R Erdmann

Summary

Country: Germany

Publications

  1. pmc Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor
    R Erdmann
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    J Cell Biol 135:111-21. 1996
  2. pmc Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p
    R Erdmann
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York 10021
    J Cell Biol 128:509-23. 1995
  3. ncbi Identification of a yeast peroxisomal member of the family of AMP-binding proteins
    F Blobel
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, USA
    Eur J Biochem 240:468-76. 1996
  4. ncbi Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p
    P Rehling
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093 0668, USA
    J Biol Chem 275:3593-602. 2000
  5. ncbi Identification of peroxisomal acyl-CoA thioesterases in yeast and humans
    J M Jones
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 274:9216-23. 1999
  6. ncbi Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11
    A Gurvitz
    Institut für Biochemie und Molekulare Zellbiologie der Universität Wien and Ludwig Boltzmann Forschungsstelle für Biochemie, Vienna Biocenter, Dr Bohrgasse 9, A 1030 Vienna, Austria
    J Biol Chem 276:31825-30. 2001
  7. pmc Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
    W Girzalsky
    Freie Universitat Berlin, Institut fur Biochemie, 12203 Berlin, Germany
    J Cell Biol 144:1151-62. 1999
  8. ncbi Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism
    B V Geisbrecht
    Department of Biological Chemistry, Department of Pediatrics, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland, 21205, USA
    Biochem Biophys Res Commun 260:28-34. 1999
  9. pmc Identification and characterization of the human orthologue of yeast Pex14p
    G K Will
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Mol Cell Biol 19:2265-77. 1999
  10. pmc Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins
    E H Hettema
    Department of Biochemistry, University of Amsterdam, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    EMBO J 19:223-33. 2000

