Tanja Fehm

Summary

Country: Germany

Publications

  1. doi request reprint Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial
    Malgorzata Banys
    Department of Gynecology and Obstetrics, Heinrich Heine University of Dusseldorf, Moorenstr, 5, 40225, Dusseldorf, Germany
    BMC Cancer 13:480. 2013
  2. pmc Selective microdochectomy after ductoscopic wire marking in women with pathological nipple discharge
    M Hahn
    Department of Obstetrics and Gynaecology, University Hospital Tuebingen, Tuebingen, Germany
    BMC Cancer 9:151. 2009
  3. ncbi request reprint Changes of serum HER2 status during clinical course of metastatic breast cancer patients
    T Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
    Anticancer Res 24:4205-10. 2004
  4. pmc Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
    Breast Cancer Res 8:R60. 2006
  5. pmc Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse, D 72076 Tuebingen, Germany
    Breast Cancer Res 9:R74. 2007
  6. doi request reprint Bisphosphonate-induced osteonecrosis of the jaw (ONJ): Incidence and risk factors in patients with breast cancer and gynecological malignancies
    T Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Gynecol Oncol 112:605-9. 2009
  7. pmc ERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patients
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Germany
    Breast Cancer Res 10:R76. 2008
  8. ncbi request reprint Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer patients
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Erlangen Nuremberg, Erlangen, Germany
    Breast Cancer Res Treat 75:97-106. 2002
  9. doi request reprint Tumor cell dormancy: implications for the biology and treatment of breast cancer
    T Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    APMIS 116:742-53. 2008
  10. pmc Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    Tanja Fehm
    Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
    Breast Cancer Res 11:R59. 2009

Collaborators

Detail Information

Publications85

  1. doi request reprint Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial
    Malgorzata Banys
    Department of Gynecology and Obstetrics, Heinrich Heine University of Dusseldorf, Moorenstr, 5, 40225, Dusseldorf, Germany
    BMC Cancer 13:480. 2013
    ..This controlled randomized open-label multi-center study aimed to investigate the influence of zoledronic acid (ZOL) on DTC and survival of breast cancer patients (Clinical Trial Registration Number: NCT00172068)...
  2. pmc Selective microdochectomy after ductoscopic wire marking in women with pathological nipple discharge
    M Hahn
    Department of Obstetrics and Gynaecology, University Hospital Tuebingen, Tuebingen, Germany
    BMC Cancer 9:151. 2009
    ..To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge...
  3. ncbi request reprint Changes of serum HER2 status during clinical course of metastatic breast cancer patients
    T Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
    Anticancer Res 24:4205-10. 2004
    ....
  4. pmc Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
    Breast Cancer Res 8:R60. 2006
    ..The aim of this study was to investigate the incidence of disseminated tumor cells (DTC), including apoptotic DTC, in breast cancer patients after NST, and to investigate the correlation of DTC status with therapy response...
  5. pmc Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse, D 72076 Tuebingen, Germany
    Breast Cancer Res 9:R74. 2007
    ..The aim of this study was therefore to determine the HER2 status in serum and corresponding CTCs in patients with metastatic breast cancer whose primary tumors were HER2 negative or of unknown HER2 status...
  6. doi request reprint Bisphosphonate-induced osteonecrosis of the jaw (ONJ): Incidence and risk factors in patients with breast cancer and gynecological malignancies
    T Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Gynecol Oncol 112:605-9. 2009
    ..The aim of this study was to describe the incidence and risk factors of ONJ in patients with breast cancer or gynecological malignancies receiving bisphosphonates (BP)...
  7. pmc ERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patients
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Germany
    Breast Cancer Res 10:R76. 2008
    ..Of particular interest is their oestrogen-receptor (ER) status because endocrine adjuvant therapy remains a cornerstone of breast cancer treatment...
  8. ncbi request reprint Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer patients
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Erlangen Nuremberg, Erlangen, Germany
    Breast Cancer Res Treat 75:97-106. 2002
    ..The serum profiles of c-erbB-2 and CA 15-3 were similar in 17 patients. In summary, our results suggest that serial determinations of serum c-erbB-2 are useful to monitor breast cancer patients...
  9. doi request reprint Tumor cell dormancy: implications for the biology and treatment of breast cancer
    T Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    APMIS 116:742-53. 2008
    ..In this review, we summarize findings on different factors for tumor cell dormancy and potential therapeutic implications that should help to reduce metastatic relapse in cancer patients...
  10. pmc Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    Tanja Fehm
    Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
    Breast Cancer Res 11:R59. 2009
    ....
  11. ncbi request reprint Evaluation of ERalpha, PR and ERbeta isoforms in neoadjuvant treated breast cancer
    Martin Wurster
    Department of Obstetrics and Gynecology, University of Tuebingen, D 72076 Tuebingen, Germany
    Oncol Rep 24:653-9. 2010
    ..047). Results on ERalpha and PR corroborate findings of previous studies. Our data demonstrate that changes of ERbeta expression occur during PST and that total ERbeta expression and ERbeta2 may have a predictive value for PST...
  12. ncbi request reprint HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor
    Natalia Krawczyk
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Anticancer Res 29:4019-24. 2009
    ..The aim of this study was to assess HER2 status of persistent DTCs to determine whether the use of HER2-targeted agents might be a therapeutic option in patients with tumor cell persistence...
  13. doi request reprint Bone marrow versus sentinel lymph node involvement in breast cancer: a comparison of early hematogenous and early lymphatic tumor spread
    Andreas D Hartkopf
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
    Breast Cancer Res Treat 131:501-8. 2012
    ..Conversely, a high correlation between nodal status and tumor size, histology, ER-status and lymph vessel invasion was found. Hematogenous and lymphatic tumor spread seem to be because of independent pathways of cancer progression...
  14. doi request reprint Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast
    Malgorzata Banys
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076, Tuebingen, Germany
    Breast Cancer Res Treat 131:801-8. 2012
    ..The clinical relevance of these cells has to be further evaluated...
  15. doi request reprint Pooled analysis of the prognostic relevance of disseminated tumor cells in the bone marrow of patients with ovarian cancer
    Tanja Fehm
    Department of Gynecology and Obstetrics, University Hospital Dusseldorf, University of Dusseldorf, Germany
    Int J Gynecol Cancer 23:839-45. 2013
    ..Recent studies demonstrated that DTCs may serve as a prognostic factor in ovarian cancer. The aim of this 3-center study was to evaluate the impact of BM status on survival in a large cohort of patients with ovarian cancer...
  16. doi request reprint Overexpression of progesterone receptor membrane component 1: possible mechanism for increased breast cancer risk with norethisterone in hormone therapy
    Hans Neubauer
    University Women s Hospital, Tuebingen, Germany
    Menopause 20:504-10. 2013
    ..The same combination was used for the first time in a mouse xenograft model to determine its effects on tumor development...
  17. doi request reprint Disseminated tumor cells in bone marrow may affect prognosis of patients with gynecologic malignancies
    Malgorzata Banys
    Department of Obstetrics and Gynecology, University of Tuebingen, University of Tuebingen, Liebermeisterstrasse 8, Tuebingen, Germany
    Int J Gynecol Cancer 19:948-52. 2009
    ..The aim of our study was to evaluate the incidence of DTC and to assess their prognostic significance in patients with gynecologic malignancies...
  18. pmc Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1
    Hans Neubauer
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse, Germany
    Breast Cancer Res 10:R85. 2008
    ..Breast tumors lacking the estrogen receptor-alpha (ER-alpha) have increased incidence of resistance to therapy and poorer clinical prognosis...
  19. doi request reprint Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis
    Wolfgang Janni
    Frauenklinik der Heinrich Heine Universität, Dusseldorf, Germany
    Clin Cancer Res 17:2967-76. 2011
    ..In view of the lack of early indicators for secondary adjuvant treatment, we here evaluated whether the persistence of DTCs after adjuvant therapy increases the risk of subsequent relapse and death...
  20. ncbi request reprint Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors in ovarian cancer and its correlation to human chorionic gonadotropin-doxorubicin sensitivity
    Gerhard Gebauer
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Am J Obstet Gynecol 190:1621-8; discussion 1628. 2004
    ..Ovarian cancer cell lines and tissues express gonadotropin receptors. Conjugation of cytostatics to ligands of these receptors may increase the specificity of cytotoxic drugs...
  21. ncbi request reprint Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapy
    Sven Becker
    Department of Gynecology and Obstetrics, University Hospital Tubingen, Tubingen, Germany
    Breast Cancer Res Treat 97:91-6. 2006
    ..020). Adjuvant treatment regimens are not able to completely eliminate cytokeratin-positive cells from the bone marrow. Prospective studies need to evaluate, whether these cells could become targets for additional adjuvant therapy...
  22. pmc Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
    Claudia Lengerke
    University of Tuebingen Medical Center II, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    BMC Cancer 11:42. 2011
    ..In breast cancer, SOX2 expression was reported as a feature of basal-like tumors. In this study, we assessed SOX2 expression in 95 primary tumors of postmenopausal breast cancer patients...
  23. ncbi request reprint Primary systemic therapy does not eradicate disseminated tumor cells in breast cancer patients
    Sven Becker
    Department of Gynecology and Obstetrics, Tubingen University Hospital, Calwerstr 7, 72076 Tubingen, Germany
    Breast Cancer Res Treat 106:239-43. 2007
    ..The aim of this study was to investigate the status of tumor cell dissemination after primary systemic therapy in relation to therapy response...
  24. ncbi request reprint Her2 expression on disseminated tumor cells from bone marrow of breast cancer patients
    Sven Becker
    Tubingen University Hospital, Department of Gynecology and Obstetrics, Germany
    Anticancer Res 25:2171-5. 2005
    ..We studied the her2 expression in the BM of 105 patients with CK-positive cells present and compared it with results from the primary tumor...
  25. doi request reprint SOX2 expression associates with stem cell state in human ovarian carcinoma
    Petra M Bareiss
    Departments of Internal Medicine II and Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tuebingen, Tuebingen, Germany
    Cancer Res 73:5544-55. 2013
    ..We propose the existence of SOX2-expressing ovarian CSCs as a mechanism of tumor aggressiveness and therapy resistance in human SOC...
  26. ncbi request reprint [Detection of disseminated tumor cells in the bone marrow of breast cancer patients with a new molecular method]
    Małgorzata Banyś
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    Ginekol Pol 83:590-7. 2012
    ..Assays based on RT-PCR are available; however so far they have not been used for routine detection of DTC. Therefore, the purpose of this study was to evaluate a newly established molecular method for the detection of DTC...
  27. pmc Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tubingen, Calwerstr 7 6, 72076, Tubingen, Germany
    BMC Cancer 12:308. 2012
    ..The purpose of this study was to compare the antitumor effect of Zol with standard chemotherapy in primary breast cancer cells using ATP-tumor chemosensitivity assay (ATP-TCA)...
  28. doi request reprint The influence of removal of primary tumor on incidence and phenotype of circulating tumor cells in primary breast cancer
    Malgorzata Banys
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Breast Cancer Res Treat 132:121-9. 2012
    ..Surgery does not significantly influence the tumor cell load in the blood stream. CTC phenotype before and after the surgery generally remains identical but may differ from that of the primary tumor...
  29. doi request reprint Evaluation of a RT-PCR based routine screening tool for the detection of disseminated epithelial cells in the bone marrow of breast cancer patients
    Sven Becker
    Department of Gynaecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Breast Cancer Res Treat 117:227-33. 2009
    ..Immunocytochemistry (ICC) remains the gold standard for their detection. While assays based on RT-PCR are available, they have not been used for routine detection of DTC's...
  30. ncbi request reprint Prediction of axillary lymph node status of breast cancer patients by tumorbiological factors of the primary tumor
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, Germany
    Strahlenther Onkol 181:580-6. 2005
    ....
  31. ncbi request reprint Prognostic significance of serum HER2 and CA 15-3 at the time of diagnosis of metastatic breast cancer
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, D 72076 Tuebingen, Germany
    Anticancer Res 24:1987-92. 2004
    ....
  32. pmc Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    Bahriye Aktas
    Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Breast Cancer Res 11:R46. 2009
    ....
  33. pmc Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells
    Sabine Kasimir-Bauer
    Department of Gynecology and Obstetrics, University Hospital of Essen, University of Duisburg Essen, D 45122 Essen, Germany
    Breast Cancer Res 14:R15. 2012
    ..Data were correlated with the presence of disseminated tumor cells (DTC) in the bone marrow (BM) and with clinicopathological data of the patients...
  34. doi request reprint Fertility conservation in breast cancer patients
    Barbara Lawrenz
    Department of Obstetrics and Gynaecology, University Hospital for Women, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Womens Health (Lond Engl) 7:203-12. 2011
    ..Early counseling on fertility-preserving strategies is of utmost importance, so that the fertility-preserving method can be integrated into the oncologic therapy regime...
  35. doi request reprint Comparison of estrogen and progesterone receptor status of circulating tumor cells and the primary tumor in metastatic breast cancer patients
    Bahriye Aktas
    Department of Gynecology and Obstetrics, University of Essen, Hufelandstrase 55, 45122 Essen, Germany
    Gynecol Oncol 122:356-60. 2011
    ..It was the purpose of the present study (1) to reevaluate the ER/PR expression by CTCs and (2) to compare the hormone receptor status expression profile of CTCs with the primary tumor...
  36. doi request reprint Prevalence and prognostic value of disseminated tumor cells in primary endometrial, cervical and vulvar cancer patients
    Christina Barbara Walter
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
    Future Oncol 10:41-8. 2014
    ..Disseminated tumor cell (DTC) detection in bone marrow (BM) of primary breast cancer patients predicts poor prognosis. This study investigates the prevalence of DTCs and their prognostic significance in primary gynecologic malignancies...
  37. ncbi request reprint Symptomatic bone marrow involvement in breast cancer--clinical presentation, treatment, and prognosis: a single institution review of 22 cases
    Hans Georg Kopp
    Department of Hematology Oncology, Eberhard Karls University, Otfried Mueller Str 10, D 72076 Tuebingen, Germany
    Anticancer Res 31:4025-30. 2011
    ..The objective of this study was to provide our institution's experience with the clinical presentation, prognosis, treatment, and associated complications of marrow involvement in breast cancer...
  38. ncbi request reprint Influence of platinum-based chemotherapy on disseminated tumor cells in blood and bone marrow of patients with ovarian cancer
    Pauline Wimberger
    Department of Gynecology and Obstetrics, University of Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Gynecol Oncol 107:331-8. 2007
    ....
  39. ncbi request reprint Image analysis systems for the detection of disseminated breast cancer cells on bone-marrow cytospins
    Sven Becker
    Department of Gynecology and Obstetrics, University of Tubingen, Germany
    J Clin Lab Anal 19:115-9. 2005
    ..Using ACIS, we were able to determine the bone marrow status of patients with nonmetastatic breast cancer faster, with greater accuracy, and with greater reproducibility than with the manual technique...
  40. ncbi request reprint Predicting resistance to platinum-containing chemotherapy with the ATP tumor chemosensitivity assay in primary ovarian cancer
    Hans Neubauer
    Department of Obstetrics and Gynecology, University of Tuebingen, 72076 Tuebingen, Germany
    Anticancer Res 28:949-55. 2008
    ..Our purpose was to define the optimal calculation method for the adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA) applied to PEOC treated with platinum-containing chemotherapy and to analyze its predictive relevance...
