Anne Ephrussi

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint Hrp48, a Drosophila hnRNPA/B homolog, binds and regulates translation of oskar mRNA
    Tamaki Yano
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 6:637-48. 2004
  2. ncbi request reprint Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis
    Jean Baptiste Coutelis
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 134:1419-30. 2007
  3. pmc Drosophila Ge-1 promotes P body formation and oskar mRNA localization
    Shih Jung Fan
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS ONE 6:e20612. 2011
  4. ncbi request reprint Seeing is believing: the bicoid morphogen gradient matures
    Anne Ephrussi
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 116:143-52. 2004
  5. pmc Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation
    Florence Besse
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 23:195-207. 2009
  6. ncbi request reprint Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia
    Veit Riechmann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:5897-907. 2004
  7. ncbi request reprint A translation-independent role of oskar RNA in early Drosophila oogenesis
    Andreas Jenny
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 133:2827-33. 2006
  8. doi request reprint Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA
    Sanjay Ghosh
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Struct Mol Biol 19:441-9. 2012
  9. ncbi request reprint Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles
    Marina Chekulaeva
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 124:521-33. 2006
  10. ncbi request reprint The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells
    Thomas Vaccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 15:255-61. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Hrp48, a Drosophila hnRNPA/B homolog, binds and regulates translation of oskar mRNA
    Tamaki Yano
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 6:637-48. 2004
    ..Our data also show that Hrp48, which binds to the 5' and 3' regions of oskar mRNA, plays an important role in restricting Oskar activity to the posterior of the oocyte, by repressing oskar mRNA translation during transport...
  2. ncbi request reprint Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis
    Jean Baptiste Coutelis
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 134:1419-30. 2007
    ..These findings highlight the central role of vesicular trafficking in the establishment of polarity and in determinant localization in Drosophila...
  3. pmc Drosophila Ge-1 promotes P body formation and oskar mRNA localization
    Shih Jung Fan
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS ONE 6:e20612. 2011
    ..Our findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo...
  4. ncbi request reprint Seeing is believing: the bicoid morphogen gradient matures
    Anne Ephrussi
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 116:143-52. 2004
    ..Here we discuss the impact of this ground-breaking work and review recent results on bicoid mRNA localization and the dual role of Bicoid as a transcription and translation factor...
  5. pmc Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation
    Florence Besse
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 23:195-207. 2009
    ..Thus, PTB is a key structural component of oskar RNP complexes that dually controls formation of high-order RNP particles and translational silencing...
  6. ncbi request reprint Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia
    Veit Riechmann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:5897-907. 2004
    ..Furthermore, our analysis reveals two phases of Exu-dependent bicoid mRNA localisation: an early phase that is strictly dependent on Exu phosphorylation and a late phase that is less phosphorylation dependent...
  7. ncbi request reprint A translation-independent role of oskar RNA in early Drosophila oogenesis
    Andreas Jenny
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 133:2827-33. 2006
    ..Our analysis thus reveals an unexpected role for oskar RNA during early oogenesis, independent of Oskar protein. These findings indicate that oskar RNA acts as a scaffold or regulatory RNA essential for development of the oocyte...
  8. doi request reprint Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA
    Sanjay Ghosh
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Struct Mol Biol 19:441-9. 2012
    ..The SOLE complements the EJC in formation of a functional unit that, together with the oskar 3' UTR, maintains proper kinesin-based motility of oskar mRNPs and posterior mRNA targeting...
  9. ncbi request reprint Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles
    Marina Chekulaeva
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 124:521-33. 2006
    ..Bruno-dependent mRNA oligomerization into silencing particles emerges as a mode of translational control that may be particularly suited to coupling with mRNA transport...
  10. ncbi request reprint The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells
    Thomas Vaccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 15:255-61. 2005
    ..Our data indicate that the spacer domain of PAR-1 is required for lateral PM localization of PAR-1 kinase and for development of a polarized FE...
  11. doi request reprint The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo
    Ritsuko Suyama
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 136:95-105. 2009
    ....
  12. ncbi request reprint Bruno regulates gurken during Drosophila oogenesis
    Paolo Filardo
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mech Dev 120:289-97. 2003
    ..We conclude that Bruno plays similar roles in translational regulation of gurken and oskar...
  13. ncbi request reprint Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte
    Stefania Castagnetti
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 130:835-43. 2003
    ..We conclude that Orb-mediated cytoplasmic polyadenylation stimulates oskar translation to achieve the high levels of Oskar protein necessary for posterior patterning and germline differentiation...
  14. ncbi request reprint Drosophila development: RNA interference ab ovo
    Marina Chekulaeva
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 14:R428-30. 2004
    ..In armitage mutants, oocyte polarity and the regulation of oskar mRNA translation are impaired, suggesting that RNA silencing regulates the first steps of Drosophila development...
  15. doi request reprint Assembly of endogenous oskar mRNA particles for motor-dependent transport in the Drosophila oocyte
    Alvar Trucco
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 139:983-98. 2009
    ..Finally, we show that both kinesin and dynein associate with oskar particles and are the primary microtubule motors responsible for transport of the RNPs within the oocyte...
