E Lacroix

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint Computer-aided design of beta-sheet peptides
    M Lopez de la Paz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    J Mol Biol 312:229-46. 2001
  2. pmc De novo designed peptide-based amyloid fibrils
    Manuela Lopez de la Paz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany Europe
    Proc Natl Acad Sci U S A 99:16052-7. 2002
  3. ncbi request reprint Computer-assisted re-design of spectrin SH3 residue clusters
    I Angrand
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany
    Biomol Eng 18:125-34. 2001
  4. ncbi request reprint Insights into the origin of the tendency of the PI3-SH3 domain to form amyloid fibrils
    Salvador Ventura
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Mol Biol 322:1147-58. 2002
  5. pmc Computational estimation of specific side chain interaction energies in alpha helices
    S Fisinger
    European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
    Protein Sci 10:809-18. 2001
  6. ncbi request reprint Conformational strain in the hydrophobic core and its implications for protein folding and design
    Salvador Ventura
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Struct Biol 9:485-93. 2002
  7. ncbi request reprint A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains
    Eva S Cobos
    Department of Physical Chemistry and Institute of Biotechnology, Faculty of Sciences, University of Granada, 18071, Spain
    J Mol Biol 342:355-65. 2004
  8. pmc Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides
    Maria Teresa Pastor
    Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, E 46100 Burjassot, Spain
    Proc Natl Acad Sci U S A 99:614-9. 2002
  9. pmc A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
    Jean Charles Epinat
    CELLECTIS S A, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 31:2952-62. 2003
  10. ncbi request reprint Computer-aided design of a PDZ domain to recognize new target sequences
    Jose Reina
    Cell Biology and Biophysics Program, EMBL, 69117 Heidelberg, Germany
    Nat Struct Biol 9:621-7. 2002

Collaborators

  • Salvador Ventura
  • Jesus Zurdo
  • C M Dobson
  • Luis Serrano
  • Manuela Lopez de la Paz
  • L Serrano
  • Eva S Cobos
  • Jean Charles Epinat
  • Maria Teresa Pastor
  • Jose Reina
  • S Fisinger
  • I Angrand
  • M Lopez de la Paz
  • M Cristina Vega
  • Javier Ruiz-Sanz
  • Jose C Martinez
  • M Teresa Pisabarro
  • Pascal Rochaix
  • Sylvain Arnould
  • Clémence Puzin
  • Alexandre Zanghellini
  • Patrick Chames
  • Amélie Patin
  • Frédéric Pâques
  • Dominique Desfontaines
  • Kenneth Goldie
  • Andreas Hoenger
  • Vladimir Rybin
  • Enrique Pérez-Payá
  • Cayetano Gonzalez
  • Gregorio Fernandez-Ballester
  • Markus S Schwab
  • Scott D Hobson
  • M Ramirez-Alvarado

Detail Information

Publications10

  1. ncbi request reprint Computer-aided design of beta-sheet peptides
    M Lopez de la Paz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    J Mol Biol 312:229-46. 2001
    ..Our results show that automatic design algorithms can be successfully applied to the design of beta-sheet peptides...
  2. pmc De novo designed peptide-based amyloid fibrils
    Manuela Lopez de la Paz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany Europe
    Proc Natl Acad Sci U S A 99:16052-7. 2002
    ..The present results, in conjunction with x-ray fiber diffraction, electron microscopy, and Fourier transform infrared measurements, have allowed us to propose a detailed structural model of the fibrils...
  3. ncbi request reprint Computer-assisted re-design of spectrin SH3 residue clusters
    I Angrand
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany
    Biomol Eng 18:125-34. 2001
    ..25, 0.70 and 1.0 kcal mol(-1)) than the wild-type protein. These successful protein re-designs, and similar examples found in the literature, establish the quality of the structure-based computational approach to protein design...
  4. ncbi request reprint Insights into the origin of the tendency of the PI3-SH3 domain to form amyloid fibrils
    Salvador Ventura
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Mol Biol 322:1147-58. 2002
    ..It is the amino acid residue sequence of the protein and probably its parts that play a determinant role in shifting this balance in one direction or the other...
  5. pmc Computational estimation of specific side chain interaction energies in alpha helices
    S Fisinger
    European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
    Protein Sci 10:809-18. 2001
    ....
  6. ncbi request reprint Conformational strain in the hydrophobic core and its implications for protein folding and design
    Salvador Ventura
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Struct Biol 9:485-93. 2002
    ..Strained interactions could have been introduced, and a reduction in the buried volume could result in a large increase in stability and a reduction in unfolding rates...
  7. ncbi request reprint A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains
    Eva S Cobos
    Department of Physical Chemistry and Institute of Biotechnology, Faculty of Sciences, University of Granada, 18071, Spain
    J Mol Biol 342:355-65. 2004
    ..The application of this strategy may help in the design of ligands for other polyproline-recognition domains such as WW, PX or EVH1, and even for the in vivo application of these miniproteins...
  8. pmc Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides
    Maria Teresa Pastor
    Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, E 46100 Burjassot, Spain
    Proc Natl Acad Sci U S A 99:614-9. 2002
    ..Our results show how combinatorial approaches can be used to obtain highly structured peptide sequences that could be used as templates in which functionality can be introduced...
  9. pmc A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
    Jean Charles Epinat
    CELLECTIS S A, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 31:2952-62. 2003
    ..These results are a first step toward the generation of custom endonucleases for the purpose of targeted genome engineering...
  10. ncbi request reprint Computer-aided design of a PDZ domain to recognize new target sequences
    Jose Reina
    Cell Biology and Biophysics Program, EMBL, 69117 Heidelberg, Germany
    Nat Struct Biol 9:621-7. 2002
    ..Our results suggest that by combining different backbone templates with computer-aided protein design, PDZ domains could be engineered to specifically recognize a large number of proteins...