Peter Falkai

Summary

Country: Germany

Publications

  1. doi request reprint [Schizophrenia as a brain disorder and its development]
    P Falkai
    Abteilung für Psychiatrie und Psychotherapie, Georg August Universitat Gottingen, Germany
    Fortschr Neurol Psychiatr 76:S63-7. 2008
  2. doi request reprint Limitations of current therapies: why do patients switch therapies?
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    Eur Neuropsychopharmacol 18:S135-9. 2008
  3. ncbi request reprint [Advances in neurobiological understanding of schizophrenia. Perspectives for new therapeutic concepts]
    P Falkai
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Göttingen, Gottingen
    Nervenarzt 77:S65-74; quiz S75-6. 2006
  4. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
  5. doi request reprint A roadmap to disentangle the molecular etiology of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, 37075 Goettingen, Germany
    Eur Psychiatry 23:224-32. 2008
  6. ncbi request reprint Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
  7. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
  8. doi request reprint Cortical neurochemistry in euthymic patients with bipolar I disorder
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, 37075 Goettingen, Germany
    World J Biol Psychiatry 10:285-94. 2009
  9. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
  10. doi request reprint Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms
    Ilona Henseler
    Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Department of Psychiatry and Psychotherapy, Georg August University, D 37075 Goettingen, Germany
    J Psychiatr Res 44:364-72. 2010

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. doi request reprint [Schizophrenia as a brain disorder and its development]
    P Falkai
    Abteilung für Psychiatrie und Psychotherapie, Georg August Universitat Gottingen, Germany
    Fortschr Neurol Psychiatr 76:S63-7. 2008
    ..The outlined pathophysiological hypotheses are used to discuss possible causal pharmacological treatment options...
  2. doi request reprint Limitations of current therapies: why do patients switch therapies?
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    Eur Neuropsychopharmacol 18:S135-9. 2008
    ....
  3. ncbi request reprint [Advances in neurobiological understanding of schizophrenia. Perspectives for new therapeutic concepts]
    P Falkai
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Göttingen, Gottingen
    Nervenarzt 77:S65-74; quiz S75-6. 2006
    ..Furthermore, pharmacogenetics is currently unable to give a clear answer as to whether a single patient is responding to treatment or not...
  4. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  5. doi request reprint A roadmap to disentangle the molecular etiology of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, 37075 Goettingen, Germany
    Eur Psychiatry 23:224-32. 2008
    ..The coming calls of the frame work program will be used to strengthen this network in order to achieve substantial progress in understanding and treating this devastating illness...
  6. ncbi request reprint Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ....
  7. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  8. doi request reprint Cortical neurochemistry in euthymic patients with bipolar I disorder
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, 37075 Goettingen, Germany
    World J Biol Psychiatry 10:285-94. 2009
    ..The aim of this study was to re-investigate prefrontal and anterior cingulate neurochemistry in a sample of euthymic patients with bipolar I disorder...
  9. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
    ..In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD...
  10. doi request reprint Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms
    Ilona Henseler
    Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Department of Psychiatry and Psychotherapy, Georg August University, D 37075 Goettingen, Germany
    J Psychiatr Res 44:364-72. 2010
    ..The relationship between working memory (WM) impairment, disturbed functional connectivity, and the characteristic symptoms of schizophrenia, however, remains elusive...
  11. pmc Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning
    David Zilles
    Department of Psychiatry, Center for Translational Research in Systems Neuroscience and Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:667-76. 2012
    ....
  12. pmc Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:565-77. 2012
    ..It is hypothesized that abnormal expression of these and related genes has a major impact on the pathophysiology of schizophrenia...
  13. doi request reprint Early onset of obsessive-compulsive disorder and associated comorbidity
    Deborah Janowitz
    Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    Depress Anxiety 26:1012-7. 2009
    ..This study was undertaken to discriminate the subtypes of OCD in different AOO levels and to test the hypothesis that different AOO bands are associated with a differential pattern of comorbidity...
  14. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  15. doi request reprint Cognitive impairment of executive function as a core symptom of schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 10:442-51. 2009
    ..In conclusion, these results may suggest a cognitive endophenotype in schizophrenia and underline the role of the prefrontal cortex in schizophrenic pathophysiology...
  16. doi request reprint Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms
    Martin Begemann
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 67:879-88. 2010
    ..In particular, the specific contribution of risk or candidate gene variants to the complex schizophrenic phenotype is largely unknown...
  17. doi request reprint Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1651-9. 2008
    ..Finally, CSF Abeta42 levels declined significantly in both groups within 12 months supporting the notion that CSF Abeta42 may be valid not only for diagnostic but also for prognostic purposes in AD...
  18. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  19. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  20. doi request reprint Impulsive personality and the ability to resist immediate reward: an fMRI study examining interindividual differences in the neural mechanisms underlying self-control
    Esther Kristina Diekhof
    Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, Georg August University, Von Siebold Strasse 5, Goettingen, Germany
    Hum Brain Mapp 33:2768-84. 2012
    ..Collectively, these results suggest trait-specific neural mechanisms that allow HI individuals to control their desire for immediate reward...
  21. doi request reprint Functional interactions guiding adaptive processing of behavioral significance
    Esther Kristina Diekhof
    Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Hum Brain Mapp 30:3325-31. 2009
    ....
  22. doi request reprint Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder
    Oliver Gruber
    Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Hum Brain Mapp 31:115-25. 2010
    ..This pathophysiological abnormality appears to be a trait marker in bipolar disorders that can be observed even in the euthymic state and that seems to be largely independent of task performance and medication...
  23. pmc Compensatory hyperactivations as markers of latent working memory dysfunctions in patients with obsessive-compulsive disorder: an fMRI study
    Ilona Henseler
    Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    J Psychiatry Neurosci 33:209-15. 2008
    ..To test this hypothesis, we examined patients without a behavioural deficit in WM during performance of different WM tasks using functional magnetic resonance imaging (fMRI)...
  24. doi request reprint Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 11:243-50. 2010
    ..However, our study sample was small and results of this exploratory study should be verified in a larger sample...
  25. doi request reprint Deficient inhibitory cortical networks in antipsychotic-naive subjects at risk of developing first-episode psychosis and first-episode schizophrenia patients: a cross-sectional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Biol Psychiatry 72:744-51. 2012
    ..However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis...
  26. pmc A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia
    Sabrina Grube
    Divison of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 3:309-19. 2011
    ..Reduction of SK3 function may constitute a pharmacological target to improve cognition in schizophrenia and other conditions with cognitive impairment...
  27. doi request reprint SNAP-25 genotype influences NAA/Cho in left hippocampus
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    J Neural Transm 115:1513-8. 2008
    ..The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus...
  28. doi request reprint Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Germany
    Brain Res 1301:126-34. 2009
    ..Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia...
  29. pmc Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:101-11. 2010
    ..This supports the hypothesis of an abnormal glutamatergic neurotransmission in the right cerebellum in the pathophysiology of schizophrenia...
  30. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  31. doi request reprint Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  32. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 14:2-44. 2013
    ..These guidelines are primarily concerned with the biological treatment (including antipsychotic medication and other pharmacological treatment options) of adults suffering from schizophrenia...
  33. doi request reprint The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls--a randomized placebo-controlled, double-blind fMRI study
    Birgit Guse
    University Medical Centre, Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Str 5, D 37075 Gottingen, Germany
    Behav Brain Res 237:300-7. 2013
    ..This is the first fMRI study that has systematically investigated this topic within a randomized, placebo-controlled, double-blind design, contrasting the effects in schizophrenia patients and healthy controls...
  34. doi request reprint Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Brain Stimul 5:475-83. 2012
    ..However, glutamate-dependent long-term depression (LTD)-like cortical plasticity has not yet been investigated...
  35. doi request reprint Planum temporale asymmetry to the right hemisphere in first-episode schizophrenia
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Street 5, 37075 Goettingen, Germany
    Psychiatry Res 193:56-9. 2011
    ..We investigated planum temporale (PT) volume and asymmetry in 23 first-episode schizophrenia patients compared to healthy controls and found for the first time an in vivo volume asymmetry of PT to the right hemisphere...
  36. doi request reprint The orbitofrontal cortex and its role in the assignment of behavioural significance
    Esther Kristina Diekhof
    Department of Psychiatry, Georg August University, Goettingen, Germany
    Neuropsychologia 49:984-91. 2011
    ..Our findings thus further underscore the putative role of the OFC in the prioritisation of attentional selection and behavioural control...
  37. doi request reprint Neuregulin-1 haplotype HAP(ICE) is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    J Psychiatr Res 43:1-6. 2008
    ..This preliminary evidence may help to guide further research into the pathophysiological pathways that underlie this genetic susceptibility for schizophrenia...
  38. pmc Reduced prefrontal gyrification in obsessive-compulsive disorder
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:455-64. 2010
    ..In conclusion, prefrontal hypogyrification in OCD patients may be a structural correlate of the impairment in executive function of this patient group and may point to a neurodevelopmental origin of this disease...
  39. doi request reprint Reduction of gyrification index in the cerebellar vermis in schizophrenia: a post-mortem study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    World J Biol Psychiatry 12:99-103. 2011
    ..Cerebellar regions have been implicated in the pathophysiology of schizophrenia; however, the GI has not been investigated here so far...
  40. doi request reprint Automated gray level index measurements reveal only minor cytoarchitectonic changes of Brodmann area 9 in schizophrenia
    Ralf Tepest
    Department of Psychiatry and Psychotherapy, University of Cologne, Köln Cologne, Germany
    Psychiatry Res 163:183-92. 2008
    ..Since increases in GLI were found only in selected layers (V and VI) of BA9, these findings do not support a generalized neuropil reduction across all cortical layers...
  41. pmc Comorbid substance abuse and brain morphology in recent-onset psychosis
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:28-36. 2009
    ....
  42. pmc Patients with schizophrenia show deficits of working memory maintenance components in circuit-specific tasks
    David Zilles
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:519-25. 2010
    ..In contrast to a seemingly global working memory deficit, individual analysis revealed differential patterns of working memory impairments in patients with schizophrenia...
  43. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 7:5-40. 2006
    ....
  44. doi request reprint Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 117:395-407. 2009
    ....
  45. doi request reprint A similar but distinctive pattern of impaired cortical excitability in first-episode schizophrenia and ADHD
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Neuropsychobiology 67:74-83. 2013
    ..Studies on cortical excitability comparing these two diseases directly are lacking...
  46. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 13:318-78. 2012
    ..This first part of the updated guidelines covers the general descriptions of antipsychotics and their side effects, the biological treatment of acute schizophrenia and the management of treatment-resistant schizophrenia...
  47. doi request reprint Evidence for specific cognitive deficits in visual information processing in patients with OCD compared to patients with unipolar depression
    Friederike Rampacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, DE 53105 Bonn, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:984-91. 2010
    ..As yet, it has not been substantiated whether deficits in visual organization and complex visual memory are also specific to OCD and are not shared by MDD...
  48. pmc Diagnosis-specific effect of familial loading on verbal working memory in schizophrenia
    David Zilles
    Department of Psychiatry and Psychotherapy, Georg August University, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:309-15. 2009
    ..Working memory dysfunctions have been shown to be heritable and have been proposed to represent a promising endophenotype of schizophrenic psychoses...
  49. doi request reprint Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075, Goettingen, Germany
    Behav Brain Res 224:15-22. 2011
    ..Disturbances of N-methyl-d-aspartate, gamma-aminobutyric acid and dopamine receptors may account for this plasticity deficit. LTP-like plasticity deficits might be related to disturbed information processing in schizophrenia patients...
  50. doi request reprint Differential working memory performance as support for the Kraepelinian dichotomy between schizophrenia and bipolar disorder? An experimental neuropsychological study using circuit-specific working memory tasks
    David Zilles
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany
    World J Biol Psychiatry 14:258-67. 2013
    ..In this study we aimed to further clarify the diagnostic specificity of working memory deficits in schizophrenia and bipolar disorder...
  51. pmc Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence
    Berend Malchow
    Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Georg August University, Germany
    Eur Arch Psychiatry Clin Neurosci 263:3-13. 2013
    ..There is some weak evidence that cannabis abuse could affect brain structures in high-risk subjects, but replication of these studies is needed...
  52. pmc Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:415-23. 2012
    ..Dysfunctional N-methyl D-aspartate receptors or modulation of dopaminergic transmission can explain these findings. Nevertheless, the effects of antipsychotic medication still need to be considered...
  53. pmc Prefrontal cortex gyrification index in twins: an MRI study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:459-65. 2011
    ..The nonexistence of a pronounced similarity in MZ twins compared to DZ twins concerning prefrontal GI raises questions about the extent of genetic influence on GI...
  54. ncbi request reprint Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
    Psychiatry Res 132:261-71. 2004
    ..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...
  55. ncbi request reprint Neural substrates of olfactory processing in schizophrenia patients and their healthy relatives
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Psychiatry Res 155:103-12. 2007
    ..Results point to a differentiation between trait and state components in cerebral dysfunctions during emotional olfactory processing in schizophrenia...
  56. doi request reprint Fear is only as deep as the mind allows: a coordinate-based meta-analysis of neuroimaging studies on the regulation of negative affect
    Esther Kristina Diekhof
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Germany
    Neuroimage 58:275-85. 2011
    ..In addition, higher-level regulation strategies may further engage complementary neural resources to effectively deal with the emotion-eliciting events...
  57. ncbi request reprint Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients
    Ute Habel
    Department of Psychiatry and Psychotherapy, University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Am J Psychiatry 161:1806-13. 2004
    ..Brain activity was measured during mood induction in patients with schizophrenia and their first-degree nonaffected relatives...
  58. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...
  59. doi request reprint Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment
    Martina Von Wilmsdorff
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    World J Biol Psychiatry 14:490-9. 2013
    ..The influence of the neuregulin-1 (NRG1) risk genotype or effects of antipsychotics on expression of EAATs are unknown...
  60. doi request reprint A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires
    Esther K Diekhof
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Goettingen, Germany
    Brain Res 1473:63-77. 2012
    ..Together, these findings support the view of a sexual dimorphism that manifested in the recruitment of gender-specific neural resources during the successful deployment of self-control...
  61. pmc The role of the cerebellum in schizophrenia: from cognition to molecular pathways
    Peyman Yeganeh-Doost
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Clinics (Sao Paulo) 66:71-7. 2011
    ..We discuss the molecular findings in the light of the role of the cerebellum in attention and cognitive deficits in schizophrenia...
  62. pmc Effects of abstinence on brain morphology in alcoholism: a MRI study
    Thomas Wobrock
    Dept of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, Gottingen 37075, Germany
    Eur Arch Psychiatry Clin Neurosci 259:143-50. 2009
    ..It should be analyzed in further studies with larger sample sizes, if complete brain regeneration is possible maintaining abstinence over a longer period...
  63. pmc S100B and homocysteine in the acute alcohol withdrawal syndrome
    Dirk Wedekind
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, 37075 Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:133-8. 2011
    ..S100B could be of relevance in the neurobiology of alcohol withdrawal syndromes. It may be indirectly related to the level of stress level or glutamatergic activity during alcohol withdrawal...
  64. doi request reprint Serotonergic function, substance craving, and psychopathology in detoxified alcohol-addicted males undergoing tryptophan depletion
    Dirk Wedekind
    Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, D 37075 Gottingen, Germany
    J Psychiatr Res 44:1163-9. 2010
    ..Patients with the ll genotype of the serotonin transporter gene displayed lower baseline tryptophan levels compared to patients with the heterozygous genotype. Results suggest an impaired serotonergic function in alcohol-addicted males...
  65. pmc No change to grey and white matter volumes in bipolar I disorder patients
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University of Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:345-9. 2008
    ..The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder...
  66. pmc Schizophrenia as a disorder of disconnectivity
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S150-4. 2011
    ..The specificity and the neurobiological origin of these connectivity deficits and the relation to the symptom complex of schizophrenia and the glutamatergic and GABAergic system are discussed...
  67. doi request reprint The effects of combined acamprosate and integrative behaviour therapy in the outpatient treatment of alcohol dependence: a randomized controlled trial
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Drug Alcohol Depend 118:417-22. 2011
    ..The aim of this randomized, controlled, multisite trial was to evaluate the efficacy of combined treatment with integrative behaviour therapy (IBT) and acamprosate on drinking behaviour in detoxified alcohol-dependent patients...
  68. pmc Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Psychopharmacology (Berl) 208:353-63. 2010
    ..Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking...
  69. doi request reprint The power of imagination--how anticipatory mental imagery alters perceptual processing of fearful facial expressions
    Esther K Diekhof
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Goettingen, Germany
    Neuroimage 54:1703-14. 2011
    ..Anticipatory mental imagery may thus represent an effective antecedent strategy through which emotional perception can be significantly altered...
  70. pmc A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression
    Oliver Gruber
    Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:179-84. 2011
    ..As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients...
  71. pmc The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Psychiatry 10:91. 2010
    ..This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia...
  72. doi request reprint Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 12:201-15. 2011
    ..This may be partly ascribed to the origin of the materials (CSF, blood, brain tissue) or to the genes selected for the respective studies. Moreover, in some locations, inflammatory genes may be up-regulated, others may be down-regulated...
  73. ncbi request reprint Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  74. ncbi request reprint Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder
    Oliver Gruber
    Cognitive Neuroscience Unit, Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    Neurosci Lett 405:24-8. 2006
    ..The findings provide first evidence that dysfunction of a brain system subserving articulatory rehearsal could represent a biological marker which differentiates between schizophrenia and schizoaffective disorder...
  75. ncbi request reprint Obsessive-compulsive disorder and posttraumatic stress disorder
    Hans Joergen Grabe
    Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
    Psychopathology 41:129-34. 2008
    ..This study investigates the hypothesis that traumatic events and posttraumatic stress disorders (PTSD) precede the onset of OCD...
  76. pmc Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review
    Birgit Guse
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    J Neural Transm 117:105-22. 2010
    ....
  77. doi request reprint Borderline personality disorder: a dysregulation of the endogenous opioid system?
    Borwin Bandelow
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    Psychol Rev 117:623-36. 2010
    ..An understanding of the neurobiology of BPD may help in developing new treatments for patients with this severe disorder...
  78. doi request reprint Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
    Andrea Schmitt
    Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:35-9. 2008
    ..In animal models of ischemia/hypoxia, NRG1 has been shown to act as a therapeutic, neuroprotective agent and should be investigated in more detail in transgenic animal models...
  79. doi request reprint Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    J Clin Psychopharmacol 30:190-2. 2010
    ....
  80. ncbi request reprint Harm avoidance in subjects with obsessive-compulsive disorder and their families
    Susan Ettelt
    Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
    J Affect Disord 107:265-9. 2008
    ..HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis...
  81. doi request reprint Correlation between amygdala volume and age in bipolar disorder - a systematic review and meta-analysis of structural MRI studies
    Juliana Usher
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Germany
    Psychiatry Res 182:1-8. 2010
    ..A meta-regression analysis revealed a positive correlation between mean age and amygdala volume in patients with BD. We speculate that amygdala volume is reduced at the onset of the disease and increases with age...
  82. doi request reprint Functional brain abnormalities in psychiatric disorders: neural mechanisms to detect and resolve cognitive conflict and interference
    Tobias Melcher
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Brain Res Rev 59:96-124. 2008
    ..Taken together, interference resolution and performance monitoring appeared to be fruitful concepts in the investigation of neurocognitive deficits in psychiatric disorders...
  83. ncbi request reprint Effects of antipsychotics on brain structure
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany
    Curr Opin Psychiatry 19:145-50. 2006
    ..This review highlights the recent findings of different effects of typical and atypical antipsychotics on brain structure...
  84. doi request reprint Cognition in hepatitis C patients treated with pegylated interferon
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    World J Biol Psychiatry 10:819-26. 2009
    ..We conclude that neurocognitive performance was influenced by antiviral IFN-alpha-based combination treatment only in single domains and not to a clinically relevant extent in contrast to the significant worsening of depression...
  85. doi request reprint Brain mechanisms associated with background monitoring of the environment for potentially significant sensory events
    Oliver Gruber
    Department of Psychiatry, Georg August University, Goettingen, Germany
    Brain Cogn 69:559-64. 2009
    ..This fronto-parietal network may thus play an important role in adaptive responding to potentially significant events outside the current focus of attention...
  86. pmc Is brain banking of psychiatric cases valuable for neurobiological research?
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Germany
    Clinics (Sao Paulo) 63:255-66. 2008
    ....
  87. doi request reprint Functional neuroimaging of reward processing and decision-making: a review of aberrant motivational and affective processing in addiction and mood disorders
    Esther Kristina Diekhof
    Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075 Goettingen, Germany
    Brain Res Rev 59:164-84. 2008
    ..The overall goal is to critically evaluate the specificity of neurophysiological alterations identified in these psychiatric disorders and associated symptoms, and to make suggestions concerning future research...
  88. doi request reprint Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review
    Mirko Bibl
    Klinik fur Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universitat Duisburg Essen, Essen, Germany
    Dement Geriatr Cogn Disord 25:256-65. 2008
    ..The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-beta (Abeta) peptides, total tau and phospho-tau among Alzheimer's disease (AD) and vascular dementias (VAD)...
  89. doi request reprint [From identification of neurofunctional systems to individualization of treatment for schizophrenic disorders]
    O Gruber
    Zentrum für Translationale Forschung in Systemischen Neurowissenschaften und Klinischer Psychiatrie, Klinik fur Psychiatrie und Psychotherapie, Georg August Universitat, Von Siebold Strasse 5, 37075, Gottingen, Deutschland
    Nervenarzt 80:12, 14, 16-8 passim. 2009
    ..This may permit more precise diagnosis and a specification and optimization of pharmacotherapy...
  90. pmc Thalamic volumes in patients with bipolar disorder
    Katrin Radenbach
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:601-7. 2010
    ....
  91. doi request reprint Reduced cortical inhibition in first-episode schizophrenia
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, D 37075 Gottingen, Germany
    Schizophr Res 105:252-61. 2008
    ....
  92. ncbi request reprint Nocturnal urinary cortisol excretion over a randomized controlled trial with paroxetine vs. placebo combined with relaxation training or aerobic exercise in panic disorder
    D Wedekind
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, D 37075 Goettingen, Germany
    Curr Pharm Des 14:3518-24. 2008
    ..Data on basal hypothalamo-pituitary-adrenomedullary (HPA) function over controlled treatment trials with serotonergic drugs in anxiety disorders are still rare...
  93. doi request reprint [Molecular principles of tau-induced toxicity: new experimental therapy strategies for treatment of Alzheimer's disease]
    A Schneider
    Klinik fur Psychiatrie und Psychotherapie, Gedachtnisambulanz, Universitatsmedizin Gottingen, Gottingen, Deutschland
    Nervenarzt 81:1289-90, 1292, 1294, passim. 2010
    ..They are composed of hyperphosphorylated and aggregated Tau proteins. Consequently, experimental disease modifying approaches include kinase and aggregation inhibitors as well as substances which increase degradation of Tau proteins...
  94. ncbi request reprint [Treatment of schizophrenia: what the family doctor should know]
    O Gruber
    Klinik für Psychiatrie und Psychotherapie der Georg August Universität Göttingen
    MMW Fortschr Med 150:16-9; quiz 20. 2008
  95. doi request reprint [Guideline intentions of the German Society of Psychiatry, Psychotherapy and Nervous Diseases (DGPPN)]
    T Wobrock
    Abteilung für Psychiatrie und Psychotherapie, Zentrum Psychosoziale Medizin, Universitatsmedizin Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Deutschland
    Nervenarzt 81:1041-8. 2010
    ..A major aim of the German Society of Psychiatry, Psychotherapy and Nervous Diseases (DGPPN) is to assure the quality of inpatient and outpatient care of the mentally ill by developing evidence-based consensus guidelines...
  96. pmc Quality assurance in psychiatry: quality indicators and guideline implementation
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S219-26. 2009
    ..Carefully used, the use of quality indicators and improved guideline adherence can address suboptimal clinical outcomes, reduce practice variations, and narrow the gap between optimal and routine care...
  97. doi request reprint A systematic fMRI investigation of the brain systems subserving different working memory components in schizophrenia
    I Henseler
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur J Neurosci 30:693-702. 2009
    ....
  98. ncbi request reprint [Pharmacotherapy of schizophrenia and comorbid substance use disorder. A systematic review]
    T Wobrock
    Klinik fur Psychiatrie und Psychotherapie, Georg August Universitat Gottingen, 37075, Gottingen
    Nervenarzt 79:17-8, 20-2, 24-6 passim. 2008
    ....
  99. doi request reprint Motor circuit abnormalities in first-episode schizophrenia assessed with transcranial magnetic stimulation
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Pharmacopsychiatry 42:194-201. 2009
    ....
  100. ncbi request reprint Compartmental volumetry of the superior temporal gyrus reveals sex differences in schizophrenia--a post-mortem study
    K Vogeley
    Department of Psychiatry and Psychotherapy, Friedrich Wilhelms University Bonn, Germany
    Schizophr Res 31:83-7. 1998
    ..This may have been related to reduced length of this region, particularly in schizophrenic females. These results reflect the problematic issue of defining boundaries of macroscopic brain structures...
  101. ncbi request reprint Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003
    ..Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn...