Martin Fassnacht

Summary

Country: Germany

Publications

  1. ncbi request reprint Comprehensive mutation scanning of NF1 in apparently sporadic cases of pheochromocytoma
    Birke Bausch
    Medizinische Universitatsklinik, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Clin Endocrinol Metab 91:3478-81. 2006
  2. doi request reprint New targets and therapeutic approaches for endocrine malignancies
    Martin Fassnacht
    Endocrine and Diabetic Unit, Department of Internal Medicine I, University Hospital, University of Wurzburg, Germany
    Pharmacol Ther 123:117-41. 2009
  3. doi request reprint Laparoscopic versus open adrenalectomy for adrenocortical carcinoma: surgical and oncologic outcome in 152 patients
    David Brix
    Department of Urology and Paediatric Urology, University Hospital, University of Wurzburg, Wurzburg, Germany
    Eur Urol 58:609-15. 2010
  4. doi request reprint High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors
    Silviu Sbiera
    Department of Internal Medicine I, University Hospital of Wuerzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:E161-71. 2010
  5. pmc Influence of short-term glucocorticoid therapy on regulatory T cells in vivo
    Silviu Sbiera
    Endocrinology and Diabetology Unit, Department of Internal Medicine I, University Hospital, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e24345. 2011
  6. doi request reprint Combination chemotherapy in advanced adrenocortical carcinoma
    Martin Fassnacht
    Department of Internal Medicine I, University Hospital, Wurzburg, Germany
    N Engl J Med 366:2189-97. 2012
  7. ncbi request reprint Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma
    Martin Fassnacht
    University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit, Wuerzburg, Germany
    J Clin Endocrinol Metab 91:4501-4. 2006
  8. doi request reprint [Current TNM classification systems for adrenocortical carcinoma]
    M Fassnacht
    Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie, Universitatsklinikum Wurzburg, Oberdürrbacher Str 6, 97080, Wurzburg, Deutschland
    Pathologe 31:374-8. 2010
  9. doi request reprint What is the best approach to an apparently nonmetastatic adrenocortical carcinoma?
    Martin Fassnacht
    Department of Internal Medicine I, Endocrine Unit, University Hospital, University of Wurzburg, Germany
    Clin Endocrinol (Oxf) 73:561-5. 2010
  10. doi request reprint Clinical management of adrenocortical carcinoma
    Martin Fassnacht
    Dept of Internal Medicine I, Endocrinology and Diabetes Unit, University Hospital, University of Wurzburg, Wurzburg, Germany
    Best Pract Res Clin Endocrinol Metab 23:273-89. 2009

Detail Information

Publications63

  1. ncbi request reprint Comprehensive mutation scanning of NF1 in apparently sporadic cases of pheochromocytoma
    Birke Bausch
    Medizinische Universitatsklinik, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Clin Endocrinol Metab 91:3478-81. 2006
    ..The 57-exon susceptibility gene NF1 has so far not been systematically scanned for unexpected germline mutations in individuals with sporadic pheochromocytoma...
  2. doi request reprint New targets and therapeutic approaches for endocrine malignancies
    Martin Fassnacht
    Endocrine and Diabetic Unit, Department of Internal Medicine I, University Hospital, University of Wurzburg, Germany
    Pharmacol Ther 123:117-41. 2009
    ..This review covers these recent molecular and clinical advances which most likely will dramatically alter the treatment of endocrine malignancies within the coming decade...
  3. doi request reprint Laparoscopic versus open adrenalectomy for adrenocortical carcinoma: surgical and oncologic outcome in 152 patients
    David Brix
    Department of Urology and Paediatric Urology, University Hospital, University of Wurzburg, Wurzburg, Germany
    Eur Urol 58:609-15. 2010
    ..The role of laparoscopic adrenalectomy in the treatment of patients with adrenocortical carcinoma (ACC) is controversial...
  4. doi request reprint High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors
    Silviu Sbiera
    Department of Internal Medicine I, University Hospital of Wuerzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:E161-71. 2010
    ....
  5. pmc Influence of short-term glucocorticoid therapy on regulatory T cells in vivo
    Silviu Sbiera
    Endocrinology and Diabetology Unit, Department of Internal Medicine I, University Hospital, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e24345. 2011
    ..Pre- and early clinical studies on patients with autoimmune diseases suggested that induction of regulatory T(T(reg)) cells may contribute to the immunosuppressive effects of glucocorticoids (GCs)...