  41. doi request reprint HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial
    Tanja Fehm
    Department of Gynecology and Obstetrics, University of Tubingen, Calwer Strasse 7, 72076, Tubingen, Germany
    Breast Cancer Res Treat 124:403-12. 2010
    ..Therefore, it will be mandatory to correlate the assay-dependent HER2 status of CTCs to the clinical response on HER2-targeted therapies...
  42. ncbi request reprint Number of hysteroscopies and the time interval between hysteroscopy and surgery: influence on peritoneal cytology in patients with endometrial cancer
    Ingolf Juhasz-Böss
    Department of Obstetrics and Gynecology, University of Saarland, Kirrbergerstr 100, 66424 Homburg Saar, Germany
    Anticancer Res 30:2425-30. 2010
    ..As yet, no data are available showing whether the time interval between hysteroscopy and definitive surgery, or the number of preoperative hysteroscopies, have an influence on the intraperitoneal cytology results...
  43. ncbi request reprint Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis
    Christina S Schuetz
    Department of Obstetrics and Gynecology, Microarray Facility, Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Cancer Res 66:5278-86. 2006
    ....
  44. doi request reprint Pregnancy after breast cancer: case report and review of the literature
    Barbara Lawrenz
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Arch Gynecol Obstet 283:837-43. 2011
    ..The question whether to become pregnant must be discussed individually with the patient, based on tumor characteristics, stage of the disease and patient's wishes...
  45. ncbi request reprint A laminin-rich basement membrane matrix influences estrogen receptor beta expression and morphology of MDA-MB-231 breast cancer cells
    Hans Neubauer
    Department of Obstetrics and Gynaecology, University of Tuebingen, 72076 Tuebingen, Germany
    Oncol Rep 21:475-81. 2009
    ..A laminin-111-rich microenvironment seems to keep ERbeta1 at very low levels in breast cancer cells...
  46. doi request reprint Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells
    Tatjana Kaiser
    Department of Gynecology and Obstetrics, University of Tubingen, Calwerstrasse 7, Tubingen, Germany
    Breast Cancer Res Treat 140:35-48. 2013
    ..Changing the osteoblast metabolism by BPs modulates migration and adhesion of breast cancer cells as well. ..
  47. doi request reprint Circulating tumor cells in breast cancer
    Malgorzata Banys
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    Clin Chim Acta 423:39-45. 2013
    ..Evaluation of CTCs might be useful for therapy monitoring and their characterization might help to identify novel targets for biological therapies aimed at disrupting earliest steps of metastatic cascade...
  48. ncbi request reprint Evaluation of CA125, physical and radiological findings in follow-up of ovarian cancer patients
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tuebingen, D 72076 Tuebingen, Germany
    Anticancer Res 25:1551-4. 2005
    ..Imaging techniques did not add clinically relevant information during follow-up and should therefore only be performed prior to surgical or therapeutical intervention...
  49. ncbi request reprint Relationship between circulating tumor cells and peripheral T-cells in patients with primary breast cancer
    Ines Gruber
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwer Straße 7, 72076 Tuebingen, Germany
    Anticancer Res 33:2233-8. 2013
    ..Recent studies have found evidence for immunological influence on tumor cell dormancy. We therefore investigated the relationship between peripheral T-cells and CTCs, as immunological factors may contribute to the fate of CTCs...
  50. doi request reprint Pregnancy after successful cancer treatment: what needs to be considered?
    Barbara Lawrenz
    University Women s Hospital, Tuebingen, Tuebingen, Germany
    Onkologie 35:128-32. 2012
    ..The effect is more pronounced after prepubertal radiation than for postpubertal radiation. The former cancer patient's desire to conceive can nevertheless be supported, given that pregnancy and birth are closely monitored...
