E Conti

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha
    E Conti
    Laboratory of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York 10021, USA
    Structure 8:329-38. 2000
  2. pmc The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain
    E Liker
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 19:5587-98. 2000
  3. ncbi Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor
    S Fribourg
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Mol Cell 8:645-56. 2001
  4. ncbi Nucleocytoplasmic transport enters the atomic age
    E Conti
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Cell Biol 13:310-9. 2001
  5. ncbi Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
    E Conti
    Laboratories of Molecular Biophysics, The Rockefeller University, New York, New York 10021, USA
    Cell 94:193-204. 1998
  6. ncbi Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
    I C Braun
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Biol Chem 276:20536-43. 2001
  7. ncbi Use of DHPLC for rapid screening of recombinant clones
    A Colosimo
    IRCCS CSS, San Giovanni Rotondo and CSS Mendel Institute, Rome, Italy
    Biotechniques 34:706-8. 2003
  8. ncbi Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit
    L Berti
    Department of Protein Biochemistry, Institute of Molecular Immunology GSF, Munich, 81377, Germany
    Genomics 74:320-32. 2001
  9. ncbi Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L)
    G Novelli
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma, Italy
    Biochim Biophys Acta 1396:158-62. 1998
  10. ncbi A novel PTPN11 mutation in LEOPARD syndrome
    E Conti
    Ospedale CSS, IRCCS, San Giovanni Rotondo, Italy
    Hum Mutat 21:654. 2003

Collaborators

  • Elisa Izaurralde
  • Adriano Mari
  • A Colosimo
  • I C Braun
  • B Dallapiccola
  • G Novelli
  • L Berti
  • S Fribourg
  • E Liker
  • F Amati
  • V Guida
  • E Flex
  • B G├╝nzler
  • G Stelzer
  • M Rode
  • G Mittler
  • M Hrabe de Angelis
  • M Meisterernst
  • G K Przemeck
  • A Herold
  • E Fernandez
  • A Pizzuti
  • M Bengala
  • R Bordoni
  • A Ratti
  • F Pandolfi
  • F Sangiuolo
  • R Crinelli
  • A Baldini
  • M Magnani

Detail Information

Publications10

  1. ncbi Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha
    E Conti
    Laboratory of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York 10021, USA
    Structure 8:329-38. 2000
    ..Distinct classes of NLSs (monopartite and bipartite) have been identified that are only partly conserved with respect to one another but are nevertheless recognized by the same receptor...
  2. pmc The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain
    E Liker
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 19:5587-98. 2000
    ..Our in vitro and in vivo functional studies using structure-based mutants suggest that a phylogenetically conserved surface of the LRR domain of TAP may have different roles in the export of viral and cellular RNAs...
  3. ncbi Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor
    S Fribourg
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Mol Cell 8:645-56. 2001
    ..In general, our findings suggest that FG repeats bind with a similar conformation to different classes of transport factors...
  4. ncbi Nucleocytoplasmic transport enters the atomic age
    E Conti
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Opin Cell Biol 13:310-9. 2001
    ..Furthermore, a conserved family of proteins, which is distinct from the well characterized family of importin beta-like nuclear export receptors, is implicated in the export of messenger RNA to the cytoplasm...
  5. ncbi Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
    E Conti
    Laboratories of Molecular Biophysics, The Rockefeller University, New York, New York 10021, USA
    Cell 94:193-204. 1998
    ..Binding of the NLS peptide occurs at two sites within a helical surface groove that is lined by conserved residues. The structure reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs...
  6. ncbi Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
    I C Braun
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Biol Chem 276:20536-43. 2001
    ..Our data indicate that formation of TAP/p15 heterodimers is required for TAP-mediated export of mRNA and show that the LRR domain of TAP plays an essential role in this process...
  7. ncbi Use of DHPLC for rapid screening of recombinant clones
    A Colosimo
    IRCCS CSS, San Giovanni Rotondo and CSS Mendel Institute, Rome, Italy
    Biotechniques 34:706-8. 2003
  8. ncbi Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit
    L Berti
    Department of Protein Biochemistry, Institute of Molecular Immunology GSF, Munich, 81377, Germany
    Genomics 74:320-32. 2001
    ..Together with the observed haploinsufficiency of PCQAP in DGS/VCFS patients, this finding is consistent with a possible role for this novel Mediator subunit in the development of some of the structures affected in DGS/VCFS...
  9. ncbi Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L)
    G Novelli
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma, Italy
    Biochim Biophys Acta 1396:158-62. 1998
    ..Expression profile and promoter characteristics suggest UFD1L is a housekeeping gene with implications in the pathogenesis of DiGeorge/velo-cardio-facial syndrome, due to 22q11.2 deletions...
  10. ncbi A novel PTPN11 mutation in LEOPARD syndrome
    E Conti
    Ospedale CSS, IRCCS, San Giovanni Rotondo, Italy
    Hum Mutat 21:654. 2003
    ..This report demonstrates that rarer mutations other than Tyr279Cys and Thr468Met can be found in LS patients and the need of screening the whole gene in those negative for the commonest mutations...