  6. doi request reprint Combination chemotherapy in advanced adrenocortical carcinoma
    Martin Fassnacht
    Department of Internal Medicine I, University Hospital, Wurzburg, Germany
    N Engl J Med 366:2189-97. 2012
    ..Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment...
  7. ncbi request reprint Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma
    Martin Fassnacht
    University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit, Wuerzburg, Germany
    J Clin Endocrinol Metab 91:4501-4. 2006
    ..Although radiotherapy is often considered ineffective in the treatment of ACC, the limited number of available studies does not support this statement...
  8. doi request reprint [Current TNM classification systems for adrenocortical carcinoma]
    M Fassnacht
    Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie, Universitatsklinikum Wurzburg, Oberdürrbacher Str 6, 97080, Wurzburg, Deutschland
    Pathologe 31:374-8. 2010
    ..Furthermore, exact documentation of the resection status is essential for optimal decisions on treatment...
  9. doi request reprint What is the best approach to an apparently nonmetastatic adrenocortical carcinoma?
    Martin Fassnacht
    Department of Internal Medicine I, Endocrine Unit, University Hospital, University of Wurzburg, Germany
    Clin Endocrinol (Oxf) 73:561-5. 2010
    ..In all patients a structured follow-up for 10 years is strongly recommended...
  10. doi request reprint Clinical management of adrenocortical carcinoma
    Martin Fassnacht
    Dept of Internal Medicine I, Endocrinology and Diabetes Unit, University Hospital, University of Wurzburg, Wurzburg, Germany
    Best Pract Res Clin Endocrinol Metab 23:273-89. 2009
    ..Several targeted therapies are under investigation (e.g. IGF-1 inhibitors, sunitinib, sorafenib) and may lead to new treatment options...
  11. ncbi request reprint AKT is highly phosphorylated in pheochromocytomas but not in benign adrenocortical tumors
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:4366-70. 2005
    ..Activation of AKT plays a major role in a variety of human neoplasias. In mice, a heterozygous deletion of the Pten gene is associated with increased activation of AKT and with development of pheochromocytomas...
  12. doi request reprint Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification
    Martin Fassnacht
    Department of Medicine I, Endocrine and Diabetes Unit, University Hospital, University of Wurzburg, Wurzburg Germany
    Cancer 115:243-50. 2009
    ..However, to date, the prognostic value of the proposed classification has not been evaluated...
  13. doi request reprint Adrenocortical carcinoma: a clinician's update
    Martin Fassnacht
    Department of Internal Medicine I, Endocrine Unit, University Hospital, University of Wurzburg, Oberdürrbacher Straße 6, 97080 Wurzburg, Germany
    Nat Rev Endocrinol 7:323-35. 2011
    ..New targeted therapies, for example, IGF-1 receptor inhibitors, are under investigation and may soon improve current treatment options...
  14. doi request reprint [¹²³I]Iodometomidate imaging in adrenocortical carcinoma
    Michael C Kreissl
    Department of Nuclear Medicine, University Hospital of Wuerzburg, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 98:2755-64. 2013
    ..Imaging with [¹²³I]iodometomidate ([¹²³I]IMTO) has been shown to diagnose adrenocortical lesions with high sensitivity and specificity...
  15. doi request reprint Improved survival in patients with stage II adrenocortical carcinoma followed up prospectively by specialized centers
    Martin Fassnacht
    Department of Internal Medicine I, University Hospital, University of Wurzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:4925-32. 2010
    ..We hypothesized that these results may have been affected by a referral bias because many patients may contact specialized centers only after recurrence...
  16. ncbi request reprint Less common genotype variants of TP53 polymorphisms are associated with poor outcome in adult patients with adrenocortical carcinoma
    Britta Heinze
    Endocrinology and Diabetes Unit, Department of Internal Medicine I, University Hospital of Wuerzburg, University of Wuerzburg, Oberduerrbacher Strasse 6, D 97080 Wuerzburg, Germany
    Eur J Endocrinol 170:707-17. 2014
    ..Also, TP53 polymorphisms have been shown to influence both cancer risk and clinical outcome in several tumor entities. We, therefore, investigated TP53 polymorphisms in a cohort of adult patients with ACC...
