M Fendt

Summary

Country: Germany

Publications

  1. ncbi request reprint TMT-induced autonomic and behavioral changes and the neural basis of its processing
    Markus Fendt
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Neurosci Biobehav Rev 29:1145-56. 2005
  2. ncbi request reprint Behavioral changes induced in rats by exposure to trimethylthiazoline, a component of fox odor
    Thomas Endres
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, Tubingen, Germany
    Behav Neurosci 119:1004-10. 2005
  3. ncbi request reprint Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Behav Brain Res 74:127-34. 1996
  4. ncbi request reprint Metabotropic glutamate receptors are involved in amygdaloid plasticity
    Markus Fendt
    Tierphysiologie, Zool Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Eur J Neurosci 15:1535-41. 2002
  5. ncbi request reprint Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle
    Markus Fendt
    Fakultat fur Biologie, Universität corrected Tübingen, Tubingen, Germany
    Behav Neurosci 119:834-8. 2005
  6. ncbi request reprint Brain stem circuits mediating prepulse inhibition of the startle reflex
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Psychopharmacology (Berl) 156:216-24. 2001
  7. ncbi request reprint Noradrenaline transmission within the ventral bed nucleus of the stria terminalis is critical for fear behavior induced by trimethylthiazoline, a component of fox odor
    Markus Fendt
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, D 72076 Tubingen, Germany
    J Neurosci 25:5998-6004. 2005
  8. ncbi request reprint Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe for drug-related motivational states
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Psychopharmacology (Berl) 155:242-50. 2001
  9. ncbi request reprint Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle and freezing
    M Fendt
    Tierphysiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Neurosci 21:4111-5. 2001
  10. ncbi request reprint Expression and conditioned inhibition of fear-potentiated startle after stimulation and blockade of AMPA/Kainate and GABA(A) receptors in the dorsal periaqueductal gray
    M Fendt
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076, Tubingen, Germany
    Brain Res 880:1-10. 2000

