A Ephrussi

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
    S Castagnetti
    Developmental Biology and Gene Expression Programmes, European Molecular Biology Laboratory, Meyerhofstrasse 1, Germany
    Development 127:1063-8. 2000
  2. ncbi request reprint Oskar protein interaction with Vasa represents an essential step in polar granule assembly
    W Breitwieser
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Genes Dev 10:2179-88. 1996
  3. ncbi request reprint Oocyte polarity depends on regulation of gurken by Vasa
    P Tomancak
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 125:1723-32. 1998
  4. ncbi request reprint Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa
    F H Markussen
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Cold Spring Harb Symp Quant Biol 62:13-7. 1997
  5. ncbi request reprint Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes
    J B Glotzer
    Programme in Developmental Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, D 69117, Germany
    Curr Biol 7:326-37. 1997
  6. ncbi request reprint Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport
    O Hachet
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 11:1666-74. 2001
  7. ncbi request reprint Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly
    F H Markussen
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:3723-32. 1995
  8. ncbi request reprint Axis formation during Drosophila oogenesis
    V Riechmann
    European Molecular Biology Laboratory, Meyerhofstrabetae 1, Postfach10 2209, D 69012, Heidelberg, Germany
    Curr Opin Genet Dev 11:374-83. 2001
  9. ncbi request reprint A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation
    P Tomancak
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Cell Biol 2:458-60. 2000
  10. ncbi request reprint The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors
    A Guichet
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 385:548-52. 1997

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
    S Castagnetti
    Developmental Biology and Gene Expression Programmes, European Molecular Biology Laboratory, Meyerhofstrasse 1, Germany
    Development 127:1063-8. 2000
    ..The approach that we describe opens new avenues to investigate translational regulation in Drosophila oogenesis at a biochemical level...
  2. ncbi request reprint Oskar protein interaction with Vasa represents an essential step in polar granule assembly
    W Breitwieser
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Genes Dev 10:2179-88. 1996
    ..These results suggest that the Oskar-Vasa interaction constitutes an initial step in polar granule assembly. In addition, we discuss the possible biological role of the Oskar-Staufen interaction...
  3. ncbi request reprint Oocyte polarity depends on regulation of gurken by Vasa
    P Tomancak
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 125:1723-32. 1998
    ..A variety of early oogenesis phenotypes observed in vasa ovaries, which cannot be attributed to the defect in gurken expression, suggest that vasa also affects expression of other mRNAs...
  4. ncbi request reprint Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa
    F H Markussen
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Cold Spring Harb Symp Quant Biol 62:13-7. 1997
  5. ncbi request reprint Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes
    J B Glotzer
    Programme in Developmental Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, D 69117, Germany
    Curr Biol 7:326-37. 1997
    ..The mechanisms by which osk RNA is localized are unknown...
  6. ncbi request reprint Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport
    O Hachet
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 11:1666-74. 2001
    ..It was recently shown that human Y14, a nuclear protein that associates with mRNAs upon splicing and shuttles to the cytoplasm, interacts with MAGOH, the human homolog of Mago-nashi...
  7. ncbi request reprint Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly
    F H Markussen
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:3723-32. 1995
    ..Finally, we show that when oskar RNA is localized, accumulation of Oskar protein requires the functions of vasa and tudor, as well as oskar itself, suggesting a positive feedback mechanism in the induction of pole plasm by oskar...
  8. ncbi request reprint Axis formation during Drosophila oogenesis
    V Riechmann
    European Molecular Biology Laboratory, Meyerhofstrabetae 1, Postfach10 2209, D 69012, Heidelberg, Germany
    Curr Opin Genet Dev 11:374-83. 2001
    ..A microtubule motor, Kinesin, is directly implicated in localisation of oskar mRNA to the posterior pole of the oocyte...
  9. ncbi request reprint A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation
    P Tomancak
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Cell Biol 2:458-60. 2000
  10. ncbi request reprint The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors
    A Guichet
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 385:548-52. 1997
    ..This interaction suggests that other nuclear receptor/homeodomain protein interactions maybe important and common in developing organisms...
  11. ncbi request reprint Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
    J Mata
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 101:511-22. 2000
    ..By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination...
  12. ncbi request reprint Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization
    M Erdelyi
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 377:524-7. 1995
    ..Here we show that mutations in tropomyosin II (TmII) virtually abolish oskar RNA localization to the posterior pole, suggesting an involvement of the actin network in oskar RNA localization...
  13. ncbi request reprint Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene
    B Florence
    Department of Genetics, University of Wisconsin, Madison 53706, USA
    Development 124:839-47. 1997
    ..We also report the existence of a separate negative regulatory element that apparently responds to odd-skipped...
  14. pmc Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA
    N Gunkel
    European Molecular Biology Laboratory EMBL, Developmental Biology Programme, 69117 Heidelberg, Germany
    Genes Dev 12:1652-64. 1998
    ..We discuss the possible involvement of these factors as well as known genes in the process of localization-dependent translation...
  15. ncbi request reprint Oskar organizes the germ plasm and directs localization of the posterior determinant nanos
    A Ephrussi
    Whitehead Institute for Biomedical Research Howard Hughes Medical Institute, Cambridge, Massachusetts 02142
    Cell 66:37-50. 1991
    ..We propose that the pole plasm is assembled stepwise and that continued interaction among its components is required for germ cell determination...
  16. pmc Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning
    G Jimenez
    Institut de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 14:224-31. 2000
    ..cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms...
  17. ncbi request reprint Induction of germ cell formation by oskar
    A Ephrussi
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Nature 358:387-92. 1992
    ..Of the eight genes necessary for germ cell formation at the posterior, only three, oskar, vasa and tudor, are essential at an ectopic site...