  17. doi request reprint Expression of excision repair cross complementing group 1 and prognosis in adrenocortical carcinoma patients treated with platinum-based chemotherapy
    Cristina L Ronchi
    Endocrine and Diabetes Unit, Department of Medicine I, University Hospital, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Endocr Relat Cancer 16:907-18. 2009
    ..2, 95% CI 1.0-4.5, P=0.038). Our findings suggest that ERCC1 expression is the first factor for predicting survival in ACC patients treated with platinum-based chemotherapy...
  18. ncbi request reprint Radiotherapy in adrenocortical carcinoma
    Buelent Polat
    Department of Radiation Oncology, University Hospital, University of Wurzburg, Wurzburg, Germany
    Cancer 115:2816-23. 2009
    ..However, the authors concluded that prospective investigations would be required to fully define the therapeutic potential of this important treatment option...
  19. doi request reprint The role of surgery in the management of recurrent adrenocortical carcinoma
    Ilknur Erdogan
    Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Wurzburg, University of Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 98:181-91. 2013
    ..Surgery is the standard of care for localized adrenocortical carcinomas, but its role for recurrent disease is not well defined...
  20. doi request reprint Functional characterization of adrenal lesions using [123I]IMTO-SPECT/CT
    Stefanie Hahner
    Endocrinology and Diabetes Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 98:1508-18. 2013
    ..Conventional imaging often provides only limited information on the origin of these lesions. Novel specific imaging methods are, therefore, of great clinical interest...
  21. pmc Deficits in the management of patients with adrenocortical carcinoma in Germany
    Sarah Johanssen
    Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie und Diabetologie, Universitatsklinikum Wurzburg, Germany
    Dtsch Arztebl Int 107:885-91. 2010
    ..Often, the physicians who first treat patients with ACC have no prior experience with the disease. The aim of our study was to evaluate the quality of medical care for patients with ACC in Germany...
  22. doi request reprint Impact of lymphadenectomy on the oncologic outcome of patients with adrenocortical carcinoma
    Joachim Reibetanz
    Department of General, Visceral, Vascular, and Pediatric Surgery, University Hospital, University of Wurzburg, Wurzburg, Germany
    Ann Surg 255:363-9. 2012
    ..The impact of a locoregional lymph node dissection (LND) has never been defined in this disease. We report the disease-specific outcome of patients treated with or without LND during primary adrenalectomy...
  23. doi request reprint Sunitinib in refractory adrenocortical carcinoma: a phase II, single-arm, open-label trial
    Matthias Kroiss
    University Hospital, University of Wurzburg, Department of Internal Medicine I, Oberdurrbacher Strasse 6, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 97:3495-503. 2012
    ..Treatment of refractory adrenocortical carcinoma (ACC) is not established. Animal experiments pointed toward adrenal toxicity of sunitinib...
  24. pmc Low SGK1 expression in human adrenocortical tumors is associated with ACTH-independent glucocorticoid secretion and poor prognosis
    Cristina L Ronchi
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher Strasse 6, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 97:E2251-60. 2012
    ..Using single-nucleotide polymorphism analysis, we observed allelic loss of the gene for serum glucocorticoid (GC) kinase 1 (SGK1), a GC-responsive kinase involved in multiple cellular functions, in a subset of cortisol-secreting adenomas...
  25. doi request reprint [131I]iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Oberduerrbacher Strasse 6, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 97:914-22. 2012
    ..We have shown high and specific retention of [123I]metomidate ([123I]IMTO) in ACC lesions, suggesting that labeling of metomidate with 131I offers targeted radionuclide therapy for advanced ACC...
  26. doi request reprint Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wurzburg, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Eur J Endocrinol 162:597-602. 2010
    ..Adrenal crisis (AC) is a life-threatening complication of adrenal insufficiency (AI). Here, we evaluated frequency, causes and risk factors of AC in patients with chronic AI...
  27. ncbi request reprint Evidence against a role of human airway trypsin-like protease--the human analogue of the growth-promoting rat adrenal secretory protease--in adrenal tumourigenesis
    Stefanie Hahner
    Department of Medicine, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Eur J Endocrinol 152:143-53. 2005
    ..AsP may therefore play a crucial role in adrenal growth and tumourigenesis. The aim of this study was to further characterize the human homologue of AsP and its possible role in adrenal tumourigenesis...
  28. ncbi request reprint N-terminal proopiomelanocortin acts as a mitogen in adrenocortical tumor cells and decreases adrenal steroidogenesis
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg 97080, Germany
    J Clin Endocrinol Metab 88:2171-9. 2003
    ..The distinct roles of 1-28-POMC and ACTH in the regulation of adrenal growth and steroidogenesis suggest that the adrenal cortex is under the dual opposing control of fragments from the same mother peptide POMC...
