Eric Karsenti

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. pmc A journey from reductionist to systemic cell biology aboard the schooner Tara
    Eric Karsenti
    European Molecular Biology Laboratory, D69117 Heidelberg, Germany
    Mol Biol Cell 23:2403-6. 2012
  2. pmc A holistic approach to marine eco-systems biology
    Eric Karsenti
    European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    PLoS Biol 9:e1001177. 2011
  3. doi request reprint Self-organization in cell biology: a brief history
    Eric Karsenti
    Eric Karsenti is at the Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Rev Mol Cell Biol 9:255-62. 2008
  4. ncbi request reprint Modelling microtubule patterns
    Eric Karsenti
    European Molecular Systems Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 8:1204-11. 2006
  5. ncbi request reprint The mitotic spindle and actin tails
    Eric Karsenti
    Cell Biology and Biophysics Program, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Biol Cell 96:237-40. 2004
  6. pmc Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2
    Claudia M Casanova
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 19:4900-8. 2008
  7. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
  8. doi request reprint Regulation of microtubule dynamics by reaction cascades around chromosomes
    Chaitanya A Athale
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Science 322:1243-7. 2008
  9. pmc ISWI is a RanGTP-dependent MAP required for chromosome segregation
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 187:813-29. 2009
  10. ncbi request reprint Spatial coordination of spindle assembly by chromosome-mediated signaling gradients
    Maiwen Caudron
    Cell Biology and Biophysics Department, European Molecular Biology Laboratory EMBL, EMBL, 69117 Heidelberg, Germany
    Science 309:1373-6. 2005