  16. ncbi request reprint The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein
    Thomas Vaccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 12:1524-8. 2002
    ....
  17. ncbi request reprint Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism
    Luis Teixeira
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Mech Dev 120:1071-81. 2003
    ..This work demonstrates that Lsd2 has an evolutionarily conserved function in lipid metabolism and establishes Drosophila melanogaster as a new in vivo model for studies on the PAT-family of proteins...
  18. ncbi request reprint Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization
    Olivier Hachet
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10 2209, D 69117 Heidelberg, Germany
    Nature 428:959-63. 2004
    ..Our results reveal an important new function for splicing: regulation of messenger ribonucleoprotein complex assembly and organization for mRNA cytoplasmic localization...
  19. ncbi request reprint PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning
    Shoko Yoshida
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 131:1401-10. 2004
    ..These data demonstrate that PKA mediates the spatial restriction of Oskar for anteroposterior patterning of the Drosophila embryo and that control of PKA activity by PKA-R1 is crucial in this process...
  20. pmc Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte
    Helena Jambor
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 17:2049-57. 2011
    ..Our analysis provides insight into the molecular basis of RNA hitchhiking, whereby localization-incompetent RNA molecules can become locally enriched in the cytoplasm, by virtue of their association with transport-competent RNAs...
  21. ncbi request reprint Oskar anchoring restricts pole plasm formation to the posterior of the Drosophila oocyte
    Nathalie F Vanzo
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1 69117 Heidelberg, Germany
    Development 129:3705-14. 2002
    ..This study reveals cortical anchoring of the posterior determinant Oskar as a crucial step in pole plasm assembly and restriction, required for proper development of Drosophila melanogaster...
  22. doi request reprint An intracellular transmission control protocol: assembly and transport of ribonucleoprotein complexes
    Virginie Marchand
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Cell Biol 24:202-10. 2012
    ..Here we review some of the recent findings that have emerged from research from the RNA localization field, from the birth of mRNAs in the nucleus, to their delivery at specific sites within the cytoplasm...
  23. doi request reprint A single Drosophila embryo extract for the study of mitosis ex vivo
    Ivo A Telley
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
    Nat Protoc 8:310-24. 2013
    ..The assay enables a unique combination of genetic, biochemical, optical and mechanical manipulations of the mitotic machinery...
  24. doi request reprint A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization
    Andrea Leibfried
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Development 140:362-71. 2013
    ..This most likely allows for the robustness in symmetry breaking in the cell...
  25. pmc The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses
    Florence Besse
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    J Cell Biol 177:843-55. 2007
    ..We thus propose that Bsg is part of a transsynaptic complex regulating synaptic compartmentalization and strength, and coordinating plasma membrane and cortical organization...
  26. doi request reprint Translational control of localized mRNAs: restricting protein synthesis in space and time
    Florence Besse
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Rev Mol Cell Biol 9:971-80. 2008
    ..Functional studies have revealed that the inactivation of these repressors, either by pre-localized proteins or in response to conserved signalling pathways, triggers local protein synthesis...
  27. pmc Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo
    Ivo A Telley
    Cell Biology and Biophysics Unit and 2 Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 197:887-95. 2012
    ..These activities define a characteristic separation length scale that appears to be a conserved property of developing insect embryos...
  28. ncbi request reprint The EJC Binding and Dissociating Activity of PYM Is Regulated in Drosophila
    Sanjay Ghosh
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Genet 10:e1004455. 2014
    ..This, together with the fact that the EJC-disassembly activity of DmPYM is regulated, implicates PYM as an effector of EJC homeostasis in vivo. ..
  29. ncbi request reprint Par-1 regulates stability of the posterior determinant Oskar by phosphorylation
    Veit Riechmann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10 2209, D 69012 Heidelberg, Germany
    Nat Cell Biol 4:337-42. 2002
    ..We show in cell-free extracts that Osk protein is intrinsically unstable and that it is stabilized after phosphorylation by Par-1. Our data indicate that posteriorly localized Par-1 regulates posterior patterning by stabilizing Osk...
  30. ncbi request reprint Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte
    Nathalie Vanzo
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, 118 Rte de Narbonne, 31062 Toulouse Cedex 04, France
    Dev Cell 12:543-55. 2007
    ..We propose that Oskar maintains its localization at the posterior pole through dual functions in regulating endocytosis and F-actin dynamics...
  31. ncbi request reprint Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila
    Joël Anne
    Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 134:137-46. 2007
    ..Our results thus reveal the role of a PRMT in protein localization in germ cells...
  32. pmc Gain-of-function screen for genes that affect Drosophila muscle pattern formation
    Nicole Staudt
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    PLoS Genet 1:e55. 2005
    ....
  33. ncbi request reprint A germline-specific gap junction protein required for survival of differentiating early germ cells
    Salli I Tazuke
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 129:2529-39. 2002
    ....