Fabienne C Fiesel

Summary

Country: Germany

Publications

  1. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
  2. pmc TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Otfried Mueller Str, 27, Tuebingen, 72076, Germany
    Mol Neurodegener 6:64. 2011
  3. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
  4. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
  5. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm 117:599-604. 2010
  6. pmc TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, 72076 Tubingen, Germany
    Nucleic Acids Res 40:2668-82. 2012
  7. doi request reprint TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration
    Fabienne C Fiesel
    Department of Neurodegeneration, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    FEBS J 278:3550-68. 2011
  8. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010

Collaborators

Detail Information

Publications8

  1. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
    ..In conclusion, loss of functional TDP-43 causes HDAC6 downregulation and might thereby contribute to pathogenesis...
  2. pmc TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Otfried Mueller Str, 27, Tuebingen, 72076, Germany
    Mol Neurodegener 6:64. 2011
    ..abstract:..
  3. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
    ....
  4. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
    ..Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders...
  5. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm 117:599-604. 2010
    ..Thus, PD-associated DJ-1 contributes to regulation of innate immunity...
  6. pmc TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, 72076 Tubingen, Germany
    Nucleic Acids Res 40:2668-82. 2012
    ..This indicates a novel mechanism of deregulated translational control upon TDP-43 deficiency, which might contribute to pathogenesis of the protein aggregation diseases frontotemporal dementia and amyotrophic lateral sclerosis...
  7. doi request reprint TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration
    Fabienne C Fiesel
    Department of Neurodegeneration, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    FEBS J 278:3550-68. 2011
    ..In this minireview the specific functions of TDP-43 and FUS are described and discussed in the context of how TDP-43 and FUS may contribute to the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis...
  8. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010
    ..Thus, our data provide functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease...