G Brix

Summary

Affiliation: Federal Office for Radiation Protection
Country: Germany

Publications

  1. doi Risks and safety aspects related to PET/MR examinations
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Eur J Nucl Med Mol Imaging 36:S131-8. 2009
  2. ncbi Radiation risk and protection of patients in clinical SPECT/CT
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingolstädter Landstraße 1, 85764, Oberschleissheim, Germany
    Eur J Nucl Med Mol Imaging 41:S125-36. 2014
  3. ncbi Cumulative radiation exposure and cancer risk of patients with ischemic heart diseases from diagnostic and therapeutic imaging procedures
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingoldstädter Landstraße 1, D 85764 Oberschleissheim, Germany Electronic address
    Eur J Radiol 82:1926-32. 2013
  4. doi On impulse response functions computed from dynamic contrast-enhanced image data by algebraic deconvolution and compartmental modeling
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Phys Med 28:119-28. 2012
  5. doi [Dynamic contrast-enhanced computed tomography. Tracer kinetics and radiation hygienic principles]
    G Brix
    Abteilung für Medizinischen und Beruflichen Strahlenschutz, Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764 Neuherberg
    Radiologe 52:277-94; quiz 295-6. 2012
  6. ncbi Estimation of heat transfer and temperature rise in partial-body regions during MR procedures: an analytical approach with respect to safety considerations
    Gunnar Brix
    Federal Office for Radiation Protection, Institute of Radiation Hygiene, Department of Medical Radiation Hygiene, Neuherberg, Germany
    Magn Reson Imaging 20:65-76. 2002
  7. ncbi [Recovery coefficients for the quantification of the arterial input functions from dynamic PET measurements: experimental and theoretical determination]
    G Brix
    Bundesamt fur Strahlenschutz, Institut für Strahlenhygiene, Abteilung für Medizinische Strahlenhygiene, Neuherberg, Deutschland
    Nuklearmedizin 41:184-90. 2002
  8. ncbi Radiation exposure in multi-slice versus single-slice spiral CT: results of a nationwide survey
    G Brix
    Division of Medical Radiation Hygiene and Dosimetry, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Eur Radiol 13:1979-91. 2003
  9. doi Radiation exposures of cancer patients from medical X-rays: how relevant are they for individual patients and population exposure?
    Gunnar Brix
    Department of Medical Radiation Hygiene and Dosimetry, Federal Office for Radiation Protection, Ingolstädter Landstrasse, Neuherberg, Germany
    Eur J Radiol 72:342-7. 2009
  10. ncbi Static magnetic fields affect capillary flow of red blood cells in striated skin muscle
    Gunnar Brix
    Federal Office for Radiation Protection, Department of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany
    Microcirculation 15:15-26. 2008

Detail Information

Publications62

  1. doi Risks and safety aspects related to PET/MR examinations
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Eur J Nucl Med Mol Imaging 36:S131-8. 2009
    ..On the other hand, there are also risks and health effects associated with the use of diagnostic MR devices that have to be considered carefully...
  2. ncbi Radiation risk and protection of patients in clinical SPECT/CT
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingolstädter Landstraße 1, 85764, Oberschleissheim, Germany
    Eur J Nucl Med Mol Imaging 41:S125-36. 2014
    ..In any case, SPECT/CT studies have to be optimized, e.g. by adapting dose reduction measures from state-of-the-art CT practice, and exposure levels should not exceed the national diagnostic reference levels for standard situations...
  3. ncbi Cumulative radiation exposure and cancer risk of patients with ischemic heart diseases from diagnostic and therapeutic imaging procedures
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingoldstädter Landstraße 1, D 85764 Oberschleissheim, Germany Electronic address
    Eur J Radiol 82:1926-32. 2013
    ..To present a detailed analysis of the cumulative radiation exposure and cancer risk of patients with ischemic heart diseases (IHD) from diagnostic and therapeutic imaging...
  4. doi On impulse response functions computed from dynamic contrast-enhanced image data by algebraic deconvolution and compartmental modeling
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Phys Med 28:119-28. 2012
    ..To avoid misinterpretations and systematic errors, users must be aware of the pitfalls inherent to the different concepts...
  5. doi [Dynamic contrast-enhanced computed tomography. Tracer kinetics and radiation hygienic principles]
    G Brix
    Abteilung für Medizinischen und Beruflichen Strahlenschutz, Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764 Neuherberg
    Radiologe 52:277-94; quiz 295-6. 2012
    ..Clinically established as well as potential future applications of DCE-CT will be presented in a subsequent paper...
  6. ncbi Estimation of heat transfer and temperature rise in partial-body regions during MR procedures: an analytical approach with respect to safety considerations
    Gunnar Brix
    Federal Office for Radiation Protection, Institute of Radiation Hygiene, Department of Medical Radiation Hygiene, Neuherberg, Germany
    Magn Reson Imaging 20:65-76. 2002
    ..The analysis revealed that the partial-body SAR limits indicated in the IEC standard may not guarantee under all circumstances compliance with the basic restrictions concerning temperature rise...
  7. ncbi [Recovery coefficients for the quantification of the arterial input functions from dynamic PET measurements: experimental and theoretical determination]
    G Brix
    Bundesamt fur Strahlenschutz, Institut für Strahlenhygiene, Abteilung für Medizinische Strahlenhygiene, Neuherberg, Deutschland
    Nuklearmedizin 41:184-90. 2002
    ..It was the purpose of this study to experimentally and theoretically determine recovery coefficients for cylinders as a function of the diameter and level of background activity...
  8. ncbi Radiation exposure in multi-slice versus single-slice spiral CT: results of a nationwide survey
    G Brix
    Division of Medical Radiation Hygiene and Dosimetry, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Eur Radiol 13:1979-91. 2003
    ..To avoid an increase in the collective effective dose from CT procedures, a clear medical justification is required in each case...
  9. doi Radiation exposures of cancer patients from medical X-rays: how relevant are they for individual patients and population exposure?
    Gunnar Brix
    Department of Medical Radiation Hygiene and Dosimetry, Federal Office for Radiation Protection, Ingolstädter Landstrasse, Neuherberg, Germany
    Eur J Radiol 72:342-7. 2009
    ..A large fraction of this dose is radiobiologically ineffective due to the reduced life expectancy of cancer patients...
  10. ncbi Static magnetic fields affect capillary flow of red blood cells in striated skin muscle
    Gunnar Brix
    Federal Office for Radiation Protection, Department of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany
    Microcirculation 15:15-26. 2008
    ....
  11. ncbi Assessment of a theoretical formalism for dose estimation in CT: an anthropomorphic phantom study
    G Brix
    Department of Radiation Protection and Health, Division of Medical Radiation Hygiene and Dosimetry, Federal Office for Radiation Protection, 85764 Neuherberg, Germany
    Eur Radiol 14:1275-84. 2004
    ....
  12. ncbi Tracer kinetic analysis of signal time series from dynamic contrast-enhanced MR imaging
    Gunnar Brix
    Federal Office for Radiation Protection, Department of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany
    Biomed Tech (Berl) 51:325-30. 2006
    ..The clinical application of dynamic MRI techniques is demonstrated by two representative studies...
  13. ncbi Microcirculation and microvasculature in breast tumors: pharmacokinetic analysis of dynamic MR image series
    Gunnar Brix
    Division of Medical Radiation Hygiene and Dosimetry, Department of Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Magn Reson Med 52:420-9. 2004
    ..The functional imaging technique presented appears promising to quantitatively characterize tumor pathophysiology. Its impact on diagnosis and therapy management of breast tumors, however, has to be evaluated in larger patient studies...
  14. ncbi PET/CT: dose-escalated image fusion?
    G Brix
    Federal Office for Radiation Protection, Division of Medical Radiation Hygiene and Dosimetry, Neuherberg, Germany
    Nuklearmedizin 44:S51-7. 2005
    ..In addition various dose reduction measures are discussed, some of which can be adopted from CT practice, while others mandate modifications to the existing hard- and software of PET/CT systems...
  15. ncbi Radiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations
    Gunnar Brix
    Division of Medical Radiation Hygiene and Dosimetry, Federal Office for Radiation Protection, Neuherberg, Germany
    J Nucl Med 46:608-13. 2005
    ..We investigated radiation exposure of patients undergoing whole-body 18F-FDG PET/CT examinations at 4 hospitals equipped with different tomographs...
