Robert B Russell

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint A structural perspective on protein-protein interactions
    Robert B Russell
    EMBL, Heidelberg, Germany
    Curr Opin Struct Biol 14:313-24. 2004
  2. pmc 3did: interacting protein domains of known three-dimensional structure
    Amelie Stein
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 33:D413-7. 2005
  3. doi request reprint A careful disorderliness in the proteome: sites for interaction and targets for future therapies
    Robert B Russell
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    FEBS Lett 582:1271-5. 2008
  4. pmc DILIMOT: discovery of linear motifs in proteins
    Victor Neduva
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 34:W350-5. 2006
  5. pmc Accurate prediction of peptide binding sites on protein surfaces
    Evangelia Petsalaki
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Comput Biol 5:e1000335. 2009
  6. ncbi request reprint Targeting and tinkering with interaction networks
    Robert B Russell
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Chem Biol 4:666-73. 2008
  7. ncbi request reprint Classification of protein folds
    Robert B Russell
    Structural Bioinformatics, EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Mol Biotechnol 36:238-47. 2007
  8. ncbi request reprint Structure-based assembly of protein complexes in yeast
    Patrick Aloy
    European Molecular Biology Laboratory, Structural and Computational Biology Programme, 1, 69117 Heidelberg, Germany
    Science 303:2026-9. 2004
  9. ncbi request reprint Protein complexes: structure prediction challenges for the 21st century
    Patrick Aloy
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Struct Biol 15:15-22. 2005
  10. ncbi request reprint InterPreTS: protein interaction prediction through tertiary structure
    Patrick Aloy
    EMBL, Meyerhofstrasse, 1, D 69117, Heidelberg, Germany
    Bioinformatics 19:161-2. 2003

Detail Information

Publications68

  1. ncbi request reprint A structural perspective on protein-protein interactions
    Robert B Russell
    EMBL, Heidelberg, Germany
    Curr Opin Struct Biol 14:313-24. 2004
    ..Recent advances and applications of these methods emphasize the need for hybrid approaches that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness...
  2. pmc 3did: interacting protein domains of known three-dimensional structure
    Amelie Stein
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 33:D413-7. 2005
    ..The database also contains Gene Ontology-based functional annotations and interactions between yeast proteins from large-scale interaction discovery studies. A web-based tool to query 3did is available at http://3did.embl.de...
  3. doi request reprint A careful disorderliness in the proteome: sites for interaction and targets for future therapies
    Robert B Russell
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    FEBS Lett 582:1271-5. 2008
    ..These regions also offer new possibilities into how interactions can be targeted by small molecules...
  4. pmc DILIMOT: discovery of linear motifs in proteins
    Victor Neduva
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 34:W350-5. 2006
    ..The results are displayed via a visual interface for easy perusal. The server is available at http://dilimot.embl.de...
  5. pmc Accurate prediction of peptide binding sites on protein surfaces
    Evangelia Petsalaki
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Comput Biol 5:e1000335. 2009
    ..The method, and associated statistics, is an excellent tool for predicting and studying binding sites for newly discovered peptides mediating critical events in biology...
  6. ncbi request reprint Targeting and tinkering with interaction networks
    Robert B Russell
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Chem Biol 4:666-73. 2008
    ....
  7. ncbi request reprint Classification of protein folds
    Robert B Russell
    Structural Bioinformatics, EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Mol Biotechnol 36:238-47. 2007
    ..We also provide worked examples showing how these tools can have an impact on the understanding of protein function prior to experimental studies...
  8. ncbi request reprint Structure-based assembly of protein complexes in yeast
    Patrick Aloy
    European Molecular Biology Laboratory, Structural and Computational Biology Programme, 1, 69117 Heidelberg, Germany
    Science 303:2026-9. 2004
    ..We also consider interactions between complexes (cross-talk) and use these to construct a structure-based network of molecular machines in the cell...
  9. ncbi request reprint Protein complexes: structure prediction challenges for the 21st century
    Patrick Aloy
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Struct Biol 15:15-22. 2005
    ..To produce the best models, new prediction methods have to somehow combine partial structures with a mixed bag of experimental data, including interactions and low-resolution electron microscopy images...
  10. ncbi request reprint InterPreTS: protein interaction prediction through tertiary structure
    Patrick Aloy
    EMBL, Meyerhofstrasse, 1, D 69117, Heidelberg, Germany
    Bioinformatics 19:161-2. 2003
    ..InterPreTS includes a useful interface for visualising molecular details of any predicted interaction...
  11. pmc Systematic discovery of new recognition peptides mediating protein interaction networks
    Victor Neduva
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 3:e405. 2005
    ..We estimate that there are dozens or even hundreds of linear motifs yet to be discovered that will give molecular insight into protein networks and greatly illuminate cellular processes...
  12. pmc GlobPlot: Exploring protein sequences for globularity and disorder
    Rune Linding
    European Molecular Biology Laboratory, Biocomputing Unit, D 69117 Heidelberg, Germany
    Nucleic Acids Res 31:3701-8. 2003
    ..GlobPlot has a pipeline interface--GlobPipe--for the advanced user to do whole proteome analysis. GlobPlot can also be used as a generic infrastructure package for graphical displaying of any possible propensity...
  13. pmc Identification of Drosophila MicroRNA targets
    Alexander Stark
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 1:E60. 2003
    ..While the screen is likely to miss some targets, our study shows that valid targets can be identified from sequence alone...
  14. ncbi request reprint Predictions without templates: new folds, secondary structure, and contacts in CASP5
    Patrick Aloy
    EMBL, Heidelberg, Germany
    Proteins 53:436-56. 2003
    ..For contact predictions, accuracies are still low, although there were several instances of accurate and useful contacts predicted de novo, and new approaches hint at future progress...
  15. ncbi request reprint A model for statistical significance of local similarities in structure
    Alexander Stark
    EMBL, Structural and Computational Biology Programme, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    J Mol Biol 326:1307-16. 2003
    ..The approach is highly complementary to fold comparison for providing functional clues for new structures, and is key for the detection of recurrences of any new pattern...
  16. ncbi request reprint Ten thousand interactions for the molecular biologist
    Patrick Aloy
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Biotechnol 22:1317-21. 2004
    ..We currently know fewer than 2,000, and at the present rate of structure determination, it will be more than 20 years before we know a full representative set...
  17. ncbi request reprint The relationship between sequence and interaction divergence in proteins
    Patrick Aloy
    Structural and Computational Biology Programme, EMBL Heidelberg, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    J Mol Biol 332:989-98. 2003
    ..We also discuss the rare instances of fold similarities interacting the same way, and those where obviously homologous proteins interact differently...
  18. ncbi request reprint Protein disorder prediction: implications for structural proteomics
    Rune Linding
    EMBL, Biocomputing Unit, Meyerhofstr 1, D 69117 Heidelberg, Germany
    Structure 11:1453-9. 2003
    ..The tool is freely available via a web interface (http://dis.embl.de) and can be downloaded for use in large-scale studies...
  19. ncbi request reprint Peptides mediating interaction networks: new leads at last
    Victor Neduva
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Biotechnol 17:465-71. 2006
    ..Concurrently, other work has demonstrated that it is possible to target these interactions using small molecules. Together these developments hold great promise for future efforts to target chemically precise details of complex systems...
  20. pmc Principles of microRNA-target recognition
    Julius Brennecke
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 3:e85. 2005
    ....
  21. ncbi request reprint Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution
    Alexander Stark
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 123:1133-46. 2005
    ..This mutually exclusive expression argues that microRNAs confer accuracy to developmental gene-expression programs, thus ensuring tissue identity and supporting cell-lineage decisions...
  22. ncbi request reprint A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains
    Raphaël Métivier
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell 10:1019-32. 2002
    ..This model gives insights into the dynamic properties of full-length ERalpha and into the structure of unliganded ERalpha...
  23. pmc Annotation in three dimensions. PINTS: Patterns in Non-homologous Tertiary Structures
    Alexander Stark
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 31:3341-4. 2003
    ..To aid functional annotation of proteins, we allow comparisons of pre-defined patterns against databases of complete structures and of entire structures to databases of particular residues likely to be functionally important...
  24. ncbi request reprint Getting the most from your protein sequence
    Richard R Copley
    EMBL, Heidelberg, Germany
    Methods Mol Biol 211:411-30. 2003
  25. ncbi request reprint Proteome organization in a genome-reduced bacterium
    Sebastian Kühner
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 326:1235-40. 2009
    ..The data set provides a blueprint of the minimal cellular machinery required for life...
  26. ncbi request reprint Proteome survey reveals modularity of the yeast cell machinery
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
    ..This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling...
  27. ncbi request reprint Finding functional sites in structural genomics proteins
    Alexander Stark
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Structure 12:1405-12. 2004
    ..The approach is applied weekly to all new structures, providing a resource for those interested in using structure to infer function...
  28. ncbi request reprint Proline-rich regions in transcriptional complexes: heading in many directions
    Victor Neduva
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Sci STKE 2007:pe1. 2007
    ..The results underscore the importance of protein modularity in complex organization, as well as the role of irregular or disordered parts of proteins in crucial biological processes...
  29. pmc Combinations of protein-chemical complex structures reveal new targets for established drugs
    Olga V Kalinina
    Cell Networks, University of Heidelberg, Heidelberg, Germany
    PLoS Comput Biol 7:e1002043. 2011
    ..The growth rate of confident predictions is twice that of experimental complexes, meaning that a complete structural drug-protein repertoire will be available at least ten years earlier than by X-ray and NMR techniques alone...
  30. pmc Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium
    Vera van Noort
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, EMBL, Heidelberg, Germany
    Mol Syst Biol 8:571. 2012
    ..The results imply previously unreported hidden layers of post-transcriptional regulation intertwining phosphorylation with lysine acetylation and other mechanisms that define the functional state of a cell...
  31. pmc Combining specificity determining and conserved residues improves functional site prediction
    Olga V Kalinina
    EMBL Heidelberg, Heidelberg, Germany
    BMC Bioinformatics 10:174. 2009
    ..g. in the hydrophobic core). Many protein families bind and/or act on a variety of ligands, meaning that conserved residues often only bind a common ligand sub-structure or perform general catalytic activities...
  32. ncbi request reprint Structure-based systems biology: a zoom lens for the cell
    Patrick Aloy
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    FEBS Lett 579:1854-8. 2005
    ..We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins...
  33. ncbi request reprint The third dimension for protein interactions and complexes
    Patrick Aloy
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Trends Biochem Sci 27:633-8. 2002
  34. pmc A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae
    Oriol Gallego
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, EMBL, Heidelberg, Germany
    Mol Syst Biol 6:430. 2010
    ....
  35. ncbi request reprint Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins
    Esben Lorentzen
    European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, D 22603 Hamburg, Germany
    J Biol Chem 278:47253-60. 2003
    ..Structural comparisons, furthermore, establish an evolutionary link to the triosephosphate isomerases, a superfamily hitherto considered independent from the superfamily of aldolases...
  36. pmc Structural similarity to bridge sequence space: finding new families on the bridges
    Parantu K Shah
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Protein Sci 14:1305-14. 2005
    ..We quantify the associated increase in structural information in Swissprot and discuss examples illustrating the applicability of this approach to understand functional and evolutionary relationships between protein families...
  37. pmc Interrogating protein interaction networks through structural biology
    Patrick Aloy
    European Molecular Biology Laboratory EMBL, Postfach 10 22 09, D 69012, Heidelberg, Germany
    Proc Natl Acad Sci U S A 99:5896-901. 2002
    ..We provide confirmation for several interactions, in addition to suggesting molecular details of how they occur...
  38. ncbi request reprint Peptide-mediated interactions in biological systems: new discoveries and applications
    Evangelia Petsalaki
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Biotechnol 19:344-50. 2008
    ..We propose that projects to uncover the protein-peptide repertoire used in Nature in a systematic way will have numerous applications in molecular biology and medicine...
  39. ncbi request reprint The hard cell: from proteomics to a whole cell model
    Matthew J Betts
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    FEBS Lett 581:2870-6. 2007
    ..In this minireview, we discuss these data, and the issues of turning them into whole cell models...
  40. pmc Harry Potter and the structural biologist's (Key)stone
    Damien Devos
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Genome Biol 7:333. 2006
  41. doi request reprint WD40 proteins propel cellular networks
    Christian U Stirnimann
    European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Biochem Sci 35:565-74. 2010
    ..We discuss the WD40 domain distributions in protein networks and structures of WD40-containing assemblies to demonstrate their versatility in mediating critical cellular functions...
  42. ncbi request reprint Evolutionary relationship between the bacterial HPr kinase and the ubiquitous PEP-carboxykinase: expanding the P-loop nucleotidyl transferase superfamily
    Robert B Russell
    Structural and Computational Biology Programme, EMBL, Heidelberg, Germany
    FEBS Lett 517:1-6. 2002
    ..We used the structure-based sequence alignment containing residues specific to HPrK/PCK to identify additional members of this P-loop containing family...
  43. pmc Genomics, proteomics and bioinformatics: all in the same boat
    Robert B Russell
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Genome Biol 3:REPORTS4034. 2002
    ..A report on the Genomics, Proteomics and Bioinformatics for Medicine (GPBM) 2002 meeting, St. Petersburg to Moscow, Russia, 22-30 June 2002...
  44. ncbi request reprint A more complete, complexed and structured interactome
    Damien Devos
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Struct Biol 17:370-7. 2007
    ..As a result, we have a more complete view of how many complexes are in living systems, what they look like and the roles they play in the cell...
  45. ncbi request reprint Linear motifs: evolutionary interaction switches
    Victor Neduva
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    FEBS Lett 579:3342-5. 2005
    ..In this Minireview, we discuss various aspects of these critically important functional regions...
  46. pmc Content disputes in Wikipedia reflect geopolitical instability
    Gordana Apic
    Cell Networks, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e20902. 2011
    ..For some countries, changes over a four year period appear to correlate with world events related to conflicts or economic problems...
  47. pmc Geminate structures of African cassava mosaic virus
    Bettina Bottcher
    Structural and Computational and Biology Programme EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Virol 78:6758-65. 2004
    ..The differences of ACMV and MSV virion shapes are discussed with reference to their different animal vectors...
  48. pmc Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions
    José Antonio Márquez
    European Molecular Biology Laboratory, Structural and Computational Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Proc Natl Acad Sci U S A 99:3458-63. 2002
    ..Thus, we propose that our structure represents a product/substrate mimic of the kinase/phosphatase reaction...
  49. pmc A complex prediction: three-dimensional model of the yeast exosome
    Patrick Aloy
    EMBL, Meyerhofstrasse, Heidelberg, Germany
    EMBO Rep 3:628-35. 2002
    ..The model suggests numerous experiments to probe exosome function, particularly with respect to subunits making direct atomic contacts and conserved, possibly functional residues within the predicted central pore of the complex...
  50. pmc Computational identification of novel amino-acid interactions in HIV Gag via correlated evolution
    Olga V Kalinina
    Cellnetworks, BIOQUANT, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e42468. 2012
    ..A reduction in infectivity caused by mutating one member of a significant pair could be rescued by a compensatory mutation of the other...
  51. pmc An automated stochastic approach to the identification of the protein specificity determinants and functional subfamilies
    Pavel V Mazin
    Cellnetworks, University of Heidelberg, Heidelberg, Germany
    Algorithms Mol Biol 5:29. 2010
    ....
  52. pmc Taking the mystery out of biological networks
    Patrick Aloy
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 5:349-50. 2004
  53. pmc Structural similarity to link sequence space: new potential superfamilies and implications for structural genomics
    Patrick Aloy
    EMBL, Biocomputing, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Protein Sci 11:1101-16. 2002
    ..We discuss implications for Structural Genomics initiatives and for improvements to sequence comparison methods...
  54. ncbi request reprint bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
  55. pmc Fold recognition without folds
    Kristin K Koretke
    Microbial Bioinformatics Group, GlaxoSmithKline, Collegeville, Pennsylvania 19426 0989, USA
    Protein Sci 11:1575-9. 2002
    ..Since the method, SENSER, does not require knowledge of the three-dimensional structure, it can be used to infer relationships that are not tractable by methods dependent on structural templates...
  56. ncbi request reprint Classification of protein folds
    Robert B Russell
    SmithKline Beecham Pharmaceuticals, Research and Development, Bioinformatics Research Group, New Frontiers Science Park North, Harlow, Essex, UK
    Mol Biotechnol 20:17-28. 2002
    ..Two examples (adenylate cyclase/DNA polymerase and glycogen phosphorylase/beta-glucosyltransferase) are presented to illustrate problems associated with protein classification...
  57. pmc SuperTarget and Matador: resources for exploring drug-target relationships
    Stefan Günther
    Structural Bioinformatics Group, Institute of Molecular Biology and Bioinformatics, Charite University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany
    Nucleic Acids Res 36:D919-22. 2008
    ..SuperTarget and Matador are available at http://insilico.charite.de/supertarget and http://matador.embl.de...
  58. pmc Systematic discovery of in vivo phosphorylation networks
    Rune Linding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 129:1415-26. 2007
    ..Applying this approach to DNA damage signaling, we show that 53BP1 and Rad50 are phosphorylated by CDK1 and ATM, respectively. We describe a scalable strategy to evaluate predictions, which suggests that BCLAF1 is a GSK-3 substrate...
  59. ncbi request reprint Systematic searches for molecular synapomorphies in model metazoan genomes give some support for Ecdysozoa after accounting for the idiosyncrasies of Caenorhabditis elegans
    Richard R Copley
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Evol Dev 6:164-9. 2004
    ..We conclude that the results from the intensively sampled ribosomal RNA genes supporting the Ecdysozoa hypothesis provide the most credible current estimates of metazoan phylogeny...
  60. ncbi request reprint CASH--a beta-helix domain widespread among carbohydrate-binding proteins
    Francesca D Ciccarelli
    Max Delbrueck Centrum, PO Box 740238, D 13092 Berlin, Germany
    Trends Biochem Sci 27:59-62. 2002
    ..The CASH domain is characterized by internal repetitions of glycines and hydrophobic residues that correspond to the repetitive units of a predicted or observed right-handed beta-helix structure of the pectate lyase superfamily...
  61. ncbi request reprint Fast fitting of atomic structures to low-resolution electron density maps by surface overlap maximization
    Hugo Ceulemans
    EMBL Structural Bioinformatics Group, Meyerhofstrasse 1 D 69117 Heidelberg, Germany
    J Mol Biol 338:783-93. 2004
    ..For targets for which partial complexes are available, the speed and performance of the method make it an attractive complement to existing methods, as many different hypotheses can be tested quickly on a single processor...
  62. doi request reprint Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity
    Silje A Solheim
    The Biotechnology Centre of Oslo, University of Oslo, Norway
    FEBS J 275:4863-74. 2008
    ..The presented data demonstrate a potential method for modulation of Src family kinase tyrosine phosphorylation through minor changes of the substrate SH3-interacting motif...
  63. doi request reprint Subunit architecture of intact protein complexes from mass spectrometry and homology modeling
    Thomas Taverner
    Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB2 1EW, UK
    Acc Chem Res 41:617-27. 2008
    ..Overall therefore this mass spectrometry and homology modeling approach has given significant insight into the structure of two previously intractable protein complexes and as such has broad application in structural biology...
  64. ncbi request reprint A shortcut to peptides to modulate platelets
    Gordana Apic
    Nat Chem Biol 3:83-4. 2007
  65. ncbi request reprint Illuminating drug discovery with biological pathways
    Gordana Apic
    Cambridge Cell Networks, William Gates Building, Cambridge CB3 0FD, UK
    FEBS Lett 579:1872-7. 2005
    ..A "systems" approach can help identify pathways related to a disease and can suggest secondary effects of drugs that might cause these problems and thus ultimately improve the drug discovery pipeline...
  66. ncbi request reprint Structural systems biology: modelling protein interactions
    Patrick Aloy
    Institucio Catalana de Recerca i Estudis Avancats, Barcelona, Spain
    Nat Rev Mol Cell Biol 7:188-97. 2006
    ..Structural details can ultimately turn abstract system representations into models that more accurately reflect biological reality...
  67. ncbi request reprint Potential artefacts in protein-interaction networks
    Patrick Aloy
    FEBS Lett 530:253-4. 2002