Research Topics
| Claudia ChicaSummaryAffiliation: European Molecular Biology Laboratory Country: Germany Publications
| Collaborators
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Detail Information
Publications
Evidence for the concerted evolution between short linear protein motifs and their flanking regionsClaudia Chica
Structural and Computational Biology Unit, EMBL Heidelberg, Heidelberg, Germany
PLoS ONE 4:e6052. 2009..Sometimes linear motifs appear as isolated islands of conservation in multiple sequence alignments. However, they also occur in larger blocks of sequence conservation, suggesting an active role for the neighbouring amino acids...
ELM: the status of the 2010 eukaryotic linear motif resourceCathryn M Gould
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nucleic Acids Res 38:D167-80. 2010..Using the links, researchers can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation...
Phospho.ELM: a database of phosphorylation sites--update 2011Holger Dinkel
SCB Unit, EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Nucleic Acids Res 39:D261-7. 2011..Finally, special emphasis has been put on linking to external resources such as interaction networks and other databases...
KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factorsFrancesca Diella
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Bioinformatics 25:1-5. 2009..The KEPEmotif appears to be restricted to the metazoan lineage and has three length variants-short, medium and long-which do not appear to interchange...
Understanding eukaryotic linear motifs and their role in cell signaling and regulationFrancesca Diella
Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Front Biosci 13:6580-603. 2008..The discrete deterministic properties implicit to these assemblies suggest that models for cell regulatory networks in systems biology should neither be overly dependent on stochastic nor on smooth deterministic approximations...
ELM--the database of eukaryotic linear motifsHolger Dinkel
Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany
Nucleic Acids Res 40:D242-51. 2012..The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances...
Phospho.ELM: a database of phosphorylation sites--update 2008Francesca Diella
Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Nucleic Acids Res 36:D240-4. 2008..Phospho.ELM is available on line at: http://phospho.elm.eu.org...
Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservationSushama Michael
Structural and Computational Biology Unit, EMBL, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
Bioinformatics 24:453-7. 2008..A similar number of weaker candidates were present. These proteins have yet to be tested for APC/C targeted destruction, providing potential new avenues of research...
