posterior cerebellum...
  18. ncbi request reprint High impact running improves learning
    Bernward Winter
    Department of Neurology, University of Muenster, Muenster, Germany
    Neurobiol Learn Mem 87:597-609. 2007
    ..Thus, BDNF and two of the catecholamines seem to be mediators by which physical exercise improves learning...
  19. pmc Imaging short- and long-term training success in chronic aphasia
    Ricarda Menke
    Department of Neurology, University of Munster, Munster, Germany
    BMC Neurosci 10:118. 2009
    ..In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versus long-term success of intensive language training in chronic post-stroke aphasia patients...
  20. ncbi request reprint A shift of paradigm: from noradrenergic to dopaminergic modulation of learning?
    Caterina Breitenstein
    Department of Neurology, University of Muenster, Germany IZKF Münster, University of Muenster, Germany
    J Neurol Sci 248:42-7. 2006
    ..Both d-amphetamine and levodopa are thus potent drugs in enhancing learning in humans. We here discuss why the efficiency of both d-amphetamine and levodopa may be related to dopaminergic rather than noradrenergic actions...
  21. doi request reprint Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity
    A Veronica Witte
    Department of Neurology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 32:4553-61. 2012
    ..Moreover, they show that genotype-related differences in neurophysiology translate into behavioral differences. These findings might contribute to a better understanding of the mechanisms of interindividual differences in cognition...
  22. pmc Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex
    Friedhelm C Hummel
    Brain Imaging and Neurostimulation BINS Laboratory, Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Neurobiol Aging 31:2160-8. 2010
    ..We conclude that anodal tDCS applied over M1 can facilitate performance of skilled hand functions required for activities of daily living in older subjects...
  23. pmc Effects of brain polarization on reaction times and pinch force in chronic stroke
    Friedhelm C Hummel
    Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Neurosci 7:73. 2006
    ..Here we tested the effects of tDCS on pinch force (PF) and simple reaction time (RT) tasks in patients with chronic stroke in a double-blind cross-over Sham-controlled experimental design...
  24. doi request reprint Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia
    Marcus Meinzer
    University of Munster, Department of Neurology, Munster, Germany
    Neuroimage 53:283-90. 2010
    ..Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures...
  25. ncbi request reprint Tonic dopaminergic stimulation impairs associative learning in healthy subjects
    Caterina Breitenstein
    Department of Neurology, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 31:2552-64. 2006
    ..Thus, phasic signaling seems to be the critical mechanism by which dopamine enhances associative learning in healthy subjects and stroke patients...
  26. doi request reprint Grammar learning in older adults is linked to white matter microstructure and functional connectivity
    Daria Antonenko
    Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neuroimage 62:1667-74. 2012
    ....
  27. ncbi request reprint Atypical hemispheric dominance for attention: functional MRI topography
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1430, USA
    J Cereb Blood Flow Metab 25:1197-208. 2005
    ..The present findings suggest that not the hemispheric side, but the intrahemispheric pattern of activation is the distinct feature for the neural processes underlying language and attention...
  28. ncbi request reprint Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke
    Friedhelm Hummel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Brain 128:490-9. 2005
    ....
  29. doi request reprint Non-invasive brain stimulation improves object-location learning in the elderly
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurobiol Aging 33:1682-9. 2012
    ..In conclusion, retention of object-location learning in the elderly may be modulated by noninvasive brain stimulation, a finding of potential relevance not only for normal aging but also for memory deficits in pathological aging...
  30. doi request reprint Influence of somatosensory input on interhemispheric interactions in patients with chronic stroke
    Agnes Floel
    Human Cortical Physiology Section and Stroke Neuro rehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20817 1428, USA
    Neurorehabil Neural Repair 22:477-85. 2008
    ..Ischemia-induced cutaneous anesthesia of the healthy hand in patients with chronic stroke elicits transient improvements of motor performance in the contralateral, paretic hand...
  31. ncbi request reprint Levodopa: faster and better word learning in normal humans
    Stefan Knecht
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Ann Neurol 56:20-6. 2004
    ..These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails...
  32. ncbi request reprint Dominance for language and spatial processing: limited capacity of a single hemisphere
    Andreas Jansen
    Department of Neurology, University of Munster, Munster, Germany
    Neuroreport 16:1017-21. 2005
    ..These findings suggest that hemispheric specializations for language and spatial functions interfere to some extent and favour additional recruitment of the opposite hemispheres for spatial functions...
  33. doi request reprint Age affects chunk-based, but not rule-based learning in artificial grammar acquisition
    Julia Kürten
    Department of Neurology, University of Munster, Munster, Germany
    Neurobiol Aging 33:1311-7. 2012
    ..Our findings may explain divergent results on implicit learning tasks in previous studies on aging. They may also help to better understand compensatory mechanisms during the aging process...
  34. pmc Reperfusion does not improve impaired rapid-onset cortical plasticity in patients with severe stenosis of the internal carotid artery
    Jonathan List
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e41004. 2012
    ..Carotid endarterectomy (CEA) in patients with severe ICA stenosis reduces stroke risk, but the impact on cognition or physiology of the respective hemisphere remains controversial...
  35. doi request reprint Enhanced rapid-onset cortical plasticity in CADASIL as a possible mechanism of preserved cognition
    Jonathan List
    Department of Neurology, University Hospital of Munster, 48149 Munster, Germany
    Cereb Cortex 21:2774-87. 2011
    ..ctDCS revealed no evidence of cortical dysplasticity. We conclude that increased rapid-onset cortical plasticity may contribute to largely preserved cognitive and motor function despite extensive ischemic SVD...