  51. doi request reprint Clinical implications of the detection of circulating tumor cells in breast cancer patients
    Malgorzata Banys
    Department of Obstetrics and Gynecology, University of Tuebingen, Germany
    Biomark Med 6:109-18. 2012
    ..The evaluation of circulating tumor cells may become one of the crucial markers for prediction of survival and therapy monitoring, and its characterization might enable specific targeting of minimal residual, and metastatic disease...
  52. doi request reprint Optimal treatment for patients with ectopic pregnancies and a history of fertility-reducing factors
    Sven Becker
    Women s University Hospital, Tubingen University, Calwerstrasse 7, Tubingen, Germany
    Arch Gynecol Obstet 283:41-5. 2011
    ..The aim of this study was to evaluate long-term reproductive outcome after salpingotomy versus salpingectomy in patients with and without additional fertility-reducing factors...
  53. ncbi request reprint A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tubingen, Tubingen, Germany
    Cancer 107:885-92. 2006
    ....
  54. doi request reprint ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof
    Sarah Schott
    Medical School, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, 69115, Germany
    Invest New Drugs 29:506-13. 2011
    ....
  55. ncbi request reprint Abnormal cytology during pregnancy--a retrospective analysis of patients in a dysplasia clinic
    Melanie Henes
    Tuebingen University Hospital for Women, Calwerstr 7, D 72076 Tuebingen, Germany
    Anticancer Res 33:711-5. 2013
    ..Often there is need to advise pregnant women with an abnormal cervical cytology result and monitor them throughout pregnancy, without endangering the mother or child...
  56. ncbi request reprint Changing levels of circulating tumor cells in monitoring chemotherapy response in patients with metastatic breast cancer
    Andreas D Hartkopf
    Department of Obstetrics and Gynaecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
    Anticancer Res 31:979-84. 2011
    ..The aim of this study was to investigate whether changing CTC levels during the course of chemotherapy treatment would also be useful in monitoring response to treatment...
  57. doi request reprint The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells
    Hans Neubauer
    University Women s Hospital, Tuebingen, Germany
    Menopause 18:845-50. 2011
    ..The aim of this project was to investigate the influence of different estradiol (E2) concentrations and the addition of two progestogens on MCF-7 breast cancer cells overexpressing PGRMC1...
  58. pmc Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
    Tanja Fehm
    Department of Gynecology and Obstetrics, University Tübingen, Tubingen, Germany
    Breast Cancer Res 10:S1. 2008
    ..In addition, understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts...
  59. doi request reprint Presence of disseminated tumor cells in bone marrow correlates with tumor stage and nodal involvement in cervical cancer patients
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Duesseldorf, Duesseldorf, Germany
    Int J Cancer 134:925-31. 2014
    ..Tumor cell dissemination into BM is thus a common phenomenon in cervical cancer and correlates with higher tumor load but lacks prognostic relevance. Alternative detection methods may be needed to establish prognostic potential. ..
  60. pmc The PACOVAR-trial: a phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer
    Michael Eichbaum
    University of Heidelberg Medical School, Department of Gynecology and Obstetrics, Voss Str, 9, 69115 Heidelberg, Germany
    BMC Cancer 11:453. 2011
    ..A combined therapy consisting of pazopanib and metronomic oral cyclophosphamide may offer a well-tolerable treatment option to patients with recurrent, pretreated EOC...
  61. doi request reprint Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients
    Helen Schneck
    Department of Obstetrics and Gynecology, Eberhard Karls University of Tuebingen, Calwerstr 7, 72076 Tuebingen, Germany Electronic address
    Mol Oncol 7:976-86. 2013
    ....
  62. doi request reprint HER2-positive DTCs/CTCs in breast cancer
    Andreas D Hartkopf
    Department of Obstetrics and Gynecology, University of Tuebingen, Calwer Strasse 7, 72076, Tuebingen, Germany
    Recent Results Cancer Res 195:203-15. 2012
    ..Phenotyping of CTCs/DTCs will thus help to understand mechanism of resistance to HER2-directed therapy. Moreover, patients that are likely to benefit from HER2-directed therapy despite a HER2-negative primary tumor might be identified. ..
