Maria J Macias

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi Structural analysis of WW domains and design of a WW prototype
    M J Macias
    Forschungsinstitut fur Molekulare Pharmakologie, Alfred Kowalke Str 4, 10315 Berlin, Germany
    Nat Struct Biol 7:375-9. 2000
  2. ncbi WW and SH3 domains, two different scaffolds to recognize proline-rich ligands
    Maria J Macias
    Structural and Computational Biology Program, EMBL Heidelberg, Heidelberg, Germany
    FEBS Lett 513:30-7. 2002
  3. ncbi Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40
    Silke Wiesner
    Structural Biology Programme, EMBL Heidelberg, Meyerhofstr 1, 69117 Heidelberg, Germany
    J Mol Biol 324:807-22. 2002
  4. ncbi The structure of Prp40 FF1 domain and its interaction with the crn-TPR1 motif of Clf1 gives a new insight into the binding mode of FF domains
    Alexander Gasch
    Structural Biology Program, EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 281:356-64. 2006
  5. ncbi Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily
    Concepcion Civera
    Dpto Quimica Fisica II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Proteins 58:354-66. 2005
  6. ncbi Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain
    Alison Z Shaw
    ICREA and the Biomedical Research Institute of Barcelona, Barcelona Science Park, Barcelona, Spain
    Proteins 60:558-60. 2005
  7. ncbi Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains
    Marina Brucet
    Macrophage Biology Group, Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain
    J Biol Chem 282:14547-57. 2007
  8. ncbi Structural characterization of a new binding motif and a novel binding mode in group 2 WW domains
    Ximena Ramirez-Espain
    Institute for Research in Biomedicine Protein NMR group, and the Institució catalana de recerca i estudis avançats ICREA, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    J Mol Biol 373:1255-68. 2007
  9. ncbi NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands
    Begoña Morales
    Institute of Research in Biomedicine, Institucio Catalana de Recerca i Estudis Avancats, Passeig Lluis Companys 23, 08010 Barcelona, Spain
    Structure 15:473-83. 2007

Collaborators

  • Silke Wiesner
  • Marius Sudol
  • H Oschkinat
  • Ximena Ramirez-Espain
  • Pau Martin-Malpartida
  • Lidia Ruiz
  • Alison Z Shaw
  • Begoña Morales
  • Antonio Celada
  • Marina Brucet
  • Miriam Royo
  • Francesc Yraola
  • Alexander Gasch
  • Concepcion Civera
  • Ester Sánchez-Tilló
  • Ignacio Fita
  • Maria Serra
  • Jorge Lloberas
  • Kamila Bertlik
  • Consol Farrera
  • Jordi Querol-Audi
  • Bernd Simon
  • Gunter Stier
  • Michael Sattler

Detail Information

Publications9

  1. ncbi Structural analysis of WW domains and design of a WW prototype
    M J Macias
    Forschungsinstitut fur Molekulare Pharmakologie, Alfred Kowalke Str 4, 10315 Berlin, Germany
    Nat Struct Biol 7:375-9. 2000
    ....
  2. ncbi WW and SH3 domains, two different scaffolds to recognize proline-rich ligands
    Maria J Macias
    Structural and Computational Biology Program, EMBL Heidelberg, Heidelberg, Germany
    FEBS Lett 513:30-7. 2002
    ..The binding surface of the modeled WW domain of Npw38 protein shows a remarkable similarity to the SH3 domain of Sem5 protein, confirming biochemical data on similar binding predilections of both domains...
  3. ncbi Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40
    Silke Wiesner
    Structural Biology Programme, EMBL Heidelberg, Meyerhofstr 1, 69117 Heidelberg, Germany
    J Mol Biol 324:807-22. 2002
    ..In contrast, no interaction was observed between the Prp40 WW domains and the CTD repeats used in this work...
  4. ncbi The structure of Prp40 FF1 domain and its interaction with the crn-TPR1 motif of Clf1 gives a new insight into the binding mode of FF domains
    Alexander Gasch
    Structural Biology Program, EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 281:356-64. 2006
    ..Our results also revealed that not all FF domains in Prp40 are functionally equivalent. We proposed that at least two different interaction surfaces exist in FF domains that have evolved to recognize distinct binding motifs...
  5. ncbi Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily
    Concepcion Civera
    Dpto Quimica Fisica II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Proteins 58:354-66. 2005
    ..This suggests a role of the pleckstrin DEP domain in intramolecular domain interactions, which is distinct from the functions of other DEP domain subfamilies found so far...
  6. ncbi Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain
    Alison Z Shaw
    ICREA and the Biomedical Research Institute of Barcelona, Barcelona Science Park, Barcelona, Spain
    Proteins 60:558-60. 2005
  7. ncbi Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains
    Marina Brucet
    Macrophage Biology Group, Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain
    J Biol Chem 282:14547-57. 2007
    ..Co-immunoprecipitation studies confirmed this interaction with the full-length TREX1 protein, thereby suggesting that TREX1 participates in more functional complexes than previously thought...
  8. ncbi Structural characterization of a new binding motif and a novel binding mode in group 2 WW domains
    Ximena Ramirez-Espain
    Institute for Research in Biomedicine Protein NMR group, and the Institució catalana de recerca i estudis avançats ICREA, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    J Mol Biol 373:1255-68. 2007
    ..Our results represent the first observation of protein-ligand recognition where a pair of WW and two consecutive motifs in a ligand participate simultaneously...
  9. ncbi NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands
    Begoña Morales
    Institute of Research in Biomedicine, Institucio Catalana de Recerca i Estudis Avancats, Passeig Lluis Companys 23, 08010 Barcelona, Spain
    Structure 15:473-83. 2007
    ..This hydrogen-bond formation is precluded in the variant, explaining the inhibition upon phosphorylation. Our results suggest that phosphorylation at position 30 in ItchWW domains can be a mechanism to inhibit target recognition in vivo...