Collaborators

Detail Information

Publications31

  1. pmc A journey from reductionist to systemic cell biology aboard the schooner Tara
    Eric Karsenti
    European Molecular Biology Laboratory, D69117 Heidelberg, Germany
    Mol Biol Cell 23:2403-6. 2012
    ....
  2. pmc A holistic approach to marine eco-systems biology
    Eric Karsenti
    European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    PLoS Biol 9:e1001177. 2011
    ..The Tara Oceans consortium organizes expeditions to help fill this gap at the global level...
  3. doi request reprint Self-organization in cell biology: a brief history
    Eric Karsenti
    Eric Karsenti is at the Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Rev Mol Cell Biol 9:255-62. 2008
    ..Self-organization concepts that were first developed in chemistry and physics and then applied to various morphogenetic problems in biology over the past century are now beginning to be applied to the organization of the living cell...
  4. ncbi request reprint Modelling microtubule patterns
    Eric Karsenti
    European Molecular Systems Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 8:1204-11. 2006
    ..We illustrate how this led to the beginning of an understanding of dynamic cellular patterns that have precise functions...
  5. ncbi request reprint The mitotic spindle and actin tails
    Eric Karsenti
    Cell Biology and Biophysics Program, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Biol Cell 96:237-40. 2004
    ..We wonder in this respect whether lower eukaryotes such as yeasts are different from higher eukaryotes such as vertebrates...
  6. pmc Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2
    Claudia M Casanova
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 19:4900-8. 2008
    ..Our data indicate that HURP and TPX2 have nonredundant functions essential for chromatin-induced microtubule assembly...
  7. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
    ..Our results indicate that Cdk11 is responsible for RanGTP-dependent MT stabilization around chromosomes and that this local stabilization is essential for normal rates of spindle assembly and spindle function...
  8. doi request reprint Regulation of microtubule dynamics by reaction cascades around chromosomes
    Chaitanya A Athale
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, Heidelberg, Germany
    Science 322:1243-7. 2008
    ..We propose a reaction-diffusion model that combines the chromosome generated Ran-guanosine triphosphate-Importin reaction network to a secondary phosphorylation network as a potential mechanism for the generation of such gradients...
  9. pmc ISWI is a RanGTP-dependent MAP required for chromosome segregation
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 187:813-29. 2009
    ..Our results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle MTs in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation...
  10. ncbi request reprint Spatial coordination of spindle assembly by chromosome-mediated signaling gradients
    Maiwen Caudron
    Cell Biology and Biophysics Department, European Molecular Biology Laboratory EMBL, EMBL, 69117 Heidelberg, Germany
    Science 309:1373-6. 2005
    ..This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle...
  11. pmc Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts
    Stephane Brunet
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Heidelberg 69 117, Germany
    Mol Biol Cell 15:5318-28. 2004
    ..These and previous results suggest that under physiological conditions, TPX2 is essential for microtubule nucleation around chromatin and functions in a network of other molecules, some of which also are regulated by RanGTP...
  12. pmc XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract
    Iva Kronja
    Department of Cell Biology and Biophysics, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Biol Cell 20:2684-96. 2009
    ..Therefore, the XMAP215-EB1 interaction is required for proper spindle organization and chromosome segregation in Xenopus egg extracts...
  13. ncbi request reprint Gradients in the self-organization of the mitotic spindle
    Philippe Bastiaens
    Cell Biology and Biophysics Program, EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Trends Cell Biol 16:125-34. 2006
    ..We argue that such reaction diffusion processes are involved in the self-organization of supramolecular structures in the cell...
  14. ncbi request reprint Stathmin-tubulin interaction gradients in motile and mitotic cells
    Philipp Niethammer
    European Molecular Biology Laboratory, EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 303:1862-6. 2004
    ..These interaction patterns are likely to reflect phosphorylation of stathmin in these areas...
  15. ncbi request reprint TPX or not TPX?
    Eric Karsenti
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 19:431-2. 2005
    ..elegans. The diverse roles of these two proteins in spindle assembly leave us to beckon the true C. elegans TPX2 ortholog to center stage...
  16. doi request reprint Chromatin shapes the mitotic spindle
    Ana Dinarina
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg D 69117, Germany
    Cell 138:502-13. 2009
    ..Our results show that chromatin defines spindle shape and orientation. For a video summary of this article, see the PaperFlick file available with the online Supplemental Data...
  17. pmc Discrete states of a protein interaction network govern interphase and mitotic microtubule dynamics
    Philipp Niethammer
    Cell Biology and Biophysics Department, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 5:e29. 2007
    ..This provides the beginning of a biochemical description of the notion of "cytoplasmic states" regarding the microtubule system...
  18. ncbi request reprint Long-range communication between chromatin and microtubules in Xenopus egg extracts
    Rafael E Carazo-Salas
    Cell Biology and Biophysics Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Biol 13:1728-33. 2003
    ..To our knowledge, this is the first direct evidence of a long-range guidance effect at the sub-cellular level...
  19. ncbi request reprint Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
    Oliver J Gruss
    EMBL, Meyerhofstrasse 1, 69 117 Heidelberg, Germany
    Nat Cell Biol 4:871-9. 2002
    ..This indicates that chromosome-induced microtubule production is a general requirement for the formation of functional spindles in animal cells...
  20. ncbi request reprint Self-organisation and forces in the microtubule cytoskeleton
    Francois Nedelec
    EMBL, Cell Biology and Biophysics Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Cell Biol 15:118-24. 2003
    ..Together, these observations suggest that the spindle can be experimentally deconstructed, and that its defining characteristics can be studied in a simplified context, in the absence of the full division machinery...
  21. ncbi request reprint Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein
    Véronique Pizon
    European Molecular Biology Laboratory, Cell Biology Division, Heidelberg, Germany
    J Cell Sci 115:4469-82. 2002
    ..MURF2 can therefore act as a transient adaptor between microtubules, titin and nascent myosin filaments, as well as being involved in signalling from the sarcomere to the nucleus...
  22. pmc Importin alpha-regulated nucleation of microtubules by TPX2
    Christoph A Schatz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 22:2060-70. 2003
    ..The data suggest that the critical early function in spindle formation regulated by importin alpha is TPX2-mediated microtubule nucleation...
  23. doi request reprint Collective behavior of minus-ended motors in mitotic microtubule asters gliding toward DNA
    Chaitanya A Athale
    Division of Biology, IISER Pune, Sai Trinity, Sutarwadi Road, Pashan, Pune 411021, India Cell Biology and Biophysics Division, EMBL, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Phys Biol 11:016008. 2014
    ..Overall, our model is in good agreement with experimental data in Xenopus cytoplasmic extracts and predicts novel features of the collective effects of motor-MT interactions. ..
  24. ncbi request reprint XMAP215 is required for the microtubule-nucleating activity of centrosomes
    Andrei V Popov
    Cell Biology Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Curr Biol 12:1326-30. 2002
    ....
  25. ncbi request reprint Cytoskeleton: spindle saga
    Eric Karsenti
    Nature 432:563-4. 2004
  26. ncbi request reprint Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked
    Mimi Shirasu-Hiza
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 14:1941-5. 2004
    ..These results suggest that Eg5 is responsible for flux-associated MT translocation and that dynein and Xklp2 regulate flux-associated microtubule depolymerization at spindle poles...
  27. ncbi request reprint Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome
    Adam J Liska
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Proteomics 4:2707-21. 2004
    ..These findings were made possible due to the application of sequence-similarity methods, which extended mass spectrometric protein identification capabilities by 2-fold compared to conventional methods...
  28. ncbi request reprint Stu2p and XMAP215: turncoat microtubule-associated proteins?
    Andrei V Popov
    INSERM Unité 366, DRDC CS, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Trends Cell Biol 13:547-50. 2003
    ..Two related MAPs, XMAP215 and Stu2p, are known to stabilize MTs. However, recent studies report that these proteins have a MT-destabilizing function as well. Here we discuss the implications of these reports...
  29. pmc Microtubule-dependent transport and organization of sarcomeric myosin during skeletal muscle differentiation
    Véronique Pizon
    Institut Jacques Monod, Paris, France
    EMBO J 24:3781-92. 2005
    ..Collectively, our results strongly suggest that MTs become organized into a scaffold that provides directional cues for the positioning and organization of myosin filaments during sarcomere formation...
  30. ncbi request reprint Detection and quantification of protein-microtubules interactions using green fluorescent protein photoconversion
    Stephane Brunet
    Biologie du Développement, CNRS UMR 7622 bat C 5ème, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Traffic 7:1283-9. 2006
    ..It has the potential to be extended to study interactions of proteins or multi-protein complexes with different biopolymers like actin microfilaments or organelle membranes...