  16. pmc Pharmacokinetic analysis of tissue microcirculation using nested models: multimodel inference and parameter identifiability
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, D 85762 Oberschleissheim, Germany
    Med Phys 36:2923-33. 2009
    ..The presented concept of pharmacokinetic analysis of noisy DCE data using three nested models under an information-theoretic paradigm offers promising prospects for the noninvasive quantification of physiological tissue parameters...
  17. ncbi A survey of PET activity in Germany during 1999
    Gunnar Brix
    Federal ffice for Radiaton Protectin, Institute of Radiaton Hygiene, Department of Medical Radiation Hygeine, Neuherberg, Germany
    Eur J Nucl Med Mol Imaging 29:1091-7. 2002
    ....
  18. doi Estimation of tissue perfusion by dynamic contrast-enhanced imaging: simulation-based evaluation of the steepest slope method
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Eur Radiol 20:2166-75. 2010
    ..It was thus the aim of this study to systematically evaluate the reliability of this analysis method on the basis of simulated tissue curves...
  19. ncbi [Reduction of radiation exposure in PET examinations by data acquisition in the 3D mode]
    G Brix
    Abteilung für Medizinische Strahlenhygiene und nichtionisierende Strahlung, Institut für Strahlenhygiene, Neuherberg
    Nuklearmedizin 38:75-9. 1999
    ....
  20. ncbi Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging
    G Brix
    Division of Medical Radiation Hygiene, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Magn Reson Med 42:936-43. 1999
    ..Magn Reson Med 42:936-943, 1999...
  21. ncbi [Diagnostic evaluation of the breast using PET: optimization of data acquisition and postprocessing]
    G Brix
    Abteilung für Medizinische Strahlenhygiene, Institut für Strahlenhygiene, Bundesamt fur Strahlenschutz, Neuherberg, Deutschland
    Nuklearmedizin 39:62-6. 2000
    ..Development and evaluation of an optimized protocol for PET examinations of the female breast with 2-F-18-fluoro-2-deoxyglucose (F-18-FDG)...
  22. ncbi [Radiation exposure of patients from diagnostic and interventional X-ray procedures. Facts, assessment and trends]
    G Brix
    Abteilung für Medizinische Strahlenhygiene und Dosimetrie, Bundesamt für Strahlenschutz Neuherberg
    Radiologe 45:340-9. 2005
    ....
  23. ncbi Sampling and evaluation of specific absorption rates during patient examinations performed on 1.5-Tesla MR systems
    G Brix
    Department of Medical Radiation Hygiene, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Magn Reson Imaging 19:769-79. 2001
    ....
  24. doi [Radiation hygiene in medical X-ray imaging: part 2: Assessment of radiation exposure and radiation protection measures]
    G Brix
    Fachbereich Strahlenschutz und Gesundheit, Abteilung für Medizinischen und Beruflichen Strahlenschutz, Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764, Neuherberg, Deutschland
    Radiologe 50:913-25; quiz 926-7. 2010
    ..In addition, practical measures for reducing the radiation exposure of patients and personnel will be discussed...
  25. ncbi Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience
    G Brix
    Research Program Radiological Diagnostics and Therapy, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Eur Radiol 11:2058-70. 2001
    ..An advantage of PET, however, is its ability to localize lymph node involvement and distant metastases as an integral part of the examination...
  26. doi Dynamic contrast-enhanced CT studies: balancing patient exposure and image noise
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Invest Radiol 46:64-70. 2011
    ..To establish the essential basis for balancing the dose versus noise trade-off in dynamic contrast-enhanced (DCE) CT by means of a phantom study...
  27. ncbi [Restriction of high-frequency exposure of patients in MR examinations]
    G Brix
    Institut für Strahlenhygiene, Abteilung für Medizinische Strahlenhygiene, Bundesamt fur Strahlenschutz, Ingolstadter Landstrasse 1, 85764 Neuherberg
    Radiologe 42:51-9; quiz 60-1. 2002
  28. doi Tracer kinetic modelling of tumour angiogenesis based on dynamic contrast-enhanced CT and MRI measurements
    Gunnar Brix
    Department of Medical and Occupational Radiation Protection, Oberschleissheim, Germany
    Eur J Nucl Med Mol Imaging 37:S30-51. 2010
    ..It is the aim of this review to summarize the biophysical and tracer kinetic principles underlying this emerging imaging technique offering great potential for non-invasive characterization of tumour angiogenesis...