  29. pmc Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways
    Cristina L Ronchi
    Unit of Endocrinology, Department of Internal Medicine I, University Hospital of Wurzburg, Wurzburg, Germany
    Neoplasia 14:206-18. 2012
    ..Furthermore, they implicate that the Notch1 signaling pathway might be involved in the molecular pathogenesis of adrenocortical tumors...
  30. doi request reprint Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma
    Sebastian Wortmann
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital of Wurzburg, University of Wurzburg, Oberdurrbacher Strasse 6, 97080 Wurzburg, Germany
    Eur J Endocrinol 162:349-56. 2010
    ..However, there is no evidence for any therapy beneficial in patients failing these therapies. Therefore, we evaluated the effects of the anti-VEGF antibody bevacizumab plus capecitabine as salvage therapy in ACC...
  31. doi request reprint Osteopontin stimulates invasion of NCI-h295 cells but is not associated with survival in adrenocortical carcinoma
    Dirk Weismann
    University Hospital of Wurzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit, Wurzburg, Germany
    J Pathol 218:232-40. 2009
    ..This relationship remains of relevance to our understanding of carcinogenesis, but further studies are needed to address the physiological and pathological function of OPN in adrenal tissue...
  32. ncbi request reprint Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 92:3912-22. 2007
    ..Here we evaluated the subjective health status in primary and secondary AI and the effect of concomitant disease...
  33. doi request reprint TP53 germline mutations in adult patients with adrenocortical carcinoma
    Leonie J M Herrmann
    Endocrinology and Diabetes Unit, Department of Internal Medicine I, University Hospital of Wuerzburg, University of Wuerzburg, Oberduerrbacher Strasse 6, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 97:E476-85. 2012
    ..However, whereas such mutations have been detected with high frequency in childhood ACC, a large cohort of adult patients with ACC has never been investigated for TP53 germline mutations...
  34. doi request reprint Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma
    Wiebke Fenske
    Endocrine and Diabetic Unit, Department of Internal Medicine I, University Hospital of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Endocr Relat Cancer 16:919-28. 2009
    ..31 (1.80-15.62) in patients with metastatic ACC and in patients after radical resection the HR for disease-free survival was 6.10 (2.16-16.94). In conclusion, GLUT1 is a highly promising stage-independent, prognostic marker in ACC...
  35. pmc Single nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence?
    Cristina L Ronchi
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, University of Wurzburg, Wuerzburg, Germany
    PLoS ONE 8:e73959. 2013
    ..Using these data, we postulate an adenoma-carcinoma sequence for these tumors...
  36. doi request reprint [123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wuerzburg, Josef Schneider Strasse 2, Wuerzburg, Germany
    J Clin Endocrinol Metab 93:2358-65. 2008
    ..New specific imaging methods would therefore be of great clinical value. We, therefore, studied the potential of iodometomidate (IMTO) as tracer for molecular imaging of cytochrome P450 family 11B (Cyp11B) enzymes...
  37. doi request reprint Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma
    Matthias Kroiss
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital Wurzburg, and University of Würzburg, Wurzburg, Germany
    Clin Endocrinol (Oxf) 75:585-91. 2011
    ..Thus, induction of CYP3A4 by mitotane needs to be considered in the design of future clinical trials in ACC...
  38. ncbi request reprint The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease
    Immo A Hansen
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wuerzburg, Germany
    Endocrinology 145:1898-905. 2004
    ..These findings indicate a multifunctional role of these proteases beyond adrenal proliferation...
  39. ncbi request reprint Intraoperative haemodynamic stability in patients with phaeochromocytoma--minimally invasive vs conventional open surgery
    Dirk Weismann
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, Wuerzburg, Germany
    Clin Endocrinol (Oxf) 65:352-8. 2006
    ..There is conflicting evidence, whether or not minimally invasive adrenalectomy (MA) is associated with an increased perioperative cardiovascular instability in phaeochromocytomas compared to conventional open adrenalectomy (CA)...
  40. pmc Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells
    Matthias Kroiss
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, University of Würzburg Würzburg, Germany
    Front Endocrinol (Lausanne) 2:27. 2011
    ..Sunitinib exhibits anti-proliferative effects in vitro, and appears to specifically block adrenal steroidogenesis by down-regulation of HSD3B2, rendering it a promising option for treatment of ACC...
