K Fassbender

Summary

Country: Germany

Publications

  1. ncbi request reprint Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide
    K Fassbender
    Department of Neurology, University of Goettingen, Goettingen, Germany
    Neurology 59:1257-8. 2002
  2. ncbi request reprint The LPS receptor (CD14) links innate immunity with Alzheimer's disease
    K Fassbender
    Department of Neurology, University of Goettingen, 37075 Goettingen, FRG
    FASEB J 18:203-5. 2004
  3. ncbi request reprint Endothelin-1 in subarachnoid hemorrhage: An acute-phase reactant produced by cerebrospinal fluid leukocytes
    K Fassbender
    Department of Neurology, Clinic Mannheim, University of Heidelberg, Germany
    Stroke 31:2971-5. 2000
  4. pmc Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    K Fassbender
    Department of Neurology, Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 98:5856-61. 2001
  5. ncbi request reprint Aggregation-Dependent interaction of the Alzheimer's beta-amyloid and microglia
    F Muehlhauser
    Department of Neurology, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 39:313-6. 2001
  6. ncbi request reprint Temporal profile of release of interleukin-1beta in neurotrauma
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135, Mannheim, Germany
    Neurosci Lett 284:135-8. 2000
  7. ncbi request reprint Alzheimer's disease: molecular concepts and therapeutic targets
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Naturwissenschaften 88:261-7. 2001
  8. ncbi request reprint Innate immune receptor expression in normal brain aging
    M Letiembre
    University of Gottingen, Department of Neurology, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuroscience 146:248-54. 2007
  9. pmc Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, 68135 Mannheim, Germany
    J Neurol Neurosurg Psychiatry 70:534-7. 2001

Detail Information

Publications9

  1. ncbi request reprint Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide
    K Fassbender
    Department of Neurology, University of Goettingen, Goettingen, Germany
    Neurology 59:1257-8. 2002
    ..However, these changes were not associated with altered intrathecal secretion of Alzheimer Abeta...
  2. ncbi request reprint The LPS receptor (CD14) links innate immunity with Alzheimer's disease
    K Fassbender
    Department of Neurology, University of Goettingen, 37075 Goettingen, FRG
    FASEB J 18:203-5. 2004
    ....
  3. ncbi request reprint Endothelin-1 in subarachnoid hemorrhage: An acute-phase reactant produced by cerebrospinal fluid leukocytes
    K Fassbender
    Department of Neurology, Clinic Mannheim, University of Heidelberg, Germany
    Stroke 31:2971-5. 2000
    ..In our study, we performed clinical and in vitro experiments to investigate the origin and the mechanisms of the secretion of endothelin-1 in SAH...
  4. pmc Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    K Fassbender
    Department of Neurology, Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 98:5856-61. 2001
    ..Lowered levels of Abeta42 may provide the mechanism for the observed reduced incidence of dementia in statin-treated patients and may open up avenues for therapeutic interventions...
  5. ncbi request reprint Aggregation-Dependent interaction of the Alzheimer's beta-amyloid and microglia
    F Muehlhauser
    Department of Neurology, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 39:313-6. 2001
    ..In the case of the living brain, the presence of deposits of fibrillar amyloid peptide could maintain a chronic microglial activation, ultimately leading to the progressive neurodegeneration associated with Alzheimer's disease...
  6. ncbi request reprint Temporal profile of release of interleukin-1beta in neurotrauma
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135, Mannheim, Germany
    Neurosci Lett 284:135-8. 2000
    ..This so far unrecognized acuity of IL-1beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response...
  7. ncbi request reprint Alzheimer's disease: molecular concepts and therapeutic targets
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Naturwissenschaften 88:261-7. 2001
    ....
  8. ncbi request reprint Innate immune receptor expression in normal brain aging
    M Letiembre
    University of Gottingen, Department of Neurology, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuroscience 146:248-54. 2007
    ....
  9. pmc Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, 68135 Mannheim, Germany
    J Neurol Neurosurg Psychiatry 70:534-7. 2001
    ..Together, these findings suggest a role of excessive compartmentalised inflammatory host response in pathogenesis of cerebrovascular complications after SAH...