  29. doi [Radiation hygiene in medical X-ray imaging. Part 3: radiation exposure of patients and risk assessment]
    E A Nekolla
    Abteilung für Medizinischen und Beruflichen Strahlenschutz, Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764 Neuherberg, Deutschland
    Radiologe 50:1039-52; quiz 1053-4. 2010
    ..g. healthcare and screening). The basics and concepts of radiation effects and radiation epidemiology as well as examples of risk estimation and benefit-risk assessments are given...
  30. ncbi Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabine
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Nucl Med 28:418-25. 2001
    ....
  31. ncbi Quantification of [(18)F]FDG uptake in the normal liver using dynamic PET: impact and modeling of the dual hepatic blood supply
    G Brix
    Research Program Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 42:1265-73. 2001
    ..However, the hepatic blood supply may be approximated by the arterial input function as well, especially for the evaluation of liver lesions mainly fed by the hepatic artery...
  32. ncbi Pathophysiologic basis of contrast enhancement in breast tumors
    M V Knopp
    Department of Radiology, German Cancer Research Center, 69120 Heidelberg, Germany
    J Magn Reson Imaging 10:260-6. 1999
    ..MRI is able to subclassify malignant breast tumors due to their different angiogenetic properties...
  33. ncbi Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: a comparative animal study
    G Brix
    Research Program Radiological Diagnostics and Therapy, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nucl Med Biol 23:897-906. 1996
    ..The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas...
  34. doi [Radiation hygiene in medical X-ray imaging, part 1: physical and technical basics]
    A Rimpler
    Abteilung für Medizinischen und Beruflichen Strahlenschutz, Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Neuherberg, Deutschland
    Radiologe 50:809-20. 2010
    ..The aim of this paper is to explain the essential physical and technical basics of X-ray imaging and the assessment of the resulting radiation dose...
  35. doi [Diagnostic reference levels for X-ray examinations: update 2010]
    R Veit
    Abteilung für Medizinischen und Beruflichen Strahlenschutz, Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764, Neuherberg, Deutschland
    Radiologe 50:907-12. 2010
    ..Moreover DRLs for pediatric CT examinations have been newly introduced. This article briefly summarizes the concept of DRLs and the essential changes...
  36. ncbi Elastic matching of dynamic MR mammographic images
    R Lucht
    Department of Medical Radiation Hygiene, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Magn Reson Med 43:9-16. 2000
    ..Up until now, the approach has been applied to 20 dynamic MRI studies. The matching time for two image data sets with 256 x 256 x 15 voxels each was about 4 min using a PC (Pentium Pro, 200MHz)...
  37. ncbi [Application of radioactive substances in nuclear medicine research: current trends and radiation exposure of study subjects]
    V Minkov
    Bundesamt fur Strahlenschutz, Institut für Strahlenhygiene, Abteilung für Medizinische Strahlenhygiene, Neuherberg, Deutschland
    Nuklearmedizin 40:116-21. 2001
    ..Analysis of the application of radioactive substances in research in the field of nuclear medicine in human beings and of the resulting radiation exposure to study subjects...
  38. ncbi An optimized workflow for the integration of biological information into radiotherapy planning: experiences with T1w DCE-MRI
    T Neff
    Department of Medical Physics in Radiation Therapy, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Phys Med Biol 50:4209-23. 2005
    ..The results were compared with the clinical plans for radiation therapy. Generated parameter maps give additional information about tumour spread, which can be incorporated in the definition of safety margins...
  39. ncbi [Nuclear-medical irradiation during pregnancy. Risk assessment for the offspring]
    V Minkov
    Abetilung for Medizinische Strahlenhygiene und Dosimetrie, Fachbereich Strahlenschuts und Gesundheit, Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764 Oberschleissheim
    Nuklearmedizin 48:10-6. 2009
    ..AIM To estimate and evaluate the risks for the offspring due to the administration of radiopharmaceuticals to women during the first pregnancy weeks after conception (weeks p.c.)...
  40. ncbi [Introduction of a mammography screening program in Germany. Consideration of benefits and risks]
    E A Nekolla
    Fachbereich SG Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Neuherberg
    Radiologe 45:245-54. 2005
    ....
