Heiko Runz

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. pmc Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G
    Heiko Runz
    Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory, EMBL, Heidelberg, Germany
    EMBO J 25:2953-65. 2006
  2. pmc Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
    Murat Iskar
    Structural and Computational Biology Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    Mol Syst Biol 9:662. 2013
  3. doi request reprint DetecTiff: a novel image analysis routine for high-content screening microscopy
    Daniel F Gilbert
    Cell Biology Biophysics Unit, EMBL, Heidelberg, Germany
    J Biomol Screen 14:944-55. 2009
  4. pmc Niemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage
    Carolina Tängemo
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    J Lipid Res 52:813-25. 2011
  5. pmc RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function
    Peter Blattmann
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Genet 9:e1003338. 2013
  6. doi request reprint Identification of cholesterol-regulating genes by targeted RNAi screening
    Fabian Bartz
    Institute of Human Genetics, University of Heidelberg, Seminarstrasse 2, Heidelberg, Germany
    Cell Metab 10:63-75. 2009
  7. ncbi request reprint NPC-db, a Niemann-Pick type C disease gene variation database
    Heiko Runz
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Hum Mutat 29:345-50. 2008
  8. ncbi request reprint Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
    Heiko Runz
    Center for Molecular Biology, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 22:1679-89. 2002

Collaborators

Detail Information

Publications8

  1. pmc Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G
    Heiko Runz
    Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory, EMBL, Heidelberg, Germany
    EMBO J 25:2953-65. 2006
    ..Consistent with this, membrane turnover of the COPII component Sec23p is delayed in sterol-depleted cells. Altogether, our results demonstrate the importance of sterol levels in COPII mediated ER-export...
  2. pmc Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
    Murat Iskar
    Structural and Computational Biology Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    Mol Syst Biol 9:662. 2013
    ..Taken together, the identified modules reveal the conservation of transcriptional responses towards drugs across cell types and organisms, and improve our understanding of both the molecular basis of drug action and human biology...
  3. doi request reprint DetecTiff: a novel image analysis routine for high-content screening microscopy
    Daniel F Gilbert
    Cell Biology Biophysics Unit, EMBL, Heidelberg, Germany
    J Biomol Screen 14:944-55. 2009
    ..The results show that DetecTiff can be applied with high consistency for automated quantitative analysis of image data (e.g., from large-scale functional RNAi screening projects)...
  4. pmc Niemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage
    Carolina Tängemo
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    J Lipid Res 52:813-25. 2011
    ..Taken together, our approach opens perspectives not only to support diagnosis, but also to better characterize mechanisms impacting cholesterol accumulation in NPC patient-derived cells...
  5. pmc RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function
    Peter Blattmann
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Genet 9:e1003338. 2013
    ....
  6. doi request reprint Identification of cholesterol-regulating genes by targeted RNAi screening
    Fabian Bartz
    Institute of Human Genetics, University of Heidelberg, Seminarstrasse 2, Heidelberg, Germany
    Cell Metab 10:63-75. 2009
    ..Taken together, TMEM97 and other factors described here are promising to yield further insights into how cells control cholesterol levels...
  7. ncbi request reprint NPC-db, a Niemann-Pick type C disease gene variation database
    Heiko Runz
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Hum Mutat 29:345-50. 2008
    ..The user is encouraged to search contents and submit novel information, thereby contributing to generate a valuable open-access tool that will allow a better understanding of the molecular and clinical details of NPC disease...
  8. ncbi request reprint Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
    Heiko Runz
    Center for Molecular Biology, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 22:1679-89. 2002
    ..Our results suggest that the subcellular distribution of cholesterol may be an important factor in how cholesterol alters Abeta production and the risk of Alzheimer's disease...