  63. doi request reprint Influence of pregnancy on bone density: a risk factor for osteoporosis? Measurements of the calcaneus by ultrasonometry
    Bernhard Kraemer
    University Hospital for Women, University of Tuebingen, Calwerstr 7, 72076 Tuebingen, Germany
    Arch Gynecol Obstet 285:907-12. 2012
    ..The study aim was to investigate whether there is a significant alteration in maternal bone density during normal pregnancy...
  64. doi request reprint Fertility preservation in young female lymphoma patients: review of available options and initial experiences with their implementation in clinical routine
    Barbara Lawrenz
    University Women s Hospital, University Hospital Tuebingen, Calwerstrasse 7, Tuebingen, Germany
    Onkologie 34:88-93. 2011
    ..Available options are reviewed...
  65. ncbi request reprint Micrometastases in axillary lymph nodes and bone marrow of lymph node-negative breast cancer patients--prognostic relevance after 10 years
    Gerhard Gebauer
    Department of Obstetrics and Gynecology, Hannover Medical School, Podbielskistrasse 380, D 30659 Hannover, Germany
    Anticancer Res 23:4319-24. 2003
    ....
  66. doi request reprint Oncolytic virotherapy of breast cancer
    Andreas D Hartkopf
    Department of Obstetrics and Gynecology, University Clinic of Tuebingen, Tuebingen, Germany
    Gynecol Oncol 123:164-71. 2011
    ....
  67. ncbi request reprint Meconium-stained amniotic fluid--perinatal outcome and obstetrical management in a low-risk suburban population
    Sven Becker
    Universitätsfrauenklinik Tübingen, Tübingen University Medical Center, Calwerstrasse 7, 72076 Tubingen, Germany
    Eur J Obstet Gynecol Reprod Biol 132:46-50. 2007
    ..To determine whether amniotic fluid (MSAF) affects obstetrical interventions and immediate perinatal outcome in a low-risk suburban population...
  68. doi request reprint SOX2 expression and prognostic significance in ovarian carcinoma
    Deborah L Pham
    Institute of Pathology, University of Tuebingen, Tuebingen, Germany
    Int J Gynecol Pathol 32:358-67. 2013
    ..21 mo, P=0.041; median overall survival 39 vs. 25 mo, P=0.062). Further studies are needed to explore whether expression of SOX2 has a specific role in prognosis and therapy response...
  69. doi request reprint Alterations of the RANKL pathway in blood and bone marrow samples of prostate cancer patients without bone metastases
    Tilman Todenhöfer
    Department of Urology, University Hospital Tuebingen, Tuebingen, Germany
    Prostate 73:162-8. 2013
    ..We aimed to investigate whether changes of RANKL, its inhibitor osteoprotegerin (OPG) and bone marrow-mesenchymal stromal cells (BM-MSCs) occur in PC patients without manifest bone metastases...
  70. ncbi request reprint Cytotoxic effect of conjugates of doxorubicin and human chorionic gonadotropin (hCG) in breast cancer cells
    Gerhard Gebauer
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Breast Cancer Res Treat 77:125-31. 2003
    ..We conclude that the cytotoxic effect of hCG-doxorubicin conjugates is mediated specifically via the hCG receptor. By using hCG conjugates, the development of more selective cytostatics can be achieved...
  71. ncbi request reprint Development of a gel-simulation model and generation of standard tables for the complete extirpation of benign breast lesions with vacuum assisted biopsy under ultrasound guidance
    Ute Krainick-Strobel
    Department of Gynaecology and Obstetrics, Breast Centre, University of Tuebingen, Tuebingen, Germany
    Ultrasound Med Biol 32:1539-44. 2006
    ..VB is suitable for the removal of benign lesions with a diameter of up to 20 mm...