  41. ncbi request reprint Management of adrenocortical carcinoma
    Bruno Allolio
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wurzburg, Germany
    Clin Endocrinol (Oxf) 60:273-87. 2004
    ..Only large prospective multicentre trials comparing different treatment options will allow to make systematic progress in the management of ACC...
  42. ncbi request reprint Thyroid function, cardiovascular events, and mortality in diabetic hemodialysis patients
    Christiane Drechsler
    Department of Medicine 1, Division of Nephrology, University Hospital, University of Wurzburg, Wurzburg, Germany Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany Electronic address
    Am J Kidney Dis 63:988-96. 2014
    ..The aim of the present study was to analyze whether subclinical thyroid disorders were associated with CV events and mortality...
  43. pmc Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients
    Christiane Drechsler
    Division of Nephrology, Department of Internal Medicine 1, University Hospital Wurzburg, University of Wurzburg, Oberdürrbacherstr 6, D 97080, Wurzburg, Germany
    Eur Heart J 34:578-87. 2013
    ..Sudden cardiac death is common and accounts largely for the excess mortality of patients on maintenance dialysis. It is unknown whether aldosterone and cortisol increase the incidence of sudden cardiac death in dialysis patients...
  44. ncbi request reprint A dangerous liaison--pheochromocytoma in patients with malignant disease
    Dirk Weismann
    Endocrine and Diabetes Unit, Department of Medicine, University of Wuerzburg, Josef Schneider Str 2, Wuerzburg, D 97080, Germany
    Ann Surg Oncol 13:1696-701. 2006
    ..Despite improved imaging techniques, it remains difficult to distinguish an adrenal metastasis from a pheochromocytoma or a lipid-poor adrenocortical adenoma...
  45. doi request reprint Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests
    Wiebke Fenske
    Department of Internal Medicine I Endocrine Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 96:1506-15. 2011
    ..In theory, direct measurement of AVP is highly attractive but is hampered by technical difficulties...
  46. ncbi request reprint Prognostic impact of subclinical thyroid dysfunction in heart failure
    Anna Frey
    Department of Internal Medicine I, Cardiology, University Hospital Wurzburg, Germany
    Int J Cardiol 168:300-5. 2013
    ..We compared the prognostic impact of euthyroidism, subclinical thyroid dysfunction, and euthyroid sick syndrome (ESS) in systolic HF...
  47. doi request reprint Bariatric surgery for morbid obesity in craniopharyngioma
    Dirk Weismann
    Department of Internal Medicine I, Endocrine and Diabetes Unit, University of Wuerzburg, Wuerzburg, Germany
    Clin Endocrinol (Oxf) 78:385-90. 2013
    ..To retrospectively analyse the effectiveness of bariatric surgery for hypothalamic obesity in patients with craniopharyngioma (CP)...
  48. doi request reprint Ribonucleotide reductase large subunit (RRM1) gene expression may predict efficacy of adjuvant mitotane in adrenocortical cancer
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    Clin Cancer Res 18:3452-61. 2012
    ..Our aim was to evaluate the gene expression of ribonucleotide reductase large subunit 1 (RRM1) and excision repair cross-complementation group 1 (ERCC1) in ACC as potential biomarkers for clinical outcome and response to mitotane...
  49. ncbi request reprint Clinical review: Adrenocortical carcinoma: clinical update
    Bruno Allolio
    Endocrinology and Diabetes Unit, Department of Medicine I, University Hospital Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 91:2027-37. 2006
    ..Patients present with hormone excess (e.g. virilization, Cushing's syndrome) or a local mass effect (median tumor size at diagnosis > 10 cm). This paper reviews current diagnostic and therapeutic strategies in ACC...
  50. ncbi request reprint Mitotane for adrenocortical carcinoma treatment
    Stefanie Hahner
    Department of Internal Medicine I, University Hospital Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Curr Opin Investig Drugs 6:386-94. 2005
    ..The pharmacological properties of mitotane and its efficacy in the treatment of ACC are analyzed in this review...
  51. ncbi request reprint Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 88:2760-6. 2003
    ..05). Taken together, these data indicate enhanced peripheral 5 alpha-reductase activity in PCOS. Thus, not only ovary and adrenal, but also liver and peripheral target tissues, significantly contribute to steroid alterations in PCOS...