Collaborators

Detail Information

Publications25

  1. pmc Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor
    R Erdmann
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    J Cell Biol 135:111-21. 1996
    ....
  2. pmc Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p
    R Erdmann
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York 10021
    J Cell Biol 128:509-23. 1995
    ..The growth defect of delta pmp27 cells on oleic acid appears to result from the inability to segregate the giant peroxisomes to daughter cells...
  3. ncbi Identification of a yeast peroxisomal member of the family of AMP-binding proteins
    F Blobel
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, USA
    Eur J Biochem 240:468-76. 1996
    ..Pcs60p belongs to the family of proteins which act via an ATP-dependent covalent binding of AMP to their substrates and shows the highest degree of similarity to the Escherichia coli long chain acyl-CoA synthetase...
  4. ncbi Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p
    P Rehling
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093 0668, USA
    J Biol Chem 275:3593-602. 2000
    ..In pex8Delta cells, the PTS1 and PTS2 receptor still associate with membrane bound components of the protein import machinery, supporting the assumption that the Pex8p function in protein translocation follows the docking event...
  5. ncbi Identification of peroxisomal acyl-CoA thioesterases in yeast and humans
    J M Jones
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 274:9216-23. 1999
    ..Instead, the observation that PTE1 contributes to growth on fatty acids implicates this thioesterase in fatty acid oxidation...
  6. ncbi Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11
    A Gurvitz
    Institut für Biochemie und Molekulare Zellbiologie der Universität Wien and Ludwig Boltzmann Forschungsstelle für Biochemie, Vienna Biocenter, Dr Bohrgasse 9, A 1030 Vienna, Austria
    J Biol Chem 276:31825-30. 2001
    ..We conclude that overlapping ORE and UAS1 elements in conjunction with their binding factors Pip2p-Oaf1p and Adr1p coordinate the carbon flux through beta-oxidation with peroxisome proliferation...
  7. pmc Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
    W Girzalsky
    Freie Universitat Berlin, Institut fur Biochemie, 12203 Berlin, Germany
    J Cell Biol 144:1151-62. 1999
    ..We also found Pex13p to be required for peroxisomal association of Pex14p, yet the SH3 domain of Pex13p may not provide the only binding site for Pex14p at the peroxisomal membrane...
  8. ncbi Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism
    B V Geisbrecht
    Department of Biological Chemistry, Department of Pediatrics, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland, 21205, USA
    Biochem Biophys Res Commun 260:28-34. 1999
    ..This result suggested that Yor180Cp might associate with Eci1p in vivo, and a Yor180Cp-Eci1p interaction was detected using the yeast two-hybrid system. Potential roles for Yor180Cp in peroxisomal fatty acid metabolism are discussed...
  9. pmc Identification and characterization of the human orthologue of yeast Pex14p
    G K Will
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Mol Cell Biol 19:2265-77. 1999
    ..The role of HsPex14p in mammalian peroxisome biogenesis makes HsPEX14 a candidate PBD gene for being responsible for an unrecognized complementation group of human peroxisome biogenesis disorders...
  10. pmc Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins
    E H Hettema
    Department of Biochemistry, University of Amsterdam, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    EMBO J 19:223-33. 2000
    ..Our results show that Pex3p and Pex19p are required for the proper localization of all PMPs tested, including Pex15p, whereas the other Pex proteins might only be required for targeting/import of matrix proteins...
  11. ncbi Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase
    B V Geisbrecht
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:33184-91. 1998
    ..We conclude that YLR284C encodes the yeast peroxisomal Delta3,Delta2-enoyl-CoA isomerase and propose a new name, ECI1, to reflect its enoyl-CoA isomerase activity...
  12. pmc Pex19p, a farnesylated protein essential for peroxisome biogenesis
    K Gotte
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, Germany
    Mol Cell Biol 18:616-28. 1998
    ..Farnesylation of Pex19p was shown to be essential for the proper function of the protein in peroxisome biogenesis. Pex19p was shown to interact with Pex3p in vivo, and this interaction required farnesylation of Pex19p...
  13. ncbi Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
    M Albertini
    Abteilung für Zellbiochemie, Ruhr Universitat Bochum, Germany
    Cell 89:83-92. 1997
    ..The data presented here are consistent with the idea of a common translocation machinery for both PTS-dependent protein import pathways in the peroxisomal membrane...
  14. pmc Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    EMBO J 20:5049-59. 2001
    ..The physiological role of Ant1p in S.cerevisiae is probably to transport cytoplasmic ATP into the peroxisomal lumen in exchange for AMP generated in the activation of fatty acids...
  15. pmc PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes
    M Marzioch
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, Germany
    EMBO J 13:4908-18. 1994
    ..However, in a thiolase-deficient mutant, Pas7p was entirely found in the cytoplasm. We suggest that Pas7p mediates the binding of thiolase to these organelles...
  16. ncbi The 2.8 A crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha beta alpha beta alpha structure constructed from two core domains of identical topology
    M Mathieu
    EMBL, Heidelberg, Germany
    Structure 2:797-808. 1994
    ....
  17. pmc Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae
    R Erdmann
    Institute of Physiological Chemistry, Ruhr University, Bochum, Federal Republic of Germany
    Proc Natl Acad Sci U S A 86:5419-23. 1989
    ..These pas mutants may provide useful tools for future studies on the molecular mechanisms involved in peroxisomal assembly...
  18. pmc Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression
    K U Fröhlich
    Physiologisch chemisches Institut der Universität Tübingen, Federal Republic of Germany
    J Cell Biol 114:443-53. 1991
    ..This similarity suggests that CDC48p participates in a cell cycle function related to that of N-ethylmaleimide-sensitive fusion protein/Sec18p in Golgi transport...
  19. ncbi PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases
    R Erdmann
    Abteilung für Zellbiochemie, Ruhr Universitat Bochum, Federal Republic of Germany
    Cell 64:499-510. 1991
    ..We suggest that these proteins are members of a novel family of putative ATPases and may be descendants of one common ancestor...
  20. ncbi Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product
    J K Hiltunen
    Abteilung für Zellbiochemie, Medizinische Fakultat, Ruhr Universitat Bochum, Federal Republic of Germany
    J Biol Chem 267:6646-53. 1992
    ..These results clearly demonstrate that the beta-oxidation of fatty acids in S. cerevisiae follows a previously unknown stereochemical course, namely it occurs via a D-3-hydroxyacyl-CoA intermediate...
  21. ncbi Protein translocation machineries of peroxisomes
    C Holroyd
    , , Thielallee 63, 14195, Berlin, Germany
    FEBS Lett 501:6-10. 2001
    ....
  22. ncbi Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum
    D Warnecke
    Universitat Hamburg, Institut fur Allgemeine Botanik, 22609 Hamburg, Germany
    J Biol Chem 274:13048-59. 1999
    ..These data prove that the cloned genes encode sterol-beta-D-glucosyltransferases and that sterol glucoside synthesis is an inherent feature of eukaryotic microorganisms...
  23. ncbi IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids
    B Henke
    Department of Physiological Chemistry, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Biol Chem 273:3702-11. 1998
    ..cerevisiae contain the enzyme equipment needed for the degradation of unsaturated fatty acids, including an NADP-dependent isocitrate dehydrogenase, a putative constituent of a peroxisomal NADPH-regenerating redox system...
  24. pmc A unified nomenclature for peroxisome biogenesis factors
    B Distel
    Department of Biochemistry, University of Amsterdam, The Netherlands
    J Cell Biol 135:1-3. 1996
  25. ncbi Peroxisome biogenesis
    J H Eckert
    Institut fur Physiologische Chemie, Medizinische Fakultat, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Rev Physiol Biochem Pharmacol 147:75-121. 2003
    ....