  72. doi request reprint Management of fertility preservation in young breast cancer patients in a large breast cancer centre
    B Lawrenz
    Department of Obstetrics and Gynecology, University of Tuebingen, 72076 Tubingen, Germany
    Arch Gynecol Obstet 282:547-51. 2010
    ..We present the fertility-preserving procedures performed after routine counselling for primary breast cancer patients in a large certified breast cancer centre...
  73. doi request reprint Oncolytic virotherapy of gynecologic malignancies
    Andreas D Hartkopf
    Department of Obstetrics and Gynaecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
    Gynecol Oncol 120:302-10. 2011
    ..Here, we provide an overview of different OVs currently being used for virotherapy of gynecologic cancers and discuss challenges and implications for their future development...
  74. ncbi request reprint Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection
    Hans Neubauer
    University Women s Hospital, Tubingen, Germany
    Electrophoresis 27:1840-52. 2006
    ..This study demonstrates the potential of ProteoTope and LCM to enable extremely sensitive and precise differential analyses from well-defined primary clinical specimen...
  75. ncbi request reprint Circulating tumor cells in patients with breast cancer dormancy
    Songdong Meng
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8576, USA
    Clin Cancer Res 10:8152-62. 2004
    ....
  76. ncbi request reprint A pooled analysis of bone marrow micrometastasis in breast cancer
    Stephan Braun
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    N Engl J Med 353:793-802. 2005
    ..We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis...
  77. pmc HER-2 gene amplification can be acquired as breast cancer progresses
    Songdong Meng
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:9393-8. 2004
    ..e., 37.5% (95% confidence interval of 18.8-59.4%). Four of the 9 patients were treated with Herceptin-containing therapy. One had a complete response and 2 had a partial response...
  78. ncbi request reprint Patterns of aneusomy for three chromosomes in individual cells from breast cancer tumors
    Tanja Fehm
    Cancer Immunobiology Center, UT Southwestern Medical Center, Dallas, TX 75390 8576, USA
    Breast Cancer Res Treat 75:227-39. 2002
    ....
  79. ncbi request reprint Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant
    Tanja Fehm
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 8:2073-84. 2002
    ..The purpose of this investigation was to determine (a) whether CECs in patients including those with early tumors are aneusomic and (b) whether their aneusomic patterns match those from the primary tumor, indicating common clonality...
  80. ncbi request reprint Changes in tumour biological markers during primary systemic chemotherapy (PST)
    Hans Neubauer
    Department of Gynaecology and Obstetrics, University of Tubingen, Tubingen, Germany
    Anticancer Res 28:1797-804. 2008
    ..The influence of primary systemic therapy (PST) on the expression of relevant therapeutic markers is still under investigation...
  81. doi request reprint Systemic spread is an early step in breast cancer
    Yves Hüsemann
    Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
    Cancer Cell 13:58-68. 2008
    ..Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis...
  82. pmc Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling
    Dino Bullinger
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, University Hospital Tubingen, Otfried Müller Str, 45, 72076 Tubingen, Germany
    BMC Biochem 8:25. 2007
    ....
  83. ncbi request reprint Tumor size, axillary lymph node status and steroid receptor expression in breast cancer: prognostic relevance 5 years after surgery
    Gerhard Gebauer
    Sidney Kimmel Cancer Center, San Diego, CA, USA
    Breast Cancer Res Treat 75:167-73. 2002
    ..To summarize, prognostic factors obtained at the time of surgery can lose their significance with increasing disease-free survival...
  84. ncbi request reprint Proteomic expression profiling of breast cancer
    Hans Neubauer
    Universitats Frauenklinik Tubingen, Germany
    Recent Results Cancer Res 176:89-120. 2007
    ....
  85. ncbi request reprint Time is an important factor when processing samples for the detection of disseminated tumor cells in blood/bone marrow by reverse transcription-PCR
    Sven Becker
    Clin Chem 50:785-6. 2004