  41. ncbi Diagnostic nuclear medicine procedures in Germany between 1996 and 2002: application frequencies and collective effective doses
    A Stamm-Meyer
    Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Ingolstadter Landstrasse 1, 85764 Oberschleissheim Neuherberg
    Nuklearmedizin 45:1-9. 2006
    ..It was therefore the aim of the present study, to provide public health information concerning diagnostic nuclear medicine procedures carried out in Germany between 1996 and 2002...
  42. doi [Changes in the "medical research" licensing procedure under the German Radiation Protection Ordinance]
    M Habeck
    Fachbereich Strahlenschutz und Gesundheit, Bundesamt fur Strahlenschutz, Neuherberg
    Rofo 184:513-9. 2012
    ..An expert statement will be issued by the DRG within four weeks of an inquiry. This consulting service is subject to confidentiality, and is free of charge for inquirers and without any commitment...
  43. ncbi Classification of signal-time curves from dynamic MR mammography by neural networks
    R E Lucht
    Division of Medical Radiation Hygiene, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Magn Reson Imaging 19:51-7. 2001
    ..More precise specification of the type of the benign lesion will require incorporation of additional morphological or pharmacokinetic information...
  44. doi Dose reduction by automatic exposure control in multidetector computed tomography: comparison between measurement and calculation
    U Lechel
    Department of Medical Radiation Hygiene and Dosimetry, Federal Office for Radiation Protection, Neuherberg, Germany
    Eur Radiol 19:1027-34. 2009
    ..The dose to patients undergoing a MDCT examination can be reduced considerably by applying a current-modulated AEC. Dosimetric algorithms using a constant current-time product provide reliable estimates of the effective dose...
  45. ncbi Morpho-functional visualization of dynamic MR-mammography
    K H Englmeier
    GSF National Research Center for Environment and Health, Institute of Medical Informatics Ingolstäder Landstrasse 1, Neuherberg, Germany
    Stud Health Technol Inform 107:838-41. 2004
    ..Especially, detection and localization of multiple breast lesions may be an important application..
  46. doi Radiation exposure of medical staff from interventional x-ray procedures: a multicentre study
    Uwe Häusler
    Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Kopenicker Allee 120 130, 10318, Berlin, Germany
    Eur Radiol 19:2000-8. 2009
    ..However, relatively high exposures were measured to the hand in some cases and could cause a partial-body dose above the annual dose limit of 500 mSv. Thus, the use of finger dosimeters is strongly recommended...
  47. ncbi [Radiation risk associated with mammography screening examinations for women younger than 50 years of age]
    Elke A Nekolla
    Abteilung für Medizinischen und Beruflichen Strahlenschutz, Bundesamt fur Strahlenschutz, Neuherberg
    Z Med Phys 18:170-9. 2008
    ..With the present data--with regard to both, the benefit and the radiation risk--it appears not to be justified to expose women from the age of 40 years to the additional radiation exposure associated with a mammography screening...
  48. ncbi Classification of signal-time curves obtained by dynamic magnetic resonance mammography: statistical comparison of quantitative methods
    Robert E A Lucht
    Federal Office for Radiation Protection, Department of Radiation and Health, Division of Medical Radiation Hygiene and Dosimety, Neuherberg, Germany
    Invest Radiol 40:442-7. 2005
    ..This study compares the performance of quantitative methods for the characterization of signal-time curves acquired by dynamic contrast-enhanced magnetic resonance mammography from 253 females...
  49. ncbi [understanding and radiation hygiene assessment of solar UV exposure in Germany]
    M Steinmetz
    , ,
    Z Med Phys 11:227-35. 2001
    ..10%. Nevertheless, in consideration of the manifold factors affecting the acquired data, the measuring period of 5 years is still insufficient to demonstrate an ozone-dependent effect...
  50. ncbi [Establishment and application of diagnostic reference levels for nuclear medicine procedures in Germany]
    D Nosske
    Bundesamt fur Strahlenschutz, Ingolstadter Landstr 1, 85764 Oberschleissheim
    Nuklearmedizin 43:79-84. 2004
    ..AIM of this paper is to acquaint with and to justify the determined DRL as well as to provide information on the practical use of the concept of the DRL...