  36. ncbi request reprint Language perception activates the hand motor cortex: implications for motor theories of speech perception
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive, Building 10, Bethesda, MD 20892 1430, USA
    Eur J Neurosci 18:704-8. 2003
    ..The amount of motor system activation was comparable in both hemispheres. Our data support the theory that language may have evolved within a general and bilateral action-perception network...
  37. pmc G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Muenster, Germany
    PLoS ONE 6:e17770. 2011
    ..It therefore appears as an attractive and feasible drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). The current pilot study was performed to determine whether treatment with G-CSF in ALS patients is feasible...
  38. doi request reprint Short-term anomia training and electrical brain stimulation
    Agnes Floel
    Charite Universitatsmedizin, Department of Neurology, Center for Stroke Research Berlin and Cluster of Excellence NeuroCure, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 42:2065-7. 2011
    ..Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy...
  39. ncbi request reprint Influence of somatosensory input on motor function in patients with chronic stroke
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 56:206-12. 2004
    ....
  40. doi request reprint Pain is associated with regional grey matter reduction in the general population
    Ruth Ruscheweyh
    Department of Neurology, University of Munster, Munster, Germany
    Pain 152:904-11. 2011
    ..The lack of morphometric anomalies in subjects with past pain supports recent evidence suggesting that pain-related grey matter changes are reversible after cessation of pain...
  41. ncbi request reprint Prefrontal cortex asymmetry for memory encoding of words and abstract shapes
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH, Bethesda, MD 20892-1430, USA
    Cereb Cortex 14:404-9. 2004
    ..These results demonstrate a functionally relevant lateralization of prefrontal contribution for verbal and nonverbal memory encoding...
  42. pmc Granulocyte-colony stimulating factor (G-CSF) in stroke patients with concomitant vascular disease--a randomized controlled trial
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e19767. 2011
    ..G-CSF has been shown in animal models of stroke to promote functional and structural regeneration of the central nervous system. It thus might present a therapy to promote recovery in the chronic stage after stroke...
  43. doi request reprint Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease
    Jonathan List
    Department of Neurology, University Hospital of Munster, Chariteplatz 1, Munster, Germany
    Hum Brain Mapp 34:1464-76. 2013
    ..Enhanced cortical plasticity in subjects with lower white matter integrity in memory-relevant areas might thus indicate a compensatory mechanism to counteract memory decline in severe SVD...
  44. doi request reprint Electrical brain stimulation improves cognitive performance by modulating functional connectivity and task-specific activation
    Marcus Meinzer
    Department of Neurology, Center for Stroke Research Berlin, and Cluster of Excellence NeuroCure, Charite Universitatsmedizin, Berlin 10117, Germany
    J Neurosci 32:1859-66. 2012
    ....
  45. doi request reprint Consensus: Can transcranial direct current stimulation and transcranial magnetic stimulation enhance motor learning and memory formation?
    Janine Reis
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1430, USA
    Brain Stimul 1:363-9. 2008
    ....
  46. ncbi request reprint Translational studies in neurorehabilitation: from bench to bedside
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1430, USA
    Cogn Behav Neurol 19:1-10. 2006
    ..The intent of this review is to describe these strategies, the basic science principles on which they are based, and the clinical applications that have emerged so far...
  47. pmc The influence of spatial registration on detection of cerebral asymmetries using voxel-based statistics of fractional anisotropy images and TBSS
    Siawoosh Mohammadi
    Department of Neurology, University of Munster, Munster, Germany
    PLoS ONE 7:e36851. 2012
    ..Finally, we demonstrated that the "multi-contrast individual-hemisphere" approach showed the least residual spatial misregistrations and thus might be most appropriate for cerebral FA-VBS analyses...
  48. ncbi request reprint Determining the hemispheric dominance of spatial attention: a comparison between fTCD and fMRI
    Andreas Jansen
    Department of Neurology, University of Munster, D 4829 Münster, Germany
    Hum Brain Mapp 23:168-80. 2004
    ..Therefore, scanning large cohorts with fTCD for hemispheric dominance during Landmark task will provide results consistent with fMRI. FMRI can then be used for in depth assessment of the specific patterns of activation...
  49. ncbi request reprint Pharmacological enhancement of motor recovery in subacute and chronic stroke
    Nina Rösser
    Department of Neurology and IZKF Münster, University of Munster, Munster, Germany
    NeuroRehabilitation 23:95-103. 2008
    ..Although preliminary data from animal and human experimental studies on these agents are promising, larger clinical trials are needed before any of the available agents may be recommended for routine use...
  50. doi request reprint Effects of COMT polymorphisms on brain function and behavior in health and disease
    A Veronica Witte
    Department of Neurology, Charite University Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Brain Res Bull 88:418-28. 2012
    ..Future studies should try to disentangle the complex effects of COMT Val158Met on brain functions by taking gender, age, ethnicity, endophenotypes, as well as gene-environment and gene-gene interactions into account...
  51. doi request reprint Differential effects of dual and unihemispheric motor cortex stimulation in older adults
    Robert Lindenberg
    Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite University Medicine, 10117 Berlin, Germany
    J Neurosci 33:9176-83. 2013
    ....
  52. pmc Cortical swallowing processing in early subacute stroke
    Inga K Teismann
    Department of Neurology, University of Muenster, Albert Schweitzer Str, 33, 48149 Muenster, Germany
    BMC Neurol 11:34. 2011
    ..The aim of the present study was to determine the different patterns of cortical swallowing processing in patients with hemispheric and brainstem stroke with and without dysphagia in the early subacute phase...