Research Topics
Genomes and Genes | A EphrussiSummaryAffiliation: European Molecular Biology Laboratory Country: Germany Publications
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Detail Information
Publications
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovariesS Castagnetti
Developmental Biology and Gene Expression Programmes, European Molecular Biology Laboratory, Meyerhofstrasse 1, Germany
Development 127:1063-8. 2000..The approach that we describe opens new avenues to investigate translational regulation in Drosophila oogenesis at a biochemical level...- Oskar protein interaction with Vasa represents an essential step in polar granule assemblyW Breitwieser
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Genes Dev 10:2179-88. 1996..These results suggest that the Oskar-Vasa interaction constitutes an initial step in polar granule assembly. In addition, we discuss the possible biological role of the Oskar-Staufen interaction... - Oocyte polarity depends on regulation of gurken by VasaP Tomancak
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Development 125:1723-32. 1998..A variety of early oogenesis phenotypes observed in vasa ovaries, which cannot be attributed to the defect in gurken expression, suggest that vasa also affects expression of other mRNAs... - Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase VasaF H Markussen
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Cold Spring Harb Symp Quant Biol 62:13-7. 1997 - Cytoplasmic flows localize injected oskar RNA in Drosophila oocytesJ B Glotzer
Programme in Developmental Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, D 69117, Germany
Curr Biol 7:326-37. 1997..The mechanisms by which osk RNA is localized are unknown... - Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transportO Hachet
Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Curr Biol 11:1666-74. 2001..It was recently shown that human Y14, a nuclear protein that associates with mRNAs upon splicing and shuttles to the cytoplasm, interacts with MAGOH, the human homolog of Mago-nashi... - Translational control of oskar generates short OSK, the isoform that induces pole plasma assemblyF H Markussen
Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
Development 121:3723-32. 1995..Finally, we show that when oskar RNA is localized, accumulation of Oskar protein requires the functions of vasa and tudor, as well as oskar itself, suggesting a positive feedback mechanism in the induction of pole plasm by oskar... - Axis formation during Drosophila oogenesisV Riechmann
European Molecular Biology Laboratory, Meyerhofstrabetae 1, Postfach10 2209, D 69012, Heidelberg, Germany
Curr Opin Genet Dev 11:374-83. 2001..A microtubule motor, Kinesin, is directly implicated in localisation of oskar mRNA to the posterior pole of the oocyte... - A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formationP Tomancak
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Nat Cell Biol 2:458-60. 2000 - The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactorsA Guichet
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Nature 385:548-52. 1997..This interaction suggests that other nuclear receptor/homeodomain protein interactions maybe important and common in developing organisms... - Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysisJ Mata
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Cell 101:511-22. 2000..By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination... - Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localizationM Erdelyi
European Molecular Biology Laboratory, Heidelberg, Germany
Nature 377:524-7. 1995..Here we show that mutations in tropomyosin II (TmII) virtually abolish oskar RNA localization to the posterior pole, suggesting an involvement of the actin network in oskar RNA localization... - Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed geneB Florence
Department of Genetics, University of Wisconsin, Madison 53706, USA
Development 124:839-47. 1997..We also report the existence of a separate negative regulatory element that apparently responds to odd-skipped... 
Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNAN Gunkel
European Molecular Biology Laboratory EMBL, Developmental Biology Programme, 69117 Heidelberg, Germany
Genes Dev 12:1652-64. 1998..We discuss the possible involvement of these factors as well as known genes in the process of localization-dependent translation...- Oskar organizes the germ plasm and directs localization of the posterior determinant nanosA Ephrussi
Whitehead Institute for Biomedical Research Howard Hughes Medical Institute, Cambridge, Massachusetts 02142
Cell 66:37-50. 1991..We propose that the pole plasm is assembled stepwise and that continued interaction among its components is required for germ cell determination... - Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterningG Jimenez
Institut de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
Genes Dev 14:224-31. 2000..cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms... - Induction of germ cell formation by oskarA Ephrussi
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Nature 358:387-92. 1992..Of the eight genes necessary for germ cell formation at the posterior, only three, oskar, vasa and tudor, are essential at an ectopic site...