  51. ncbi Dynamic MR mammography: three-dimensional real-time visualization of contrast enhancement in virtual reality
    Gesine Hellwig
    GSF National Research Center for Environment and Health, In stitute of Medical Informatics, Neuherberg, Germany
    Acad Radiol 9:1255-63. 2002
    ..In view of the increasing use of breast magnetic resonance (MR) imaging to supplement x-ray mammography. the authors developed a method for fast and efficient analysis of dynamic MR images of the female breast...
  52. ncbi Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring?
    F Kiessling
    Department of Oncological Diagnostics and Therapy, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur Radiol 14:1226-33. 2004
    ..Tumor perfusion was dependent on tumor size and localization, but not on histology. Furthermore, perfusion CT disclosed blood supply from both pulmonary and/or bronchial vessels in some tumors...
  53. ncbi Neural network-based segmentation of dynamic MR mammographic images
    Robert Lucht
    Division of Medical Radiation Hygiene, Institute of Radiation Hygiene, Federal Office for Radiation Protection, Neuherberg, Germany
    Magn Reson Imaging 20:147-54. 2002
    ....
  54. ncbi Fast implementation of the single scatter simulation algorithm and its use in iterative image reconstruction of PET data
    Alexander Werling
    German Cancer Research Center, Heidelberg
    Phys Med Biol 47:2947-60. 2002
    ..The results demonstrate that this approach leads to a more exact estimation of the scatter component which cannot be obtained by a simple sequential data processing strategy...
  55. ncbi Quantification of pulmonary blood flow and volume in healthy volunteers by dynamic contrast-enhanced magnetic resonance imaging using a parallel imaging technique
    Konstantin Nikolaou
    Department of Clinical Radiology, University of Munich, Munich, Germany
    Invest Radiol 39:537-45. 2004
    ....
  56. ncbi Static magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels
    Sebastian Strieth
    Department of Otorhinolaryngology, Universityof Munich LMU, Marchioninistr 15, Munich 81377 Germany
    Cancer Biol Ther 7:814-9. 2008
    ..These reversible changes may have implications for functional measurements of tumor microcirculation by MRI and new therapeutic strategies using strong SMFs...
  57. ncbi [Acquisition and assessment of patient exposure in diagnostic radiology and nuclear medicine]
    Dieter Regulla
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Strahlenschutz, Neuherberg
    Z Med Phys 13:127-35. 2003
    ..05 examinations annually per head of population. The paper discusses factors influencing the calculation of exposure, as well as the lack of an internationally accepted protocol to evaluate patient exposure...
  58. ncbi Quantification of renal perfusion using an intravascular contrast agent (part 1): results in a canine model
    Silke Aumann
    Department of Radiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Magn Reson Med 49:276-87. 2003
    ..72, P < 0.05) was established. The influence of the arterial input function (AIF), T(1) relaxation effects, and repeated measurements on the precision of the perfusion quantitation is discussed...
  59. ncbi Assessment of hepatic perfusion in transplanted livers by pharmacokinetic analysis of dynamic magnetic resonance measurements
    Johann Scharf
    Department of Neuroradiology, University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Invest Radiol 42:224-9. 2007
    ..The purpose of this study was to validate the assessment of hepatic perfusion by pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance image series...
  60. ncbi Non-invasive assessment of vessel morphology and function in tumors by magnetic resonance imaging
    Fabian Kiessling
    Junior Group Molecular Imaging, German Cancer Research Center, INF 280, 96121, Heidelberg, Germany
    Eur Radiol 17:2136-48. 2007
    ..This review summarizes strategies for non-invasive characterization of tumor vascularization by functional and molecular MRI, hereby introducing representative preclinical and clinical applications...
  61. ncbi Biodistribution and pharmacokinetics of the (19)F-labeled radiosensitizer 3-aminobenzamide: assessment by (19)F MR imaging
    Gunnar Brix
    Research Program Innovative Diagnosis and Therapy, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Magn Reson Imaging 23:967-76. 2005
    ..Therefore, the development of effective carrier systems is mandatory to improve tumor-selective delivery...
  62. ncbi Improved vascular opacification in cerebral computed tomography angiography with 80 kVp
    Malte L Bahner
    Department of Radiology E010, Deutsches Krebsforschungs Zentrum, Heidelberg, Germany
    Invest Radiol 40:229-34. 2005
    ..We sought to intraindividually compare computed tomography angiographies (CTAs) acquired at 80 kVp and 120 kVp with respect to vessel contrast, noise level, and radiation dose...