A R Nebreda

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint p38 MAP kinases: beyond the stress response
    A R Nebreda
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Biochem Sci 25:257-60. 2000
  2. ncbi request reprint Regulation of the meiotic cell cycle in oocytes
    A R Nebreda
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Opin Cell Biol 12:666-75. 2000
  3. pmc A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes
    I Ferby
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 13:2177-89. 1999
  4. ncbi request reprint Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins
    A Karaiskou
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 276:36028-34. 2001
  5. pmc A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1
    A Palmer
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO J 17:5037-47. 1998
  6. ncbi request reprint Xkid, a chromokinesin required for chromosome alignment on the metaphase plate
    C Antonio
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 102:425-35. 2000
  7. ncbi request reprint Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
    R H Adams
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:109-16. 2000
  8. ncbi request reprint A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    J Rouse
    Department of Biochemistry, University of Dundee, Scotland
    Cell 78:1027-37. 1994
  9. ncbi request reprint Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
  10. pmc Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells
    A Cuenda
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
    EMBO J 15:4156-64. 1996

Collaborators

  • A Porras
  • G Alonso
  • R Klein
  • E Karsenti
  • I Vernos
  • C Hugh Reynolds
  • I Ferby
  • M Jones
  • A Palmer
  • M E Terret
  • A Karaiskou
  • C Antonio
  • R H Adams
  • A Cuenda
  • L H Perez
  • M H Verlhac
  • R Ozon
  • C Jessus
  • P Cohen
  • L Perez
  • S Panelli
  • K Vintersten
  • A Valladares
  • H Wilhelm
  • M Blazquez
  • R Eritja
  • A C Gavin
  • J Rouse
  • R Meier
  • N Morrice
  • A Alonso-Llamazares
  • S Trigon
  • D Zamanillo
  • T Hunt
  • M Morange

Detail Information

Publications11

  1. ncbi request reprint p38 MAP kinases: beyond the stress response
    A R Nebreda
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Biochem Sci 25:257-60. 2000
  2. ncbi request reprint Regulation of the meiotic cell cycle in oocytes
    A R Nebreda
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Opin Cell Biol 12:666-75. 2000
    ..New insights have been made recently into the signalling mechanisms that induce G2-arrested oocytes to resume and complete the meiotic cell cycle...
  3. pmc A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes
    I Ferby
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 13:2177-89. 1999
    ..Our results identify a novel p34(cdc2) binding and activating protein that regulates the G(2)/M transition during oocyte maturation...
  4. ncbi request reprint Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins
    A Karaiskou
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 276:36028-34. 2001
    ..Our results indicate that Cdk-RINGO complexes may be active under conditions in which cyclin-bound Cdks are inhibited and can therefore play different regulatory roles...
  5. pmc A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1
    A Palmer
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO J 17:5037-47. 1998
    ..Our results suggest that during oocyte maturation MAPK activates p90(rsk) and that p90(rsk) in turn down-regulates Myt1, leading to the activation of p34(cdc2)/cyclin B...
  6. ncbi request reprint Xkid, a chromokinesin required for chromosome alignment on the metaphase plate
    C Antonio
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 102:425-35. 2000
    ..Our results show that these forces are essential to ensure that kinetochores and chromosome arms align on a narrow equatorial plate during metaphase, a prerequisite for proper chromosome segregation...
  7. ncbi request reprint Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
    R H Adams
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:109-16. 2000
    ..Our results indicate that p38alpha is required for placental organogenesis but is not essential for other aspects of mammalian embryonic development...
  8. ncbi request reprint A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    J Rouse
    Department of Biochemistry, University of Dundee, Scotland
    Cell 78:1027-37. 1994
    ..The RKK, RK, and MAPKAP kinase-2 constitute a new stress-activated signal transduction pathway in vertebrates that is distinct from the classical MAPK cascade...
  9. ncbi request reprint Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
    ..Thus, the three MAP kinases and GSK3beta are importantly all strong candidates as tau kinases that may be involved in the pathogenic hyperphosphorylation of tau in Alzheimer's disease...
  10. pmc Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells
    A Cuenda
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
    EMBO J 15:4156-64. 1996
    ..The murine and human SAPKK3 were 97% identical in their amino acid sequences. We also cloned a different murine cDNA that appears to encode a SAPKK3 protein truncated at the N-terminus. SAPKK3 is identical to the recently cloned MKK6...
  11. ncbi request reprint RINGO efficiently triggers meiosis resumption in mouse oocytes and induces cell cycle arrest in embryos
    M E Terret
    Biologie Moleculaire et Cellulaire du Developpement, UMR 7622, CNRS Universite Pierre et Marie Curie, Paris, France
    Biol Cell 93:89-97. 2001
    ..The injection of RINGO mimics Mos effects: GVBD induction and efficient cleavage arrest. However, our results in mouse oocytes suggest that RINGO may have additional functions in meiosis regulation...