Genomes and Genes


F Fend


Country: Germany


  1. Nann D, Schneckenburger P, Steinhilber J, Metzler G, Beschorner R, Schwarze C, et al. Pediatric Langerhans cell histiocytosis: the impact of mutational profile on clinical progression and late sequelae. Ann Hematol. 2019;: pubmed publisher
    ..Infants below 2 years more frequently had BRAFV600 mutations (p = 0.013). Despite favorable prognosis, pediatric LCH shows a high frequency of relapses and long-term medical sequelae. ..
  2. Fend F, Quintanilla Martinez L. [Clonal evolution of early lymphoproliferations]. Pathologe. 2018;39:247-249 pubmed publisher
  3. Federmann B, Abele M, Rosero Cuesta D, Vogel W, Boiocchi L, Kanz L, et al. The detection of SRSF2 mutations in routinely processed bone marrow biopsies is useful in the diagnosis of chronic myelomonocytic leukemia. Hum Pathol. 2014;45:2471-9 pubmed publisher
    ..The role of SRSF2 mutations in cases with hybrid features between primary myelofibrosis and CMML needs further investigation. ..
  4. Montes Mojarro I, Steinhilber J, Bonzheim I, Quintanilla Martinez L, Fend F. The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL). Cancers (Basel). 2018;10: pubmed publisher
    ..In this review, we will focus on the morphological, immunophenotypical, and molecular features of systemic ALK+ and ALK− ALCL. In addition, BI-ALCL will be discussed. ..
  5. Bösmüller H, Pfefferle V, Bittar Z, Scheble V, Horger M, Sipos B, et al. Microvessel density and angiogenesis in primary hepatic malignancies: Differential expression of CD31 and VEGFR-2 in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Pathol Res Pract. 2018;214:1136-1141 pubmed publisher
    ..Whether these differences can be exploited for improvements in imaging of hepatic tumors and may play a role for anti-angiogenic treatment strategies requires further studies. ..
  6. Federmann B, Mueller M, Steinhilber J, Horger M, Fend F. Diagnosis of Richter transformation in chronic lymphocytic leukemia: histology tips the scales. Ann Hematol. 2018;97:1859-1868 pubmed publisher
    ..In conclusion, our findings confirm the central role of tissue biopsy in the diagnostic work up in case of clinically suspected RT. ..
  7. Dojcinov S, Fend F, Quintanilla Martinez L. EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts. Pathogens. 2018;7: pubmed publisher
    ..The current knowledge regarding the pathogenesis of B-cell lymphomas that can be EBV-associated including Burkitt lymphoma, plasmablastic lymphoma and classic Hodgkin lymphoma will be also explored. ..
  8. Haen S, Stroebel P, Marx A, Suesskind D, Fend F, Reichmann U, et al. Choroidal metastases from thymic carcinoma during pregnancy: Case Report. BMC Cancer. 2015;15:972 pubmed publisher
    ..Choroidal metastases from a thymic carcinoma have never been reported before but should be included into the differential diagnosis of choroidal masses. ..
  9. Federmann B, Bonzheim I, Yazdi A, Schmidt J, Fend F, Metzler G. Generalized palisaded neutrophilic and granulomatous dermatitis-a cutaneous manifestation of chronic myelomonocytic leukemia? A clinical, histopathological, and molecular study of 3 cases. Hum Pathol. 2017;64:198-206 pubmed publisher

More Information


  1. Rimsza L, Pittaluga S, Dirnhofer S, Copie Bergman C, de Leval L, Facchetti F, et al. The clinicopathologic spectrum of mature aggressive B cell lymphomas. Virchows Arch. 2017;471:453-466 pubmed publisher
  2. Fend F, Süsskind D, Deuter C, Coupland S. [Malignant lymphomas of the eye]. Pathologe. 2017;38:515-520 pubmed publisher
    ..Novel techniques such as detection of MYD88 mutations common in PVRL can increase diagnostic sensitivity. Close cooperation with clinical colleagues and rapid specimen processing are fundamental for successful diagnosis...
  3. Lengerke C, Fehm T, Kurth R, Neubauer H, Scheble V, Müller F, et al. Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. BMC Cancer. 2011;11:42 pubmed publisher
    ..Our data suggest that SOX2 plays an early role in breast carcinogenesis and high expression may promote metastatic potential. Further studies are needed to explore whether SOX2 can predict metastatic potential at an early tumor stage. ..
  4. Braun M, Menon R, Nikolov P, Kirsten R, Petersen K, Schilling D, et al. The HOPE fixation technique--a promising alternative to common prostate cancer biobanking approaches. BMC Cancer. 2011;11:511 pubmed publisher
    ..Aim of the study was to compare HOPE-fixed, FFPE and fresh-frozen bio-specimens for their accessibility for diagnostic and research purposes...