  52. doi request reprint Silencing of the mineralocorticoid receptor by ribonucleic acid interference in transgenic rats disrupts endocrine homeostasis
    Hee Young Lim
    University of Wurzburg, Wurzburg, Germany
    Mol Endocrinol 22:1304-11. 2008
    ..In conclusion, this is the first example of a human disease model based on RNA interference in rats...
  53. doi request reprint Does bariatric surgery change olfactory perception? Results of the early postoperative course
    Christian Ferdinand Jurowich
    Department of General, Visceral, Vascular and Paediatric Surgery, University Hospital of Wurzburg, Oberdürrbacher Str 6, 97080, Wurzburg, Germany
    Int J Colorectal Dis 29:253-60. 2014
    ..It has been hypothesized that olfactory perception as an integral part of food selection might be altered after bariatric surgery...
  54. ncbi request reprint Potency and tolerance of calcitonin stimulation with high-dose calcium versus pentagastrin in normal adults
    Patricia Doyle
    Department of Nuclear Medicine, University of Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    J Clin Endocrinol Metab 94:2970-4. 2009
    ....
  55. ncbi request reprint The pro-opiomelanocortin gene of the zebrafish (Danio rerio)
    Immo A Hansen
    Endocrinology and Diabetes Unit, University of Wuerzburg, Josef Schneider Strasse 2, Germany
    Biochem Biophys Res Commun 303:1121-8. 2003
    ..These findings will facilitate the use of the zebrafish as a model organism in the study of the physiological role of POMC-derived peptides...
  56. ncbi request reprint Dendritic cells as potential adjuvant for immunotherapy in adrenocortical carcinoma
    Claudia Papewalis
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Clin Endocrinol (Oxf) 65:215-22. 2006
    ..The aim of this study was to elaborate two methods of antigen delivery to DCs and to evaluate an immunotherapy protocol in ACC patients...
  57. ncbi request reprint Adjuvant mitotane treatment for adrenocortical carcinoma
    Massimo Terzolo
    Universita di Torino, Turin, Italy
    N Engl J Med 356:2372-80. 2007
    ..Whether the use of mitotane is beneficial as an adjuvant treatment has been controversial. Our aim was to evaluate the efficacy of adjuvant mitotane in prolonging recurrence-free survival...
  58. ncbi request reprint Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R
    Urs D Lichtenauer
    Institute of Molecular Medicine and Cell Research, Centre for Systems Biology, Albert Ludwigs University Freiburg, D 79085 Freiburg, Germany
    Endocrinology 149:1314-22. 2008
    ..Taken together, these findings provide evidence that Hoechst dye exclusion, in contrast to what has been reported for other tumor entities, is not a major tumor stem cell defining marker in adrenocortical NCI h295R tumor cells...
  59. doi request reprint Treatment of advanced adrenocortical carcinoma with erlotinib plus gemcitabine
    Marcus Quinkler
    Clinical Endocrinology, Charite Campus Mitte, Charite University Medicine Berlin, Germany
    J Clin Endocrinol Metab 93:2057-62. 2008
    ..However, many patients have progressive disease despite treatment with these regimens...
  60. pmc Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production
    Anthony P Coll
    Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    J Endocrinol 190:515-25. 2006
    ..In a mouse model which lacks all endogenous POMC peptides, s.c. treatment with synthetic 1-28 POMC alone can reduce food intake and body weight, but has no impact upon adrenal growth or steroidogenesis...
  61. ncbi request reprint Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy
    Martin Fassnacht
    Center for Translational Research, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 11:5566-71. 2005
    ..In this study, we describe a method to screen for human stromal products that have not triggered significant tolerance and could therefore serve as candidate antigens for cancer immunotherapy...
  62. ncbi request reprint Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts
    Jaewoo Lee
    Center for Translational Research, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 65:11156-63. 2005
    ..The study suggests that FAP, a product which is preferentially expressed in tumor-associated fibroblasts, could function as a tumor rejection antigen in a broad range of cancers...
  63. ncbi request reprint Peroxisome proliferator-activated receptor-gamma agonists suppress adrenocortical tumor cell proliferation and induce differentiation
    Matthias J Betz
    Division of Endocrinology and Diabetes, Department of Internal Medicine II, University of Freiburg, Germany
    J Clin Endocrinol Metab 90:3886-96. 2005
    ..Adrenocortical carcinoma (ACC) is a rare tumor entity with poor prognosis due to its highly malignant phenotype and lack of effective treatment options...