K Simons

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. pmc Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    M Simons
    Cell Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10 2209, D 69012 Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:6460-4. 1998
  2. ncbi request reprint Lipid rafts and signal transduction
    K Simons
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 1:31-9. 2000
  3. pmc Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p
    L A Huber
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 123:47-55. 1993
  4. ncbi request reprint Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily
    V M Olkkonen
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Sci 106:1249-61. 1993
  5. ncbi request reprint VIP17/MAL, a proteolipid in apical transport vesicles
    D Zacchetti
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    FEBS Lett 377:465-9. 1995
  6. pmc VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells
    K Fiedler
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 13:1729-40. 1994
  7. pmc Caveolin-1 and -2 in the exocytic pathway of MDCK cells
    P Scheiffele
    Cell Biology Programme, European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    J Cell Biol 140:795-806. 1998
  8. ncbi request reprint Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
    T Harder
    European Molecular Biology Laboratory, Cell Biology Programme, Heidelberg, Germany
    Curr Opin Cell Biol 9:534-42. 1997
  9. pmc Caveolae and sorting in the trans-Golgi network of epithelial cells
    P Dupree
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:1597-605. 1993
  10. pmc Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
    L A Huber
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 123:35-45. 1993

Detail Information

Publications28

  1. pmc Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    M Simons
    Cell Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10 2209, D 69012 Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:6460-4. 1998
    ..Our results show that cholesterol is required for Abeta formation to occur and imply a link between cholesterol, Abeta, and Alzheimer's disease...
  2. ncbi request reprint Lipid rafts and signal transduction
    K Simons
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 1:31-9. 2000
    ..Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades...
  3. pmc Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p
    L A Huber
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 123:47-55. 1993
    ..However, no effect was observed on axonal transport of influenza HA. From these results we conclude that rab8p is involved in transport of proteins to the dendritic surface in neurons...
  4. ncbi request reprint Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily
    V M Olkkonen
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Sci 106:1249-61. 1993
    ..Finally, rab24 was found in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures. The localization of rab24 may indicate its involvement in autophagy-related processes...
  5. ncbi request reprint VIP17/MAL, a proteolipid in apical transport vesicles
    D Zacchetti
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    FEBS Lett 377:465-9. 1995
    ..These and other results suggest that VIP17/MAL is an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane...
  6. pmc VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells
    K Fiedler
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 13:1729-40. 1994
    ....
  7. pmc Caveolin-1 and -2 in the exocytic pathway of MDCK cells
    P Scheiffele
    Cell Biology Programme, European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    J Cell Biol 140:795-806. 1998
    ..Thus, we suggest that caveolin-1 homooligomers play a role in apical transport...
  8. ncbi request reprint Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
    T Harder
    European Molecular Biology Laboratory, Cell Biology Programme, Heidelberg, Germany
    Curr Opin Cell Biol 9:534-42. 1997
    ..Recent data suggest that clustering of raft components could regulate raft dynamics and therefore represents an important feature in the function of these membrane microdomains...
  9. pmc Caveolae and sorting in the trans-Golgi network of epithelial cells
    P Dupree
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:1597-605. 1993
    ..This connection is confirmed by the recent finding that the amino acid sequence of VIP21 is almost identical to that of caveolin, a protein previously localized to caveolae...
  10. pmc Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
    L A Huber
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 123:35-45. 1993
    ..We conclude that rab8 plays a role in membrane traffic from the TGN to the basolateral plasma membrane in MDCK cells...
  11. pmc Annexin XIIIb associates with lipid microdomains to function in apical delivery
    F Lafont
    European Molecular Biology Laboratory, Cell Biology and Biophysics Programme, D 69012 Heidelberg, Germany
    J Cell Biol 142:1413-27. 1998
    ..These results suggest that annexin XIIIb directly participates in apical delivery...
  12. ncbi request reprint Identification of components of trans-Golgi network-derived transport vesicles and detergent-insoluble complexes by nanoelectrospray tandem mass spectrometry
    A Shevchenko
    Peptide and Protein Group, European Molecular Biology Laboratory, Heidelberg, Germany
    Electrophoresis 18:2591-600. 1997
    ..With these approaches and with the previously published data we have now identified most of the major low molecular weight proteins recovered in detergent-insoluble glycolipid-enriched complexes...
  13. ncbi request reprint The differential miscibility of lipids as the basis for the formation of functional membrane rafts
    A Rietveld
    European Molecular Biology Laboratory, Cell Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Biochim Biophys Acta 1376:467-79. 1998
    ..These domains are dynamic assemblies to which specific proteins are selectively sequestered while others are excluded. The proteins associated to rafts can act as organizers and can modulate raft size and function...
  14. ncbi request reprint Multicolour imaging of post-Golgi sorting and trafficking in live cells
    P Keller
    Cell Biology/Biophysics Programme, European Molecular Biology Laboratory (EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
    Nat Cell Biol 3:140-9. 2001
    ..Fusion with the plasma membrane was detected by total internal reflection microscopy and reveals differences between apical and basolateral carriers as well as new 'hot spots' for exocytosis...
  15. ncbi request reprint Characterization of VIP36, an animal lectin homologous to leguminous lectins
    K Fiedler
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Sci 109:271-6. 1996
    ..Glycopeptides obtained from [3H]galactose-labelled cells bind to VIP36 and can be eluted with N-acetyl-D-galactosamine. Our data imply that VIP36 functions as a lectin in post-Golgi trafficking...
  16. ncbi request reprint Post-Golgi biosynthetic trafficking
    P Keller
    European Molecular Biology Laboratory, Cell Biology Programme, D 69012 Heidelberg, Germany
    J Cell Sci 110:3001-9. 1997
    ..While much remains to be learned about these sorting mechanisms, it is apparent that a number of pathways previously believed to be restricted to certain cell types might be used more commonly...
  17. ncbi request reprint Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
    A Rietveld
    Cell Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 274:12049-54. 1999
    ..They further suggest sterol modification as a novel mechanism for targeting proteins to raft membranes and raise the possibility that signaling and polarized intracellular transport of Hedgehog are based on raft association...
  18. ncbi request reprint How cells handle cholesterol
    K Simons
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse, 01307 Dresden, Germany
    Science 290:1721-6. 2000
    ..The regulation of cholesterol homeostasis is now receiving a new focus, and this changed perspective may throw light on diseases caused by cholesterol excess, the prime example being atherosclerosis...
  19. ncbi request reprint Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation
    T Harder
    Max Planck Institute for Molecular Cell Biology and Genetics, and Cell Biology and Biophysics Programme, Heidelberg, Germany
    Eur J Immunol 29:556-62. 1999
    ..These observations show a link between raft-mediated signaling and the interaction of actin cytoskeleton with raft membrane domains...
  20. pmc Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast
    M Bagnat
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Mol Biol Cell 12:4129-38. 2001
    ..We suggest that clustering facilitates partition of Pma1p into rafts and transport to the cell surface...
  21. ncbi request reprint Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain
    V M Olkkonen
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Gene 138:207-11. 1994
    ..A Northern analysis revealed that the rab23 mRNA is predominantly expressed in the brain, which places the protein, together with Rab3a and Rab15, in the group of small GTPases characteristic of the nervous system...
  22. pmc Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila
    S Eaton
    Programme in Cell Biology, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 135:1277-89. 1996
    ..During hair formation, the apical microtubules that point distally elongate and fill the emerging wing hair. As the hair elongates, junctional proteins are reorganized on the proximal and distal edges of each cell...
  23. pmc Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling
    F Lafont
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 98:3180-4. 2001
    ..Because Cbl is known to interact with the FcepsilonRI signaling complex, ubiquitination is likely to be an important parameter regulating IgE-triggered signaling occurring in rafts...
  24. pmc Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane
    K Fiedler
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    J Cell Biol 128:1043-53. 1995
    ..We propose that annexin XIIIb plays a role in vesicular transport to the apical plasma membrane in MDCK cells...
  25. pmc VIP21/caveolin is a cholesterol-binding protein
    M Murata
    European Molecular Biology Laboratory, Cell Biology Programme, Heidelberg, Germany
    Proc Natl Acad Sci U S A 92:10339-43. 1995
    ..These findings suggest that VIP21/caveolin, through its cholesterol-binding properties, serves a specific function in microdomain formation during membrane trafficking...