Affiliation: European Molecular Biology Laboratory
- Engineering stability in gene networks by autoregulationA Becskei
EMBL, Structures and Biocomputing, Heidelberg, Germany
Nature 405:590-3. 2000..Here we have designed and constructed simple gene circuits consisting of a regulator and transcriptional repressor modules in Escherichia coli and we show the gain of stability produced by negative feedback...
- Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversionA Becskei
European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
EMBO J 20:2528-35. 2001..These results have implications for understanding the graded and probabilistic mechanisms of enhancer action and cell differentiation...