Fabienne C Fiesel

Summary

Country: Germany

Publications

  1. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
  2. pmc TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Otfried Mueller Str, 27, Tuebingen, 72076, Germany
    Mol Neurodegener 6:64. 2011
  3. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
  4. pmc UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination
    Friederike Hans
    From the Graduate School of Cellular and Molecular Neuroscience, University of Tubingen, Tubingen 72076, Germany, Laboratory of Functional Neurogenetics, Department of Neurodegeneration, German Center for Neurodegenerative Diseases DZNE, Tubingen 72076, Germany, Laboratory of Functional Neurogenetics, Department of Neurodegeneration and
    J Biol Chem 289:19164-79. 2014
  5. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
  6. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm (Vienna) 117:599-604. 2010
  7. pmc TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, 72076 Tubingen, Germany
    Nucleic Acids Res 40:2668-82. 2012
  8. doi request reprint TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration
    Fabienne C Fiesel
    Department of Neurodegeneration, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    FEBS J 278:3550-68. 2011
  9. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010

Collaborators

Detail Information

Publications9

  1. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
    ..In conclusion, loss of functional TDP-43 causes HDAC6 downregulation and might thereby contribute to pathogenesis...
  2. pmc TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Otfried Mueller Str, 27, Tuebingen, 72076, Germany
    Mol Neurodegener 6:64. 2011
    ..abstract:..
  3. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
    ....
  4. pmc UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination
    Friederike Hans
    From the Graduate School of Cellular and Molecular Neuroscience, University of Tubingen, Tubingen 72076, Germany, Laboratory of Functional Neurogenetics, Department of Neurodegeneration, German Center for Neurodegenerative Diseases DZNE, Tubingen 72076, Germany, Laboratory of Functional Neurogenetics, Department of Neurodegeneration and
    J Biol Chem 289:19164-79. 2014
    ..Thus, UBE2E3 and UBPY participate in the regulation of TDP-43 ubiquitination, solubility, and neurodegeneration. ..
  5. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
    ..Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders...
  6. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm (Vienna) 117:599-604. 2010
    ..Thus, PD-associated DJ-1 contributes to regulation of innate immunity...
  7. pmc TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, 72076 Tubingen, Germany
    Nucleic Acids Res 40:2668-82. 2012
    ..This indicates a novel mechanism of deregulated translational control upon TDP-43 deficiency, which might contribute to pathogenesis of the protein aggregation diseases frontotemporal dementia and amyotrophic lateral sclerosis...
  8. doi request reprint TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration
    Fabienne C Fiesel
    Department of Neurodegeneration, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    FEBS J 278:3550-68. 2011
    ..In this minireview the specific functions of TDP-43 and FUS are described and discussed in the context of how TDP-43 and FUS may contribute to the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis...
  9. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010
    ..Thus, our data provide functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease...