P Rørth

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint Gal4 in the Drosophila female germline
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Mech Dev 78:113-8. 1998
  2. ncbi request reprint Guidance of cell migration by the Drosophila PDGF/VEGF receptor
    P Duchek
    European Molecular Biology Laboratory, Developmental Biology Programme, 69117 Heidelberg, Germany
    Cell 107:17-26. 2001
  3. pmc Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion
    Anne Pacquelet
    European Molecular Biology Laboratory EMBL, 69117 Heidelberg, Germany
    J Cell Biol 170:803-12. 2005
  4. pmc Binding site for p120/delta-catenin is not required for Drosophila E-cadherin function in vivo
    Anne Pacquelet
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    J Cell Biol 160:313-9. 2003
  5. ncbi request reprint The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation
    P Rørth
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:23-30. 2000
  6. ncbi request reprint Systematic gain-of-function genetics in Drosophila
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Development 125:1049-57. 1998
  7. ncbi request reprint Specification of C/EBP function during Drosophila development by the bZIP basic region
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210
    Science 266:1878-81. 1994
  8. ncbi request reprint Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
    J Mata
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 101:511-22. 2000
  9. ncbi request reprint Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis
    P Duchek
    Developmental Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Science 291:131-3. 2001
  10. ncbi request reprint Cloning and expression of sprint, a Drosophila homologue of RIN1
    K Szabo
    Developmental Biology Programme, European Molecular Biology Laboratory, 69117, Heidelberg, Germany
    Mech Dev 101:259-62. 2001

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Gal4 in the Drosophila female germline
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Mech Dev 78:113-8. 1998
    ..FGF signaling guides tracheal cell migration in the embryo. However, misexpression of branchless in the ovary had no effect on border cell migration. Thus border cells and tracheal cells appear to be guided differently...
  2. ncbi request reprint Guidance of cell migration by the Drosophila PDGF/VEGF receptor
    P Duchek
    European Molecular Biology Laboratory, Developmental Biology Programme, 69117 Heidelberg, Germany
    Cell 107:17-26. 2001
    ..Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal...
  3. pmc Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion
    Anne Pacquelet
    European Molecular Biology Laboratory EMBL, 69117 Heidelberg, Germany
    J Cell Biol 170:803-12. 2005
    ..The nature of this additional function is discussed...
  4. pmc Binding site for p120/delta-catenin is not required for Drosophila E-cadherin function in vivo
    Anne Pacquelet
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    J Cell Biol 160:313-9. 2003
    ..Surprisingly, DE-cadherin-AAA was able to substitute for the wild-type protein in all contexts with no detectable perturbations. Thus, interaction with p120/delta-catenin does not appear to be required for DE-cadherin function in vivo...
  5. ncbi request reprint The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation
    P Rørth
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:23-30. 2000
    ..The Ubp64 ubiquitin hydrolase acts as a stabilizer of Slbo protein. A novel gene, tribbles, is a negative regulator of slbo in vivo. Tribbles acts by specifically targeting Slbo for rapid degradation via ubiquitination...
  6. ncbi request reprint Systematic gain-of-function genetics in Drosophila
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Development 125:1049-57. 1998
    ..These studies demonstrate the ability of the modular misexpression system to identify developmentally important genes and suggest that it will be generally useful for genetic interaction screens...
  7. ncbi request reprint Specification of C/EBP function during Drosophila development by the bZIP basic region
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210
    Science 266:1878-81. 1994
    ..Mammalian C/EBPs were also functional in Drosophila. In contrast, 9 of 25 single amino acid substitutions in the basic region disrupted biological function. Thus, the conserved basic region specifies DmC/EBP activity in the organism...
  8. ncbi request reprint Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
    J Mata
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 101:511-22. 2000
    ..By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination...
  9. ncbi request reprint Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis
    P Duchek
    Developmental Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Science 291:131-3. 2001
    ..The transforming growth factor-alpha (TGF-alpha)-like ligand Gurken appears to serve as the guidance cue. To mediate this guidance function, EGFR signals via a pathway that is independent of Raf-MAP kinase and receptor-specific...
  10. ncbi request reprint Cloning and expression of sprint, a Drosophila homologue of RIN1
    K Szabo
    Developmental Biology Programme, European Molecular Biology Laboratory, 69117, Heidelberg, Germany
    Mech Dev 101:259-62. 2001
    ..The expression patterns of the two sprint isoforms are temporally distinct suggesting that the isoforms may have unique functions...
  11. ncbi request reprint Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development
    P Rørth
    Howard Hughes Research Laboratory, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genes Dev 6:2299-311. 1992
    ..The strict requirement for C/EBP during Drosophila embryogenesis, coupled with its structural and functional similarities to mammalian C/EBP, provides a useful genetic system in which to study the role of C/EBP in development...
  12. pmc A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Proc Natl Acad Sci U S A 93:12418-22. 1996
    ..Thus, biologically relevant phenotypes and genetic interactions are identified using this method. The screen is a powerful new tool for developmental genetics; similar approaches can also be developed for other organisms...