Asifa Akhtar

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi request reprint In and around the nucleus
    Asifa Akhtar
    European Molecular Biology Laboratory EMBL, Gene Expression Program, Meyerhof Str 1, 69117 Heidelberg, Germany
    Nat Cell Biol 8:3-6. 2006
  2. pmc X chromosomal regulation in flies: when less is more
    Erinc Hallacli
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Chromosome Res 17:603-19. 2009
  3. pmc The right dose for every sex
    Sascha Mendjan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Chromosoma 116:95-106. 2007
  4. ncbi request reprint The nuclear envelope and transcriptional control
    Asifa Akhtar
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Rev Genet 8:507-17. 2007
  5. pmc X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3
    Alessia Buscaino
    Gene Expression Programme, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 7:531-8. 2006
  6. doi request reprint Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
    Jop Kind
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 133:813-28. 2008
  7. pmc Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster
    Oliver Bell
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mol Cell Biol 28:3401-9. 2008
  8. pmc Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes
    Jop Kind
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Genes Dev 21:2030-40. 2007
  9. ncbi request reprint Chromatin mechanisms in Drosophila dosage compensation
    Mikko Taipale
    European Molecular Biology Laboratory, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Prog Mol Subcell Biol 38:123-49. 2005
  10. ncbi request reprint MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex
    Alessia Buscaino
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Mol Cell 11:1265-77. 2003

Collaborators

Detail Information

Publications21

  1. ncbi request reprint In and around the nucleus
    Asifa Akhtar
    European Molecular Biology Laboratory EMBL, Gene Expression Program, Meyerhof Str 1, 69117 Heidelberg, Germany
    Nat Cell Biol 8:3-6. 2006
    ....
  2. pmc X chromosomal regulation in flies: when less is more
    Erinc Hallacli
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Chromosome Res 17:603-19. 2009
    ..Future studies integrating these aspects promise to shed more light into this epigenetic phenomenon...
  3. pmc The right dose for every sex
    Sascha Mendjan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Chromosoma 116:95-106. 2007
    ..Taken together, these findings suggest a role of the MSL complex in transcription elongation, RNA processing, and/or nuclear organization...
  4. ncbi request reprint The nuclear envelope and transcriptional control
    Asifa Akhtar
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Rev Genet 8:507-17. 2007
    ..Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner...
  5. pmc X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3
    Alessia Buscaino
    Gene Expression Programme, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 7:531-8. 2006
    ..Our results demonstrate that MSL-3 localization to the male X chromosome and transcriptional upregulation of X-linked genes are two separable functions of the MSL-3 protein...
  6. doi request reprint Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
    Jop Kind
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 133:813-28. 2008
    ..Therefore, MOF is not only involved in the onset of dosage compensation, but also acts as a regulator of gene expression in the Drosophila genome...
  7. pmc Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster
    Oliver Bell
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mol Cell Biol 28:3401-9. 2008
    ..Thus, H3K36me3 marks the body of all active genes yet is utilized in a chromosome-specific manner to enhance histone acetylation at sites of dosage compensation...
  8. pmc Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes
    Jop Kind
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Genes Dev 21:2030-40. 2007
    ..We propose a model of dynamic MSL complex binding to active genes based on exposed DNA target elements...
  9. ncbi request reprint Chromatin mechanisms in Drosophila dosage compensation
    Mikko Taipale
    European Molecular Biology Laboratory, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Prog Mol Subcell Biol 38:123-49. 2005
    ..This process requires an RNA/protein-containing dosage compensation complex. Here, we discuss the current status of the known Drosophila complex members as well as the recent views on targeting, assembly and spreading mechanisms...
  10. ncbi request reprint MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex
    Alessia Buscaino
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Mol Cell 11:1265-77. 2003
    ..We propose that regulated acetylation of MSL-3 may provide a mechanistic explanation for spreading of the dosage compensation complex along the male X chromosome...
  11. ncbi request reprint Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila
    Sascha Mendjan
    European Molecular Biology Laboratory, Gene Expression Programme, Meyerhofstrasse 169117, Heidelberg, Germany
    Mol Cell 21:811-23. 2006
    ..These results reveal an unexpected physical and functional connection between nuclear pore components and chromatin regulation through MSL proteins, highlighting the role of nucleoporins in gene regulation in higher eukaryotes...
  12. doi request reprint The nonspecific lethal complex is a transcriptional regulator in Drosophila
    Sunil Jayaramaiah Raja
    Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mol Cell 38:827-41. 2010
    ..Taken together, we conclude that the NSL complex acts as a major transcriptional regulator in Drosophila...
  13. ncbi request reprint Dosage compensation: an intertwined world of RNA and chromatin remodelling
    Asifa Akhtar
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Curr Opin Genet Dev 13:161-9. 2003
    ..Furthermore, non-coding RNAs appear to play a dual role, being targeting modules as well as encoding for target sites for complex recognition...
  14. pmc hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells
    Mikko Taipale
    European Molecular Biology Laboratory, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mol Cell Biol 25:6798-810. 2005
    ..Taken together, our data show that hMOF is required for histone H4 lysine 16 acetylation in mammalian cells and suggest that hMOF has a role in DNA damage response during cell cycle progression...
  15. ncbi request reprint roX RNAs: non-coding regulators of the male X chromosome in flies
    Ibrahim Ilik
    Gene Expression Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    RNA Biol 6:113-21. 2009
    ..In this review we discuss both aspects of roX function and propose an integrated model for possible mechanisms how these RNAs might be involved in epigenetic regulation of the male X chromosome...
  16. pmc X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila
    Gaelle Legube
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 20:871-83. 2006
    ..Our results, therefore, provide a comprehensive overview of MSL-1 binding and dosage-compensated status of X-linked genes and suggest a more global effect of MSL complex on X-chromosome regulation...
  17. ncbi request reprint A general precursor ion-like scanning mode on quadrupole-TOF instruments compatible with chromatographic separation
    Ricarda Niggeweg
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Proteomics 6:41-53. 2006
    ....
  18. pmc The epigenome network of excellence
    Asifa Akhtar
    European Molecular Biology Laboratory in Heidelberg, Germany
    PLoS Biol 3:e177. 2005
    ..An initiative funded by the European Union is building a collaborative network of established and younger research groups to tackle key questions in epigenetics...
  19. pmc Functional integration of the histone acetyltransferase MOF into the dosage compensation complex
    Violette Morales
    Adolf Butenandt Institut, Molekularbiologie, Munich, Germany
    EMBO J 23:2258-68. 2004
    ..Activation of MOF's HAT activity upon integration into the DCC may serve to restrict the critical histone modification to the male X chromosome...
  20. ncbi request reprint Structure of the chromo barrel domain from the MOF acetyltransferase
    Peter R Nielsen
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 280:32326-31. 2005
    ..This structural similarity suggests a probable evolutionary pathway from these other modules to the canonical chromo domains (or vice versa) with the chromo barrel domain representing an intermediate structure...
  21. pmc The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization
    Karim Bouazoune
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat, Schillerstrasse 44, D 80336 MUnchen, Germany
    EMBO J 21:2430-40. 2002
    ..Furthermore, we identify DNA binding as a novel chromodomain-associated activity...