M Saraste

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint Oxidative phosphorylation at the fin de siècle
    M Saraste
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D 69012, Heidelberg, Germany
    Science 283:1488-93. 1999
  2. pmc Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center
    M Wilmanns
    European Molecular Biology Laboratory, Heidelberg, Germany
    Proc Natl Acad Sci U S A 92:11955-9. 1995
  3. ncbi request reprint Structure of the pleckstrin homology domain from beta-spectrin
    M J Macias
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 369:675-7. 1994
  4. ncbi request reprint Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
    E Baraldi
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D 69012 Heidelberg, Germany
    Structure 7:449-60. 1999
  5. ncbi request reprint Reaction of carbon monoxide with the reduced active site of bacterial nitric oxide reductase
    J H Hendriks
    European Molecular Biology Laboratory, Meyerhofstrasse 1 D-69126 Heidelberg, Germany
    Biochemistry 40:13361-9. 2001
  6. ncbi request reprint A second terminal oxidase in Sulfolobus acidocaldarius
    M Lubben
    European Molecular Biology Laboratory, Heidelberg, Germany
    Eur J Biochem 224:151-9. 1994
  7. ncbi request reprint Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex
    J van der Oost
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Mol Biol 229:794-6. 1993
  8. pmc Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin
    M E Noble
    EMBL, Heidelberg, Germany
    EMBO J 12:2617-24. 1993
  9. pmc Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia
    M Hyvonen
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 16:3396-404. 1997
  10. ncbi request reprint Bacillus subtilis cytochrome oxidase mutants: biochemical analysis and genetic evidence for two aa3-type oxidases
    J van der Oost
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Microbiol 5:2063-72. 1991

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Oxidative phosphorylation at the fin de siècle
    M Saraste
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D 69012, Heidelberg, Germany
    Science 283:1488-93. 1999
    ..This work, and new enzymological studies of ATP synthase's unusual catalytic mechanism, are reviewed here...
  2. pmc Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center
    M Wilmanns
    European Molecular Biology Laboratory, Heidelberg, Germany
    Proc Natl Acad Sci U S A 92:11955-9. 1995
    ..The residues that are distinct in cytochrome c and quinol oxidases are around the dinuclear copper center. Structural comparison suggests a common ancestry for subunit II of cytochrome oxidase and blue copper-binding proteins...
  3. ncbi request reprint Structure of the pleckstrin homology domain from beta-spectrin
    M J Macias
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 369:675-7. 1994
    ..There is a distant relationship to the peptidyl-prolyl-cis-trans-isomerase FKBP in which this pocket is involved in the binding of the macrocyclic compound FK506 (refs 8-11)...
  4. ncbi request reprint Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
    E Baraldi
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D 69012 Heidelberg, Germany
    Structure 7:449-60. 1999
    ..Point mutations in the PH domain might abolish membrane binding, preventing signalling via Btk...
  5. ncbi request reprint Reaction of carbon monoxide with the reduced active site of bacterial nitric oxide reductase
    J H Hendriks
    European Molecular Biology Laboratory, Meyerhofstrasse 1 D-69126 Heidelberg, Germany
    Biochemistry 40:13361-9. 2001
    ..2 x 10(5) M(-1) x s(-1)). This suggests that an existing heme distal ligand (water/OH-) may be displaced to elicit the spin-state change observed in the RT-MCD spectrum...
  6. ncbi request reprint A second terminal oxidase in Sulfolobus acidocaldarius
    M Lubben
    European Molecular Biology Laboratory, Heidelberg, Germany
    Eur J Biochem 224:151-9. 1994
    ..We suggest that SoxM is the core component of a second terminal oxidase complex and that this complex may share a subunit (SoxC) with the SoxABCD complex...
  7. ncbi request reprint Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex
    J van der Oost
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Mol Biol 229:794-6. 1993
    ..coli, purified and crystallized. Crystals were grown using ammonium sulphate as a precipitant. They have space group I222 or I2(1)2(1)2(1) and diffract X-rays to 2.3 A resolution...
  8. pmc Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin
    M E Noble
    EMBL, Heidelberg, Germany
    EMBO J 12:2617-24. 1993
    ..These loops are different in tyrosine kinase and spectrin SH3 domains. They could modulate the binding properties of the aromatic surface...
  9. pmc Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia
    M Hyvonen
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 16:3396-404. 1997
    ..Our structure opens up new ways to study the role of the PH domain and Btk motif in the cellular function of Btk and the molecular basis of its dysfunction in XLA patients...
  10. ncbi request reprint Bacillus subtilis cytochrome oxidase mutants: biochemical analysis and genetic evidence for two aa3-type oxidases
    J van der Oost
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Microbiol 5:2063-72. 1991
    ..Radioactive haem-labelling was used to identify subunit II, which contains a haem C, and cytochrome c-550 among the membrane-bound c-type cytochromes of B. subtilis...
  11. ncbi request reprint New archaebacterial genes coding for redox proteins: implications for the evolution of aerobic metabolism
    J Castresana
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Mol Biol 250:202-10. 1995
    ..A phylogenetic analysis of the new protein sequences gives support to the view that an elaborate aerobic respiratory chain was already present in the last common ancestor of all living organisms...
  12. ncbi request reprint High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides
    A Musacchio
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Struct Biol 1:546-51. 1994
    ..Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3...
  13. ncbi request reprint Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil
    J Pascual
    European Molecular Biology Laboratory, Meyerhofstr 1, Heidelberg, 69012, Germany
    J Mol Biol 273:740-51. 1997
    ..Model building by homology of the "tetramerization" repeat from human erythrocyte spectrin illuminates the possible role of point mutations which cause hemolytic anemias...
  14. ncbi request reprint States and transitions during forced unfolding of a single spectrin repeat
    P F Lenne
    European Molecular Biology, Cell Biology and Biophysics Programme, P O Box 10 2209, D 69012, Heidelberg, Germany
    FEBS Lett 476:124-8. 2000
    ..Single molecule force spectroscopy appears to open a new window for the analysis of transition probabilities between different conformational states...
  15. ncbi request reprint Crystal structure of the alpha-actinin rod reveals an extensive torsional twist
    J Ylanne
    European Molecular Biology Laboratory, EMBL, Structural and Computational Biology Programme, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Structure 9:597-604. 2001
    ..The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins...
  16. ncbi request reprint Crystallization and preliminary X-ray diffraction studies of perchloric acid soluble protein (PSP) from rat liver
    K Djinovic Carugo
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Acta Crystallogr D Biol Crystallogr 55:667-8. 1999
    ..90 A and two molecules per asymmetric unit, as indicated from a Vm value of 2.12 A3 Da-1 and self-rotation function computation. Screening for heavy-atom derivatives identified a platinum compound and xenon that bind to the protein...
  17. ncbi request reprint Two cysteines, two histidines, and one methionine are ligands of a binuclear purple copper center
    M Kelly
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Biol Chem 268:16781-7. 1993
    ..In contrast, substitution of the invariant glutamate residue, which is located between the copper-binding cysteines, leads to a minor perturbation of the optical spectrum...
  18. ncbi request reprint Properties of the detergent solubilised cytochrome c oxidase (cytochrome cbb(3)) purified from Pseudomonas stutzeri
    A Urbani
    European Molecular Biology Laboratory, Structural and Computational Biology Programme, Meyerhof Str 1, D 69117 Heidelberg, Germany
    FEBS Lett 508:29-35. 2001
    ..Crystals diffracting to 5.0 A resolution have been grown by the vapour diffusion sitting drop method to an average size of 0.1 x 0.1 x 0.3 mm. This is the first crystallisation report of a (cbb(3))-type oxidase...
  19. pmc Molecular mechanism of the calcium-induced conformational change in the spectrin EF-hands
    G Trave
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 14:4922-31. 1995
    ..Our results allow formulation of the rules which govern the movement induced by calcium. These rules may be generalized to other EF-hands since the key residues involved are conserved within the calmodulin family...
  20. ncbi request reprint From NO to OO: nitric oxide and dioxygen in bacterial respiration
    J Hendriks
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Bioenerg Biomembr 30:15-24. 1998
    ..This review is a brief summary of the current knowledge on molecular biology, structure, and bioenergetics of NOR as a member of the oxidase superfamily...
  21. ncbi request reprint The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme
    M Saraste
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Eur J Biochem 195:517-25. 1991
    ..subtilis [de Vrij, W., Azzi, A. & Konings, W. N. (1983) Eur. J. Biochem. 131, 97-103] is not encoded by the ctaC-F genes; thus, there seems to be two different cytochrome-aa3-type oxidases in this Gram-positive bacterium...
  22. pmc An archaebacterial terminal oxidase combines core structures of two mitochondrial respiratory complexes
    M Lubben
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 11:805-12. 1992
    ....
  23. pmc Structure of the binding site for inositol phosphates in a PH domain
    M Hyvonen
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 14:4676-85. 1995
    ..They could also participate in a response to a second messenger such as inositol trisphosphate, organizing cross-roads in cellular signalling...
  24. ncbi request reprint Crystal structure of a calponin homology domain
    K Djinovic Carugo
    Nat Struct Biol 4:175-9. 1997
    ..The three-dimensional structure of the calponin homology domain present in many actin binding cytoskeletal and signal-transducing proteins has been determined at 2.0 A resolution...
  25. ncbi request reprint pH-induced conformational transition in the soluble CuA domain of Paracoccus denitrificans cytochrome oxidase
    S Gupta
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India
    Biochemistry 40:6180-9. 2001
    ..The results are discussed in the light of understanding the pH-induced conformational change in the beta-barrel structure of the protein and its effect on the coordination geometry of the metal site...
  26. ncbi request reprint Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria
    J E Walker
    J Mol Biol 184:677-701. 1985
    ..The counterpart of the bacterial delta-subunit is bovine oligomycin sensitivity conferral protein, which helps to bind F1 to the inner mitochondrial membrane.(ABSTRACT TRUNCATED AT 400 WORDS)..
  27. pmc Primary structure of the brain alpha-spectrin
    V M Wasenius
    Department of Pathology, University of Helsinki, Finland
    J Cell Biol 108:79-93. 1989
    ..Comparative analysis showed that alpha-spectrin is well conserved across the species boundaries from Xenopus to man, and that the human erythrocyte alpha-spectrin is divergent from the other spectrins...
  28. ncbi request reprint Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7
    T Pikkarainen
    J Biol Chem 262:10454-62. 1987
    ..Using somatic cell hybrid methodology and in situ hybridization to metaphase chromosomes it was established that the human laminin B1 gene (LAMB1) is located in the q22 region of chromosome 7...
  29. ncbi request reprint The unc operon. Nucleotide sequence, regulation and structure of ATP-synthase
    J E Walker
    Biochim Biophys Acta 768:164-200. 1984
  30. ncbi request reprint Structural comparisons of calponin homology domains: implications for actin binding
    S Banuelos
    European Molecular Biology Laboratory Postfach 10 2209 D 69012 Heidelberg, Germany
    Structure 6:1419-31. 1998
    ..The three-dimensional structures of three CH domains are known, but they have not yet clarified the molecular details of the interaction between actin filaments and proteins harbouring CH domains...
  31. pmc The atp operon: nucleotide sequence of the genes for the gamma, beta, and epsilon subunits of Escherichia coli ATP synthase
    M Saraste
    Nucleic Acids Res 9:5287-96. 1981
    ..The genes for the alpha and beta subunits have evolved from a common ancestor...
  32. pmc Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
    J E Walker
    EMBO J 1:945-51. 1982
    ....
  33. ncbi request reprint Crystal structure of a Src-homology 3 (SH3) domain
    A Musacchio
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 359:851-5. 1992
    ..We suggest that a protein ligand binds to this conserved surface of SH3...