Detail Information

Publications38

  1. ncbi request reprint TMT-induced autonomic and behavioral changes and the neural basis of its processing
    Markus Fendt
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Neurosci Biobehav Rev 29:1145-56. 2005
    ..Finally, we compare these studies with those using a natural predator or predator odor to induce fear and discuss the possible use of TMT exposure in rodents as an animal model of unconditioned fear in humans...
  2. ncbi request reprint Behavioral changes induced in rats by exposure to trimethylthiazoline, a component of fox odor
    Thomas Endres
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, Tubingen, Germany
    Behav Neurosci 119:1004-10. 2005
    ..In addition, the authors tested the rats for dose dependency of TMT-induced freezing behavior. The study confirmed that behavioral changes observed during TMT exposure are caused by TMT-induced fear and are dose dependent...
  3. ncbi request reprint Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Behav Brain Res 74:127-34. 1996
    ..The baseline ASR amplitude was not influenced by CG lesions. We discuss possible pathways and mechanisms underlying the expression of conditioned and unconditioned fear in rats...
  4. ncbi request reprint Metabotropic glutamate receptors are involved in amygdaloid plasticity
    Markus Fendt
    Tierphysiologie, Zool Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Eur J Neurosci 15:1535-41. 2002
    ..These experiments show for the first time in vivo and in vitro that mGluR5 receptors are necessary for plasticity in the amygdala...
  5. ncbi request reprint Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle
    Markus Fendt
    Fakultat fur Biologie, Universität corrected Tübingen, Tubingen, Germany
    Behav Neurosci 119:834-8. 2005
    ..These data indicate that without a dorsal hippocampus rats are unable to acquire trace conditioning but can acquire contextual fear when fear is measured by potentiation of the startle response...
  6. ncbi request reprint Brain stem circuits mediating prepulse inhibition of the startle reflex
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Psychopharmacology (Berl) 156:216-24. 2001
    ..Prepulse inhibition (PPI) of the startle reflex occurs when brief, non-startling tactile, acoustic or visual stimuli are presented 20-500 ms before the startling stimulus...
  7. ncbi request reprint Noradrenaline transmission within the ventral bed nucleus of the stria terminalis is critical for fear behavior induced by trimethylthiazoline, a component of fox odor
    Markus Fendt
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, D 72076 Tubingen, Germany
    J Neurosci 25:5998-6004. 2005
    ..The present data clearly show that the noradrenergic innervation of the ventral BNST is important for the full expression of behavioral signs of fear to the predator odor TMT...
  8. ncbi request reprint Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe for drug-related motivational states
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Psychopharmacology (Berl) 155:242-50. 2001
    ..However, existing reports of opiate-related effects on baseline ASR have not validated ASR as a measure of drug-related motivation...
  9. ncbi request reprint Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle and freezing
    M Fendt
    Tierphysiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Neurosci 21:4111-5. 2001
    ..Possible reasons for some discrepant results in earlier studies are also discussed...
  10. ncbi request reprint Expression and conditioned inhibition of fear-potentiated startle after stimulation and blockade of AMPA/Kainate and GABA(A) receptors in the dorsal periaqueductal gray
    M Fendt
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076, Tubingen, Germany
    Brain Res 880:1-10. 2000
    ..The present results together with findings from the literature indicate that glutamate in the dorsal periaqueductal gray is a critical substrate for the expression and modulation of fear-related behaviours...
  11. ncbi request reprint The neuroanatomical and neurochemical basis of conditioned fear
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Neurosci Biobehav Rev 23:743-60. 1999
    ..On the basis of these studies, we describe the pathways mediating and modulating fear. We identify several key unanswered questions and discuss possible implications for the understanding of human anxiety disorders...
  12. ncbi request reprint Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus
    M Fendt
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076, Tubingen, Germany
    Brain Res 833:81-5. 1999
    ..Based on these results we discuss the role of the SC in a hypothetical neuronal circuit mediating PPI of the ASR...
  13. ncbi request reprint Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat
    M Fendt
    Tierphysiologie, Universitat Tubingen, Germany
    Eur J Pharmacol 370:101-7. 1999
    ..These findings lend support to the hypothesis that muscarinic acetylcholine receptors in the caudal pontine reticular nucleus inhibit the acoustic startle response and are involved in the mediation of prepulse inhibition of startle...
  14. ncbi request reprint Different regions of the periaqueductal grey are involved differently in the expression and conditioned inhibition of fear-potentiated startle
    M Fendt
    Universitat Tubingen, Germany
    Eur J Neurosci 10:3876-84. 1998
    ..Based on the present results, the possible pathways underlying the expression and conditioned inhibition of fear-potentiated startle in rats are discussed...
  15. ncbi request reprint Temporary inactivation of the bed nucleus of the stria terminalis but not of the amygdala blocks freezing induced by trimethylthiazoline, a component of fox feces
    Markus Fendt
    Tierphysiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Neurosci 23:23-8. 2003
    ..These results, and other findings in the literature, suggest that the BNST is critically involved in unlearned fear, whereas the amygdala is more involved in the acquisition and expression of learned fear...
  16. ncbi request reprint Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats
    M Koch
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, 72076, Tubingen, Germany
    Behav Brain Res 117:153-62. 2000
    ..We conclude that the SNR exerts a tonic GABAergic inhibition on sensorimotor behavior that is regulated by the dorsal and the ventral striatum...
  17. ncbi request reprint Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine
    B Schulz
    Tierphysiologie, , Germany
    Psychopharmacology (Berl) 156:177-81. 2001
    ..These findings may be relevant for current hypotheses relating schizophrenic symptoms to sensitization...
  18. ncbi request reprint Carbachol injections into the nucleus accumbens disrupt acquisition and expression of fear-potentiated startle and freezing in rats
    I Schwienbacher
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Neuroscience 140:769-78. 2006
    ..Taken together, the present results indicate that acetylcholine within the nucleus accumbens is important for the learning and retrieval of conditioned fear...
  19. doi request reprint Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: implications for schizophrenia
    M Fendt
    Animal Physiology, Zoological Institute, Faculty of Biology, University of Tubingen, Tubingen, Germany
    Pharmacopsychiatry 41:138-45. 2008
    ..The present study investigated the effects of weak chronic neonatal hypoxia in rats on different behavioural animal models of schizophrenia...
  20. ncbi request reprint Effects of clonidine injections into the bed nucleus of the stria terminalis on fear and anxiety behavior in rats
    Judith Schweimer
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Eur J Pharmacol 507:117-24. 2005
    ..Neurosci. 17, 9375-9383.)...
  21. doi request reprint Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear
    Stephanie Siegl
    Animal Physiology, University of Tubingen, Germany
    Neuroreport 19:1147-50. 2008
    ..Our data clearly show that intra-amygdala injection of AMN082 impairs fear acquisition. This finding demonstrates that amygdaloid mGluR7 controls the learning of conditioned fear...
  22. doi request reprint Inactivation of the lateral septum blocks fox odor-induced fear behavior
    Thomas Endres
    Animal Physiology, Zoological Institute, Faculty of Biology, University of Tubingen, Germany
    Neuroreport 19:667-70. 2008
    ..This indicates that the lateral septum is important for the processing of TMT-induced fear and suggests that the lateral septum is also involved in fear behavior induced by natural predator odors...
  23. ncbi request reprint Are rats predisposed to learn 22 kHz calls as danger-predicting signals?
    Thomas Endres
    Animal Physiology, University of Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Behav Brain Res 185:69-75. 2007
    ..In particular, our data indicate that better encoding of such learning in rats leads to a stable memory which better resists extinction...
  24. ncbi request reprint Conditioned behavioral responses to a context paired with the predator odor trimethylthiazoline
    Thomas Endres
    Tierphysiologie, Zoologisches Institut, Fakultat fur Biologie, Universitat Tubingen, Tubingen, Germany
    Behav Neurosci 121:594-601. 2007
    ..These results indicate that expression of conditioned fear behavior in response to a TMT-paired context is dependent on the experimental setup used, as well as the strategy of the individual rat...
  25. ncbi request reprint Exposure to urine of canids and felids, but not of herbivores, induces defensive behavior in laboratory rats
    Markus Fendt
    Tierphysiologie, Zoologisches Institut, Fakultat fur Biologie, Universitat Tubingen, Auf der Morgenstelle 28, 72076, Tubingen, Germany
    J Chem Ecol 32:2617-27. 2006
    ..Taken together, the study provides support for the hypothesis that there is an innate recognition of predator odors in laboratory rats...
  26. ncbi request reprint Prefrontal dopamine D4 receptors are involved in encoding fear extinction
    Ulrich J Pfeiffer
    Graduate School of Neural and Behavioural Sciences, International Max Planck Research School, University of Tubingen, Tubingen, Germany
    Neuroreport 17:847-50. 2006
    ..These results suggest that medial prefrontal cortex dopamine D4 receptors are involved in the consolidation of fear extinction memory...
  27. ncbi request reprint Clonidine injections into the lateral nucleus of the amygdala block acquisition and expression of fear-potentiated startle
    Brigitte Schulz
    Department of Animal Physiology, University of Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Eur J Neurosci 15:151-7. 2002
    ..Surprisingly, both the acquisition and the expression of conditioned fear were blocked after amygdaloid injections of clonidine, suggesting that amygdaloid noradrenaline is necessary to induce both unconditioned and conditioned fear...
  28. ncbi request reprint Detecting danger--or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammals
    Matthias Laska
    Department of Medical Psychology, University of Munich Medical School, Goethestr 31, D 80336 Munich, Germany
    Physiol Behav 84:211-5. 2005
    ..Thus, these results support the assumption that the behavioral relevance of an odorant may be an important determinant of a species' olfactory sensitivity...
  29. ncbi request reprint Temporary inactivation of the medial and basolateral amygdala differentially affects TMT-induced fear behavior in rats
    Martin Muller
    Graduate School of Neural and Behavioural Sciences, International Max Planck Research School, University of Tubingen, Tubingen, Germany
    Behav Brain Res 167:57-62. 2006
    ..Since the medial amygdala is also involved in the processing of cat odor-induced fear, the finding of the present study points towards a general role of the medial amygdala in the processing of predator odor-induced fear...
  30. ncbi request reprint Effects of the mGluR8 agonist (S)-3,4-DCPG in the lateral amygdala on acquisition/expression of fear-potentiated startle, synaptic transmission, and plasticity
    Susanne Schmid
    Tierphysiologie, Zool Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Neuropharmacology 50:154-64. 2006
    ....
  31. ncbi request reprint Amphetamine injections into the nucleus accumbens affect neither acquisition/expression of conditioned fear nor baseline startle response
    Isabel Schwienbacher
    Tierphysiologie, Zoologisches Institut, Fakultat fur Biologie, Universitat Tubingen, Auf der Morgenstelle 28, 72076, Tubingen, Germany
    Exp Brain Res 160:538-44. 2005
    ..These results suggest that dopamine within the NAC is not involved in modulation of fear-potentiated startle and baseline startle...
  32. ncbi request reprint Temporary inactivation of the rostral perirhinal cortex induces an anxiolytic-like effect on the elevated plus-maze and on the yohimbine-enhanced startle response
    Brigitte Schulz-Klaus
    Tierphysiologie, Zoologisches Institut, Universitat Tubingen, Germany
    Behav Brain Res 163:168-73. 2005
    ..Taken together, these data clearly show that the rostral perirhinal cortex is involved in the processing of emotional stimuli and is critical for the expression of unconditioned fear (anxiety)...
  33. ncbi request reprint Temporary inactivation of the perirhinal cortex by muscimol injections block acquisition and expression of fear-potentiated startle
    Brigitte Schulz
    Animal Physiology, University of Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Eur J Neurosci 19:713-20. 2004
    ..Taken together, the present data show that the PRh is critical for the processing of aversive information and is necessary for the expression of emotional learning...
  34. ncbi request reprint Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats
    Mehret Yerdaw Banjaw
    Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Germany
    Behav Brain Res 160:365-73. 2005
    ..edulis extract, or commercial cathinone, induces prepulse inhibition deficit and clozapine reverses both C. edulis or cathinone-induced sensitised locomotion and prepulse inhibition deficit...
  35. ncbi request reprint Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats
    Isabel Schwienbacher
    Animal Physiology, University of Tuebingen, Auf der Morgenstelle 28, D 72076 Tuebingen, Germany
    Brain Res 1027:87-93. 2004
    ..Taken together, these results show that the NAC is crucial for acquisition and expression of long-term conditioned fear, as measured by fear-potentiated startle, to discrete CSs, but not short-term conditioned fear to a context...
  36. ncbi request reprint Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice
    Daniela Mohr
    Animal Physiology, University of Tubingen, Auf der Morgenstelle Tübingen, Germany
    Neuroreport 18:1493-7. 2007
    ..These results stand in contrast to data after systemic injections in mice and rats and intra-accumbal infusions in rats, suggesting that the role of dopamine D2 receptors within the NAC in mice differs from their role in rats...
  37. ncbi request reprint Dopamine D1 receptors and adenosine A1 receptors in the rat nucleus accumbens regulate motor activity but not prepulse inhibition
    Isabel Schwienbacher
    Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, Germany
    Eur J Pharmacol 444:161-9. 2002
    ....
  38. ncbi request reprint Carbachol injections into the nucleus accumbens induce 50 kHz calls in rats
    Markus Fendt
    Tierphysiologie, Zoologisches Institut, Fakultat fur Biologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Neurosci Lett 401:10-5. 2006
    ..We hypothesize that acetylcholine transmission within the NAC plays an important role in the induction of those ultrasonic calls indicating an appetitive state...